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윤탁 한국국제경제학회 2001 국제경제연구 Vol.7 No.3
필립스 곡선의 식에 명목이자율이 명시적으로 포함된다면 재정정책이 경기변동에 미치는 효과는 통화정책의 운용방식에 따라 달라질 수 있다. 기업의 자금조달제약이 존재할 때 그렇지 않은 경우와는 달리 필립스 곡선의 식에 명목이자율이 포함된다. 기업의 자금조달제약이 존재하는 경제에서 중앙은행이 인플레이션에 대하여 적극적으로 대응하는 이자율 준칙을 선택한다면 재정적자의 경기부양효과가 사라지고 오히려 경기위축이 초래될 수 있다. 그러나 소극적인 이자율 준칙에서는 재정적자의 경기부양효과와 인플레이션 효과가 나타난다. 또한 이와 같은 경제에서 인플레이션에 대하여 적극적인 통화정책이 실시될 때 재정흑자로 인한 물가상승률의 하향안정과 경기확대현상이 나타날 수도 있다.
윤탁,김흥태,한지윤,윤성진,김혜영,남병호,이진수 대한암학회 2016 Cancer Research and Treatment Vol.48 No.2
Purpose Paclitaxel (P) and gemcitabine (G) are clinically synergistic in small cell lung cancer (SCLC). We evaluated the efficacy of PG as a salvage treatment for SCLC patients whose disease progressed after a platinum-containing regimen. Materials and Methods Eligibility included histologically confirmed SCLC, one dimensionally measurable disease, Eastern Cooperative Oncology Group performance status 0-2, and progressive disease after platinum-based chemotherapy. Treatment consisted of P (80 mg/m2) and G (1,000 mg/m2) on days 1 and 8 of each cycle of 21 days until disease progression. Results Thirty-three patients seen between December 2005 and February 2009 were selected into this study. Thirty patients (91%) had received irinotecan-platinum, and three had received etoposide-platinum. Sixteen patients (49%) had a treatment-free interval of less than 3 months. The overall response rate was 30.3% (29.4% in sensitive relapse and 31.3% in refractory relapse). The median time to progression was 12.0 weeks and median overall survival (OS) 31.0 weeks, with a 1-year OS rate of 30.3%. Toxicities were moderate and manageable with 18.2% grade (G) 4 neutropenia, 24.2% G3 thrombocytopenia, 6.1% G3 sensory neuropathy, and 3% G3 asthenia. One patient developed febrile neutropenia. Conclusion Second-line paclitaxel and gemcitabine were well-tolerated and moderately active in SCLC patients previously treated with platinum-based chemotherapy.
갑상선 분화암에 대한 방사성요오드치료 후 발생한 급성 림프구성 백혈병 1예
윤탁,김대영,이근욱,김대희,윤성수,박선양,김병국 대한내과학회 2004 대한내과학회지 Vol.66 No.4
고형암의 치료와 관련되어 발생하는 이차백혈병의 예후는 불량한 것으로 알려져 있다. 저자들은 갑상선 유두암으로 진단 후 900 mCi의 방사성 요오드치료를 받은 환자에게 발생한 급성 림프구성 백혈병으로 동종조혈모세포이식을 시행하고 완전 관해 중인 환자 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. During the last decade the issue of therapy-related myelodysplasia (t-MDS) and acute myeloid leukemia (t-AML) following high-dose chemotherapy (HD-CT) and autologous stem cell transplantation (ASCT) or conventional chemotherapy, radiotherapy for malignant diseases has become increasingly important. The number of patients with hematologic malignancies and chemosensitive or radiosensitive solid tumors undergoing this new type of treatment has expanded dramatically. Recently, we experienced a case of 35-tear-old female patient with therapy-related acute lympho-blastic leukemia (t-ALL) after ^(131)I treatment for thyroid papillary carcinoma. Total ^(131)I dose the patient received was 900mCi and patient was diagnosed as having ALL 11 months after last ^(131)I treatment. Although the prognosis of therapy-related acute leukemia/myelodysplastic syndrome is poor, the patient is alive in complete remission after allogeneic bone marrow transplantation from HLA-matched sibling donor. Given the rarity of this case, we report the case with literature reviews.
윤탁,정도언,Youn, Tak,Jeong, Do-Un 대한수면의학회 2001 수면·정신생리 Vol.8 No.1
The change of sleep pattern is one of the most often altered normal physiological functions in elderly people. Besides normal change of sleep, insomnia and sleep apnea syndrome (SAS) are (one of) the main complaints. In addition, parasomnia is also frequent in this age group. Several parasomnias frequently found in the elderly are reviewed. Periodic limb movements in sleep (PLMS), restless legs syndrome (RLS), and REM sleep behavior disorder are the most frequent parasomnias in old age. Most parasomnias could be diagnosed by polysomnography, and be treated easily. Therefore, early and precise diagnosis and management for parasomnia in aging people are needed.
노인 기질성 정신장애 환자의 급성 정신증상에 대한 리스페달 사셰와 할로페리돌 근주의 효과 비교
윤탁,Youn, Tak 대한생물정신의학회 2007 생물정신의학 Vol.14 No.2
Objectives : The purpose of present study was to investigate the effect, safety and tolerability of risperdal sachet(oral solution) with lorazepam tablet versus intramuscular haloperidol and lorazepam injection for management of acute psychotic symptom in the elderly with organic mental disorder. Methods : Total 37 patients who have dementia, medical or physical diseases, associated with acute psychotic symptom were randomly assigned to oral treatment with 1mg of risperdal sachet(oral solution) plus 1mg of lorazepam(N=17) or to intramuscular treatment with 2.5mg of haloperidol plus 2mg of lorazepam (N=20). The change of CGI scores was used for the evaluation of efficacy. Results : Mean score improvements at 15, 30, 60, and 120 minutes after treatment were statistically significant at each time point in both groups(p<0.001) and were similar in both groups(p=0.189). Conclusion : A single oral dose of risperdal sachet(oral solution) plus lorazepam was as effective and tolerable as parenterally administered haloperidol plus lorazepam for the rapid control of acute psychotic symptom in the elderly with organic mental disorder.
정신분열병 환자에서 40Hz 뇌 사건관련전위에 관한 연구 : 분석 방법론적 측면
윤탁,박해정,강도형,김명선,김재진,권준수,Youn, Tak,Park, Hae-Jeong,Kang, Do-Hyung,Kim, Myung-Sun,Kim, Jae-Jin,Kwon, Jun Soo 대한생물정신의학회 2001 생물정신의학 Vol.8 No.2
Backgrounds : Gamma band oscillatory activity is considered to be related to cognitive functions and illustrates that the concept of event-related oscillations bridges the gap between single neurons and neural assemblies. An event-related gamma oscillation is the time-locked responses of specific frequency, and can be identified by computing the amplitude frequency characteristics of the averaged event-related potentials(ERPs) after stimulation. Objectives : We purposed to present experimental paradigm to investigate ${\gamma}$-band oscillation activities from the recording of ERPs by using auditory oddball paradigm and investigate the difference of ${\gamma}$-band activity between schizophrenia and normal controls. Methods : The ERPs resulting from auditory stimuli with oddball paradigm in a group of schizophrenics(n=11), and also a group of age-, sex-, and handedness matched normal controls, were recorded by 128 channel EEG. The ${\gamma}$-band oscillatory activities were calculated by using time-frequency wavelet decomposition of the signal between 20 and 80Hz. The ${\gamma}$-band oscillatory activities of both groups were compared by t-test. Results : The ${\gamma}$-band oscillatory of the leads Fz, Cz, and Pz of both groups were represented well in the time-frequency maps. Significant increases of the ${\gamma}$-band activity in normal controls compared with schizophrenics were observed around 160 msec, 350 msec, and 800 msec after stimulation. Conclusions : Our results suggested that the increment in ${\gamma}$-band oscillatory activity during cognitive operations and decreased ${\gamma}$-band activity in schizophrenics may be associated with the cognitive dysfunctions and the pathophysiology of the schizophrenia.