한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

9-12%Cr강의 첨가원소 및 열처리에 따른 미세조직거동과 경도변화

주성욱,유정훈,신기삼,허성강,이재현,석진익,김병훈,김정태 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-

9-12%Cr steel are getting increasing attention for expanded application as high temperature materials applicable for gas turbine compressors, steam turbine rotors, blade and casing. For efficient and extensive application of 9-12%Cr steel, the data in addition to the improvement of mechanical properties on the correlation of microstructural evolution and mechanical properties are inevitable and thus the investigation in this study is performed for the determination for the specimens heat-treated at 600, 650 and 700℃ for 1000, 3000 and 5000hrs. The microstructure of as-received specimen was tempered martensite, with a high dislocation density and secondary phases. Upon high temperature heat-treatment, the martensite lath got larger and dislocation density decreased resulting the reduction of the strength. In addition, sharp growth of secondary phases was observed in the specimen heat-treated at 700℃ for 5000hrs. A specimen aged at 600℃ and 650℃ Laves phase was observed. The hardness showed close relationship with the secondary phase particle and dislocation density.

Proteomic analyses reveal that ginsenoside Rg3(S) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin

Ik-Soon Jang,Eunbi Jo,Soo Jung Park,Su Jeong Baek,In-Hu Hwang,Hyun Mi Kang,Je-Ho Lee,권요셉,Junik Son,HO JEONG KWON,최종순 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.1

Background: The cellular senescence of primary cultured cells is an irreversible process characterized bygrowth arrest. Restoration of senescence by ginsenosides has not been explored so far. Rg3(S) treatmentmarkedly decreased senescence-associated b-galactosidase activity and intracellular reactive oxygenspecies levels in senescent human dermal fibroblasts (HDFs). However, the underlying mechanism of thiseffect of Rg3(S) on the senescent HDFs remains unknown. Methods: We performed a label-free quantitative proteomics to identify the altered proteins in Rg3(S)-treated senescent HDFs. Upregulated proteins induced by Rg3(S) were validated by real-time polymerasechain reaction and immunoblot analyses. Results: Finally, 157 human proteins were identified, and variable peroxiredoxin (PRDX) isotypes werehighly implicated by network analyses. Among them, the mitochondrial PRDX3 was transcriptionally andtranslationally increased in response to Rg3(S) treatment in senescent HDFs in a time-dependent manner. Conclusion: Our proteomic approach provides insights into the partial reversing effect of Rg3 on senescentHDFs through induction of antioxidant enzymes, particularly PRDX3.

Proteomic analyses reveal that ginsenoside Rg3(S) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin

Jang, Ik-Soon,Jo, Eunbi,Park, Soo Jung,Baek, Su Jeong,Hwang, In-Hu,Kang, Hyun Mi,Lee, Je-Ho,Kwon, Joseph,Son, Junik,Kwon, Ho Jeong,Choi, Jong-Soon The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.1

Background: The cellular senescence of primary cultured cells is an irreversible process characterized by growth arrest. Restoration of senescence by ginsenosides has not been explored so far. Rg3(S) treatment markedly decreased senescence-associated β-galactosidase activity and intracellular reactive oxygen species levels in senescent human dermal fibroblasts (HDFs). However, the underlying mechanism of this effect of Rg3(S) on the senescent HDFs remains unknown. Methods: We performed a label-free quantitative proteomics to identify the altered proteins in Rg3(S)-treated senescent HDFs. Upregulated proteins induced by Rg3(S) were validated by real-time polymerase chain reaction and immunoblot analyses. Results: Finally, 157 human proteins were identified, and variable peroxiredoxin (PRDX) isotypes were highly implicated by network analyses. Among them, the mitochondrial PRDX3 was transcriptionally and translationally increased in response to Rg3(S) treatment in senescent HDFs in a time-dependent manner. Conclusion: Our proteomic approach provides insights into the partial reversing effect of Rg3 on senescent HDFs through induction of antioxidant enzymes, particularly PRDX3.

Dependence of optical trapping efficiency on the beam radius-to-aperture radius ratio

Hyun Ik Kim,Cha Hwan Oh,In Je Joo,Kang Bin Im 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.43 No.I

Microparticles were optically trapped and manipulated by using optical tweezers. The optical trapping efficiency on a 5 $\mu$m-sized microsphere was measured as a function of the ratio of the beam radius-to-the aperture radius ($W_0 / R$). The optical trapping efficiency increased with the ratio of the beam radius-to-the aperture radius and became constant over the region $W_0 / R > 1.5$. We analyzed this behavior of the optical trapping efficiency by using the ray optics model. From the experimental results, we confirmed that the ratio could be a factor causing wide variability of the reported experimental data concerning force or efficiency measurements. Also, these results may be helpful in reducing the optical damage in trapping of biological cells.

고강도 유산소운동에 따른 청소년의 최대산소섭취량 성장 관련 호르몬 세로토닌과 작업기억의 관련성

강익원(Kang, Ik-Won),조원제(Cho, Won-Je) 한국체육과학회 2015 한국체육과학회지 Vol.24 No.1

The purpose of this study was to observe the relationship on maximal oxygen uptake, growth related hormone, serotonin and working memory by high-intensity aerobic exercise for 12weeks. The participants were male middle-school students who were divided into two groups; control group(n=8, non-exercise) and high-intensity aerobic exercise group(n=10) by treadmill 75 % VO₂max intensity did 12 weeks for 3 times a week. Also Measured was for performed in pre and post(after 12 weeks) same test by body composition, maximal oxygen uptake, blood sampling and working memory test. All data were analyzed descriptive statistics and one-way ANOVA for repeated measurement in case of significant within groups and interaction. Also after high-intensity aerobic exercise data influence analyzed with multiple regression analysis. Result was shown maximal oxygen uptake, GH, serotonin, working memory not significant within groups, however shown to difference significant in the period(p<.05), (p<.05), (p<.05), (p<.05). Especially interaction effect between groups and period was significant in maximal oxygen uptake, serotonin, working memory(p<.05), (p<.05), (p<.05). The correlation analysis from after high-intensity aerobic exercise between GH and testosterone were negative correlation(p<.01), between GH and maximal oxygen uptake were positive correlation(p<.01). And correlation analysis from after high-intensity aerobic exercise between working memory and serotonin(p<.05). Also predicted into positive influence from maximal oxygen uptake to GH, serotonin, working memory by after high-intensity aerobic exercise(p<.001), (p<.05), (p<.01). Thus, we known through this study result that positive influence for increasing maximal oxygen uptake on the GH, serotonin and working memory in adolescent male by 75%VO₂max of high-intensity aerobic exercise.

규칙적인 걷기운동 참여가 중년여성의 정신 건강 상태와 건강 관련 삶의 질에 미치는 영향

강익원(Kang, Ik-Won),조원제(Cho, Won-Je) 한국웰니스학회 2016 한국웰니스학회지 Vol.11 No.1

이 연구는 2013년 제 6기 1차년도 국민건강영양조사를 토대로 40-64세의 중년여성을 추출하여 걷기운동의 참여 유·무에 응답한 1,446명을 대상으로 실시하였다. 그 중 ‘전혀 하지 않음’으로 응답한 대상자 551명을 비운동 집단으로, ‘하루에 10분 이상 걷기운동을 3일 이상 한다.’라고 응답한 895명을 걷기운동 집단으로 구분하여 정신건강 상태와 건강관련 삶의 질의 차이를 관찰하였다. 그 결과 정신건강 하위요인인 스트레스 인지도와 우울감 여부에서 걷기운동 집단이 비운동집단에 비해 유의하게 낮은 것으로 나타났고, 건강관련 삶의 질 하위요인인 운동능력은 걷기운동 집단이 높았으며 불안/우울은 걷기운동 집단이 유의하게 낮은 것으로 나타났다. 따라서 노년을 준비하는 시기인 중년여성에게 주 3회 이상 규칙적인 걷기운동은 정신건강과 삶의 질을 개선하는 것으로 나타났다. This study was conducted with 1,446 women aged 40-64 years who responded to participation of the Walking exercise based on Korea National Health and Nutrition Examination Survey in 2013. In this study, 551 respondents who responded as ‘non exercise’ were classified in ‘control group’. The other 895 respondents who responded as ‘the walking exercise more than 10 minutes a day and more than three times a week’ were classified in ‘walking exercise group’. With those two groups analysis was conducted for finding differences between mental-health status and health-related quality of life. The result, there showed significantly lower walking exercise group than non-exercise group on stress perception and depression in mental-health status. Also there showed significantly higher walking exercise group than non-exercise group on activity ability and showed significantly lower anxiety/depression in health-related quality of life. Therefore, the regular walking exercise of three times a week to middle-aged women was shown improve in mental-health status and health-related quality of life.

Altered Thalamo-Cortical White Matter Connectivity: Probabilistic Tractography Study in Clinical-High Risk for Psychosis and First-Episode Psychosis

Cho, Kang Ik K.,Shenton, Martha E.,Kubicki, Marek,Jung, Wi Hoon,Lee, Tae Young,Yun, Je-Yeon,Kim, Sung Nyun,Kwon, Jun Soo Oxford University Press 2016 Schizophrenia bulletin Vol.42 No.3

<P>Disrupted thalamo-cortical connectivity is regarded as a core psychopathology in patients diagnosed with schizophrenia. However, whether the thalamo-cortical white matter connectivity is disrupted before the onset of psychosis is still unknown. To determine this gap in knowledge, the strength of thalamo-cortical white matter anatomical connectivity in subjects at clinical-high risk for psychosis (CHR) was compared to that of first-episode psychosis (FEP) and healthy controls. A total of 37 CHR, 21 FEP, and 37 matched healthy controls underwent diffusion-weighted magnetic resonance imaging to examine the number of probabilistic tractography 'counts' representing thalamo-cortical white matter connectivity. We also investigated the relationship with psychopathology. For FEP, the connectivity between the thalamus and parietal cortex was significantly increased (F = 5.65, P <.05) compared to that of healthy controls. However, the connectivity between thalamus and orbitofrontal cortex was significantly reduced compared to both healthy controls (F = 11.86, P <.005) and CHR (F = 6.63, P <.05). Interestingly, CHR exhibited a similar pattern as FEP, albeit with slightly reduced magnitude. Compared to healthy controls, there was a significant decrease (F = 4.16, P <.05) in CHR thalamo-orbitofrontal connectivity. Also, the strength of the thalamo-orbitofrontal connectivity was correlated with the Global Assessment of Functioning score in CHR (r =.35, P <.05). This observed pattern of white matter connectivity disruptions in FEP and in CHR suggests that this pattern of disconnectivity not only highlights the involvement of thalamus but also might be useful as an early biomarker for psychosis.</P>

저공해 고효율 석탄 연소시스템 개발과 실기 적용 사례

이익형(Ik-hyung Lee),송시홍(Si Hong Song),하종광(Jong-Kwong Ha),이건명(Gun-Myung Lee),김상현(Sang-Hyeun Kim),안상택(Sang Ta Ahn),김혁제(Hyuk-Je Kim),강병구(Byong-gu kang),김혁필(Hyeuk-Pill Kim) 대한기계학회 2003 대한기계학회 춘추학술대회 Vol.2003 No.11

저 NOx 미분탄 버너와 회전형 분리장치 미분기를 근간으로 하는 저공해 고효율 석탄 연소시스템의 기술적인 특징과 적용 사례를 소개하고자 한다. 저 NOx 미분탄 버너에는 특허를 취득한 미분탄 노즐과 유통 변수를 최적화한 air register가 장착되어 연소 중에 발생하는 fuel-NOx를 효과적으로 저감할 수 있다. 그리고 회전형 분리장치미분기애는 특허를 획득한 회전형 분리기가 장착되어 있으며, 회전형 분리기는 미분도를 향상시켜 회중 UBC의 감소 및 연소 안정화에 기여한다. 이러한 특징을 가지는 저 NOx 미분탄 버너와 회전형 분리장치 미분기를 HUVIS(주) 전주공장의 130ton/hr 보일러의 개보수공사에 적용하였다. 본 공사를 통해 회전형 미분기는 200mesh 85%이상의 미분도를 나타내었으며, 저 NOx 버너는 석탄 전소시 170ppm(@6% O2)의 NOx 배출량 특성을 나타내었다.

Dental complications associated with neonatal intubation in preterm infants

Kim, Ik-Hwan,Kang, Chung-Min,Song, Je Seon,Lee, Jae-Ho The Korean Dental Society of Anesthsiology 2019 Journal of Dental Anesthesia and Pain Medicine Vol.19 No.5

This paper describes the potential oral complications in preterm infants who have undergone orotracheal intubation. Neonatal intubation may have adverse effects on the developing deciduous teeth, oral soft tissues, and even the permanent teeth. However, endotracheal intubation may be essential for the survival of premature infants, owing to incomplete tracheal development. Excessive pressure to the oral tissue must be avoided, in cases where orotracheal intubation is inevitable. Moreover, the potential oral complications must be considered when neonatal intubation is performed for the patient's survival, and subsequent reevaluation and proper oral health care are needed.