Anticorit Prelube oils for sheet metal forming

A. LOSCH,F. KUBICKI 한국트라이볼로지학회 2004 한국트라이볼로지학회 학술대회 Vol.39 No.-

The pressing of car body parts is one of the most important sheet metal drawing processes. The corrosion protection oil applied by the steel mills plays a part in every sheet metal forming operation and also makes up the largest proportion of lubricants used. The idea to combine the corrosion protection properties of a corrosion preventive oil with the lubricity of a drawing oil lead to the development of the Anticorit prelubes. Applied at the finishing lines of the steel mills, they finally serve as lubricant in the press shops. A prerequisite for the suitability of a prelube-type oil is the absolute compatibility with all single processes from the coil to the Body in White. The use of prelubes in steel mills reduces the number and quantity of spot lubricants for additional press shop oiling dramatically. But their true benefits can only be fully achieved if the compatibility principle is applied throughout the manufacturing chain. Therefore, modem prelubes systems are modular, even different viscosities can be part of the same concept. This results in a far-reaching multi-functionality of the Anticorit prelube system for all applications.

Altered Thalamo-Cortical White Matter Connectivity: Probabilistic Tractography Study in Clinical-High Risk for Psychosis and First-Episode Psychosis

Cho, Kang Ik K.,Shenton, Martha E.,Kubicki, Marek,Jung, Wi Hoon,Lee, Tae Young,Yun, Je-Yeon,Kim, Sung Nyun,Kwon, Jun Soo Oxford University Press 2016 Schizophrenia bulletin Vol.42 No.3

<P>Disrupted thalamo-cortical connectivity is regarded as a core psychopathology in patients diagnosed with schizophrenia. However, whether the thalamo-cortical white matter connectivity is disrupted before the onset of psychosis is still unknown. To determine this gap in knowledge, the strength of thalamo-cortical white matter anatomical connectivity in subjects at clinical-high risk for psychosis (CHR) was compared to that of first-episode psychosis (FEP) and healthy controls. A total of 37 CHR, 21 FEP, and 37 matched healthy controls underwent diffusion-weighted magnetic resonance imaging to examine the number of probabilistic tractography 'counts' representing thalamo-cortical white matter connectivity. We also investigated the relationship with psychopathology. For FEP, the connectivity between the thalamus and parietal cortex was significantly increased (F = 5.65, P <.05) compared to that of healthy controls. However, the connectivity between thalamus and orbitofrontal cortex was significantly reduced compared to both healthy controls (F = 11.86, P <.005) and CHR (F = 6.63, P <.05). Interestingly, CHR exhibited a similar pattern as FEP, albeit with slightly reduced magnitude. Compared to healthy controls, there was a significant decrease (F = 4.16, P <.05) in CHR thalamo-orbitofrontal connectivity. Also, the strength of the thalamo-orbitofrontal connectivity was correlated with the Global Assessment of Functioning score in CHR (r =.35, P <.05). This observed pattern of white matter connectivity disruptions in FEP and in CHR suggests that this pattern of disconnectivity not only highlights the involvement of thalamus but also might be useful as an early biomarker for psychosis.</P>

Atomic-scale Speciation of Cadmium Occurring in Aggregates of Biogenic ZnS Nanoparticles in Wetlands

Soh-joung Yoon,Carolina Yanez,James Kubicki,Mary Ann Bruns,Carmen Enid Mart?nez 대한지질학회 2007 대한지질학회 학술대회 Vol.2007 No.

Abnormal asymmetry of white matter tracts between ventral posterior cingulate cortex and middle temporal gyrus in recent-onset schizophrenia

Joo, Sung Woo,Chon, Myong-Wuk,Rathi, Yogesh,Shenton, Martha E.,Kubicki, Marek,Lee, Jungsun Elsevier 2018 SCHIZOPHRENIA RESEARCH Vol.192 No.-

<P><B>Abstract</B></P> <P><B>Introduction</B></P> <P>Previous studies have reported abnormalities in the ventral posterior cingulate cortex (vPCC) and middle temporal gyrus (MTG) in schizophrenia patients. However, it remains unclear whether the white matter tracts connecting these structures are impaired in schizophrenia. Our study investigated the integrity of these white matter tracts (vPCC-MTG tract) and their asymmetry (left versus right side) in patients with recent onset schizophrenia.</P> <P><B>Method</B></P> <P>Forty-seven patients and 24 age-and sex-matched healthy controls were enrolled in this study. We extracted left and right vPCC-MTG tract on each side from T1W and diffusion MRI (dMRI) at 3T. We then calculated the asymmetry index of diffusion measures of vPCC-MTG tracts as well as volume and thickness of vPCC and MTG using the formula: 2×(right−left)/(right+left). We compared asymmetry indices between patients and controls and evaluated their correlations with the severity of psychiatric symptoms and cognition in patients using the Positive and Negative Syndrome Scale (PANSS), video-based social cognition scale (VISC) and the Wechsler Adult Intelligence Scale (WAIS-III).</P> <P><B>Results</B></P> <P>Asymmetry of fractional anisotropy (FA) and radial diffusivity (RD) in the vPCC-MTG tract, while present in healthy controls, was not evident in schizophrenia patients. Also, we observed that patients, not healthy controls, had a significant FA decrease and RD increase in the left vPCC-MTG tract. There was no significant association between the asymmetry indices of dMRI measures and IQ, VISC, or PANSS scores in schizophrenia.</P> <P><B>Conclusion</B></P> <P>Disruption of asymmetry of the vPCC-MTG tract in schizophrenia may contribute to the pathophysiology of schizophrenia.</P>

Increased diffusivity in gray matter in recent onset schizophrenia is associated with clinical symptoms and social cognition

Lee, J.S.,Kim, C.Y.,Joo, Y.H.,Newell, D.,Bouix, S.,Shenton, M.E.,Kubicki, M. ELSEVIER SCIENCE DIVISION 2016 SCHIZOPHRENIA RESEARCH Vol.176 No.2

Introduction: Diffusion weighted MRI (dMRI) is a method sensitive to pathological changes affecting tissue microstructure. Most dMRI studies in schizophrenia, however, have focused solely on white matter. There is a possibility, however, that subtle changes in diffusivity exist in gray matter (GM). Accordingly, we investigated diffusivity in GM in patients with recent onset schizophrenia. Methods: We enrolled 45 patients and 21 age and sex-matched healthy controls. All subjects were evaluated using the short form of the Wechsler Adult Intelligence Scale, the Positive and Negative Syndrome Scale (PANSS), and the video based social cognition scale. DMRI and T1W images were acquired on a 3 Tesla magnet, and mean Fractional Anisotropy (FA), Trace (TR) and volume were calculated for each of the 68 cortical GM Regions of Interest parcellated using FreeSurfer. Results: There was no significant difference of FA and GM volume between groups after Bonferroni correction. For the dMRI measures, however, patients evinced increased TR in the left bank of the superior temporal sulcus, the right inferior parietal, the right inferior temporal, and the right middle temporal gyri. In addition, higher TR in the right middle temporal gyrus and the right inferior temporal gyrus, respectively, was associated with decreased social function and higher PANSS score in patients with schizophrenia. Conclusion: This study demonstrates high sensitivity of dMRI to subtle pathology in GM in recent onset schizophrenia, as well as an association between increased diffusivity in temporal GM regions and abnormalities in social cognition and exacerbation of psychiatric symptoms.

Reduced fronto‐callosal fiber integrity in unmedicated OCD patients: A diffusion tractography study

Oh, Jungsu S.,Jang, Joon Hwan,Jung, Wi Hoon,Kang, Do‐,Hyung,Choi, Jung‐,Seok,Choi, Chi‐,Hoon,Kubicki, Marek,Shenton, Martha E.,Kwon, Jun Soo Wiley Subscription Services, Inc., A Wiley Company 2012 Human brain mapping Vol.33 No.10

<P><B>Abstract</B></P><P>It is widely accepted that abnormalities in the frontal area of the brain underpin the pathophysiology of obsessive‐compulsive disorder (OCD). Fundamental to this investigation is the delineation of frontal white matter tracts including dorsal and ventral frontal projections of interhemispheric connections. While previous investigations of OCD have examined the dorsal and ventral frontal regions, the corresponding callosal connections have not been investigated, despite their importance. We recruited twenty patients with OCD (15 drug‐naïve and 5 currently unmedicated) and demographically similar healthy controls, and conducted fiber tractography and <I>post hoc</I> quantitative analysis using diffusion tensor imaging. We extracted fractional anisotropy (FA) of the fronto‐callosal fibers along the entire length of the tract. Function‐specific [by the Brodmann area region‐of‐interest (ROI) approach] and region‐specific (by the length‐parameterization approach) tracts were defined. In addition, we devised a new index of dorsal‐ventral imbalance (DVII) of fiber integrity. Significant FA decreases were observed in orbitofrontal and dorsolateral prefrontal projections of the corpus callosum (<I>P</I> < 0.05, false discovery rate‐corrected) with higher function/region sensitivity than voxel‐based or ROI‐based approaches. Importantly, OCD patients also exhibited significantly higher ventral‐greater‐than‐dorsal asymmetry of FA values than normal controls (<I>P</I> < 0.05, FDR‐corrected). This study is the first to investigate fiber integrity in the dorsal/ventral frontal parts of the callosal tractography in unmedicated OCD patients. Using a more quantitative method in terms of functional and regional specificity than previous studies, we report abnormalities in interhemispheric connectivity of both dorsal and ventral networks in the pathophysiology of OCD. Hum Brain Mapp 33:2441–2452, 2012. © 2011 Wiley Periodicals, Inc.</P>

Abnormalities in brain white matter in adolescents with 22q11.2 deletion syndrome and psychotic symptoms

Kikinis, Zora,Cho, Kang Ik K.,Coman, Ioana L.,Radoeva, Petya D.,Bouix, Sylvain,Tang, Yingying,Eckbo, Ryan,Makris, Nikos,Kwon, Jun Soo,Kubicki, Marek,Antshel, Kevin M.,Fremont, Wanda,Shenton, Martha E. Springer-Verlag 2017 BRAIN IMAGING AND BEHAVIOR Vol.11 No.5

<P>Microstructural abnormalities in brain white matter are present in adolescent subjects with prodromal psychotic symptoms.</P>