위의 유암종과 선종의 병발 1례

장재식,강혁주,이중현,서영범,윤병구,김용섭,이구,서정일,양창헌,이창우,김정란,윤환중 東國大學校醫學硏究所 2000 東國醫學 Vol.7 No.-

유암종은 전신에 퍼져 잇는 장크롬친화성 세포에서 기원하는데 위의 유암종은 비교적 드문 질환으로 모든 유암종의 1.9~2.2%에 해당하며 위에 발생하는 종양의 1% 미만에서 보고되고 있다. 유암종은 일반적으로 증상이 비특이적이고 면역조직화학검사에 의해서 진단되기 때문에 과거에는 드물게 발견되었으나 최근 내시경 기기 및 술기의 발전과 검사 빈도의 증가 및 면역조직화학검사의 발달로 진단율이 증가 추세에 있으며, 드물지만 유암종에서 선암과 공존하는 예들이 보고되고 있다. 저자들은 심와부 동통을 주소로 내원한 70세 남자 환자의 상부위장관내시경 검사에서 위체상부의 대만곡에서 0.4×0.4 cm 크기의 중간 함몰을 가진 Yamada 1형의 용종과 함께 전정부의 전벽에서 0.8×0.5 cm 크기의 융기된 점막 소견을 보여 조직학적으로 각각 위유암종 및 위선종임을 확진한 후 내시경적 용종 절제술로 치료한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Carcinoid tumors are arisen from enterochromaffin cells, which are scattered throughout the body. These tumors are composed of variable numbers of cells that contain endocrine granules in their cytoplasm, which can be identified by immunohistochemistry and electron microscopy. Gastric carcinoid tumors are relatively rare tumor, the reported incidence being 1.9~2.2% of all carcinoid tumors and less than 1% of all gastric tumors. Sometimes, composite carcinoid tumors and adenocarcinoma is reported. We experienced a case of the coincidence of carcinoid tumor and adenoma at the other site of the stomach in a 70 year old male patient. Gastrofiberscope showed 0.4×0.4 cm sized Yamada type I polyp with central depression on the greater curvature of the proximal body and 0.8×0.5 cm sized focal slightly elevated mucosa on the anterior wall of the antrum. The endoscopic biopsy specimens revealed carcinoid tumor and tubular adenoma with moderate atypism, respectively. The carcinoid tumor and adenoma were removed by endoscopic polypectomy. According to the follow-up gastrofiberoscopy after 7 month later, both lesions were nearly normal mucosa except whitish atrophic change after polypectomy.

정책목표와 연계한 전략적 R&D 투자재원배분 및 연구과제 선정방안연구

서창교,박정우 한국경영과학회 1999 經營 科學 Vol.16 No.2

We propose a strategic R&D resource allocation and project selection model based on national R&D policy and objectives First, contributions to R&D policy and objectives for each R&D area are evaluated by using analytical hierarchy process (AHP) Second, fuzzy Delphi are proposed to estimate R&D budget for each R&D area Then, a project selection grid is also introduced to implement two-phased evaluation for R&D project selection We also discuss how to improve the consistency in AHP and how to reduce the pairwise comparison in AHP The proposed model enables the decision makers to allocate R&D budget, and to evaluate and select the R&D proposals based on both the contribution to national R&D policy and objectives, and the size of each R&D area concurrently

직접분사식 디젤기관에서 메탄올 혼합연료의 배기 배출물에 관한 연구

서정주,왕우경,김상암 여수대학교 2001 論文集 Vol.16 No.-

In this study, the fuel injection system of a DI diesel engine was modified slightly with installing two agitators and a F.O supply pump to use the methanol-blended fuel. The emission concentrations were compared with the case of diesel oil and the methanol-blended fuel in a DI diesel engine. The results are as follows : The concentrations of NOx and HC in exhaust emissions were lower than those of diesel oil as blending ratio of methanol increased, but the concentration of CO was higher slightly. As it was used the methanol-blended fuel of 10%∼20%, the exhaust emissions of NOx and HC were improved no significant difference of the engine performance in comparison with diesel oil. As the load was increased, the concentration of CO2 in exhaust emissions was high and that of O2 was low, and concentration of those in exhaust emissions was no significant difference among the fuels at constant loads.

Agrobacterium transformation 에 의해 Manganese SOD가 과발현된 transgenic tobacco의 개발에 대한 연구

徐廷彬,金榮照,李宇成 성균관대학교 기초과학연구소 1995 論文集 Vol.46 No.2

식물체는 냉해, 가뭄, air pollutants 등과 같은 다양한 외부 환경적인 스트레스에 노출되어짐으로써 매우 활동적인 oxygen radicals 생성을 유도한다. 이러한 활동적인 oxygen radicals 는 식물체 내의 수 많은 생리적 문제를 유발시킨다. 이러한 스트레스에 적응하고자 식물체 내에는 다양한 방어 기작이 있으며, 그 중 하나가 superoxide를 Hydrogen peroxide로 바꾸는 효소인 superoxide dismutase (SOD, EC 1.15.1.1)이다. 방어 기작에 있어서 SOD의 역할을 조사해 보고자, 본 실험에서는 담배의 엽록체에 완두의 manganese SOD를 과발현시킨 형질 전환 식물체를 개발하였다. Northern hybridization과 SOD activity gel staining을 해 본 결과, 이러한 형질 전환된 담배 엽록체 내에서 완두의 manganese SOD가 안정적으로 발현되고 있음을 확인할 수 있었다. Upon exposure of plant to diverse environmental stress such as chilling, drought, and air pollutants, the activated oxygen radicals are actively produced. These reactive oxygen species are associated with a number of physiological disorders in plant. One of the enzymes involved in the defense is superoxde dismutase (SOD, EC 1.15.1.1) which converts superoxide into hydrogen peroxide. To test the role of SOD in the defense system, We produce transgenic plants which are overexpressed Mn SOD of pea (Pisum sativum L.) in chloroplasts of tobacco (Nicotiana tabacum L. cv Xanthi). Using Northern hybridization and SOD activity gel staining, it was confirmed that these transgenic plants overexpressed the introduced gene.

고빌리루빈혈증을 동반한 자가면역성 간염 1례

서영범,김성욱,장재식,강혁주,이중현,윤병구,김욱년,이광헌,이구,유석동,양창헌,이정호,이영현,이창우,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

자가면역성 간염은 대개 만성 경과를 가지며, 혈중 자가면역항체와 혈청 글로불린치의 상승, 그리고 조직학적으로 괴사 염증성 변화를 특징으로 하는 질환으로 아직 정확한 병인이 밝혀져 있지 않은 상태이다. 발병연령은 대개 젊은 영자(15-25세)에서 호발한다. 이 질환은 급성 간염의 임상경과를 보일 수 있으나, 심한 급성 간염이나 전격성 간염으로도 나타날 수 있는데, 이 경우 아주 나쁜 예후를 보인다고 한다. 치료는 자가면역성 간염 임상 경과의 다양성이나 병인, 병리기전의 불확실성에도 불구하고 대개 steroid 치료에 반응하는 것으로 알려져 있으며 대개 80%의 관해율을 나타내며 궁극적으로 간경변으로의 진행을 막을 수 있는 것으로 보인다. 저자들은 58세 남자에서 발생한 급성의 경과를 가지고 심한 황달을 동반한 자가면역성 간염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level. The age of onset of AIH show a peak between the age of 15 and 25 years. AIH can develop and be manifested as acute hepatitis, but severe form of acute hepatitis or fulminant hepatic failure has a poor prognosis. Although AIH is likely to progress from chronic active hepatitis to cirrhosis, steroid therapy can control the disease activity, prolong survival, improve the quality of life , and defer liver transplantation. In the present report we describe a 58-year-old man who admitted because of progressive jaundice and fatigue. He was diagnosed with AIH from laboratory test result showing positivity for antinuclear antibodies, anti-smooth muscle antibodies, and negativity for hepatitis viral markers and from liver biopsy. Steroid therapy, oral administration of prednisolone, was effective in improving the liver function test. Following liver biopsy 6 months after onset shows markedly improved necroinflammatory activity.

Water glass로부터 ZSM-5의 합성

우훈희,홍지숙,서정권,이관영,이정민 한국공업화학회 2002 응용화학 Vol.6 No.2

In order to seek optimum conditions for ZSM-5 formation in the absence of organic template,the effects of both starting composition and water glass as silica source were examined. Water glass was most inexpensive among silica sources, but this was difficulty in reactant control because of contained much alkali ingredient, Considering environmental problem and economic performance,chose alkali drawing-out method to use methanol newly to remove alkali ingredient of waterglass. Characterization of ZSM-5 was carried out by means of XRD, SEM.

사망진단서(사체검안서) 상의 선행사인으로부터 사망통계의 원사인이 선정되는 비율 : 3개 대학병원에서 교부된 사망진단서를 중심으로

박우성,박석건,정철원,김우철,탁우택,김부연,서순원,김광환,서진숙,부유경 한국의료QA학회 2004 한국의료질향상학회지 Vol.11 No.1

Background : To exatnine the problems intolved in writing practice of death certificates, we cotnpated the determination of underlying cause of death for wital statistics using recorded underlying cause of death in issued death statistics. Methods : We collected 688 rnortality certificates issue in year of 2,000 from 3 university hospitals. And we also collected vital statistics from ministry of statistics. The causes of death were coded by experienced medical record wpecialists. And causes of death determined at ministry of statistics for national vita statistics were mapped to causes of death recorded at each death certificates. The rate that underlying causes of death for vital statistics were derived from underlying causes of death recorded at issued death certificaties sere analysed. Results : 64.5% of underlying cause of death for could be derived from underlying cause of death recorded at issued death certificates, 8.6% derived from intermediate cause of death, and 3.9% derived from direct cause of death. In 23% of cases, underlying cause of death could not be derived using issued death certificates. The rate that underlying cause of death for vital statistics could be derived from underlying cause of death recorded at death certificates was different between 3 university hospitals. Ane the rate was also different between death certificates and postmortem certificates. We classified the causes of death using 21 major categories. The rate was different between diseases or conditions tha caused death too. Conclusion : When we examined the correctness of death certificate writing practice using abpve methods, cortectness of writing could not be told as satisfactory. There was difference in correctness of writing between hospotals, between death certificates and postmortem certificates, and between diseases and conditions that caused death. With this results, we suggested some strategy to improve the correctness of death certificate writing practice.

정용 봄베를 이용한 단일 영역 연소 모델에 관한 연구

왕우경,서정주 여수대학교 1998 論文集 Vol.13 No.2

Combustion experiments were performed with fuel oils and injection rates in a constant volume combustion bomb simplified influences of combustion. Empirical coefficients of equations based on single zone model have been obtained by analysis of experimental data. The calculation results of single zone model showed similar trends comparing with the experimental data. But, it is necessary to examine exactly that the chemical characteristics of fuel oils have an effect of the beginning of the burning period. This combustion simulation program and empirical coefficients can be applied usefully to predict the combustion characteristics.

Triamcinolone Acetonide가 배양 켈로이드 섬유아세포의 G1 세포주기 관련 유전자 발현에 미치는 영향

설정현,우상현,백원기,서성일,서민호 大韓成形外科學會 1998 Archives of Plastic Surgery Vol.25 No.2

The effect of triamcinolone acetonide(TA) on the expression of Gl related genes was investigated the cultured keloid fibroblast. The addition of TA to the culture medium resulted in growth inhibition of keloid fibroblast. TA reduced the expression of cyclin A, B, E and cyclin dependent kinase(CDK) 2 mRNA, but unexpectedly, the expression of cyclin C, Dl and CDK4 mRAN was not affected significantly as compared with those of normal fibroblast. Expressions of p16, p21 and p27, the wellestabilished CDK-inhibitors, were also investigated. The level of p16 was not detected in both normal and keloid fibroblasts and the expression of p27 was significantly decreased in keloid fibroblast. The expression of p21 was dramatically increased in keloid fibroblast but not significantly changed in normal fibroblast. Also the expressions of p53 and pRb, the well known tumor suppressor genes, were increased by the addition of TA. These data suggested that the observed growth inhibitory effect of TA may be related to transcriptional inactivation of cyclin A, B, E and CDK2 and to the transcriptional activation of p21, but the mechanisms of unchanged expression of cyclin C, Dl and CDK4 mRNA remain to be elucidated.

디젤기관의 경유-메탄올 혼합유 사용에 관한 실험적 조사

왕우경,서정주 여수대학교 2001 論文集 Vol.16 No.-

The combustion and performance of diesel engines fueled with alcohol-diesel oil have been investigated because of its potential for low NOx and particulates emissions. One of the problems encountered in the use of alcohol-diesel oil blended fuel is the phase separation between two fuels. In this study, diesel oil and methanol were mixed compulsorily in preventing phase separation with installing agitators and a fuel oil boost pump on fuel oil line of test engine. The effects of diesel oil-methanol blended fuel on combustion characteristics and engine performance were investigated under various loads and blending ratio. The results showed that the engine performance and combustion characteristics were influenced by methanol blending ratio and variation of load. Especially, the result of 30% methanol blended fuel was different from those of other test fuels.