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Bak Su-Bin,Choi Hansol,Kim Gyoung-Deuck,Kim Ju Gyeong,Kwon Da-Ae,Kim Ha-Young,Son Dong-Won,Jeong Jang-Hun,Lee Byung-Woo,An Hyo-Jin,Lee Hak Sung 한국독성학회 2024 Toxicological Research Vol.40 No.2
HemoHIM G is a functional food ingredient composed of a triple herbal combination of Angelica sinensis, Ligusticum chuanxiong, and Paeonia lactiflora, to improve impaired immune function. Considering the pharmacological benefits of its constituent herbal components, HemoHIM G is anticipated to have various health benefits; however, its toxicity has not been thoroughly evaluated. Here, we conducted a comprehensive study to assess the safety of HemoHIM G in terms of acute oral toxicity, 13-week repeat-dose toxicity, and genotoxicity. In the oral acute toxicity study, Sprague–Dawley rats were orally administered a single dose of HemoHIM G at 5000 mg/kg/day, the limit dose for the acute study. No abnormal findings or adverse effects were observed in this study, as confirmed by gross pathology. A 13-week repeated-dose toxicity study was conducted with HemoHIM G at doses of 1250, 2500, and 5000 mg/kg/day to examine the subchronic toxicity in both male and female rats after 28 days of dose-range finding study. No test substance-related clinical signs or mortality was observed at any of the tested doses. Gross pathology, hematology, blood chemistry, and histopathology were within normal ranges, further supporting the safety of HemoHIM G. Therefore, the NOAEL of HemoHIM G was considered to be at 5000 mg/kg/ day for both sexes of rats. Bacterial reverse mutation tests, a chromosome aberration test in human peripheral blood lymphocytes, and a mouse micronuclei test were conducted to identify the potential genotoxicity of HemoHIM G. HemoHIM G is non-mutagenic and non-clastogenic. Collectively, these findings provide valuable evidence for the safe use of HemoHIM G as a functional food ingredient.
BAK, HANA,LEE, HYUN JU,CHANG, SUNG-EUN,CHOI, JEE-HO,KIM, MYEUNG NAM,KIM, BEOM JOON Blackwell Publishing Inc 2009 Dermatologic surgery Vol.35 No.8
<P>BACKGROUND</P><P>Characteristic clinical features of melasma are symmetry of hyperpigmentation and distribution related to trigeminal nerves, which suggest that the neural involvement could play a part in the pathogenic mechanisms of pigmentation.</P><P>OBJECTIVE</P><P>To evaluate whether some neuropeptides and neurotrophins and their receptors were associated with the pathogenesis of melasma.</P><P>METHODS</P><P>To investigate the involvement of neuronal system and neuropeptides in melasma, we examined the expression of nerve growth factor receptor (NGFR) and neural endopeptidase (NEP) in melasma lesional and nonlesional skin. Skin biopsies were obtained from lesional and nonlesional facial skin of six Korean women with melasma. Confocal laser scanning microscopic examination and western blot were performed.</P><P>RESULTS</P><P>Melasma lesions showed markedly greater expression of NGFR and NEP than nonlesional skin.</P><P>CONCLUSION</P><P>We suggest that neuroactive molecules, including NGF, is one of the critical factors for the pathogenesis of melasma, which may directly affect the microenvironment around melanocytes through a NGFR immunoreactivity (NGFR-IR) nerve fiber pathway, and higher levels of NEP in melasma has an important role in regulation of melanogenesis.</P>
Ahn, Sang Jung,Bak, Hye Jin,Park, Ju Hyeon,Lee, Jin Young,Kim, Na Young,Han, Jin Woo,Jo, Hyae In,Chung, Joon Ki,Lee, Hyung Ho Humana Press 2013 Applied biochemistry and biotechnology Vol.170 No.5
<P>Cystatins are endogenous inhibitors of mammalian lysosomal cysteine proteinases, such as cathepsins B, L, H, and S. Cystatin C belongs to the type 2 cystatin family. In this study, the 751-bp cystatin C cDNA (PoCystatin C) of olive flounder (Paralichthys olivaceus) was cloned by screening from the olive flounder cDNA library. The mRNA expression of the PoCystatin C gene was examined in various tissues from normal and lipopolysaccharide (LPS)-stimulated olive flounder by RT-PCR and was compared with inflammatory cytokines IL-1β, IL-6, and IL-8. PoCystatin C transcripts ubiquitously existed in all normal and LPS-stimulated tissues that were tested. The recombinant PoCystatin C protein was expressed in Escherichia coli BL21(DE3) in pCold TF DNA expression vector as a 70-kDa fusion protein. The protease inhibitory activities of recombinant PoCystatin C toward papain cysteine protease, piscine cathepsins (L, S, K, F, and X), and bovine cathepsin B were measured with the synthetic fluorogenic peptide substrates. PoCystatin C tightly inhibited papain cysteine protease, whereas cathepsins L, S, K, F, X, and B were inhibited with lower affinities. Our results indicate that the P. olivaceus cystatin C is a homolog of mammalian cystatin C due to its sequence, structure, tissue expression, and biochemical activity.</P>
A clinical study on the trocar-guided mesh repair system for pelvic organ prolapse surgery
( Seul Gi Bak ),( Jeong Beom Moon ),( Sang Ki Hong ),( Kyoung Jin Kim ),( Kyoung A Kim ),( Ju Hyang Lee ) 대한산부인과학회 2016 Obstetrics & Gynecology Science Vol.59 No.3
Objective To evaluate the complication and recurrence rates in patients undergoing trocar-guided mesh implant for pelvic organ prolapse (POP) treatment. Methods A retrospective study was performed based on the medical records of patients who had undergone mesh implant by one surgeon from May 2006 to August 2013 at the Presbyterian Medical Center in Korea. We evaluated perioperative complications such as bladder injury, mesh exposure, urinary symptoms, infections, and chronic pelvic pain. Recurrence was defined as a POP-quantification system stage ≥II or any symptomatic prolapse. Results Sixty-seven patients were evaluated, and the mean age of patients was 65.4±7.2 years. Stage ≥III POP-quantification Ba was noted in 61 patients (91%). Intraoperative complications included three cases of bladder injury (4.5%). The mean follow-up period was 44.1±7.9 months. Postoperative complications occurred in seven women (10.5%): four cases of urinary symptoms (6%), two cases of infections (3%), and one case of chronic pelvic pain (1.5%). Mesh exposure did not occur (0%). Prolapse recurrence was reported in five patients (7.5%). Conclusion Based on our operational result, the trocar-guided mesh implant seems to provide safe and effective outcomes.
( Yoon Suk Bak ),( Hye Ran Kang ),( Young Kwan Cho ),( Young Sook Park ),( Seong Hwan Kim ),( Yun Ju Jo ),( Byung Kwan Son ),( Sang Bong Ahn ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Backgrounds: Primary intestinal lymphangiectasia (PIL) is a rare disease resulting by lymph leakage into the small bowel lumen. Less than 200 PIL cases have been reported globally after 1961. As lymphatic fi uid contains a lot of protein, fat, and lymphocytes, leakage of lymph will cause hypoproteinemia, hypoalbuminemia, hypogammaglobulinemia, and lymphocytopenia. 2 The most common symptoms of patients with PIL are intermittent diarrhea, nausea, and vomiting. Peripheral edema by protein-losing enteropathy, chylous ascites and chylous pleural effusion are often presented. 3 The diagnosis of PIL should exclude the secondary intestinal lymphangiectasia and be confi rmed by pathlogic fi nding from enteroscopic biopsy or surgical resection. Aims: Our purpose is to investigate the clinical characteristics of PIL, the process of distinguish the PIL from secondary intestinal lymphangiectasia and pathologic confi rmation from enteroscopic biopsy. Case report : A 73-year-old male was admitted for endoscopic submucosal dissection of gastric adenoma without any complaining symptom. In the contrast-enhanced abdominal CT, there are nodularity of inner layer with mucosal enhancement of gastric antrum, and large amount ascites without other clue of malignancy, pancreatitis or cirrhosis. In the peritoneal analysis, the fi uid was chylous ascites and negative result for infi ammation, infection and malignancy using neutrophil count, bacterial culture and cytology. By enteroscopic biopsy, lymphangiectasia was comfirmed. Based on these results, low-fat and medium-chain triglyceride diet started. Discussion : We presented a case of patient with chylous ascites accidentally detected. After exclusion of secondary cause, we confi rmed the PIL by enteroscopic biopsy. We reported a rare intestinal disease in adults.