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Bak Su-Bin,Choi Hansol,Kim Gyoung-Deuck,Kim Ju Gyeong,Kwon Da-Ae,Kim Ha-Young,Son Dong-Won,Jeong Jang-Hun,Lee Byung-Woo,An Hyo-Jin,Lee Hak Sung 한국독성학회 2024 Toxicological Research Vol.40 No.2
HemoHIM G is a functional food ingredient composed of a triple herbal combination of Angelica sinensis, Ligusticum chuanxiong, and Paeonia lactiflora, to improve impaired immune function. Considering the pharmacological benefits of its constituent herbal components, HemoHIM G is anticipated to have various health benefits; however, its toxicity has not been thoroughly evaluated. Here, we conducted a comprehensive study to assess the safety of HemoHIM G in terms of acute oral toxicity, 13-week repeat-dose toxicity, and genotoxicity. In the oral acute toxicity study, Sprague–Dawley rats were orally administered a single dose of HemoHIM G at 5000 mg/kg/day, the limit dose for the acute study. No abnormal findings or adverse effects were observed in this study, as confirmed by gross pathology. A 13-week repeated-dose toxicity study was conducted with HemoHIM G at doses of 1250, 2500, and 5000 mg/kg/day to examine the subchronic toxicity in both male and female rats after 28 days of dose-range finding study. No test substance-related clinical signs or mortality was observed at any of the tested doses. Gross pathology, hematology, blood chemistry, and histopathology were within normal ranges, further supporting the safety of HemoHIM G. Therefore, the NOAEL of HemoHIM G was considered to be at 5000 mg/kg/ day for both sexes of rats. Bacterial reverse mutation tests, a chromosome aberration test in human peripheral blood lymphocytes, and a mouse micronuclei test were conducted to identify the potential genotoxicity of HemoHIM G. HemoHIM G is non-mutagenic and non-clastogenic. Collectively, these findings provide valuable evidence for the safe use of HemoHIM G as a functional food ingredient.
Adding effects of corncob and cottonseed meal for the sawdust cultivation of Lentinula edodes
Sung-Ryul Ryu,Won-Chull Bak,Kang-Hyeon Ka,Bong-Hun Lee 한국버섯학회 2008 한국버섯학회지 Vol.6 No.2
For diversification of materials for sawdust cultivation of Lentinula edodes, this study was carried out to examine adding effects of corncob and cottonseed meal on sawdust cultivation. All treatments of corncob except 100% corncob have produced fruiting-bodies. Mushroom productivity of the fungus was decreased from 174g to 45g per 2kg sawdust-based substrate in proportion to increasing corncob contents in sawdust cultivation. Meanwhile, in treatments including less than 20% cottonseed meal, the mycelial growth of the fungus was similar to control. But, the other treatments were not suitable for the mycelial growth of fungus on sawdust-based substrate. All treatments of cottonseed meal did not produce the fruiting-body of the fungus.
Altered epidermal lipid layers induced by long‐term exposure to suberythemal‐dose ultraviolet
Bak, Hana,Hong, Seung‐,phil,Jeong, Se‐,Kyoo,Choi, Eung‐,Ho,Lee, Sang E.,Lee, Seung‐,Hun,Ahn, Sung‐,Ku Blackwell Publishing Ltd 2011 International journal of dermatology Vol.50 No.7
<P><B>Abstract</B></P><P><B>Background </B> Although several studies have reported on the biological effects of ultraviolet (UV) radiation, there have been only a few reports on the changes in epidermal lipids following long‐term UV irradiation at suberythemal dose (SED), to which people are usually exposed during their lifetime.</P><P><B>Objectives </B> To investigate the changes of epidermal lipid properties after long‐term UV radiation with SED.</P><P><B>Materials and methods </B> Hairless mice were irradiated three times weekly for 15 weeks at an SED of UV (UVB: 20 mJ/cm<SUP>2</SUP>; UVA: 14 J/cm<SUP>2</SUP>). Every three weeks, transepidermal water loss (TEWL) was measured by a Tewameter. The morphological alterations of stratum corneum (SC) lipid lamellae were examined by electron microscopy (EM). Activities of three key enzymes for mRNA of serine palmitoyl transferase, fatty acid synthase, and HMG CoA reductase were analyzed with real time reverse transcriptase‐polymerase chain reaction. We also measured the amount of ceramide, cholesterol sulfate, and free fatty acid in the SC by high‐performance thin‐layer chromatography with exposed times.</P><P><B>Results </B> The SED UV‐irradiated group showed increased TEWL after 12 weeks. Following the irradiation period, EM revealed incomplete and separated lamellae at SC intercellular space. mRNA of three key enzymes was increased until six weeks of UV irradiation and decreased thereafter. However, three major lipid amounts gradually decreased throughout the exposed period, with a notable decrease in ceramide.</P><P><B>Conclusions </B> Long‐term UV irradiation even with SED influences skin barrier function and structure with prominent ceramide decrease in SC intercellular lipid.</P>
정헌영(Hun Young Jung),이상용,백은상(Bak, Eun-Sang) 대한교통학회 2003 대한교통학회 학술대회지 Vol.44 No.-
현재 우리나라에서는 정보화 사회가 상당히 진전됨으로 인하여, 소비자들의 요구가 다양화 및 고급화 그리고 개성화되어 가고 있다. 이에 따라 소품종 대량 생산체계에서 다품종 소량 생산체제로 변화하였으며, 그 결과 화물수송의 적재효율이 저하하고 수송빈도가 증가하고 있다. 또한, 이러한 수송시스템을 지원할 수 있는 시설의 부족으로 인하여, 다양한 사회적 문제가 발생하고 있다. 이를 해결하기 위해서는, 물류거점의 정비를 포함하여 다양한 종합적인 대책이 필요하다고 본다.
정헌영(Hun Young Jung),백은상(Bak, Eun-Sang),서민관 대한교통학회 1998 대한교통학회 학술대회지 Vol.34 No.-
사람들은 나이가 들어감에 따라 건강상태와 신체적 기능이 쇠퇴한다. 그래서 대부분의 고령자들은 이동이 제한되고, 교통시스템의 이용에 어려움을 겪게된다. 본 연구는 60세 이상의 고령자를 대상으로 횡단보도, 육교와 같은 횡단시설의 이용에 대한 고령자들의 교통특성을 분석하는 것을 목적으로 하고 있다. 이를 위해서 본 연구에서는 실태조사와 설문조사를 행하여 고령자틀의 횡단보도, 육교 등의 횡단시설의 이용현황을 파악하였다. 또한, 고령자들의 연령, 성별, 건강상태, 보행능력, 계단승하강능력 등의 개인속성들 사이의 관련성을 분석하였다. 분석결과, 고령자틀의 횡단시설이용이 그들의 건강상태와 신체적 기능의 장애로 인해 매우 제한된다는 것을 보여주고 있어, 고령자의 신체기능 및 교통수단이용특성을 고려한 교통시설의 정비 및 확충이 필요함을 알 수 있었다.
한국인에서의 갑상선결절과 갑상선암의 유병률: 2004년 전국 규모 갑상선 초음파 진단 결과 분석
김성헌 ( Sung-hun Kim ),정소령 ( So-lyung Jung ),문원진 ( Won-jin Moon ),박만수 ( Man-su Park ),김용선 ( Yong-sun Kim ),이희중 ( Hee-jung Lee ),김현숙 ( Hyun-suk Kim ),이영흔 ( Young-hun Lee ),백정환 ( Jung-hwan Bak ),김형진 ( Hyu 대한갑상선학회 2009 International Journal of Thyroidology Vol.2 No.1
Background and Objectives: To examine the prevalence of thyroid nodules and cancers in Korea and to evaluate the role of the radiologists in sonography of the thyroid nodule. Materials and Methods: 6351 persons, who underwent the thyroid sonographic examination at 10 university and general hospitals in 2004, were included. The number and size of thyroid nodules and pathologic results of fine needle aspiration cytology (FNAC) and operation were retrospectively evaluated. Results: Incidence of thyroid nodules was 75.4 (4787/6351)% and that of the thyroid cancer was 8.3 (531/6351)%. Thyroid nodules were detected in 1,532 (59.0%) and thyroid cancer was confirmed in 3% (male 2.1%, female 3.4%) by screening examination in medical health center. Outpatients with thyroid nodules were 3,255 (86.2%) and the incidence of thyroid cancers was 11.8% (male 14.6, female 11.3%). Conclusion: The prevalence of thyroid nodules detected on sonography was 75.4% and there is no significant difference between male and female. The incidence of thyroid cancer in male and female was also similar at the medial health center and out-patient center. Radiologists played an important role in evaluating thyroid nodules and performing FNAC to detect the thyroid cancer.