배추(Brassica campestris L. var. pekinensis Makino)의 cDNA library 구축 및 상동성 비교

안주미,권오병,전봉균,이풍연,이정민,권무식 성균관대학교 생명과학자원연구소 1995 生命資源科學硏究 Vol.2 No.1

Expressed sequence tag(EST) has a good value to discover a new gene or to study its structure. Some 20 ESTs were generated to obtain new genetic resources of chinese cabbage(Brassian campestris L. var. pekinensis Makino). Poly A+ RNAs were isolated from 10-day-old seedlings grown at 25℃ under the day light. cDNA gene bank was constructed using λ ZAP /cDNA synthesis /Giga Pack Gold Packing kit. About a million clones were able to obtain from the library. All the clones examined so far had insert DNAs. Nucleotide compositions of randomly selected clones were determined by the Sanger mthod. The DNA sequences were compared with those deposited in the GenePept and GenBank database to figure out nucleotide homologies. Two ESTs showed significant similarities to the enlisted sequences. They are chloroplast GADPH subunit of Arabidopsis thaliana and carbonic anhydrase of A. thaliana. The full DNA sequences of the two clones are being determined. The cDNA gene bank constructed. in this experiment will being used to isolate more genes induced by the light in the plant.

방사선 치료를 받는 암 환자들의 사회적 지지와 삶의 질과의 관계

정주희,류소연,윤혜은,남택근,오윤경,안현옥,박계남,이영선 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Objective : This study was performed to investigate the relationship between social support and quality of life among cancer patients receiving radiation therapy. Matehals and Methods : The data were collected from 98 patients, who were receiving radiation therapy at two university hospitals located in GwangUJu, used by structured questionnaire. For statistical analyses of the association between quality of life and various characteristics, data were analyzed using t-test, ANOVA, Pearson 's correlation, and multiple regression analysis. Results: 1. There were 56(57.1%) males and 42(42.9%) females. Age ranged from 21 to 82 years. The primary sites of cancer were gastrointestinal tract (24.5%), lung (23.5%), breast (21.4%), and head and neck (11.2%) in order. 2. The mean scores of social, family, and medical support were 4.30 0.58, 4.49 0.78, 4.11 0.65, respectively. The score of quality of life was 5.83 1.63 (range: 1.95 ~ 9.05). 3. An analysis of the association between several factors of patients and quality of life showed that the statistically significant factors were age, the presence of distant metastasis, family support, medical support and social support. 4. As a result of the multiple regression analysis, only social support was significant (β=0.932, P=0.02) with quality of life, but age and presence of distant metastasis were not significant. Conclusion : This suggests that quality of life in cancer patients could be improved by strengthening the social support which consists of family and medical support. Further study would be necessary to evaluate separately several aspects of quality of life among cancer patients.

Fluoroacetate(Platol)중독 증상 연구 : 자살기도자를 중심으로

한창환,황주연,김경식,안석철 大韓神經精神醫學會 1984 신경정신의학 Vol.23 No.1

This study was designed to evaluate the clinical problems of fluoroacetate intoxication. The total number of the fluoroacetate intoxication patients who came to the emergency room of Han Gang Sacred Heart Hospital from Jan. 1, 1983 to Aug. 31, 1983 were 96 cases. Among them, 41 attempters who were consulted to the psychiatrist were evaluated and observed in detail. The following results were obtained. 1. The rodenticide poisoning accounts for 37.2% of all toxic substance intoxication(total 266 cases) at Han Gang Sacred Heart Hospital from Jan. 1983 to Aug. 1983. Among them, 96 cases(36.1%) of fluorcacetate intoxication were observed. 2. Female was affected 2.4 times more frequently than male. 35.5% of total cases belonged to age group 21∼30years, when incidence was most prevalent 3. As the route of drug obtainment, supplement were commonest(63.3%), purchase in 29.4%. 4. CNS disturbances such as drowsiness, stupor, semicoma and irritability were observed in 75.6% of the cases. Speech disturbances such as dysarthria, childish speech was observed in 9.8%of the cases. Convulsion(29.3%), tremor(12.2%) spasm and twitching(4.9%) were also frequently observed. Tachycardia was found in 43.8% of the cases and other frequent symptoms were nausea and vomiting(53.7%), abdominal pain(34.2%), mild or high fever(26.8%). Lower calcium(below 9mg) was found in 29.3% of the cases and lower potassium(below 3.5mEq) was found in 22.0% of the cases. EKG findings revealed QT prolongation(22.0%), ST-T change(22.0%) and u-wave, RBBB, and PVC(14.6%). 5. 92 cases(95.8%) recovered without sequelae and 4 cases(4.2%) expired.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

RNN-based Models for Effective Prediction of Crop Growth based on Environmental Factors

Ju Yeon Ahn,Hyeonji Park,Yoel Kim,Doyeon Kim,Soo Hyun Park,Hyun Kwon Suh 한국원예학회 2023 한국원예학회 학술발표요지 Vol.2023 No.5

The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations.

Ahn, Myung-Ju,Won, Hong-Hee,Lee, Jeeyun,Lee, Seung-Tae,Sun, Jong-Mu,Park, Yeon Hee,Ahn, Jin Seok,Kwon, O Jung,Kim, Hojoong,Shim, Young Mog,Kim, Jhingook,Kim, Kwhanmien,Kim, Yeul Hong,Park, Jae Yong,Ki Springer-Verlag 2012 HUMAN GENETICS Vol.131 No.3

<P>The proportion of never smoker non-small cell lung cancer (NSCLC) in Asia is about 30-40%. Despite the striking demographics and high prevalence of never smoker NSCLC, the exact causes still remain undetermined. Although several genome wide association (GWA) studies were conducted to find susceptibility loci for lung cancer in never smokers, no regions were replicated except for 5p15.33, suggesting locus heterogeneity and different environmental toxic effects. To identify genetic loci associated with susceptibility of lung cancer in never smokers, we performed a GWA analysis using the Affymetrix 6.0 SNP array. For discovery GWA set, we recruited 446 never smoking Korean patients with NSCLC and 497 normal subjects. We tested association of SNPs with lung cancer susceptibility using the Cochran-Armitage trend test. For validation, 39 SNPs were selected from the top 50 SNPs and five additional SNPs were selected in the DAB1 gene region which showed significant associations in the GWA analysis. The validation SNPs were genotyped in an independent sample including 434 patients and 1,000 controls. Among the 44 validation SNPs, two SNPs (rs11080466 and rs11663246) near the APCDD1, NAPG and FAM38B genes in the 18p11.22 region were replicated. P value of rs11080466 was 1.08 10(-6) in the combined sets (2.68 10(-5) in the discovery set and 2.60 10(-3) in the validation set) and odds ratio was 0.68 (0.58-0.79). We observed similar association for rs11663246. Our result suggests the 18p11.22 region as a novel lung cancer susceptibility locus in never smokers.</P>

Hepatoprotective effects of chitosan-caffeic acid conjugates on ethanol-induced liver damage in Balb/c mice.

Ju Hyung Um,Soo Yeon Park,Eui Jeong Han,Min Ju Kim,Na Hyeong Kim,Chang-Bum Ahn,Jae-Young Je,Ginnae Ahn 한국수산해양기술학회(구 한국어업기술학회) 2015 한국수산해양기술학회 학술발표대회 Vol.2015 No.10

Hepatoprotective effects of chitosan-caffeic acid conjugates on ethanol-induced liver damage in Balb/c mice

Ju Hyung Um,Soo Yeon Park,Eui Jeong Han,Min Ju Kim,Na Hyeong Kim,Chang-Bum Ahn,Jae-Young Je,Ginnae Ahn 한국수산과학회 양식분과 2015 한국수산과학회 양식분과 학술대회 Vol.2015 No.10

Synthesis and Free Radical Polymerization of Vinyl Ethers containing Two Electron Acceptors:The Inhibition Effect of Nitro Group

Lee, Ju-Yeon,Jin, Mi-Kyoung,Park, Eun-Ju,Ahn, Mi-Ra 인제대학교 1999 仁濟論叢 Vol.15 No.1

5-니트로-2-(2'-비닐옥시에톡시)벤질리덴말로노니트릴 (2a), 메틸 5-니트로-2-(2'-비닐옥시에톡시)벤질리덴시아노아세테이트 (2b), 3-니트로기-4-(2'-비닐옥시에톡시)벤질리덴말로노니트릴 (4a), 메틸 3-니트로-4-(2'-비닐옥시에톡시)벤질리덴시아노아세테이트 (4b), 2-니트로-5-(2'-비닐옥시에톡시)벤질리덴말로노니트릴 (6a), 메틸 2-니트로-5-(2'-비닐옥시에톡시)벤질리덴시아노아세테이트 (6b)를 5-니트로-2-(2'-비닐옥시에톡시)벤즈알데히드, 3-니트로-4-(2'-비닐옥시에톡시)벤즈알데히드 및 2-니트로들-5-(2'-비닐옥시에톡시)벤즈알데히드를 각각 말로노니트릴 또는 메틸 시아노아세테이트와 각각 축합 반응시켜 합성하였다. 삼 기능성 비닐 에테르 단량체 2a-b, 4a-b 및 6a-b는 자유라디칼 개시제에 의해서 중합되어 폴리(비닐 에테르) 7-9를 생성하였다. 화합물 2, 4 및 6의 라디칼 개시제에 대한 중합성은 니트로기의 중합 억제 효과 때문에 니트로기를 포함하지 않은 화합물 보다 작았다. 중합체 7-9는 가교화 인해서 클로로포름과 벤젠과 같은 상용 유기 용매에 녹지 않았다. 중합체 7-9는 TGA에서 280℃ 까지 열 안정성을 보였다. 5-Nitro-2-(2'-vinyloxyethoxy) benzylidenemalononitrile (2a), methyl 5-nitro-2-(2'-vinyloxyethoxy) benzylidenecyanoacetate (2b), 3-nitro-4-(2'-vinyloxyethoxy) benzylidenemalononitrile (4a), methyl 3-nitro-4-(2'-vinyloxyethoxy) benzylidenecyanoacetate (4b), 2-nitro-5-(2'-vinyloxyethoxy) benzylidenemalononitrile (6a), and methyl 2-nitro-5-(2'-vinyloxyethoxy)benzylidenecyanoacetate (6b) were prepared by the condensation of 5-nitro-2-(2'-vinyloxyethoxy) benzaldehyde (1), 3-nitro-4-(2'-vin yloxyethoxy) benzaldehyde (3), and 2-nitro-5-(2'-vinyloxyethoxy) benzaldehyde (5) with malononitrile or methyl cyanoacetate, respectively. Trifunctional vinyl ether monomers 2a-b, 4a-b, and 6a-b polymerized by free radical initiators to give poly(vinyl ethers) 7-9. Polymerizabilities of compounds 2, 4, and 6 toward radical initiators were lower than those of bifunctional derivatives without nitro group, probably due to the inhibition effect of nitro group. Polymers 7-9 were not soluble in common organic solvents such as chloroform and benzene due to crosslinking. Polymers 7-9 showed a thermal stability up to 280℃ in TGA thermograms.

신재생에너지원의 계통 수용률 향상을 위한 민감도 계수

안연주(Yeon-Ju Ahn),김은지(Eun-Ji Kim),김규호(Kyu-Ho Kim) 대한전기학회 2019 대한전기학회 학술대회 논문집 Vol.2019 No.10