당뇨병성 합병증을 가진 환자에서 혈중 Erythropoietin 농도

김동규,유기동,허광식,김상용,윤성호,조영신,권용은,김태원,김건영,정종훈,배학연 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1

연구 배경 : 고혈당성에 의한 산화환원반응 이상(가저산소증)이 조절 되지않는 당뇨병의 특징으로 혈관과 신경 기능에 대한 진성 저산소증의 효과와 유사하며, 당뇨 합병증의 병태생리에 중요한 역할을 한다. 고혈당이 있는 인슐린 비의존형 당뇨병 환자에서 인슐린 수준이 정상이듯이, 빈혈이 있는 당뇨병 환자에서 EPO의 농도는 실제 혈색소 농도의 감소비율과 차이가 있을 것이라 추측된다. Friedman 등은 당뇨병성 합병증 원인 인자로 가저산소증(pseudohypoxia) 또는 저산소증(hypoxia)을 제기하였고 이런 인자들이 EPO의 상대적 또는 절대적 결핍에 의한 것임을 보고하였다. 방법 : EPO-Trac^(TM 125)I RIA kit을 이용하여 방사면역측정법으로 EPO 수준을 검사하였다. 전혈 3㎖을 5-10㎖ 시험관에 정맥 채혈하였으며, 용혈과 장기간의 보존을 위하여 원심분리를 즉시 시행하여 혈청을 영하 200C에서 냉동 보관 후 일괄적으로 검사 결과를 얻었다. 결과 : 1996년 9월부터 1997년 2월까지 조선대학교 부속병원 내과에 입원한 2형 당뇨병 환자 63례를 대상으로 하여 다음과 같은 결과를 얻었다. 1) 당뇨병성 합병증이 없는 군과 있는 군간의 혈색소, 혈중 EPO농도의 차이는 유의한 차이가 있었으며 혈색소의 감소율보다 혈중 EPO의 감소율이 더 높았다. 2) 당뇨병성 망막증의 유무에 따른 혈색소 농도의 차이는 유의한 차이가 없었으나 혈중 EPO농도는 유의한 차이가 있었다. 증식성군에서만 혈중 EPO의 감소비율이 혈색소에 비해 높았다. 3) 당뇨병성 신증의 유무에 따른 혈색소, 혈중 EPO농도는 유의한 차이가 있었고 혈색소 감소율에 비해 EPO농도의 감소율이 높았다. 신증의 중증도에 따른 혈색소, EPO의 차이는 미세알부민뇨군을 제외하고는 유의한 차이를 보였고 혈색소 감소율에 비해 EPO의 감소율이 더높았다. 4) 당뇨병성 신경병증의 유무에 따른 혈색소 농도의 차이는 유의한 차이가 없었으며 EPO농도는 유의한 차이를 보였다. 혈색소와 EPO의 감소비율은 비슷하였다. 신경병증의 중등도에 따른 혈색소와 EPO농도의 변화는 유의한 차이가 없었으나 stage 3에서는 혈색소감소율보다 EPO감소율이 더높았다. 결론 : 당뇨병성 합병증을 가진 환자에서 빈혈의 정도는 대부분 혈청 EPO치의 절대적 감소에 의함을 간접적으로 밝혀낼 수 있었으며 차후 더 많은 대상으로 비교 분석이 필요하리라 사료된다. Background: Hyperglycemic-induced redox(pseudohypoxia) imbalance is a characteristic feature of poorly controlled diabetes that mimics the effects of true hypoxia on vascular and neural functions and plays an important role on the pathogenesis of diabetic complications. As is true for apparently "normal" insulin levels typically found in NIDDM even in the presence of hyperglycemia, a "normal" erythropoietin level in an anemic diabetic subject may be disproportionally low for the actual red cell mass. Therefore, Friedman et al suggested that pseudohypoxia or hypoxia as an etiological factor of diabetic complications are due to absolute or relative erythropoietin deficiency Method: EPO-TracTM 125I RIA kit was used for the quantitative determination of erythropoietin(EPO) in serum by radioimmunoassay. An adequate sample of blood (3ml whole blood) was collected aseptically by venipuncture in a 5~10ml glass tube to yield a minimum of 400 L of serum per assay. The serum was promptly removed from the clot by centrifugation in order to avoid hemolysis. Then to increase its storage time it was frozen at -200C in a nonself defrosting freezer. Finally, tests were undertaken simultaneously Results We studied 63 cases with diabetes mellitus, who were admitted to Chosun University Hospital from September, 1996 to February, 1997 at the Department of Internal Medicine. We defined the control group, as diabetic patients who did not have anemia(<13mg/dl), diabetic complications(retinopathy, nephropathy, neuropathy) and the remainders were defined as the experimental group(we excluded anemic patients, who had secondary causes of anemia and diabetic patients with end stage renal disease)Data were as follow 1) The relationship of Hb and the 24hr urine protein between diabetic patients with and without complications significantly differed(p=0.02, < 0.001 respectively), but the Hb level was poorly related between diabetic patients with and without retinopathy(except in preproliferative, proliferative subgroups) and neuropathy. 2) Subgroups of patients with diabetic complications had higher 24hr urine protein than patients without diabetic complications, except stage I diabetic neuropathy 3) The EPO level was significantly different between diabetic patients with and without complications. 4) The correlation between EPO and Hb was significantly different, especially in diabetic patients with retinopathy and nephropathy according to severity of diabetic complications, compared with patients who did not have diabetic complications such as retinopathy and nephropathy. Conclusion: We know that anemia induced by diabetic complications is due to relative EPO deficiency than absolute EPO deficiency, and further evaluation and studies are needed on many cases in the future

당뇨병성 합병증을 가진 환자에서 혈증 Erythropoietin 농도

김동규,유기동,허광식,김상용,윤성호,조영신,권용은,김태원,김건영,정종훈,배학연 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.

신축학교 실내공기질이 초등학생들의 인지기능에 미치는 영향

김태섭,김선주,박시영,전만중,김규태,김창윤,정종학,백성옥,사공준 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.1

목적: 신축초등학교와 대조학교를 선정하여 교실 내 포름알데히드와 TVOCs를 측정하고 컴퓨터 신경행동검사를 이용하여 실내공기 오염물질이 학생들의 인지기능에 미치는 영향을 평가하였다. 방법: 신축초등학교 5학년 71명을 실내공기 오염물질 노출군으로 하고, 개교한지 12년째인 대구시의 일개 초등학교 5학년 2학급 63명을 대조군으로 하여 실내공기 오염물질농도 측정 및 컴퓨터 신경행동검사를 실시하였다. 결과: 신축학교에서 의도적으로 창문을 개방한 학급에서 1교시 포름알데히드 농도는 34.6 ㎍/㎥, 4교시에는 27.3 ㎍/㎥, 창문을 개방하지 않은 학급에서 1교시 80.2 ㎍/㎥, 4교시 127.1 ㎍/㎥, 대조학교에서는 2학급 각각 1교시에 12.6 ㎍/㎥, 7.5 ㎍/㎥, 4교시에 19.8 ㎍/㎥, 25.2 ㎍/㎥였다. TVOCs의 경우 신축학교의 의도적으로 창문을 개방한 학급에서 1교시에 농도는 487.2 ㎍/㎥, 4교시에 428.2 ㎍/㎥, 창문을 개방하지 않은 학급에서 1 교시에 농도는 1,283.5 ㎍/㎥, 4교시에 1,715.4 ㎍/㎥, 대조학교의 경우 2학급에서 각각 1교시에 농도는 240.9 ㎍/㎥, 150.8 ㎍/㎥, 4교시에 농도는 371.9 ㎍/㎥, 448.0 ㎍/㎥였다. 부호숫자 짝짓기의 평균반응시간은 대조학급이 1교시에 2,585 msec에서 4교시에 2,459 msec으로 감소한 반면 신축학교의 창문을 의도적으로 개방한 학급은 2,343 msec에서 2,510 msec으로, 평소대로 수업한 학급은 2,340 msec에서 2,563 msec으로 반응시간이 각각 167 msec, 223 msec 증가하였다. 1교시의 부호숫자 짝짓기 의 반응시간을 100%로 했을 때 창문을 의도적으로 개방 한 학급은 4교시에 5.9% 증가하였고(p<0.01), 평소대로 수업한 학급은8.3% 증가하였다(p<0.01). 반면에 대조학급은 4교시에 5.0% 감소하였다(p<0.01). 결론: 향후 학교의 실내공기질의 안전성 평가는 샘플링 된 공기의 오염수준의 측정뿐만 아니라 학생들의 건강영향도 함께 고려되는 것이 바람직할 것이다. Objectives: Most studies on the indoor air quality of newly built schools have focused only on the number of schools exceeding a standard or on subjective symptoms, such as sneezing, irritated eyes and an irritated nose. However, there has been no report on how poor indoor air quality affects children's academic performance. This study evaluated the effects of indoor air quality on the neurobehavioral performance of elementary school children. Methods: This study measured the indoor air pollutants and compared children's performance, using a computerized neurobehavioral test, between a newly built and a 12-year-old school. In addition, a questionnaire was administered regarding the indoor air quality related symptoms of children in a newly built and a 12-year-old school. Results: In the newly built school, the formaldehyde levels in the 1^(st) and 4^(th) classes with an open window were 34.6 and 27.3 μg/㎥, respectively. The levels in the 1^(st) and 4^(th) classes with the window closed were 80.2 and 127.1 μg/㎥, respectively. In the 12-year-old school, the formaldehyde levels in 1^(st) and 4^(th) class with open and closed window were 12.6 and 7.5 μg/㎥, and 19.8 and 25.2 μg/㎥, respectively. With respect to total volatile organic compounds, the levels in the 1^(st) and 4^(th) classes with the window open in the newly built school were 87.2 and 428.2 μg/㎥, respectively. In the 1^(st) and 4^(th) classes with the window closed, the total volatile organic compounds were 1,283.5 and 1,715.4 μg/㎥, respectively. In the 12-year-old school, the total volatile organic compounds were 240.9 and 150.8 μg/㎥, and 371.9 and 448.0 μg/㎥ in the 1^(st) and 4^(th) classes, respectively. In the case of a newly built school, the performance of the students in the neurobehavioral test in the 4^(th) class with the window closed was 8.3% lower than for those in the 1^(st) class with the window closed, but was only 5.9% lower when the windows were open. There was a statistical significant difference in the total numbers of symptoms between the two schools. Conclusions: These results suggest a proper evaluation of the indoor air quality within schools is required into both the level of contamination and the health effects of these contaminants toward children.

VDT작업별 정신사회적 스트레스와 근골격계 장애에 관한 연구

백남종,강종두,주영수,배인근,권호장,박종만,조수헌,김돈규,김재용,최홍렬 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.4

It has been hypothesized that jobs that have both high psychological demands and low decision latitude("job strain") can lead to musculoskeletal disorder. The objective of this study was to test whether job strain was correlated with the presence of work-related musculoskeletal disorder, especially myofascial pain syndrome(MPS). Information on demographic factors, confounders such as household load and taking care of children or not, and scores for decision latitude, job demand, and social support was obtained by self-administered questionnaire, which had been developed in Korean language, by adopting NIOSH instrument and Extended Karasek Model(16 items). All subjects were also examined by rehabilitation medicine specialists for musculoskeletal disorders. Subjects(n=370) could be categorized into 4 groups, these were, housewives(n=89), shipyard CAD workers(n=89), general female workers(n=79; nurses, insurance counselors, public officials, clerks, etc), and telephone directory assistance operators(n=113). Results from univariate analyses indicated that all demographic factors, all confounders, scores for decision latitude and social support were not associated with the risk of musculoskeletal disorder. However, score for job demand was higher in musculoskeletal disorder cases than others. In subgroup analysis, this association was convinced again, in telephone directory assistance operators. Job strain model showed that the group of telephone directory assistance operators was high-stain group, and OR of musculo skeletal disorder was 2.446(95% C. I. : 1.174, 5.096), when comparing this with the low strain group. In conclusion, job strain is a risk factor for work-related musculoskeletal disorder.

통풍성 관절염의 임상적 고찰

윤채중,정승문,김영학,김동규,허광식,김태원,배학연,정종훈,이승일,김평남 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.2

통풍은 Purine 대사의 이상으로 발생하는 질환으로, 고뇨산혈증인 사람의 전부가 통풍으로 발현되지 않고 증상의 출현 양상이 다양하여 진단과 치료에 주의가 필요하며, 조기에 적절한 조치를 한다면 충분히 조절이 가능한 질환이다. 본대학 내과학교실에서는 통풍으로 치료한 32명의 환자에서 임상양상, 병력과 검사소견을 분석하여 다음과 같음 결과를 얻었다. 1. 32명 모두 남자이며, 최초 발병 시기는 24세에서 72세로 평균 43.8±11.9세이었으며, 30대에서 40대까지가 19명(59.4%)으로 대부분을 차지하였다. 내원 당시 나이는 27세에서 75세까지로 평균 52.3±10.4세였으며, 내원시 까지 평균 유병기간은 8.5±6.8년으로 나타났다. 2. 동반 질환으로는 고지혈증 12례, 신장질환 10례, 고혈압 12례, 비만 8례, 당뇨 2례 등이었다. 3. 이환된 관절은 단관절 침범이 19례(59.4%), 다관절 침범이 13례 이었으며, 최초 이한된 관절은 족무지 중족골지골 관절로 19례(59.4%)로 가장 많았고, 통풍 결절은 20례(62.5%)에서 관찰되었으며, 유병기간이 10년 이상된 12례중 11례 (91.7%)에서 결절이 관찰되었다. 4. 평균 혈중 요산치는 9.17±1.75 ㎎/dl이었으며, 8.0 ㎎/dl에서 9.9 ㎎/dl 사이가 19명으로 전체의 59.4%를 차지하였다. Objective: The gout is a heterogeneous group of diseases resulting from tissue deposition of monosodium urate or uric acid crystals from extracellular fluids supersaturated with respect to this end product of human purine metabolism. The clinical manifestations are such as hyperuricemia, gouty arthritis, gouty nephropathy, uric acid nephrolithiasis. We analyze of clinical manifestations and associated factors in gout. Method: We have reviewed the medical records, radiologic findings and clinical results of thirty-two patients admitted at our department from April 1996 to July 1997. Result: 1) All patients were male. The mean age at initial attack was 43.8 years old, ranging from 24 to 72 years old. 2) The mean level of serum uric acid was 9.17mg/dl on admission. 3) The first metatarsopharyngeal joint was involved in 19 cases (59.4%). Tophus was observed in 20 cases (62.5%). 4) Hyperuricemia was associated with hypertension, obesity, nephrolithiasis and hyperlipidemia.

표백에 의한 라디에타소나무의 청변 제거

김규혁,김형준,나종범,김재진 한국목재공학회 2003 목재공학 Vol.31 No.1

본 연구는 라디에타소나무 제재목의 균 변색을 제거하기 위한 표백처리의 사용 가능성을 조사하기 위하여 수행하였다. 염소계 표백제인 아염소산나트륨과 차아염소산나트륨은 표백조건(약제농도, 처리온도, 처리시간)의 조절에 따라 만족할만한 변색제거 효과를 얻을 수 있었다. 비염소계 표백제인 과산화수소는 표백조건의 조절만으로는 변색제거가 불가능하였으나 규산나트륨과 수산화나트륨을 활성제로 첨가하는 경우에는 염소계 표백제보다 탁월한 변색제거 효과를 나타내었다. 그러나 활성제 첨가에 따라 재색의 녹색화 문제가 발생하였는데, 앞으로 이러한 문제점을 해결하기 위한 연구가 진행되어야 할 것이다. 또한, 앞으로 본 연구를 통해 개발된 변색제거방법의 현장 적용을 후속 연구도 필요하다고 본다. The feasibility of using bleaching treatments for removing fungal stain was evaluated on heavily stained raiadta pine sapwood. Sodium chlorite and sodium hypochlorite appeared to destain fungal discoloration by providing proper treatment conditions (chemical concentration, treatment temperature, and treatment time), while hydrogen peroxide did not remove fungal stain under the bleaching regimes evaluated. The addition of sodium silicate and sodium hydroxide in the hydrogen peroxide solution as a buffer could remove fungal discoloration completely:; however, the color of wood surface turned faint green after bleaching, thereby reducing the lightness of bleached samples. The results suggest that hydrogen peroxide bleaching could be a feasible method for removing fungal discoloration of stained radiata pine sapwood, although further research is needed to solve the problem of color change after bleaching Also, further tests under field conditions are recommended.

CCA 처리재로부터 방부제 유효성분의 용제추출

김규혁,공일곤,나종범,조재성,김재진 한국목재공학회 2003 목재공학 Vol.31 No.4

본 연구는 CCA 처리재로부터 방부제 유효성분을 추출하기 위한 적정 용제를 선정하고, 선정된 용제의 최적추출조건을 평가하기 위 해 수행되었다. 추출수율과 용제의 사용 및 환경 안전성을 고려할 때, 과산화수소가 CCA유효성분을 추출하는 데 가장 적절한 용제로 선정되었다. 과산화수소를 이용한 추출 결과. 추출온도, 추출용제농도, 추출시간 간에 상호작용이 존재하였으나 추출온도와 추출용제의 농도가 높을수록, 그리고 추출시간이 연장될수록 CCA유효성분의 추출수율은 증가되었다. 경제적인 측면을 고려할 때 가능하면 낮은 농도의 추출용제를 사용하여 저온에서 추출하여야 하나, 이 경우에는 필요한 추출수율을 달성하기 위한 추출시간이 상당히 길어지기 때문에 40℃ 이상의 온도에서 추출이 바람직하며 사용할 추출용제의 농도는 추출시간을 고려하여 최종적으로 결정하여야 된다고 사료된다. This research was performed to select an appropriate agent to extract preservative components from CCA-treated wood, and then to evaluate the effect of reagent concentration, extracting temperature, and CCA-treated wood, and then to evaluate the effect of reagent concentration, extracting temperature, and extracting time on the removal of chrome, copper, and arsenic from treated wood. Hydrogen peroxide was selected as the best extracting agent when considered extraction yield as well as use and environmental safety. Its extraction yield was dependent on extracting variables (temperature, concentration, and time), and a highly significant interaction existed among variables. It should be possible to optimize extraction by manipulating these extracting variables. The results may suggest that the required temperature conditions for the reasonable removal of CCA components are at least above 40℃ because extracting time is too long at low temperature (20℃). Reagent concentrations for extracting at above 40℃ should be decided by considering the extracting time.

태권도 선수의 운동상해 예방을 위한 조사연구 : 전국 고등학교 태권도 선수들을 대상으로

김원규,이종희,장완성 경희대학교 체육대학 한국체육과학연구소 2003 體育學論文集 Vol.31 No.-

Taekwondo players by analyzing the primary factor of exercise injury and researching on the actual condition related to media treatment. To dot it, male and female players at 14 High Schools in Korea, who are registered in Korea, Taekwondo Association, were selected as the subjects of this study. The result of this research is as follows. 1) 73 males(52.5%) and 59 females(42.4%) appeared to have exercise injury. 2) The parts of exercise injury about male appeared to be ankle joint 87 times (11.0%), foot 80 times (10.1%), knee joint 59 times (7.4%) in the order of the frequency of occurrence and about female to be ankle joint 87 times (11.0%), foot 74 times (9.3%), knee joint 63 times (8.0%) 3) The type of exercise wound in male appeared to be bruise 154 times (19.4%), muscular pain 94 times(11.8%), and in female bruise happen 134 times(16.9%) and muscular pain 73 times(9.2%) in the order of the frequency. 4) Injury was experienced during exercise among 22 persons(15.8%) in class pin and among 19 persons (13.7%) in both class bantam and feather. 5) All pin, flight, bantam, feather and heavy weight classes showed ankle as the most frequent exercise injury region among all the injury parts during exercise. Light weight class had knee joint 25 times (3.2%) and both welter and middle classes indicated foot area as the most often wounded part. 6) In injury types happened during exercise, bruise turned out to be 298 times(31.7%), the highest level. Next, the occurrence rate of muscular pain was 20.8%(167 times). 7) It is true 165Cm to 170Cm tall persons have most exercise injuries : 39 persons (28.1%). Next, 170 Cm to 175Cm tall players with injury were 28 persons (20.1%). 8) The area injured most often during exercise was that of ankle joint as 174 times (21.9%) in 160 to 165Cm, 165 to 170 Cm 170 to 175Cm tall players and players over 185Cm Foot was most frequently hurt part as 21 times (27%) in 175Cm to 180Cm tall players. Hand & foot joint and knee joint 7 times (0.9%) in 180 to 185 Cm tall players. 9) Players under 160Cm height and 160 to 165Cm, 165 to 170Cm, 170 to 175Cm tall players and players over 185Cm, showed the highest rate of bruise as the type of injury occurred during exercise and next to it, muscular pain. 175 to 180 Cm players experienced muscular pain 33 times (4.1%), bruise 31 times(3.9%) and 180 to 185 Cm players went through with bruise 17 times(2.l%) and fracture of a bone 8 times (1.0 %). 10) When it comes to total exercise period, 54 persons(38.8%), the highest rate of male, exercise over 4 hours and as to female, 50 persons The purpose of this study is to investigate to offer the basic materials essential for protection from exercise injury of (36.0%) exercise over 4 hours. 11) The injured cause of exercise in male was their carelessness (30 persons : 22.7%), the lack of preparatory exercise and the foul of opponent players (10 persons each : 7.6% each), Instead, for women, excessive work was the cause of exercise injury in 13 persons (9.8%) and their carelessness was that of the injury in 11 persons(8.3%). 12) Male chose emergency treator as following : medical experts(19 persons : 14.4%), the person himself, a coach or an inspector (16 persons : 111%). Female chose emergency treaters following : medical expert (21 persons : 15.9%) and a coach or an inspector (16 persons : 12.1%). 13) Thorough warm-up & arrangement exercise (47 persons : 14.0%), complete recovery from tiredness, wearing protective device, being well-nourished, mental & psychological stability, reasonably held matches in numbers, and etc are shown in order as the protective way of exercise injury in males. On the other hand, in females, complete recovery from tiredness(43 persons : 12.8%), thorough warm-up & arrangement exercise, wearing protective device, mental & psychological stability, being well-nourished, reasonably held games in numbers, appear in the order of frequence.

소나무와 잣나무 원목에서 변재변색 발생

김규혁,김재진,나종범 한국목재공학회 2002 목재공학 Vol.30 No.2

본 연구는 동절기 (1월 중순)에 벌채된 후 목재집하장으로 운반되어 야적장에 저목 중인 소나무와 잣나무 원목을 대상으로 변재변색의 발생시기와 변색 특성을 조사하기 위하여 수행되었다. 벌채 후 3, 4, 5, 6, 8개월 경과시 변색 평가를 실시하였는데, 매 평가시 원목 3개를 임의로 선정하여 원목당 수축방향에 대해 일정 간격으로 7∼9개의 두께 3 ㎝ 원판을 채취하여 변색 원인균을 분리한 후 변재변색의 방사방향 최대 침투깊이와 % 변색율을 측정하였다. 변재변색은 전적으로 층형변색이었으며, 주요 변색원인균인 Ophiostomatoid 균을 매개하는 수피천공충은 소나무좀으로 확인되었다. 소나무와 잣나무 원목은 5월 이전까지는 변재변색의 위험없이 저목할 수 있으나 5월 이후부터는 원목의 변재변색이 급속하게 증가하였다. 변색의 정도는 소나무보다 잣나무에서 심하였으며, 장마철 저목 중에 소나무 원목에서 개떡버섯과 치마버섯의 자실체를 다수 관찰할 수 있었다. 본 연구를 통해 밝혀진 결과들은 앞으로 동절기에 벌채되어 저목 중인 소나무와 잣나무 원목에 발생하는 변재변색을 예방하기 위한 제반 조치를 취하는데 매우 중요한 자료로 사용될 것이다. This study was conducted to investigate the influence of storage time on the sapstain development of Japanese red pine and Korean pine logs during storage in log yard, and their stain characteristics. Japanese red pine and Korean pine trees were harvested and cut into logs in mid January of 2001. These logs were transported to the two local sawmills where they were closely stacked in remote parts of log yard. The logs were then sampled destructively by cutting seven to nine 3-㎝ long discs along the length of each log at intervals of 3, 4, 5, 6, and 8 month after felling. The stain coverage and maximal radial penetration of stain were measured from the discs of the sampled logs after the isolation of causal staining fungi. The sapstain was primarily infested by the attack of bark beetles and the species of bark beetle was identified as Tomicus piniperda. The main fungal species isolated from stained wood was Ophiostoma species. Based on the present study, the logs could be stored in log yard until May without stain; but stain development was rapid after May and the severity of stain increased proportionally with storage time. Korean pine was more susceptible to fungal stain than Japanese red pine. During summer storage, decay started to develop in logs and the main species were identified as Tyromyces sp. and Schizophyllum commune. Information provided in this paper would be very useful to develop more effective control strategies for sapstain prevention in Japanese red pine and Korean pine logs.