마에 의한 비염,구강 알레르기 증후군이 동반된 천식 증례

석수진,박종숙,김덕수,손범석,박춘식 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.2S

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알지네이트 비드를 이용한 메틸 오렌지의 봉입 및 방출에 미치는 키토산의 영향

변종찬, 이상은. 장우석, 이은주, 최진석, 박정숙 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

In this study, methyl orange-loaded alginate beads were prepared and compared to investigate the effect of chitosan on the encapsulation and release of hydrophilic methyl orange in alginate beads. Particle size and encapsulation efficiency of alginated beads were determined. Swelling ratio and disintegration of al-ginate beads were investigated in gastrointestinal environment. Particle size of beads was 1.1-1.5 mm and shape was spherical. Weight of beads was increased depending on the content of chitosan. Content of chitosan affected on the encapsulation of methyl orange. Encapsulation of methyl orange in alginate beads without chitosan was 15%, while encapsulation efficiency was increased with addition of chitosan. Beads were not disintegrated in HCl solution (pH 1.2) within 4 h, with floating and swelling. Swelling ratio of beads was in-creased to 222%. Release of methyl orange from alginate beads without chitosan was up to 70% within 2 h in HCl solution (pH 1.2). When chitosan was added to the alginate beads, release of methyl range from beads was significantly reduced. It is supposed that release of methyl orange from beads is resulted from diffusion and erosion of beads, which is pH-dependent. In condusion, chitosan-alginate beads have potentials to control release of small hydrophilic drugs by the addition of chitosan.

일개 대학병원에서 치료중인 만성질환자의 금연,절주 및 운동 실천 정도

손혜숙,전진호,이종태,정귀원,김성준,엄상화,유병철 韓國保健敎育.健康增進學會 2001 보건교육건강증진학회지 Vol.18 No.3

Background: Many chronic diseases are associated with the lifestyle such as smoking, alcohol drinking and exercise. Attention is increasingly paid on the effect of exercise for the management of chronic disease these days. Objective: The purpose of this study was to evaluate the status of the smoking habit, alcohol drinking and physical exercise of the patients with chronic diseases. Methods: Total 793 persons(normal:422, chronic disease patients:371) in a hospital were questioned regarding the habits of smoking and alcohol drinking, and a practice of physical exercise in 1999. The patients with chronic illness were divided into three groups(Group I included the patients of hypertension and diabetes mellitus. Group II includes respiratory disease and cancer. Group III included liver disease ). The rate of exercise, the rate of smoking cessation and the rate of abstinence were assessed. In logistic regression analysis with each independent variables in each disease groups(I, II and III), odds ratio for the presence of disease was controlled for age and education. Results: The rate of exercise, the rate of smoking cessation and the rate of abstinence was 31.5%, 27.3% and 9.5% in the patients with chronic disease, respectively. In control group, those were 31.5%, 21% and 2.1%, respectively. In logistic regression analysis with exercise as independent variable, odds ratios(95% CI) for age and education were significantly high, with smoking cessation, odds ratio for age was high and with abstinence, odds ratio for disease was high in all disease groups. Conclusion : It was suggested that an effort for proper changes of lifestyle related to disease such as smoking, alcohol drinking and exercise should be intervened in the patients with chronic diseases.

매우 빠른 운동에서의 시간 가변성과 힘가변성에 관한 연구

박종태,표내숙,문규진 釜山大學校 附設 體育科學硏究所 1996 體育科學硏究所 論文集 Vol.12 No.-

The present study achieved the following conclusion by analyzing of theoretical timing variability and fore variability which are controled in very rapid movement. 1. As common as the speed-accuracy trade-off phenomenon seems to be for movement behavior where spatial accuracy is major goal. 2. The primary determinant of timing accuracy is movement time, with longer movement time generating more timing error. 3. It is produced a kind of inverted-U effect that very rapid and very slow movement having the most spatial accuracy and the moderate - speed movement having the least spatial accuracy. 4. The future research require experimental study on the more complicated action because these are very simple skill.

갑상선 침세포진 시료의 주사전자현미경적 관찰

박성진,이숙희,조창호,채종민 慶北大學校 醫科大學 1995 慶北醫大誌 Vol.36 No.3

목적 : 갑상선 결절에 대한 수술전 진단을 위하여 침세포진 검사는 매우 유효하며 빈번히 시행되고 있다. 그러나 집단으로 도말된 세포들에서 때때로 종양세포의 감별진단이 어려운 경우가 있다. 주사전자현미경에 의한 세포들의 배열이나 세포 표면에 대한 관찰은 매우 드물다. 본 연구는 이러한 침세포진 검사에 있어서 주사전자현미경적 관찰을 감별 진단에 이용하고자 한다. 대상 및 방법 : 1994년 5월부터 1995년 4월까지 경북대학교병원에서 갑상선 침세포진 검사를 하고 갑상선 절제술을 시행하여 확진된 56례의 시료를 주사전자현미경으로 관찰하였다. 결과 : 결절성 비대증을 포함한 양성 병변에서는 상피세포 표면에 미세 응모가 잘 발달되어 있었으나 악성 종양의 상피세포 표면에는 미세 융모의 감소 및 완전 소실이 관찰되었다. 그러나 유두상암종에서는 미융모가 발달되어 있었으나 매우 불규칙하였다. 그리고 광학현미경상 혼돈이 되는 소포성 및 유두상 구조물의 감별이 용이하였다. 결론 : 이상의 성적으로 보아 갑상선 결절성 병변의 침세포진 검사에 있어서 감별 진단이 어려운 경우 이를 주사전자현미경으로 관찰하는 것이 감별진단에 도움이 될 것이라고 생각된다. Fine needle aspiration cytology is widely accepted as a primary method for the diagnosis of thyroid lesions. To ascertain the effective value of scanning electron microscopic features of fine needle aspiration cytologic specimens, the scanning electron microscopic study of 56 various thyroid lesions was carried out. Well developed microvilli were observed in the follicular surface almost every epithelial cell in the nodular hyperplasia. Their number was reduced in adenomas and differentiated carcinomas. Medullary carcinomas and anaplastic carcinomas usually lack microvilli. Papillary carcinomas on the other hand have abundant microvilli, but their shape was much irregular. Follicular and papillary structures were easily identified by scanning electron microscopic observation. The results suggested that observing by scanning electron microscopy of fine needle aspiration cytologic specimens may be helpful in the differential diagnosis of thyroid lesions.

완전 포상기태 이후 발생한 지속성 융모질환의 치료경험 2례.

이진희,류은석,김윤숙,김종수,최승도,선우재근,배동한 순천향의학연구소 2005 Journal of Soonchunhyang Medical Science Vol.11 No.1

Persistent tumor develops in approximately 20% of patients with a complete mole, and chemotherapy is required to achieve remission. Following evacuation of hydatidiform mole, careful hCG monitoring is mandatory since it is the most reliable and sensitive method for the early detection of gestational trophoblastic disease. In carefully selected patients in whom the risk of developing gestational trophoblastic disease is significant or when the availability of hCG testing is suboptimal, chemoprophylaxis has been shown to decrease the risk of gestational trophoblastic tumor. We report here two cases of patient, 16-year-old and 45-year-old women who experienced unusual course after the evacuation of a complete mole and markedly elevated serum β-hCG levels. The patient developed persistent gestational trophoblastic disease and were successfully treated with EMA-CO and hysterectomy.

국내에서 파상풍의 연령별 면역혈청학적 역학연구

강진한,허재균,김종현,이경일,박수은,마상혁,이명숙,반상자,홍성화,조대현,이성호 대한감염학회 2001 감염 Vol.33 No.2

Background : The incidence of tetanus in adults and neonatal tetanus have been markedly reduced by world-wide use of DTP vaccines. But, tetanus is still one kind of major health problems in many developing countries, and several serosurvey stduies in developed ountries revealed that substantial proportions of adult opulation may lack immunity against tetanus and imunity level against tetanus is continuously decreasing by age. In Korea, tetanus outbreaks have been disappeared since the 1980s by high acceptant DTaP vaccination rates. Annually, few tetanus patient has been reported since 1990s. But, there knave been no seroepide-miological studies to tetanus, no trials to assess tetanuts immunizations. And we do not use Td vaccine in adults for maintaning tetanus immunity. In this aspect, we conducted age related survey of immunity to tetanus and indirectly assessed the immunogenecity of tetanus vaccines, used in Korea. Methods : For the evaluation of age related sero-survey of tetanus immunity in Korean population, study subjects were classified into 16 groups (A∼J group; below 10 years with one year interval, K∼O group; 11~60 yrs with 10 years interval, p group; over 60 yrs). The numbers of each group were 100, and sex distributions of each group were almostly equal. And far the indirect assessment of tetanus immunization in Korean children, children under 15 years old age were classified into 6 groups (I∼VI) according to the status of DTaP vaccination. The numbers of this each group were 50, and sex ratio was almostly equal. Specific IgG antibody to tetanus toxin were detected by ELISA. And the ANOVA repeated t-test was used to compare antibody levels in study groups. Results : In age related groups, the antibody levels to tetanus toxin were well maintained until 20 years old age group (L group), but thereafter the titers abruptly decreased below 0.1 IU/mL and over 75% populations among the groups over 30 years old age needed maintenance of protective immunity to tetanus. The antibody level of male was statistically higher than that of female in P group. In the groups related DTaP vaccination status, the antibody titer was very low in pre-vaccination group (I), but the titers after primary vaccinations were sharply increased and highly maintained until 15 years. Conclusion : The results of our study revealed that the immunity to tetanus was dramatically decreased in age groups over 30 years old. This result indicates that Td vaccination program in adults should be considered for maintenance of immunity to tetanus. And our study indicate that DtaP vaccination programs and vaccines, used in Korea, are effective for acquisition and maintenance of tetanus immunity in Korean children. (Korean J Infect 33:104~111, 2001)

상호운용 가능한 멀티디미어 통신 서비스의 설계 및 구현

김종현,김진숙 동의공업대학 1998 論文集 Vol.24 No.1

This paper present a design and implementation of an interoperable multimedia stream communication services. Our design is based on CORBA and realtime features which standard networks and operating systems offer. An interoperability of heterogeneous distributed environments is solved by CORBA. An extended multimedia stream communication objects based on CORBA are defined. QoS(Quality of Service) of multimedia stream communication is guaranteed by underneath resource reservation and realtime facilities. Our initial performance evaluation indicates that our multimedia stream communication service provide a flexible and efficient model for developing an interoperable multimedia streaming applications.

유전자 재조합 사람 IFN-beta인 제네베타와 베네세린의 생물학적 활성의 비교

하종천,이협준,박봉환,김진숙,유대근,남상윤 전주대학교 자연과학종합연구소 2003 전주대학교 자연과학연구소 학술논문집 Vol.15 No.1

Background: Recombinant IFN-beta products have been approved for the treatment of several diseases. Recently, Inbionet, Co. has successfully developed rhIFN-beta product, Genebeta. This study was performed in a purpose of confirming the biological activity of Genebeta by comparison with another recombinant IFN-beta, Beneserin which was already approved. Methods: In vitro antiporliferative activity, regulation of MHC class I expression, antiviral activity, regulation of natural killer cell cytotoxicity were studied for functional comparison of these two rhIFN-beta products. Results: Proliferation assay data showed that two recombinant IFN-beta inhibited T cell and Daudi cell proliferation to a similar extent. When antiviral activity was compared, there was no significant difference between them. The treatment of these two rhIFN-beta also resulted in a similar level of upregulation of class I expression on the surface of A549 cells. Cytotoxicity experiment against tumor cells revealed that both of rhIFN-beta could enhance NK cell cytotoxicity to comparable level. Conclusion: All comparison data indicated that rhIFN-beta products, Genebeta and Beneserin have comparable potentials as a biological response modifier.

결식아동의 실태와 특성

박장숙,전진호,김성준,손혜숙,이종태 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : The unprivileged children without lunch(UCWL) has been being markedly increased and becoming one of the social problem in Korea. This study was performed to assist the development of efficient support program through the investigation of the status and characteristics of the UCWL. Methods and Material : Subjects were 104 students sho were receiving the meal aid from the six social welfare facilities and 110 ordinary students of an elementary school in Pusan area. Questionnaire survey was conducted from February to March, 2001. Data was analyzed using SPSS program(ver 10.0). Results : There was no difference in gender and school years' distribution. The phenomenon of family deficient, instability of parents' job, unsatisfaction to the home's atmosphere, ill adaptation to their school life, and be alienated from their colleague were more frequent in UCWL(p<0.05). Impulse of runaway from home and suicide showed no difference, however, the present worries, preference of way for assist showed differences(p<0.05), The majority(88%) of UCWL has been giving the meal and less than on year. The most common way was food stuff(76%) and financial support for school meal program(73%), while the most preferred way was financial support for everyday life(43%). Conclusion : UCWL satisfied and gave thankful mind to the present supports, however, showed negative aspects - like emotional unstability and difficulties in their school life. Therefore, it thought to be needed the touch on the emotional aspects, not only on the formal and economic aids.