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Effect of black chokeberry on skeletal muscle damage and neuronal cell death
( Jisu Kim ),( Kang Pa Lee ),( Suji Beak ),( Hye Ra Kang ),( Yong Kyun Kim ),( Kiwon Lim ) 한국운동영양학회 2019 Physical Activity and Nutrition (Phys Act Nutr) Vol.23 No.4
[Purpose] Numerous epidemiological studies have shown that it is possible to prescribe exercise for neurodegenerative disease, such as Alzheimer's disease and Parkinson’s disease. However, despite the availability of diverse scientific knowledge, the effects of exercise in this regard are still unclear. Therefore, this study attempted to investigate a substance, such as black chokeberry (Aronia melanocapa L.) that could improve the ability of the treatment and enhance the benefits of exercising in neurodegenerative diseases. [Methods] The cell viability was tested with 2,3-bis[2- methyloxy-4-nitro-5-sulfophenyl]-2H-tetrazolim-5- carboxanilide and the cells were stained with ethidium homodimer-1 solution. The mRNA expression levels were evaluated by microarray. The active compounds of black chokeberry ethanolic extract (BCE) were analyzed by gas chromatography. The chemical shift analysis in the brain was performed using magnetic resonance spectroscopy. [Results] BCE treatment decreased hydrogen peroxide-induced L6 cell death and beta amyloid induced primary neuronal cell death. Furthermore, BCE treatment significantly reduced the mRNA levels of the inflammatory factors, such as IL-1α, Cxcl13, IL36rn, Itgb2, Epha2, Slamf8, Itgb6, Kdm6b, Acvr1, Cd6, Adora3, Cd27, Gata3, Tnfrsf25, Cd40lg, Clec10a, and Slc11a1, in the primary neuronal cells. Next, we identified 16 active compounds from BCE, including D-mannitol. In vivo, BCE (administered orally at a dosage of 50 mg/ kg) significantly regulated chemical shift in the brain. [Conclusion] Our findings suggest that BCE can serve as a candidate for neurodegenerative disease therapy owing to its cyto-protective and anti-inflammatory effects. Therefore, BCE treatment is expected to prevent damage to the muscles and neurons of the athletes who continue high intensity exercise. In future studies, it would be necessary to elucidate the effects of combined BCE intake and exercise.
Effects of Different doses of Silk Peptide on Energy Metabolism During Exercise in Mice
( Jisu Kim ),( Jonghoon Park ),( Bokyung Kim ),( Chi-ho Lee ),( Kiwon Lim ),( Heajung Suh ) 한국운동영양학회 2017 Physical Activity and Nutrition (Phys Act Nutr) Vol.21 No.1
[Purpose] This study was carried out to determine the optimal dose of silk peptide for enhancing fat metabolism during exercise. [Methods] Fifty male ICR mice were randomly divided into five groups: Sed, SP0, SP200, SP400, and SP800. All SP mice underwent training by running on a treadmill 5 times a week for 2 weeks (20 m/min, 8° slope, 50 min/day for the first week and 25 m/min, 8° slope, 50 min/day at about 70-75% of maximum oxygen uptake for the second week). [Results] After the 2 weeks, fat oxidation was measured during a 1-h exercise at the training conditions of the second week and was found to be 1.02 ± 0.15, 1.04 ± 0.17, 0.98 ± 0.10, 1.14 ± 0.19, and 1.15 ± 0.07 g/kg/ h for Sed, SP0, SP200, SP400, and SP800 groups, respectively. The SP800 group had significantly higher fat oxidation levels than the SP0 group did at 36, 40, and 56 min and the Sed group did at 2, 4, 6, 8, 12, 14, 16, 20, 40, 46, 50, 52, 56, and 60 min. However, there was no significant difference among the groups in carbohydrate oxidation during the 1-h exercise. SP doses of 200 mg/kg and 400 mg/kg did not show any effect on fat and carbohydrate oxidation. [Conclusion] In conclusion, 800 mg/kg of silk peptide is the optimal dose for enhancing fat metabolism during exercise. In addition, silk peptide treatment could reduce body weight by enhancing fat metabolism.
Hollow Au nanoparticles-decorated silica as near infrared-activated heat generating nano pigment
Jisue Kim,Chulhwan Park,Younghun Kim 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.107 No.-
The photothermal effect resulting from the local surface plasmon phenomenon of metal nanoparticles isessentially a light–heat conversion mechanism, wherein the heat is generated around the nanoparticlesowing to the absorption of light by the nanoparticles. A pigment exhibiting the photothermal effect canbe used as a multifunctional nano-pigment providing high heat energy from a small amount of lightenergy as well as a bright color. In this study, a grayish blue nano-pigment (GBNP) was synthesized usingsilica nanoparticles and hollow Au nanoparticles that exhibited a relatively high photothermal effect inthe near-infra red (NIR) region. By irradiating light in the NIR region, GBNP could selectively producestable thermal energy with a photothermal efficiency of 39%. It was mixed with paint to confirm its applicabilityto pigments and heat-generation performance. The surface of paint containing 4 wt% GBNP wasincreased to 110 C, exhibiting a stable heat-generation performance under both repeated and continuousNIR irradiation. Furthermore, the thermal energy generated due to the photothermal effect impliedthe high evaporation efficiency of water droplets on the surface. This pigment might be utilized in applicationswhere a selectively high temperature needs to be maintained continuously for bacterial-growthprevention and moisture control.
Immobilization of phenol-containing compounds via electrochemical activation of a urazole derivative
Jisu Kim,Noo-ri Kim,김승우,김영관,여운석 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.2
We introduce an efficient method for the immobilization of phenolic compounds, based on 1,2,4,-triazoline-3,5-dione (TAD), which selectively reacts with phenolic compounds at the α position to the phenolic hydroxyl group, ensuring intact phenol functionality, and therefore, maintaining the biological activity of the phenolic compound. We prepared self-assembled monolayers on gold that presented urazole (the reduced form of TAD) as the terminal group and which were activated electrochemically without treatment with chemical oxidants, allowing on-demand activation and in situ immobilization of the phenolic compounds. We examined the immobilization of various phenolic compounds and verified the surface chemistry using electrochemistry and mass spectrometry. The proposed method is simple and straightforward and does not require complicated protocols and reagents, and thus, it can be a general and practical platform for the immobilization of phenol-containing molecules on the surfaces of various materials.
Effects of Silk Peptides Administration on Fat Utilization Over a Whole Day in Mice
( Jisu Kim ),( Jonghoon Park ),( Bokyung Kim ),( Chi-ho Lee ),( Kiwon Lim ),( Heajung Suh ) 한국운동영양학회 2016 Physical Activity and Nutrition (Phys Act Nutr) Vol.20 No.4
[Purpose] The aim of the present study was to investigate the effects of treatment with silk peptides (SP) on resting energy expenditure over a 24-h period and clarify the molecular mechanism underlying its enhancement of fat utilization in mouse skeletal muscles. [Methods] Sixteen male ICR mice (6-week-old) were divided into two groups and treated with distilled water and SP (CON and SP treatment groups, respectively). SP were dissolved in distilled water and administered to the SP group at 800 mg/kg while the CON group was administered distilled water orally daily for 2 weeks. Resting metabolic rate (RMR) was measured before and after SP ingestion for 2 weeks using an open circuit calorimetry system. After the treatments, we collected blood and skeletal muscle samples from the mice. [Results] Final body weight and body weight gain showed no significant difference in the CON and SP groups. Conversely, food intake was significantly lower in the SP group than it was in the CON group. The comparison of the respiratory exchange rate (RER) at various time points after the 2-week treatment revealed that it was significantly lower in the SP group than it was in the CON group at 9, 15, 16, and 18-22 h (Figure 3 B). The sum of the RER over 24-h was lower in the SP group than it was in the CON group, but the difference was not statistically significant. The protein levels of fatty acid translocase (FAT)/ cluster of differentiation 36 (CD36) were approximately 12% higher in the SP group than they were in the CON group but that of carnitine palmitoyltransferase I (CPTl) was not significantly different between the two groups. [Conclusion] These results suggest that treatment with SP 800 mg/kg for 2 weeks may promote fat utilization during physical activity, but not the entire day. In addition, SP treatment effectively enhanced FAT/CD36 protein level in skeletal muscle. In future investigations, it would be necessary to elucidate the effects of long-term SP intake on the resting metabolism of both animals and humans.
Field free switching of ferrimagnetic GdCo with artificially broken symmetry
Jisu Kim,Seyeop Jeong,Taekhyeon Lee,Suhyeok An,Kab-Jin Kim,Ki-Seung Lee,Chun-Yeol You,Soogil Lee,Byong-Guk Park,Sanghoon Kim 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.2
During the last decade, current-induced magnetization switching by spin-orbit torque (SOT) is of great importance to nanoelectronics due to energy-efficient control of spintronic memory and logic devices. However, it has a problem that an external magnetic field is required to switch magnetization of a device when magnetic layers are perpendicularly magnetized. This implies that there should be limitation of scalability and low energy efficiency because of necessity to use the external magnetic field. Therefore, field-free switching of a magnetization should be achieved for realization of the energy efficient and ultra-fast SOT-driven devices. Here, we report field-free SOT switching of ferrimagnetic GdCo thin films with a He ion microscope (HIM) technique. The Pt(5)/Gd36Co64(5)/Ta(3) structure is irradiated by He ions with the dose range from 5 to 50 ions/nm². We find that magnetic properties of the GdCo layer such as coercivity (HC) and magnetization compensation temperature (TM) strongly depend on ion dose of a He irradiation. Based on the idea that ferrimagnetic properties can be controlled using He ion irradiation method, we introduced a lateral gradient of magnetization by the HIM to form a broken mirror symmetry in the device. The mirror symmetry breaking was observed after the local modulation; TM and perpendicular magnetic anisotropy (PMA) properties were locally modulated by He ion irradiation. As the magnetic mirror symmetry is broken, we observed the field-free SOT switching behavior. The Sz component of the spin current generated by the broken mirror symmetry was also observed. We will discuss details about structural change in the ferrimagnetic GdCo by the He ion irradiation.
The Changes in Respiratory and Enteric Adenovirus Epidemiology in Korea From 2017 to June 2022
Kim Kyung-Ran,Won Jisu,Kim Hyungjun,Kim Bryan Inho,Kim Mi Jin,Kim Jae Young,Gwack Jin,Kim Yae-Jean 대한의학회 2023 Journal of Korean medical science Vol.38 No.9
Since October 2021, severe acute hepatitis of unknown etiology in pediatric patients has been observed in many countries around the world. Adenovirus (mainly enteric adenovirus) was detected in more than 50% of the cases. Nationwide surveillance on acute hepatitis of unknown etiology in pediatric patients was started in May 2022 in Korea. Taking into account the severity of the illness and the urgency of the epidemiological situation worldwide, we report a summary of changes in adenovirus epidemiology during the past five years and six months in Korea.