Growth Inhibition of Colon Cancer through Inactivation of STAT3 Pathway by IL-10 and IL-1ra Released from Murine Macrophage

Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4

The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway

관상동맥 스텐트 삽입술을 시행한 환자에서 안지오텐신 전환효소 억제제와 안지오텐신 수용체 차단제가 재협착에 미치는 영향

김연경,정진원,윤경호,박은미,송미진,최준호,이은미,유남진,김남호,오석규 圓光大學校 醫科學硏究所 2006 圓光醫科學 Vol.21 No.1

심근 허혈-재관류 백서 모델에서 mitogen-activated protein kinase 활성화에 대한 α-lipoic acid의 효과

김연경,박은미,최준호,윤경호,유남진,이은미,김남호,정진원,김민선,박병림,오석규 圓光大學校 醫科學硏究所 2006 圓光醫科學 Vol.21 No.1

Flavobacterium meningosepticum에 의한 균혈증 1예

장성원,유진홍,진승원,김선우,김연식,박순민,이대훈,최민호,최주연,신완식,강문원,강지민 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1

1996년 6월 카톨릭대학교 부천성가병원에 뇌경색으로 입원했던 61세 남자 환자의 혈액에서 Flavobacterium meningosepticum을 분리하였다. 환자는 폐렴을 동반한 패혈증의 예로 ceftriaxone과 metronidazole을 투여하였으나 입원 48시간만에 사망하였다. Flabovacterium meningosepticum is a rae cause of nosocomial infection which shows multi-drug resistance. It mainly invades patients with impaired immunity. Recently, we experienced a case of F. meningosepticum bacteremia in a patient with chronic debilitated state owing to stroke. The clinical progress was so rapid that he died within 48 hours. Blood culture revealed F. meningosepticum which showed characteristic yellow colony in blood agar plate.

원-달러 선물계약과 NDF계약의 헤징효율성 비교

윤원철 ( Won Cheol Yun ),안현진 ( Hyun Jin An ) 한국파생상품학회 2004 선물연구 Vol.12 No.2

급성 관동맥증후군 환자의 신기능 이상과 주요 심장사건과의 관계

이상재,윤경호,최준호,송미진,김연경,박은미,김현정,이은미,유남진,김남호,오석규,정진원 圓光大學校 醫科學硏究所 2006 圓光醫科學 Vol.21 No.1

Preference Analysis for Flower Jewelry Using Conjoint Analysis

김연희(Yeon Hee Kim),김미진(Mi Jin Kim),윤숙영(Suk Young Yun),장태원(Taeg Won Chang),최병진(Byung Jin Choi) 인간식물환경학회 2022 인간식물환경학회지 Vol.25 No.3

Background and objective: This study was conducted to determine the preferences in flower jewelry by conducting a surveyusing conjoint analysis on the perception of flower jewelry and provide basic data for development of flower jewelryproducts. Methods: For the conjoint analysis, four attributes of flower jewelry were selected. Attribute 1 was related to the mainmaterial of flower jewelry, presented in three levels: cut flowers, potted flowers, and processed flowers. Attribute 2 wasrelated to wearing area presented in five levels of wearing area: hair, neck, ear, arm (wrist) and chest (shoulder). Attribute3 was related to price provided for selling products in flower shops, presented in three levels: less than 30,000 won,50,000-70,000 won, and more than 100,000 won. Attribute 4 was related to flower jewelry wearing time, presented inthree levels: less than 6 hours, 12-24 hours, and more than 24 hours. After extracting 25 profiles through orthogonaldesign, a questionnaire survey was conducted on 402 general participants, from which the responses of 343 participantswere analyzed. Results: By attribute of flower jewelry, the respondents attached most importance to price (34.14%), followed by wearingarea (29.18%), wearing time (18.51%), and material (18.17%), proving that the general public attached most importanceto price (Pearson's R = .987, p = .000). The preference in levels by attribute was highest for processed flowers in material,less than 30,000 won in price, hair in wearing area, and 12-24 hours in wearing time. Conclusion: By making flower jewelry based on the results of the analysis, it would be possible to help increase items soldin flower shops as well as their income.

와이브로(WiBro) Model frame mapper Hardware 구조 설계

윤창중,임웅철,김진상,조원경,김영수,서덕영 경희-다반 ASIC 설계교육센터 2005 경희-다반 ASIC센터 논문집 Vol.6 No.-

WiBro는 하향 링크와 상향 링크를 시간으로 구분하는 TDD방식이 사용되며 다중접속 방식으로는 OFDMA가 사용된다. WiBro 서비스의 특징들은 frame Mapping 과정에서 잘 나타난다 frame은 하나의 frame당 42개의 symbol 단위로 mapping 되며 TFFT Block에서는 하나의 symbol 단위로 frame mapper에서 Data를 불러와 처리한 후 CP insertion, windowing 과정을 거쳐서 단말에 전송한다. 본 논문에서는 WiBro 서비스를 위하여 TTA에서 제정한 표준안을 토대로 모뎀부분을 VHDL 언어를 이용하여 하드웨어로 설계 하였고 Xilinx Vertex 8000을 Target Device로 이용하였다.

목탄분말의 입자크기가 양파 생육과 토양 이화학성에 미치는 영향

윤봉기,박인진,유영권,허원영,김병운,김용웅 한국국제농업개발학회 2004 韓國國際農業開發學會誌 Vol.16 No.3

토양개량용으로 적합한 목탄의 입자크기를 구명하기 위하여 양파 재배 토양에서 참나무 목탄분말과 소나무 목탄분말의 입자크기를 각각 1 ㎜이하, 1~5㎜, 5~10㎜의 3처리로 하여 목탄분말을 500㎏/10a 수준으로 사용하고 2001년에 시험 한 결과는 다음과 같다. 1) 시험에 사용된 목탄의 화학적 특성은 참나무 목탄은 pH10.1, T-N 0.04%, P₂O_(5) 1.63%, K₂O 0.34%이었으며 소나무 목탄은 pH 9.3, T-N 0.24%, P₂O_(5) 2.18%, K₂O 0.33%이었다. 2) 수확기의 양파 생육은 초장 50.0~62.6㎝, 엽수 6.0~6.5매, 줄기직경 11.2~16.4㎜이었으며 1 ㎜이하 크기의 목탄 시용구에서 초장. 염수, 줄기직경 등 생육이 좋았다. 3) 목탄 입자크기에 따른 수량 구성요소는 1 ㎜이하 시용 구에서 구고. 구 직경, 구중 등이 좋았으며 수량도 목탄 입자크기 1 ㎜이하 시용구에서 많았다. 4) 시험후 토양 화학성은 토양 pH 5.9~6.3, OM 14.7~15.5 g ㎏^(-1), CEC 15.6~16.8 c㏖^(+)㎏^(-1), Avail. P₂O_(5) 147~186㎎ ㎏^(-1), Exch. K 0.35~0.41c㏖^(+) ㎏^(-1)으로 시험전 토양에 비하여 OM, CEC가 증가하고 Avail. P₂O_(5), Exch. K의 축적이 경감되었다. 5) 시험후 토양의 물리성은 용적밀도 1.20~l.24g ㎝^(-3), 고상 45.1~46.6%, 공극율 53.4~54.9% 이었으며 목탄 입자크기 1 ㎜이하 시용구에서 좋아지는 경향이었다. 6) 시험후 토양의 미생물상은 세균 64.3~200.4(×10^(5))cfu g^(-1),방선균 26.4~70.3(×10^(5)), 사상균 16.9~186.2(×10³))이었으며 <1㎜, 1~5㎜ 크기의 목탄 시용구에서 세균, 방선균, 사상균이 많은 경향이었다. This experiment was conduct to find out moderating particle size of wood charcoal powder for soil improvement in 2001 year. The wood charcoal material was a black oak and pine. The particle size of wood charcoal was 1㎜ below, 1~5 ㎜ and 5~10 ㎜. An amount of wood charcoal application was 500 ㎏ l0a^(-1), Chemical properties of a black oak charcoal used experiment was pH 10.1, T-N 0.04%, P₂O_5 1.63% and K₂O 0.34%. That of pine charcoal was pH 93, T-N 0.24%, P₂O_(5) 2.18%, K₂O 033%. At harvest stage of onion, plant height was 50.5~62.6㎝. The number of leaf was 6.0~6.5ea. Stem diameter was 11.2~16.4 ㎜. Plant height, the number of leaf and stem diameter of plot treated 1 ㎜ below wood char-coal were be longer, more or bigger than those of any other particle size. Onion height, diameter and weight of plot treated 1 ㎜ below wood charcoal was higher or bigger than that of any other particle size. Yield was similar to yield component. Soil chemical properties of after experiment was pH 5.9~63, OM 14.7~15.5 g ㎏^(-1), CEC 15.6~16.8 c㏖^+ ㎏^(-1), Avail. P₂O_(5) 147~486 mg ㎏^(-1) and Exch. K 035~0.41 c㏖+ ㎏^(-1). OM and CEC was increased than that of before experiment. Avail. P₂O_5 and Exch. K was decreased than that of before experiment. Soil texture after experiment was bulk density 1.20~4.24 g ㎝^(-1), solid phase 45.1~46.6%, porosity 53.4~54.9%. Soil texture was trend to be improved by l㎜ wood charcoal. Soil microflora after experiment bacteria 64.3~200.4(×10^(5))cfu g^(-1) actinomycete 26.4~70.3(×l0^(5))cfu g^(-1) and fungi 16.9~186.2(×10³)cfu g^(-1) Bacteria, actinomycete and fungi was much at plot treated with <1 ㎜, 1~5 ㎜ wood charcoal with out relation to wood charcoal material.

목탄분말의 원료수종이 양파 생육과 토양 이화학성에 미치는 영향

윤봉기,박인진,유영권,허원영,김병운,김용웅 한국국제농업개발학회 2004 韓國國際農業開發學會誌 Vol.16 No.3

양파재배 토양에서 토양개량용으로 적합한 목탄의 원료 수종을 선발하기 위해서 관행(무처리)과 코코넛피트, 대나무, 참나무, 활엽수 수피, 소나무로 만든 목탄분말의 6처리로 시용량 500㎏· 10a^(-1)으로 하여 2002년에 시험한 결과는 다음과 같다. 1. 시험에 사용한 5종 목탄의 pH는 5.1~10.1, T-N 0.15~0.71%, P₂O_(5) 2.06~2.65%, K₂O 0.20~0.86% 범위였으며 1 ㎜이하 입자의 분포는 9.0~84.8%이었다. 2. 양파의 생육은 목탄시용으로 줄기직경이 크고 주당 엽수가 많은 경향이었으며 참나무, 활엽수 수피, 대나무 목탄처리 구에서 생육이 좋았다. 양파의 수량은 4,631~5,114㎏ 10a^(-1)으로 무처리(4,638㎏)에 비하여 구고가 크고 구중이 무거운 참나무목탄과 활엽수 수피 목탄처리구에서 각각 10%, 소나무 목탄구에서 3% 증수되었으며 유의성이 인정되었다. 3. 시험 후 토양의 물리성은 목탄 시용으로 용적밀도와 토양의 고상비율이 줄어들 고 액상과 기상, 공극율이 증가하는 경향을 보였다. 화학성은 코코넛 피트처리구 를 제외한 처리구에서 토양 pH가 개선되었고, OM, CEC 는 모든 처리구에서 증가하는 경향을 보였다. This experiment was conducted to find out moderating tree kinds of wood charcoal pow-der for soil improvement and onion growth in 2002 year. The wood charcoal materials were coconut peat, bamboo, black oak, pine, and broadleaf tree bark. Wood charcoal application rate was 500 ㎏ 10a^(-1). Results were summerized as follows; Chemical properties of wood charcoal used experiment were pH 5.11~10.1, T-N 0.15~0.71%, P₂O_(5) 2.06~2.65% and K₂O 0.20~0.86%. The particle size of <0.1 ㎜ was 9.0~84.8%. Onion growth of plot applied wood charcoal was better than that of plot not applied wood charcoal. The number of leaf and diameter of stem at plot applied wood charcoal was better than that of plot not applied wood charcoal. Growth of plot applied black oak charcoal, broadleaf tree bark char-coal, and bamboo charcoal was better than that of any other plot. Yield of plot applied wood charcoal was 4,631~5,114 ㎏ 10a^(-1). The yield of plot applied black oak charcoal, broadleaf tree bark charcoal and pine charcoal was increased 10, 10, 3% than that of control(4,638 ㎏ 10a^(-l)), respectively. It was significant at 5% level. Soil physical properties of after experiment was decreased bulk density and solid phase, but liquid phase, air phase and porosity were increased than that of control. Soil chemical properties of after experiment trend to be improved pH. Soil OM and CEC was increased than that of control.