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Jimé,nez Pé,rez, Zuly Elizabeth,Mathiyalagan, Ramya,Markus, Josua,Kim, Yeon-Ju,Kang, Hyun Mi,Abbai, Ragavendran,Seo, Kwang Hoon,Wang, Dandan,Soshnikova, Veronika,Yang, Deok Chun DOVE MEDICAL PRESS 2017 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.12 No.-
<P>There has been a growing interest in the design of environmentally affable and biocompatible nanoparticles among scientists to find novel and safe biomaterials. <I>Panax ginseng</I> Meyer berries have unique phytochemical profile and exhibit beneficial pharmacological activities such as antihyperglycemic, antiobesity, antiaging, and antioxidant properties. A comprehensive study of the biologically active compounds in ginseng berry extract (GBE) and the ability of ginseng berry (GB) as novel material for the biosynthesis of gold nanoparticles (GBAuNPs) and silver nanoparticles (GBAgNPs) was conducted. In addition, the effects of GBAuNPs and GBAgNPs on skin cell lines for further potential biological applications are highlighted. GBAuNPs and GBAgNPs were synthesized using aqueous GBE as a reducing and capping agent. The synthesized nanoparticles were characterized for their size, morphology, and crystallinity. The nanoparticles were evaluated for antioxidant, anti-tyrosinase, antibacterial, and cytotoxicity activities and for morphological changes in human dermal fibroblast and murine melanoma skin cell lines. The phytochemicals contained in GBE effectively reduced and capped gold and silver ions to form GBAuNPs and GBAgNPs. The optimal synthesis conditions (ie, temperature and v/v % of GBE) and kinetics were investigated. Polysaccharides and phenolic compounds present in GBE were suggested to be responsible for stabilization and functionalization of nanoparticles. GBAuNPs and GBAgNPs showed increased scavenging activity against 2,2-diphenyl-1-picrylhydrazyl free radicals compared to GBE. GBAuNPs and GBAgNPs effectively inhibited mushroom tyrosinase, while GBAgNPs showed antibacterial activity against <I>Escherichia coli</I> and <I>Staphylococcus aureus</I>. In addition, GBAuNPs were nontoxic to human dermal fibroblast and murine melanoma cell lines, and GBAgNPs showed cytotoxic effect on murine melanoma cell lines. The current results evidently suggest that GBAgNPs can act as potential agents for antioxidant, anti-tyrosinase, and antibacterial activities. In addition, GBAuNPs can be further developed into mediators in drug delivery and as antioxidant, anti-tyrosinase, and protective skin agents in cosmetic products. Consequently, the study showed the advantages of using nanotechnology and green chemistry to enhance the natural properties of GBs.</P>
On-Shoe Wearable Sensors for Gait and Turning Assessment of Patients With Parkinson's Disease
Jimé,nez, Mayté,Castro IEEE 2013 IEEE Transactions on Biomedical Engineering Vol.60 No.1
<P>Assessment of locomotion through simple tests such as timed up and go (TUG) or walking trials can provide valuable information for the evaluation of treatment and the early diagnosis of people with Parkinson's disease (PD). Common methods used in clinics are either based on complex motion laboratory settings or simple timing outcomes using stop watches. The goal of this paper is to present an innovative technology based on wearable sensors on-shoe and processing algorithm, which provides outcome measures characterizing PD motor symptoms during TUG and gait tests. Our results on ten PD patients and ten age-matched elderly subjects indicate an accuracy ± precision of 2.8 ± 2.4 cm/s and 1.3 ± 3.0 cm for stride velocity and stride length estimation compared to optical motion capture, with the advantage of being practical to use in home or clinics without any discomfort for the subject. In addition, the use of novel spatio-temporal parameters, including turning, swing width, path length, and their intercycle variability, was also validated and showed interesting tendencies for discriminating patients in ON and OFF states and control subjects.</P>
Lipase-Catalysed Enrichment of γ-Linolenic Acid from Evening Primrose Oil in a Solvent-Free System
Baeza-Jimé,nez, Ramiro,No, Da Som,Otero, Christina,Garcí,a, Hugo S.,Lee, Jeom Sig,Kim, In-Hwan Wiley (John WileySons) 2014 Journal of the American Oil Chemists' Society Vol.91 No.7
<P>The enrichment of gamma-linolenic acid (GLA) was carried out in a solvent-free system by lipase-catalysed esterification of free fatty acids from evening primrose oil (EPO-FA) and 1-butanol (BtOH). The lipase employed to conduct this study was a free preparation of Candida rugosa. Variables evaluated were: substrate molar ratio (1:4, 1:6, 1:8, 1:10 and 1:12, EPO-FA:BtOH), temperature (10, 20, 30, 40, 50 and 60 A degrees C), and enzyme loading (5, 10, 15 and 20 %, based on the total weight of substrates). GLA was highly enriched in the non-esterified fatty acid fraction since C. rugosa showed very low selectivity for this fatty acid. We were able to increase the content of GLA to ca. 70 wt.% under the following optimal conditions: 30 A degrees C, 10 % enzyme loading and a 1:10 molar ratio (EPO-FA:BtOH), after 24 h. An additional set of experiments was conducted whereby the amount of water was controlled by addition of molecular sieves to the reaction mixture. The latter experiments produced a higher GLA concentrate (83.74 wt.%), under the optimal conditions described above and by adding 10 % molecular sieves (based on the total weight of substrates) after 36 h.</P>
Karen M. Jimé,nez,Angela J. Pereira Morales,Diego A. Forero 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.4
Objective-The aim of this study was to examine a possible association between depressive symptoms and a functional polymorphism (rs686) that modulates the regulation of DRD1 gene by miR-504. Methods-A total of 239 young Colombian subjects were evaluated with the Patient Health Questionnaire-9 (PHQ-9) scale and geno-typed for the rs686 polymorphism. A linear regression model, corrected by age and gender, was used. Results-A significant association between the rs686 polymorphism and PHQ-9 scores was found, under a dominant genetic model (p=0.0094). Conclusion-These results provide novel evidence about the growing role of inherited variants in binding sites for brain-expressed miRNAs on depressive symptomatology
Angular dependence of photoemission time delay in helium
Heuser, Sebastian,Jimé,nez Galá,n, Á,lvaro,Cirelli, Claudio,Marante, Carlos,Sabbar, Mazyar,Boge, Robert,Lucchini, Matteo,Gallmann, Lukas,Ivanov, Igor,Kheifets, Anatoli S.,Dahlstr&oum American Physical Society 2016 Physical Review A Vol.94 No.6
<P>Time delays of electrons emitted from an isotropic initial state with the absorption of a single photon and leaving behind an isotropic ion are angle independent. Using an interferometric method involving XUV attosecond pulse trains and an IR-probe field in combination with a detection scheme, which allows for full three-dimensional momentum resolution, we show that measured time delays between electrons liberated from the 1s(2) spherically symmetric ground state of helium depend on the emission direction of the electrons relative to the common linear polarization axis of the ionizing XUV light and the IR-probing field. Such time delay anisotropy, for which we measure values as large as 60 as, is caused by the interplay between final quantum states with different symmetry and arises naturally whenever the photoionization process involves the exchange of more than one photon. With the support of accurate theoretical models, the angular dependence of the time delay is attributed to small phase differences that are induced in the laser-driven continuum transitions to the final states. Since most measurement techniques tracing attosecond electron dynamics involve the exchange of at least two photons, this is a general and significant effect that must be taken into account in all measurements of time delays involving photoionization processes.</P>
Estrustura sint?ctica y constituyentes internos en espanol
Tomás Jiménez Juliá 한국스페인어문학회 2005 스페인어문학 Vol.0 No.37
La lengua es un sistema de comunicación que se basa en gran medida en la rentabilidad de sus medios. Por ello, suele omitir toda aquella información que el contexto pueda aportar y que, por tanto, haga superflua su expresión explícita. Dentro de las omisiones existen dos tipos fundamentales: la elipsis y la elisión. La primera tiene un carácter sistemático y tiene como fin destacar lo no omitido. La segunda busca primariamente la economía de medios, y tienen un carácter coyuntural o convencional. Dentro de las elisiones convencionales hay algunas que tienen su origen en el valor consabido de un cierto complemento, esto es, de los que denominamos ‘constituyentes internos’. Habitualmente se han reconocido como constituyentes internos solamente los ‘acusativos’. El presente artículo tiene como fin describir otros constituyentes internos, además de los acusativos, que normalmente no se reconocen como tales.
Red alga <i>Grateloupia imbricata</i> (Halymeniaceae), a species introduced into the Canary Islands
Garcí,a-Jimé,nez, Pilar,Geraldino, Paul John L.,Boo, Sung Ming,Robaina, Rafael R. Blackwell Publishing Asia 2008 Phycological research Vol.56 No.3
<P>SUMMARY</P><P>Specimens of <I>Grateloupia</I> from Gran Canaria in the Canary Islands were used to molecularly ascertain which of the species has been used in physiological and bio-technological experiments. The <I>rbc</I>L sequence analysis revealed that four out of five analyzed specimens (i.e. those commonly collected for physiological research) formed a monophyletic clade with <I>G. imbricata</I> from Korea, Japan, and China, and were quite different from any other species of the genus. Another sample, which was associated with cage nets used for fish aquaculture, was grouped with <I>G. lanceolata</I> from Japan, though it appears too early as yet to identify it as such. This is, thus, proof of a new introduction of a marine macroalga, since <I>G. imbricata</I> is an Asian species, native to Japan and Korea, in the Canary Islands. The role of international shipping in the introduction of the species is discussed.</P>
Spatiotemporal Expression of Anticoagulation Factor Antistasin in Freshwater Leeches
Kwak, Hee-Jin,Park, Jeong-Su,Medina Jimé,nez, Brenda Irene,Park, Soon Cheol,Cho, Sung-Jin MDPI AG 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.16
<P>Antistasin, which was originally discovered in the salivary glands of the Mexican leech Haementeria officinalis, was newly isolated from Helobdella austinensis. To confirm the temporal expression of antistasin during embryogenesis, we carried out semi-quantitative RT-PCR. Hau-antistasin1 was uniquely expressed at stage 4 of the cleavage and was strongly expressed in the late stages of organogenesis, as were other antistasin members. In order to confirm the spatial expression of antistasin, we performed fluorescence in situ hybridization in the late stages of organogenesis. The expression of each antistasin in the proboscis showed a similar pattern and varied in expression in the body. In addition, the spatial expression of antistasin orthologs in different leeches showed the possibility of different function across leech species. Hau-antistasin1 was expressed in the same region as hedgehog, which is a known mediator of signal transduction pathway. Hau-antistasin1 is probably a downstream target of Hedgehog signaling, involved in segment polarity signal pathway.</P>