http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Cirelli, Claudio (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Chang, Po-Chun,Cirelli, Joni A.,Jin, Qiming,Seol, Yang-Jo,Sugai, James V.,D'Silva, Nisha J.,Danciu, Theodora E.,Chandler, Lois A.,Sosnowski, Barbara A.,Giannobile, William V. Mary Ann Liebert 2009 Human gene therapy Vol.20 No.5
<P>Platelet-derived growth factor (PDGF) gene therapy offers promise for tissue engineering of tooth-supporting alveolar bone defects. To date, limited information exists regarding the safety profile and systemic biodistribution of PDGF gene therapy vectors when delivered locally to periodontal osseous defects. The aim of this preclinical study was to determine the safety profile of adenovirus encoding the PDGF-B gene (AdPDGF-B) delivered in a collagen matrix to periodontal lesions. Standardized alveolar bone defects were created in rats, followed by delivery of matrix alone or containing AdPDGF-B at 5.5 x 10(8) or 5.5 x 10(9) plaque-forming units/ml. The regenerative response was confirmed histologically. Gross clinical observations, hematology, and blood chemistries were monitored to evaluate systemic involvement. Bioluminescence and quantitative polymerase chain reaction were used to assess vector biodistribution. No significant histopathological changes were noted during the investigation. Minor alterations in specific hematological and blood chemistries were seen; however, most parameters were within the normal range for all groups. Bioluminescence analysis revealed vector distribution at the axillary lymph nodes during the first 2 weeks with subsequent return to baseline levels. AdPDGF-B was well contained within the localized osseous defect area without viremia or distant organ involvement. These results indicate that AdPDGF-B delivered in a collagen matrix exhibits acceptable safety profiles for possible use in human clinical studies.</P>
-
Orientation-dependent stereo Wigner time delay and electron localization in a small molecule
Vos, J.,Cattaneo, L.,Patchkovskii, S.,Zimmermann, T.,Cirelli, C.,Lucchini, M.,Kheifets, A.,Landsman, A. S.,Keller, U. American Association for the Advancement of Scienc 2018 Science Vol.360 No.6395
<P>Attosecond metrology of atoms has accessed the time scale of the most fundamental processes in quantum mechanics. Transferring the time-resolved photoelectric effect from atoms to molecules considerably increases experimental and theoretical challenges. Here we show that orientation-and energy-resolved measurements characterize the molecular stereo Wigner time delay. This observable provides direct information on the localization of the excited electron wave packet within the molecular potential. Furthermore, we demonstrate that photoelectrons resulting from the dissociative ionization process of the CO molecule are preferentially emitted from the carbon end for dissociative (2)Sigma states and from the center and oxygen end for the (2)Pi states of the molecular ion. Supported by comprehensive theoretical calculations, this work constitutes a complete spatially and temporally resolved reconstruction of the molecular photoelectric effect.</P>
-
Angular dependence of photoemission time delay in helium
Heuser, Sebastian,Jimé,nez Galá,n, Á,lvaro,Cirelli, Claudio,Marante, Carlos,Sabbar, Mazyar,Boge, Robert,Lucchini, Matteo,Gallmann, Lukas,Ivanov, Igor,Kheifets, Anatoli S.,Dahlstr&oum American Physical Society 2016 Physical Review A Vol.94 No.6
<P>Time delays of electrons emitted from an isotropic initial state with the absorption of a single photon and leaving behind an isotropic ion are angle independent. Using an interferometric method involving XUV attosecond pulse trains and an IR-probe field in combination with a detection scheme, which allows for full three-dimensional momentum resolution, we show that measured time delays between electrons liberated from the 1s(2) spherically symmetric ground state of helium depend on the emission direction of the electrons relative to the common linear polarization axis of the ionizing XUV light and the IR-probing field. Such time delay anisotropy, for which we measure values as large as 60 as, is caused by the interplay between final quantum states with different symmetry and arises naturally whenever the photoionization process involves the exchange of more than one photon. With the support of accurate theoretical models, the angular dependence of the time delay is attributed to small phase differences that are induced in the laser-driven continuum transitions to the final states. Since most measurement techniques tracing attosecond electron dynamics involve the exchange of at least two photons, this is a general and significant effect that must be taken into account in all measurements of time delays involving photoionization processes.</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
