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Karen M. Jimé,nez,Angela J. Pereira Morales,Diego A. Forero 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.4
Objective-The aim of this study was to examine a possible association between depressive symptoms and a functional polymorphism (rs686) that modulates the regulation of DRD1 gene by miR-504. Methods-A total of 239 young Colombian subjects were evaluated with the Patient Health Questionnaire-9 (PHQ-9) scale and geno-typed for the rs686 polymorphism. A linear regression model, corrected by age and gender, was used. Results-A significant association between the rs686 polymorphism and PHQ-9 scores was found, under a dominant genetic model (p=0.0094). Conclusion-These results provide novel evidence about the growing role of inherited variants in binding sites for brain-expressed miRNAs on depressive symptomatology