A New Theoretical Equation to Estimate Poisson’s Ratio for Coated Bi-axial Warp Knitted Fabrics under Bias Tensile Loading

Jianwen Chen,Han Zhou,Bing Zhao,Wujun Chen,Mingyang Wang,Zhihong Xu 한국섬유공학회 2018 Fibers and polymers Vol.19 No.12

Tensile tests of seven bias angles with a 15 o increment with respect to the warp direction are conducted on a typical coated bi-axial warp knitted fabric (BWKF). By utilizing the Digital Image Correlation technique, the experimental results are processed, and detailed responses of strain contours and Poisson’s ratios are determined for some specific strain levels, and an extraordinary M-shaped relationship between Poisson’s ratio and bias angle is revealed. Then, the tested Poisson’s ratios are compared with corresponding theoretical predictions from the original theory for ordinary anisotropic materials, discrepancies and their possible causes are analyzed. Finally, the original theory used for Poisson’s ratio predication of ordinary anisotropic materials is modified for application to the BWKFs by considering the unique local valley at 45 o caused by structural differences and possible yarn movements. The modified theoretical equation could exhibit the Mshaped relationship between Poisson’s ratio and bias angle, and is validated due to the high similarity between the predictions and experimental results. This investigation could provide some new insights into the orientation-dependence, Poisson’s effect and complex deformation mechanism of BWKFs.

Risk Factors for Poor Outcomes Following Minimally Invasive Discectomy: A Post Hoc Subgroup Analysis of 2-Year Follow-up Prospective Data

Zihao Chen,Lei He,Lijun Huang,Zhongyu Liu,Jianwen Dong,Bin Liu,Ruiqiang Chen,Liangming Zhang,Peigen Xie,Limin Rong 대한척추신경외과학회 2022 Neurospine Vol.19 No.1

Objective: A post hoc subgroup analysis of prospectively collected data from a randomized controlled trial was conducted to identify risk factors related to poor outcomes in patients who underwent minimally invasive discectomy. Methods: Patients were divided into satisfied and dissatisfied subgroups based on Oswestry Disability Index (ODI), visual analogue scale (VAS) back pain score (VAS-back) and leg pain score (VAS-leg) at short-term and midterm follow-up according to the patient acceptable symptom state threshold. Demographic characteristics, radiographic parameters, and clinical outcomes between the satisfied and dissatisfied subgroups were compared using univariate and multivariate analysis. Results: A total of 222 patients (92.1%) completed 2-year follow-up, and the postoperative ODI, VAS-back, and VAS-leg were significantly improved after surgery as compared to preoperatively. Multivariate analysis indicated older age (p = 0.026), lateral recess stenosis (p = 0.046), and lower baseline ODI (p = 0.027) were related to poor short-term functional improvement. Higher baseline VAS-back (p = 0.048) was associated with poor short-term relief of back pain, while absence of decreased sensation (p = 0.019) and far-lateral disc herniation (p = 0.004) were associated with poorer short-term relief of leg pain. Lumbar facet joint osteoarthritis was identified as a risk factor for poor functional improvement (p = 0.003) and relief of back pain (p = 0.031). Disc protrusion (p = 0.036) predicted poorer relief of back pain at midterm follow-up. Conclusion: In this study, several factors were identified to be predictive of poor surgical outcomes following minimally invasive discectomy. (ClinicalTrials.gov number: NCT01997086).

Effects of TETA or TEPA Loading on CO2 Adsorption Properties Using Pore-Expanded KIT-6 as Support

Jianwen Wei,Dejun Mei,Zhifeng Lin,Linlin Geng,Siqi Chen,Lei Liao 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.4

Mesoporous silica pore-expanded KIT-6 was synthesized using tetraethoxysilane (TEOS) as the silica source, tri-block copolymer (P123) as a structure-directing agent and 1,3,5-trimethylbenzene (TMB) as swelling agents by a hydrothermal method. Then, pore-expanded KIT-6 (PE-KIT-6) was modified with different amounts of amines including triethylenetetramine (TETA) and tetraethylenepentamine (TEPA) by a post-synthetic impregnation method. The samples were characterized by small-angle X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), N2 adsorption/desorption, elemental analysis and thermal gravimetric analysis (TGA). Experimental results revealed that the modifiers were introduced into the samples and the CO2 adsorption capacity increased first and then decreased with the increase of TETA/TEPA loadings. Under the same loadings of TETA/TEPA, the samples modified by TEPA exhibited better CO2 adsorption capacities than the samples modified by TETA because TEPA has one more amine group than TETA in the molecule. The results also indicated that the samples had good adsorption capacities at the loadings ranging from 30% to 35%. Among them, the sample modified by TEPA with the loading of 35% had the maximum adsorption capacity of 2.9mmol/g. After five cycles of adsorption/desorption, the adsorption capacity only dropped 4.59%, indicating that the adsorbent of PE-KIT-6 modified by TEPA has good cyclic stability.

The Impact of Double Fixation with Titanium Tack and N-Butyl Cyanoacrylate Glue (NBCG) Mesh Fixation versus NBCG Fixation Only in Totally Extra-Peritoneal Hernioplasty with 3-Dimensional Configured Polyester Mesh: A Comparative Study

Kejin CHEN,Jianwen LIU,Xuefei YANG,Joe King Man Fan 대한내시경복강경외과학회 2018 Journal of Minimally Invasive Surgery Vol.21 No.3

Purpose: Our aim is to compare 3-dimensional mesh fixation using titanium tacks combine with n-butyl cyanoacrylate glue (NBCG) (COMBINE group) versus NBCG only (NBCG group) in totally extraperitoneal inguinal hernioplasty (TEP).Methods: This is a retrospectively study of patients diagnosed with unilateral inguinal hernia and underwent TEP with 3-dimensional configured polyester mesh fixation using titanium tacks combine NBCG or NBCG only at the University of Hong Kong-Shenzhen Hospital with data prospectively collected. Operative details and outcomes were compared including: operating time, size of defect, total hospital cost, post-operative pain scores and recurrence.Results: From 08.2013 to 03.2016 a total of 219 patients were included. There was no significant difference between COMBINE group and NBCG group in mean age (52.5 years versus 48.2 years), mean size of defects (2.4 cm versus 2.6 cm), and operating time (121 mins versus 111 mins). There were significant differences between COMBINE group and NBCG group in total hospital cost (3035 USD versus 2022 USD), post-operative pain score on day 2 to day 4 (VAS: 1.4 versus 1.0, 1.0 versus 0.4, 0.5 versus 0.2). There was one recurrence in COMBINE group (p=0.276) with overall recurrence of 0.46%.Conclusion: Patients with inguinal hernia underwent TEP with 3-dimensional configured polyester mesh with NBCG fixation only having comparative surgical outcome to COMBINE group. A recurrence of 0.46% can be achieved with this combination. Tacks fixation may cause more post-operative pain and increase hospital cost. Use of N-butyl cyanoacrylate glue in TEP is safe and effective in our clinical series.

YTHDF1 promotes the proliferation, migration, and invasion of prostate cancer cells by regulating TRIM44

Li Weijian,Chen Gaohuang,Feng Zhenyu,Zhu Baoyi,Zhou Lilin,Zhang Yuying,Mai Junyan,Jiang Chonghe,Zeng Jianwen 한국유전학회 2021 Genes & Genomics Vol.43 No.12

Background Prostate cancer (PCa) is one of the most common malignancies in men. YTHDF1 may play an important role in promoting PCa progression, but there is no reports to date on YTHDF1 function in PCa. Objective This study explored whether YTHDF1 could regulate TRIM44 in PCa cells. Methods By querying the TCGA database, we evaluated YTHDF1 expression in PCa, the OS and DFS of YTHDF1, and the correlation between YTHDF1 and TRIM44 in PCa. We constructed vectors to interfere with YTHDF1 expression and overexpress TRIM44 to examine the role of YTHDF1 and TRIM44 in PCa cells. Diferentially expressed mRNAs were identifed by mRNA sequencing. The levels of YTHDF1, TRIM44, LGR4, SGTA, DDX20, and FZD8 were measured by qRT-PCR and WB was used to determine YTHDF1 and TRIM44 expression. A CCK-8 assay was used to assess cell proliferation. A Transwell chamber assay was used measure cell migration and invasion ability. Results YTHDF1 was highly expressed in both Pca tissues and cells. PCa patient prognosis with high YTHDF1 expression was relatively poor. Cell function experiments showed that inhibiting YTHDF1 expression decreased cell proliferation, migration, and invasion. RNA sequencing analysis revealed that YTHDF1 may promote PCa cell proliferation, migration, and invasion by modulating TRIM44 expression. Cell function experiments further verifed that YTHDF1 promoted PCa cell proliferation, migration, and invasion by regulating TRIM44. Conclusions YTHDF1 enhances PCa cell proliferation, migration, and invasion by regulating TRIM44.

ULTIMATE BEHAVIOR OF PREDATOR-PREY SYSTEM WITH CONSTANT HARVESTING OF THE PREY IMPULSIVELY

Dong, Lingzhen,Chen, Lansun,Sun, Lihua,Jia, Jianwen 한국전산응용수학회 2006 Journal of applied mathematics & informatics Vol.22 No.1

In this paper, we consider the Lotka- Volterra predator-prey system, in which constant quantity of the prey is harvested in regular pulses. The ultimate behavior of the solutions starting from different regions is mainly studied. Further, some examples are given to illustrate our results.

Impedance Characteristics Analysis of Modular Multilevel Converter with Direct Modulation and Compensated Modulation

Jing Lyu,Jinshui Dai,Chen Zhang,Jianwen Zhang,Xu Cai 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5

This paper presents a comparative analysis of impedance characteristics of modular multilevel converter (MMC) with direct modulation and compensated modulation. The analytical derivations of the ac-side impedances of the MMC with these two modulation modes are provided, respectively, which are then validated by the measured impedances in the time-domain simulation model. Subsequently, a case study is carried out to show the impact of the two modulation modes on the stability of the MMCbased interconnected system using the impedance-based analysis method. The findings could provide a reference for controller design of MMC-based power electronic systems from a stability perspective.

Electroacupuncture-Modulated MiR106b-5p Expression Enhances Autophagy by Targeting Beclin-1 to Promote Motor Function Recovery After Spinal Cord Injury in Rats

Shuhui Guo,Jianmin Chen,Ye Yang,Xiaolu Li,Yun Tang,Yuchang Gui,Jianquan Chen,Jianwen Xu 대한척추신경외과학회 2023 Neurospine Vol.20 No.3

Objective: Electroacupuncture (EA) has a definite effect on the treatment of spinal cord injuries (SCIs), but its underlying molecular mechanism remains unclear. Meanwhile, MiR-106b-5p is an autophagy- and apoptosis-related microribonucleic acid, but whether it regulates the progression of autophagy and apoptosis in SCIs is yet undetermined. As such, this study aimed to elucidate the involvement of miR-106b-5p in the EA treatment of an SCI. Methods: The miR-106b-5p level was detected by quantitative real-time polymerase chain reaction. In vitro, SH-SY5Y cells were transfected with miR-106b-5p mimics or inhibitors to regulate the miR-106b-5p expression, while in vivo, SCI rats were treated with EA for 7 days at the bilateral Zusanli (ST36) and Jiaji (EX-B2) acupoints. The motor function was evaluated using the Basso-Beattie-Bresnahan (BBB) criteria. Further, autophagic vacuoles, pathological damage, and neuronal cell morphology were observed by transmission electron microscopy, as well as by hematoxylin and eosin and Nissl staining, respectively. Results: The miR-106b-5p level, which can interact directly with Beclin-1 by influencing its expression, as well as the expressions of P62, Caspase-3, and Bax, was upregulated after an SCI, but it decreased after EA. Moreover, the ratio of LC3-II to LC3-I was upregulated after EA. EA can enhance autophagy, reduce neuronal apoptosis, and minimize motor dysfunction and histopathological deficits after an SCI. More importantly, however, all the above effects induced by EA can be reversed after an injection of miR-106-5p agomir to produce an overexpression of miR-106b-5p. Conclusion: EA treatment could downregulate miR-106b-5p to alleviate SCI-mediated injuries by promoting autophagy and inhibiting apoptosis.

Ultimate behavior of predator-prey system with constant harvesting of the prey impulsively

Lingzhen Dong,Lansun Chen,Lihua Sun,Jianwen Jia 한국전산응용수학회 2006 Journal of applied mathematics & informatics Vol.22 No.1-2

In this paper, we consider the Lotka-Volterra predator-prey system, in which constant quantity of the prey is harvested in regular pulses. The ultimate behavior of the solutions starting from different regions is mainly studied. Further, some examples are given to illustrate our results.

Transforming Growth Factor β1/Smad4 Signaling Affects Osteoclast Differentiation via Regulation of miR-155 Expression

Zhao, Hongying,Zhang, Jun,Shao, Haiyu,Liu, Jianwen,Jin, Mengran,Chen, Jinping,Huang, Yazeng Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.3

Transforming growth factor ${\beta}1$ $(TGF{\beta}1)/Smad4$ signaling plays a pivotal role in maintenance of the dynamic balance between bone formation and resorption. The microRNA miR-155 has been reported to exert a significant role in the differentiation of macrophage and dendritic cells. The goal of this study was to determine whether miR-155 regulates osteoclast differentiation through $TGF{\beta}1/Smad4$ signaling. Here, we present that $TGF{\beta}1$ elevated miR-155 levels during osteoclast differentiation through the stimulation of M-CSF and RANKL. Additionally, we found that silencing Smad4 attenuated the upregulation of miR-155 induced by $TGF{\beta}1$. The results of luciferase reporter experiments and ChIP assays demonstrated that $TGF{\beta}1$ promoted the binding of Smad4 to the miR-155 promoter at a site located in 454 bp from the transcription start site in vivo, further verifying that miR-155 is a transcriptional target of the $TGF{\beta}1/Smad4$ pathway. Subsequently, TRAP staining and qRT-PCR analysis revealed that silencing Smad4 impaired the $TGF{\beta}1$-mediated inhibition on osteoclast differentiation. Finally, we found that miR-155 may target SOCS1 and MITF to suppress osteoclast differentiation. Taken together, we provide the first evidence that $TGF{\beta}1/Smad4$ signaling affects osteoclast differentiation by regulation of miR-155 expression and the use of miR-155 as a potential therapeutic target for osteoclast-related diseases shows great promise.