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RISS 인기검색어
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- 저자 : Zeng Jianwen (검색결과 2 건)
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Dabao Fan,Daxing Zeng,Ya Liu,Wenjuan Lu,Yulei Hou,Zirong Zhou,Jianwen Guo 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.4
This study investigates the factors affecting the topology of Rubik’s cube mechanism (RCM) and presents the synthesis theory of RCM. First, the revolute axis symmetry of the RCM is described and analyzed, and the general expression needed for the revolute axis to meet the symmetry is introduced. Next, the symmetry expression of the revolute pair contact surface (RPCS) of the RCM is given. The intersection between the RPCSs is analyzed via the adjacency matrix, and the adjacency matrix characteristics are given along with the motion characteristics of RCM. After determining the RPCS intersection, its topology is studied. Finally, the synthesis theory of RCM is presented, and the synthesis process and flowchart are proposed. The regular hexahedron RCMs with different topological structures are obtained after applying the synthesis theory. Hence, the theory proposed in this study provides strong theoretical support for the synthesis of other new RCMs.
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Li Weijian,Chen Gaohuang,Feng Zhenyu,Zhu Baoyi,Zhou Lilin,Zhang Yuying,Mai Junyan,Jiang Chonghe,Zeng Jianwen 한국유전학회 2021 Genes & Genomics Vol.43 No.12
Background Prostate cancer (PCa) is one of the most common malignancies in men. YTHDF1 may play an important role in promoting PCa progression, but there is no reports to date on YTHDF1 function in PCa. Objective This study explored whether YTHDF1 could regulate TRIM44 in PCa cells. Methods By querying the TCGA database, we evaluated YTHDF1 expression in PCa, the OS and DFS of YTHDF1, and the correlation between YTHDF1 and TRIM44 in PCa. We constructed vectors to interfere with YTHDF1 expression and overexpress TRIM44 to examine the role of YTHDF1 and TRIM44 in PCa cells. Diferentially expressed mRNAs were identifed by mRNA sequencing. The levels of YTHDF1, TRIM44, LGR4, SGTA, DDX20, and FZD8 were measured by qRT-PCR and WB was used to determine YTHDF1 and TRIM44 expression. A CCK-8 assay was used to assess cell proliferation. A Transwell chamber assay was used measure cell migration and invasion ability. Results YTHDF1 was highly expressed in both Pca tissues and cells. PCa patient prognosis with high YTHDF1 expression was relatively poor. Cell function experiments showed that inhibiting YTHDF1 expression decreased cell proliferation, migration, and invasion. RNA sequencing analysis revealed that YTHDF1 may promote PCa cell proliferation, migration, and invasion by modulating TRIM44 expression. Cell function experiments further verifed that YTHDF1 promoted PCa cell proliferation, migration, and invasion by regulating TRIM44. Conclusions YTHDF1 enhances PCa cell proliferation, migration, and invasion by regulating TRIM44.
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