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Jianquan Kan,Hui Shi,Xiong Liu,Zongdao Chen 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.6
Effects of sweet potato proteoglycans (SPG) inrats fed high lipid diets were investigated. Serum lipidindices for SPG were evaluated. SPG had hypolipidemiceffects that were correlated with dosage. There were nosignificant (p>0.05) differences in hypolipidemic effectsbetween SPG varieties of different molecular weights. SPG-1 (Mw value: 508.3 kDa) significantly (p<0.05)reduced serum total cholesterol (TC), triacylglyceride(TAG), low density lipoprotein cholesterol (LDL-C), andapolipoprotein (Apo) B levels, and the arteriosclerosisindex (AI), and induced serum high density lipoproteincholesterol (HDL-C), ApoA-I, lecithin cholesterol acyltransferase(LCAT), and liver lipoprotein lipase (LPL)activities, compared with controls. The whole blood viscosityand red blood cell (RBC) membrane microviscosity werealso decreased. Hypolipidemic effects were mediated viaelevation of the serum HDL-C concentration by inductionof LACT activity, an increased ApoA-I concentration, anda reduction in the serum lipid concentration due toregulation of LPL activity.
Shuhui Guo,Jianmin Chen,Ye Yang,Xiaolu Li,Yun Tang,Yuchang Gui,Jianquan Chen,Jianwen Xu 대한척추신경외과학회 2023 Neurospine Vol.20 No.3
Objective: Electroacupuncture (EA) has a definite effect on the treatment of spinal cord injuries (SCIs), but its underlying molecular mechanism remains unclear. Meanwhile, MiR-106b-5p is an autophagy- and apoptosis-related microribonucleic acid, but whether it regulates the progression of autophagy and apoptosis in SCIs is yet undetermined. As such, this study aimed to elucidate the involvement of miR-106b-5p in the EA treatment of an SCI. Methods: The miR-106b-5p level was detected by quantitative real-time polymerase chain reaction. In vitro, SH-SY5Y cells were transfected with miR-106b-5p mimics or inhibitors to regulate the miR-106b-5p expression, while in vivo, SCI rats were treated with EA for 7 days at the bilateral Zusanli (ST36) and Jiaji (EX-B2) acupoints. The motor function was evaluated using the Basso-Beattie-Bresnahan (BBB) criteria. Further, autophagic vacuoles, pathological damage, and neuronal cell morphology were observed by transmission electron microscopy, as well as by hematoxylin and eosin and Nissl staining, respectively. Results: The miR-106b-5p level, which can interact directly with Beclin-1 by influencing its expression, as well as the expressions of P62, Caspase-3, and Bax, was upregulated after an SCI, but it decreased after EA. Moreover, the ratio of LC3-II to LC3-I was upregulated after EA. EA can enhance autophagy, reduce neuronal apoptosis, and minimize motor dysfunction and histopathological deficits after an SCI. More importantly, however, all the above effects induced by EA can be reversed after an injection of miR-106-5p agomir to produce an overexpression of miR-106b-5p. Conclusion: EA treatment could downregulate miR-106b-5p to alleviate SCI-mediated injuries by promoting autophagy and inhibiting apoptosis.