불산 제조업체 근로자의 골밀도 변화에 관한 조사

김지용,임현술,정회경,이현경,강흥식 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

Hydrofluoric acid is one of strongest irritating, corrosive and poisonous inorganic chemicals. The most significant chronic consequence of excessive fluoride exposure is the disorder of skeletal system and connective tissue. The first stage of osteofluorosis consists of an increase in the density of flatbone such as pelvic bone and vertebral bones, with coarseness and blurring of bone trabecular. Therefore we wanted to observe the change of the bone density among workers exposed to hydrofluoric acid. Questionnairs and radiological investigations were performed for 39 hydrofluoric acid manufacturing factory worker sexposed to hydrofluoric acid. And then authors checked urinary fluoride level by fluoride ion method. The radiographs were doubly read by two radiologists for reliability. The results were as follows; 1. There was a significant difference in urinary fluoride level(p<0.01), but not in age, in tenure(p>0.05) among workers by the job title. 2. By the two radiologists, eight cases were read as bone fluorosis. The prevalence rate of bone fluorosis was 20.5%. 3. There was not a significant difference in general characteristic such as age, tenure and in muculoskeletal signs and symptoms between the fluorosis group and the normal group. 4. However, a close relationship between the occurence of the change of bone density and the degree of fluoride exposure such as burn was found. The difficulties in diagnosing fluorosis result from the questionable sensitivity of x-ray techniques and from the non-specific associated signs and symptoms. A quantitative method such as densitometry to assessosteosclerosis and bone structure alteration and a follow-up study are needed.

강건 설계를 이용한 전자제품 신뢰성 향상방법

김경모,이지수,신호균 金烏工科大學校 1997 論文集 Vol.18 No.-

Reliability is one of the important quality factor in electronic products. As it is time-consuming to estimate mean time to failure, it has not been integrated in the process of product design. In this study, we propose a method which can optimize the product with respect to robustness design and can estimate mean time to failure of electronic products by only one experimentation. This proposed method can quarantee quality improvement by making the life time of the designed products robust to customer's environment. We explaine the detailed steps of this proposed method through a case study.

난원공 개존을 통한 우심방에서 좌심방으로의 단락 진단에 있어 경흉부 심초음파 하모닉 영상의 유용성

신미승,강석민,장길진,변기현,하종원,정남식,허지회,이병인 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

Pathophysiologic and Therapeutic Perspectives Based on Thrombus Histology in Stroke

Ji Hoe Heo,Hyo Suk Nam,Young Dae Kim,Jin Kyo Choi,Byung Moon Kim,Dong Joon Kim,Il Kwon 대한뇌졸중학회 2020 Journal of stroke Vol.22 No.1

Recent advances in endovascular thrombectomy have enabled the histopathologic analysis of fresh thrombi in patients with acute stroke. Histologic analysis has shown that the thrombus composition is very heterogeneous between patients. However, the distribution pattern of each thrombus component often differs between patients with cardiac thrombi and those with arterial thrombi, and the efficacy of endovascular thrombectomy is different according to the thrombus composition. Furthermore, the thrombus age is related to the efficacy of reperfusion therapy. Recent studies have shown that neutrophils and neutrophil extracellular traps contribute to thrombus formation and resistance to reperfusion therapy. Histologic features of thrombi in patients with stroke may provide some clues to stroke etiology, which is helpful for determining the strategy of stroke prevention. Research on thrombus may also be helpful for improving reperfusion therapy, including the development of new thrombolytic agents.

Analysis of the Factors Influencing University Adult Learners’ Lifelong Education Satisfaction : Focusing on the Individual Background, Institutional Characteristics, and Learning Experience

Ji-Hoe Park,Hyun-Yong Ahn 한국성인계속교육학회 2021 성인계속교육연구 Vol.12 No.3

Cloning , Nucleotide Sequence and Expression of Gene Coding for Poly - 3 - hydroxybutyric Acid ( PHB ) Synthase of Rhodobacter sphaeroides 2.4.1

Ji Hoe Kim,Jeong Kug Lee 한국미생물생명공학회 1997 Journal of microbiology and biotechnology Vol.7 No.4

Original Articles : The Widespread Distribution of the Venomous and Poisonous Blue-Lined Octopus Hapalochlaena spp., in the East/Japan Sea: Possible Effects of Sea Warming

( Ji Hoe Kim ),( Toshiyuki Suzuki ),( Kil Bo Shim ),( Eun Gyoung Oh ) 한국수산과학회(구 한국수산학회) 2012 Fisheries and Aquatic Sciences Vol.15 No.1

The geographical distribution of the toxic blue-lined octopus (commonly known as the blue-ringed octopus), Hapalochlaena spp., around the East/Japan Sea was investigated. Observation records of the octopus were gathered using commercial search engines on the Internet. A questionnaire to complement and enhance the base data was conducted that targeted fishermen from areas where the octopus was most likely to occur, i.e., the southeast coast and islands of Korea in the East/Japan Sea. Overall, 32 observational records of the blue-lined octopus were found from Korea and Japan. In Korea, only one record, from 2003, was found on a website; none of the 240 fishermen who participated in the questionnaire reported seeing blue-lined octopus. However, a total of 31 observations of the blue-lined octopus from 2004 to July 2010 were found from 17 different regions in the East/Japan Sea and neighboring waters in Japan. Twenty-two cases were from coastal Honshu Island, and nine were from the west coast of Kyushu Island, Japan. The northern distributional boundary of the blue-lined octopus on the Japanese coast was off Fukui Prefecture around latitude 36º10` N. Our results indicate that the blue-lined octopus is distributed extensively along the Japanese coast, at a low frequency, in the East/Japan Sea.

해양세균, Shewanella sp. SR-14에 의한 규조류 Chaetoceros calcitrans의 증식저해 - 해양세균이 규조류의 지방산 조성변화에 미치는 영향 -

김지회 ( Ji Hoe Kim ),윤호동 ( Ho Dong Yoon ),박희연 ( Hee Yun Park ),이희정 ( Hee Jung Lee ),장동석 ( Dong Suck Chang ) 한국수산과학회 2003 한국수산과학회지 Vol.36 No.1

규조류 C. calcitrans와 S. costatum 그리고 Chaetoceros spp. 생육저해 활성을 가지는 해양세균, Shewanella sp. SR-14와 그 저해활성이 없는 Vibrio alginolyticus의 지방산 조성을 분석하고 이들 해양세균과 규조류를 각각 혼합배양하였을 때 규조류의 지방산 조성 변화를 측정하였다. Peptone broth에서 20˚C, 3일간 배양한 Shewanella sp. SR-14의 주요 지방산 조성은 16:1n-7 (29.4%) 과 16:0 (19.2%)이었으나, V. alginolticus의 경우는 16:0 (23.7%), 16:1n-7 (27.7%) 및 18:1n-7 (21.0%)이었으며, 이들 세균을 Conwy 배지에서 재배양하였을 때, 그 조성은 peptone broth에서 배양한 균체와 약간의 변화가 있었다. 순수배양한 미세조류의 주요 지방산은 C. calcitrans의 경우 16:1n-7 (33.3%), 16:0 (27.1%) 및 14:0 (12.1%)이었고, S. costatum mainly contained 은 6:1n-7 (28.9%), 16:0 (21.6%) 및 20:5 (19.8%)이었다. 세균과 혼합배양한 규조류의 지방산 조성은 Shewanella sp. SR-14와 혼합배양한 경우 순수배양한 조체에 비하여 포화지방산의 비율은 감소하였으나 불포화지방산의 비율은 증가하였으며, 그 변동율은 C. calcitrans의 경우가 S. costatum보다 높았다. 그러나 V. alginolticus와 혼합배양한 경우 C. calcitrans는 포화지방산이 증가한 반면 불포화지방산은 감소하는 경향을 나타내었고, S. costatum은 순수 배양한 조체와 큰 차이를 보이지 않았다. 그래서 C. calcitrans 는 Shewancella sp. SR-14에 의하여 불포화지방산의 조성이 증가되고, 이러한 지방산은 이 균이 생성하는 조류증식 저해물질과 상승적으로 작용하여 더욱 조류의 증식이 억제되는 것으로 시사되었다. In the previous reports, the authors isolated two strains of marine bacteria, shewanella sp. SR-14, which has Chaetoceros sp. growth inhibition activity, and Vibrio alginolyticus, that did not affect growth of the alga. In the present study, fatty acid compositions of diatoms, Chaetoceros calcitrans and Skeletonema costatum, and marine bacteria, Shewanella sp. SR-14 and V. alginolyticus, were analyzed. Changes of fatty acid composition in the diatoms grown with the marine bacteria were also determined. Major fatty acids of Shewanella sp. SR-14 were 16:1n-7 (29.4%) and 16:0 (19.2%) during incubation in peptone broth at 20 ˚C for 3days. The compositions of V. alginolticus detected were 16:0 (23.7%), 16:1n-7 (27.7%) and 18:1n-7 (21.0%). C. calcitrans consisted of 16:1n-7 (33.3%), 16:0 (27.1%) and 14:0 (12.1%). S. costatum mainly contained 16:1n-7 (28.9%), 16:0 (21.6%) and 20:5 (19.8%). When halves of cell numbers of C. calcitrans were moribund cells by Shewanella sp. SR-14, the C. calcitrans and S. costatum simultaneously cultured with the bacteria were harvested by filtration with GF/D glass microfibre filter. In the fatty acid composition of both diatoms, saturated fatty acid contents in both diatoms grown with Shewanells sp. SR-14 wre decreased, but unsaturated fatty acid contents were increased. The differences were greater in C. calcitrans than those in S. costatum. During the growth of diatoms with V. alginolyticus, C. calcitrans showed increase of saturated fatrty acid contents and decrease of unsaturated fatty acid contents ; however, S. costatum did not show sharp difference in fatty acid content. In this study, Shewanella sp. SR-14, which showed growth inhibition activity against C. calcitrans, influenced on the changes of fatty acid contents in the diatom. It was suggested that increased unsaturated fatty acid was synergistically activated algal growth inhibition activity of Shewanella sp. SR-14.

원저 : 임신성 당뇨병의 위험인자

박지회 ( Ji Hoe Park ),송홍지 ( Hong Ji Song ),천정기 ( Joung Ki Choun ),조정진 ( Jung Jin Cho ),백유진 ( Yu Jin Paek ),박경희 ( Kyung Hee Park ),김암 ( Ahm Kim ),이필량 ( Pyl Ryang Lee ),황종윤 ( Jong Yun Hwang ) 대한비만학회 2005 The Korean journal of obesity Vol.14 No.3

연구배경: 한국인의 임신성 당뇨병은 2~3%의 유병률을 가지며 제2형 당뇨병의 위험인자로 알려져 있다. 이에 우리나라 여성에서 임신성 당뇨병 위험 인자에 대해 알아보고 임신 전 체중과 임신 중 체중 변화가 임신성 당뇨병 발생에 미치는 영향을 보고자 하였다. 방법: 2000년 1월부터 2002년 12월까지 모 대학병원 산전 진찰을 하기위해 임신 제 1 삼분기부터 산부인과를 방문한 20~40대 산모들 중 확진 검사에서 임신성 당뇨병으로 진단된 91명의 환자군과 같은 연령대의 정상 산모군 175명에 대해 임신 전, 첫 방문 주수, 선별 검사, 확진 검사 시기별로 임상적 특성 및 산과적 과거력에 대해 분석하였다. 결과: 연구 대상자의 연령은 환자군이 평균 32.6±4.1세, 정상 대조군이 32.3±4.2세였다. 임신 전 체질량지수는 환자군에서 22.7±3.6 ㎏/㎡, 대조군에서 20.3±2.2 ㎏/㎡로 환자군에서 유의하게 높았고, 선별 검사 시행 시기의 체중도 유의한 차이를 보였다. 요검사상 요당 검출 (P<0.001), 당뇨병 가족력 (P<0.001), 임신성 당뇨병 (P<0.001)과 임신성 고혈압 과거력 (P=0.034), 전 아이 체중 (P=0.018)은 환자군에서 유의하게 높았고, 임신력, 분만력, 선별 검사 시행 시기까지 체중 변화량, 변화율, 혈압, 자궁 내 성장 지연, 거대아 출산력, 자궁 내 태아 사망, 기형아 출산, 조산 횟수는 군 간에 유의한 차이를 보이지 않았다. 다변량 분석에서 임신 전 체질량지수 (정상, 과체중, 비만군 교차비 OR=2.992, 4.811, 16.196), 요당 검출 (OR=57.160), 당뇨병 가족력 (OR=5.016)에 대해서만 유의한 차이를 보였다. 결론: 한국인의 임신성 당뇨의 산전 교정 가능한 위험 인자는 임신 전 체질량지수이고, 임신 전 체중 조절을 통해 임신성 당뇨병 위험을 줄일 수 있을 것으로 예상된다. Background: The prevalence of gestational diabetes mellitus (GDM) is 2~3% in Korean women and GDM is known as a risk factor of type 2 DM. The effects of pregestational weight and also the impact of weight change during gestational period on GDM were studied in addition to the risk factors of GDM. Methods: Subjects involved 266 pregnant women, in their twenties to forties, who visited the Obstetrics and Gynecologic clinic in a university hospital for prenatal care from January 2000 to December 2002. The GDM group consisted of 91 women, who were confirmed by 100g oral glucose tolerance test (OGTT), and the control group consisted of 175 women. Clinical characteristics and obstetric histories of the subjects were assessed and analyzed each time during pregestation period, first visit, screening test period and final test period. Results: The mean age of participants in the GDM group was 32.6±4.1 and that of the control group was 32.3±4.2. The mean pregestational body mass index (BMI) was statistically higher (22.7±3.6 ㎏/㎡) among the GDM group compared to the control group (20.3±2.2 ㎏/㎡). Other statistically significant factors were glucosuria (P<0.001), family history of DM (P<0.001), past history of GDM (P<0.001), pregnancy induced hypertension (P=0.034), previously delivered baby`s weight (P=0.018). According to the multivariate analysis, those with family history of DM (OR=5.016), high pregestational BMI (OR=4.811 (overweight), 16.196 (obesity)), and glucosuria (OR=57.160) showed statistically significant association with GDM. Conclusions: We conclude that high pregestational BMI is a significant risk factor of GDM in Korean women. The risk of GDM may be prevented by pregestational weight control.

Molecular epidemiological study on a human patient of Brucella melitensis infection occurred in Korea

Eun Ji Yum,Jin-Ju Lee,Min-Kyeong Kim,Eun-Ji Park,So-Ra Sung,Min-Hoe Lee,Soon-Seek Yoon,Moon Her,Jeong-Soo Choi 한국예방수의학회 2019 예방수의학회지 Vol.43 No.4

Brucellosis is the most common zoonosis worldwide, which is caused by Brucella spp. In humans, it can be mainly occurred by direct contact with infected animals or consumption of contaminated dairy products. This study focused on human brucellosis caused by B. melitensis discovered from Chinese worker in Korea in 2015. We investigated molecular epidemiological evidence to find the infection source. We first performed several PCR methods including 16S rRNA PCR, multiplex PCR and real-time PCR to identify Brucella species. We also conducted MLVA typing for epidemiological trace-back analysis. The isolate from the patient was confirmed to B. melitensis through Brucella-specific PCR. In clustering analysis with B. melitensis from foreign countries, this human isolate was correlated with B. melitensis isolates from humans and sheep in China by 99.9% similarity. Thus, we assumed the brucellosis patient has been already infected in China followed by migration to Korea according to molecular epidemiological analysis with history evidence. Moreover, we suggest it needs to take measures to reduce the risk for intercountry transmission of brucellosis due to the influx of infected people from abroad.