靑馬, 柳致環 論 : 詩人의 思想性을 中心으로

崔圭復 이화여자대학교 문리대학 한국어문학회 1969 韓國語文學硏究 Vol.9 No.-

CAPD 합병증에 관한 연구

최규복,윤견일 梨花女子大學校 醫科大學 醫科學硏究所 1991 EMJ (Ewha medical journal) Vol.14 No.2

Since its first introduction by Popovich in 1976. Continuous Ambulatory Peritoneal Dialysis(CAPD) has estabilished itself as an effective method maintaining the patients with end stage renal disease. But recurrent peritonitis remains the most frequent cause of the CAPD failure. So clinical studies were carried on the 15 patients on CAPD who had been treated from June 1989 to march 1991. The following results were obtained. 1) The incidence of peritonitis was 1.73 episode/patient/year. 2) Peritonitis incidence according to the sex showed 1.93 episode/patient/year with female patients and l.46 episode/patient/year with male patients. 3) Peritonitis incidence according to the underlying disease showed 1.94 episode/patient/year with diabetic patients and 1.45 episode/patient/year with non-diabetic patients. 4) The subjective symptom and sign were as follows; abdominal pain(95%). cloudy dialysate(95%). nausea(55%), abdominal tenderness(95%). decreased dialysate drainage (59%), fever(50%), and peripheral leukocytosis(18%). 5) The positive rate in Gram stain of dialysate drainage fluid was 13.6% and the positive rate in culture was 31.8%. of which staphylococcus was 42.9%. 6) The rate of catheter removal due to peritonitis was 22.7%. The most common cause was persistent peritonitis, which accounted for 60% of cases. And all cases of catheter removal were developed in female patients. 7) The complications related to catheter were as follows ; catheter exit site infection(20%), external cuff extrusion(20%), leakage of dialysate fluid(6.7%) and crack on Tenckhoff catheter(6.7%)

혈액투석후 건조체중 판정 방법의 비교 : 생화학적 지표(혈장 cGMP 농도 및 ANP 농도)와 다주파수 생체전기 임피던스 법과의 비교 The Relationship Between Biochemical Markers(ANP and cGMP) and Multifrequency Bioelectric Impedance

최규복 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.4

Objective:The accurate evaluation of dry weight followed by hemodialysis is very important. So far, dry weight has been clinically estimated by using diagnostic parameters such as weight changes during dialysis, blood pressure, extremity edema, pulmonary edema, and chest X-rays. However, these methods result in frequent trials and errors because of the low accuracy. Recently, new methods have been attempted in a non-invasive way of determining dry weight. Bioelectric impedance method has been reported to be highly related to hemodynamic parameters before and after hemodialysis, and plasma atrial natriuretic peptide(ANP) and cyclic guanosine 3', 5'-monophosphate(cGMP) concentrations have been known to represent the amount of blood. In this study, we compared and analyzed the method of dry weight evaluation followed by hemodialysis by using multifrequency bioelectric impedance method(BIA method) and biochemical index(ANP method and cGMP method). Methods:Subjects consisted of seventeen patients who had received maintenance hemodialysis. Using multifrequency bioelectric impedance method before and after hemodialysis, a RTBW/RECF ratio in the right lower extremity was measured. Plasma ANP and cGMP concentrations were measured by collecting blood in arterial port. Results: 1)Changes before and after hemodialysis: Post-dialysis weight decreased by 2.1±0.22kg. A RTBW/ RECF ratio significantly decreased from 0.3525±0.004 pre-dialysis to 0.3292±0.002 post-dialysis(p$lt; 0.01). Plasma cGMP concentration(pmol/mL) significantly decreased from 23.9±4.4 pre-dialysis to 8.8±3.4 post-dialysis(p$lt;0.01), and plasma ANP concentration(pg/mL) significantly decreased from 315±64 pre-dialysis to 222±71 post-dialysis(p$lt;0.05). The extent of weight loss was not associated with above three parameters after dialysis. 2)The relationship between RTBW/RECF ratios and biochemical parameters:No relationship was noted between two parameters before dialysis, while a significant relationship was observed with plasma cGMP concentrations or plasconcentrations after dialysis(r=0.705, p$lt;0.01; r=0.653, p$lt;0.01, respectively). 3)The measure of agreement in estimation of dry weight after dialysis(kappa value):Although the consistencies of a BIA method and a cGMP method were good(k=0.64), the consistency between a BIA method and an ANP method was low(k=0.21), and the consistency between a cGMP method and an ANP method was almost negligible(k=0.09). Conclusion:In conclusion, RTBW/RECF ratio or plasma cGMP concentration can be used, but plasma ANP concentration is not suitable for evaluating dry weight after dialysis.

심포지엄 : 만성신장병 환자의 말초혈관병

최규복 대한신장학회 2005 추계학술대회 초록집 Vol.24 No.2

태성고혈압환자에서 죽상경화증과 Endothelin 사이의 연관성

최규복,않미재,강덕희,윤견일 대한신장학회 1995 춘계학술대회 초록집 Vol.1995 No.-

구역성 다주파수 생체전기 임피던스법을 이용한 유지혈액투석 환자의 한외여과 적절도 평가

최규복 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.2

Objective:Many patients has suffered from intradialytic hypo- or hypertension. These unsatisfactory control of blood pressure(BP) may be due to inadequate ultrafiltration during HD. In this study, segmental multifrequency BIA was used to estimate dry weight(DW). Then, ultrafiltration adequacy was evaluated according to the estimated DW. Methods:Total body water resistance(RTBW) and extracellular fluid resistance(RECF) were measured on the right lower extremity in 36 maintenance HD patients(22 men and 14 women) and in 234 control subjects(171 men, 63 women). BP was measured every 30 minutes during HD. Patients with RTBW/ RECF ratio higher and lower than the mean?2SD of control subjects were considered to be over-and underhydrated, respectively. Results: 1)RTBW/RECF ratio of control subjects was 0.3402±0.0062. 2)RTBW/RECF ratio of HD patients was 0.3650±0.0190 before and 0.3445±0.0150 after dialysis(P$lt; 0.01). After dialysis, 28 out of 36(77.8%) patients were normovolemic(NV group), 7(19.4%) patients woverhydrated(OV group), and 1 patient(2.8%) was underhydrated. 3)BP changes during HD; In NV group, BP were increased significantly(P$lt;0.05). But there was no change in OV group. In one underhydrated patient, a decrease in BP, albeit not significant, was noticed. 4)Body weight reduction rate(kg/hr) was higher in NV group(0.48?0.15) than in OV group(0.25±0.14)(P$lt;0.01). Conclusion:Segmental multifrequency BIA may be useful as a method for estimating DW and evaluating ultrafiltration adequacy in maintenance HD patients.

AST-120 Improves Microvascular Endothelial Dysfunction in End-Stage Renal Disease Patients Receiving Hemodialysis

최규복,류정화,유민아,이신아,류동열,김승정,강덕희 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.4

Purpose: Endothelial dysfunction (ED) is a pivotal phenomenon in the development of cardiovascular disease (CVD) in patients receiving hemodialysis (HD). Indoxyl sulfate (IS) is a known uremic toxin that induces ED in patients with chronic kidney disease. The aim of this study was to investigate whether AST-120, an absorbent of IS, improves microvascular or macrovascular ED in HD patients. Materials and Methods: We conducted a prospective, case-controlled trial. Fourteen patients each were enrolled in respective AST-120 and control groups. The subjects in the AST-120 group were treated with AST-120 (6 g/day) for 6 months. Microvascular function was assessed by laser Doppler flowmetry using iontophoresis of acetylcholine (Ach) and sodium nitroprusside (SNP) at baseline and again at 3 and 6 months. Carotid arterial intima-media thickness (cIMT) and flow-mediated vasodilation were measuredat baseline and 6 months. The Wilcoxon rank test was used to compare values before and after AST-120 treatment. Results: Ach-induced iontophoresis (endothelium-dependent response) was dramatically ameliorated at 3 months and 6 months in the AST-120 group. SNP-induced response showed delayed improvement only at 6 months in the AST-120 group. The IS level was decreased at 3 months in the AST-120 group, but remained stable thereafter. cIMT was significantly reduced after AST-120 treatment. No significant complications in patients taking AST-120 were reported. Conclusion: AST-120 ameliorated microvascular ED and cIMT in HD patients. A randomized study including a larger population will be required to establish a definitive role of AST-120 as a preventive medication for CVD in HD patients.

혈액투석중 혈청 지질과산화물 농도 변화와 내인성 항상화제 사이의 연관성

최규복,강덕희,윤건일 대한신장학회 1995 춘계학술대회 초록집 Vol.1995 No.-

용혈이 동반된 Gilbert증후군 1예

최규복,한경숙,김미경,배윤주,이순남,경난호 梨花女子大學校 醫科大學 醫科學硏究所 1985 EMJ (Ewha medical journal) Vol.8 No.1

Gilbert's Syndrome is the name most frequently used to describe a condition which has been called constitutional heptic dysfunction, familial nonhemolytic jaundice of icterus intermittens juvenilis. It is characterized by a benign, persistent, but vari-able elevation of the plasma unconjugated bilirubin. A 27-year-old man was admitted because of general malaise, anorexia, sore throat and slight icteric sclera. On physical examination, there were mild icteric sclera and slightly injected pharynx. The liver was palpable 1 finger breath BRCM and the spleen was also palpable I finger breadth BLCM. Hematologic studies reve-aled slight anemia with slightly elevated corrected reticulocyte count. Liver func-tion tests were normal except for slightly elevated serum total bilirbin. Histolog-ic findings of the liver showed nonspecific findings of mild cholestasis. Reduction in caloric intake to 300 calrory a day for 72 hours resulted in a significant increase in the plasma bilirubin concentration(especially unconjugated form) in this patient. Now he has no subjective symptoms and leads a normal activity without specific treatment.

낭창성 신염 환자에서 혈중 및 요중 Endothelin 의 의의

최규복,윤건일,변정한,편욱범 대한신장학회 1993 Kidney Research and Clinical Practice Vol.12 No.2