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김아진,김준식,신동운,백광제,한승백,이용주 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3
Traditionally, the Rhododendron species has been used in gastrointestinal disorder or hypertension. Grayanotoxin exists in honey, flowers, pollen, and the nectar of the Rhododenron species. We experienced 3 cases of Grayanotoxin intoxication. The symptoms of intoxication were nausea, vomiting, hypotension, bradycardia, diplopia, dizziness, and chest discomfort. Generally, the treatment for Grayanotoxin intoxication is fluid resuscitation and injection of atropine sulfate. The patients who were intoxicated with Grayanotoxin were discharged without complication after supportive care.
응급센터에 내원한 비-안와-뇌 털곰팡이증(Rhino-Orbital-Cerebral Mucormycosis)환자 2례
신동운,김준식,김아진,백광제,한승백,이용주 대한응급의학회 2000 대한응급의학회지 Vol.11 No.2
Rhino-orbital-cerebral mucormycosis is a very rare, but mostly fatal infection and is usually found in diabetic or immunocompromised hostss. It has a characteristic rapid progression, so we pay close attention to patients who have symptoms associated with rhino-orbital-cerebral mucormycosis. The symptoms due to rhino-orbital-cerebral mucormycosis are fever, ulceration or necrosis in nasal cavity, edema of the periorbital area or face, decreased visual acuity, headache, decreased mentality, etc. Because of the rapid progression and high mortality rate, close attention is needed in patients who complained such symptoms and signs. We experienced two cases of rhino-orbital-cerebral mucormycosis which had a poor prognosis, and we report them here.
Personality Types of Korean Reproductive Women with Polycystic Ovary Syndrome
( Shin Hye Chung ),( Je Yeon Lee ),( Kyung Ah Jeong ),( Hye Sun Chung ),( Eun Ju Lee ),( Ju Young Lee ),( Hye Won Chung ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.11
Objective The aim of this study was to compare personality types between polycystic ovary syndrome (PCOS) patients and women with normal menstrual cycle. Methods A total of 2,311 Korean women aged 15-39 was recruited. After initial screening, 131 women were excluded who had polarity index under 45. The study subjects were divided into PCOS patients (n=833) and women with normal menstrual cycle (n=1,347). Selfadministered questionnaire surveys, somatometry, blood test and transvaginal or transrectal ultrasound test were performed. By using Myers-Briggs Types Indicator (MBTI) personality types including characteristic index, function and temperament were also assessed. Results There was no signifi cant difference in the frequency of personality types between the patient and control groups. Among 16 MBTI subtypes, the extraversion-sensing-thinking-judgement type was the most common in both groups, 25.69% in PCOS patients and 24.51% in control group. In analysis of the judgement-perception index, the perceiving type was predominant in PCOS patients (30.73%) than control group (25.09%) with a statistical signifi cance ( P=0.013). The average testosterone level in women with the extroversion type was 53.43 ± 20.13 ng/dL, which was signifi cantly higher than women with the introversion type (51.58 ± 18.60 ng/dL). Conclusion Higher frequency of the perception type is typical feature in PCOS patients. Hyperandrogenism is closely related to the extroversion type of personality.
신동운,김준식,한승백,이준희,김아진,김지혜,기웅,안성태,이용주,백광제 대한응급의학회 2002 대한응급의학회지 Vol.13 No.1
Purpose: Due to its rapidity and easy accessibility, the fingerstick blood glucometer has been used in almost all hospitals and private clinics, and even by patients themselves. We also have used it even in shock patient care, but shock shows global tissue hypoperfusion, especially in peripheral tissue. The changes of peripheral circulation have an influence on the results for fingerstick glucose. To evaluate the accuracy of the glucometer for patients with poor peripheral perfusion, we designed this study. Methods: A prospective, nonrandomized comparison group study was done. A hypotensive group and a normotensive group were compared. We obtained three data from each patient; venous blood glucose level (clinicopathologic laboratory), venous blood glucose level (by glucometer) and fingerstick glucose level (by glucometer). Results: We saw a significant difference between the fingerstick glucometer results and the laboratory glucose levels in hypotensive patients: 131.67±55.33 mg/dl vs. 147.23±62.06 mg/dl (paired t-test, p<0.05). There was no significant difference between fingerstick and laboratory glucose in normotensive patients; 101.75±20.14 mg/dl vs. 105.60±21.95 mg/dl (paired t-test, p>0.05). There was no significant difference between the results of venous glucometer and laboratory test in either group; 142.37±61.27 mg/dl vs. 147.23±62.06 mg/dl (paired t-test, p>0.05) and 102.98±17.02 mg/dl vs, 105.60±21.95 mg/dl (paired t-test, p>0.05). Although some statistical differences existed between the results, all of the error rates were in an acceptable range (within 15%, accepted by American Diabetes Association consensus). Conclusion: These results suggest that the blood glucose level of the glucometer with venous blood is more accurate than that with peripheral blood in patients with poor peripheral circulation.
Two New Phenolic Compounds from the Rhizomes of <i>Gastrodia elata</i> <small>Blume</small>
Han, Ah‐,Reum,Ji ,Shin, Hyun,Rim ,Jeon, Ha,Lee, Je‐,Hyun,Lee, Dongho,Seo, Eun‐,Kyoung WILEY‐VCH Verlag 2011 Helvetica chimica acta Vol.94 No.7
<P><B>Abstract</B></P><P>Phytochemical investigation of the rhizomes of <I>Gastrodia elata</I> <SMALL>Blume</SMALL> (Orchidaceae) led to the isolation and identification of twelve compounds, including two new phenolic compounds, 4‐hydroxybenzyl vanillyl ether (=4‐{[(4‐hydroxyphenyl)methoxy]methyl}‐2‐methoxyphenol; <B>1</B>) and 4‐{{4‐[4‐(methoxymethyl)phenoxy]benzyl}oxy}benzyl methyl ether (=1‐[4‐(methoxymethyl)phenoxy]‐4‐{[4‐(methoxymethyl)phenoxy]methyl}benzene; <B>2</B>). The structures of <B>1</B> and <B>2</B> were elucidated by spectroscopic data analysis including 1D‐ and 2D‐NMR experiments.</P>
Choi, Je-Min,Ahn, Mi-Hyun,Chae, Wook-Jin,Jung, Yung-Gook,Park, Jae-Chul,Song, Hyun-Mi,Kim, Young-Eun,Shin, Jung-Ah,Park, Choon-Sik,Park, Jung-Won,Park, Tae-Kwann,Lee, Jung-Hoon,Seo, Byung-Fhy,Kim, Kyu Nature Publishing Group 2006 Nature medicine Vol.12 No.5
CTLA-4 is a negative regulator of T-cell activation, and its inhibitory effects can be accomplished either by competition with CD28 or by transmitting negative signals through its intracellular domain. To utilize the cytoplasmic domain of CTLA-4 to suppress allergic inflammation, we fused it to a novel protein-transduction domain in the human transcriptional factor Hph-1. Transduction efficiency was verified in vitro and in vivo after ocular, intranasal and intradermal administration. After transduction into T cells, the Hph-1–ctCTLA-4 fusion protein inhibited the production of interleukin (IL)-2, and downregulated CD69 and CD25. Intranasal administration of Hph-1–ctCTLA-4 resulted in markedly reduced infiltration of inflammatory cells, secretion of T helper type 2 (T<SUB>H</SUB>2) cytokines, serum IgE levels and airway hyper-responsiveness in a mouse model of allergic airway inflammation. These results indicated that Hph-1–ctCTLA-4 constitutes an effective immunosuppressive protein drug for potential use in the treatment of allergic asthma, via nasal administration.
주의력결핍 과잉행동장애에서 파탄적 행동장애의 공존과 약물치료
강제욱(Je Wook Kang),박은진(Eun Jin Park),김성찬(Seong Chan Kim),신의진(Yee-Jin Shin),신윤미(Yun-Mi Shin),정재석(Jaesuk Jung),천근아(Keun-Ah Cheon),육기환(Ki-Hwan Yook) 대한소아청소년정신의학회 2012 소아청소년정신의학 Vol.23 No.S
Disruptive behavioral disorders [oppositional defiant disorder (ODD) and conduct disorder (CD)] are common comorbid disorders in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). ODD/CD may be comorbid up to 60% of children and adolescents with ADHD. Comorbid ODD and CD symptoms can have a significant impact on the course and prognosis o f patients with ADHD. Stimulant medications have shown effectiveness in treating both core ADHD symptoms and oppositional symptoms. Assessment and management of comorbid disruptive behavioral symptoms is an essential part in evaluation and treatment of ADHD patients. Further research is needed to investigate the efficacy and safety of various behavioral and medication regimens for ADHD, comorbid ODD and CD and to examine the relationships between ADHD, comorbid ODD and CD.
백광제,김준식,전영진,한승백,신동운,김아진 대한외상학회 1999 大韓外傷學會誌 Vol.12 No.2
$quot;Background : The object of this retrospective study was to evaluate the clinical patterns of the patients who were injured in free-fall accidents and to analyze the correlation between clinical symptoms and ultimate outcome of the treatment. Another purpose of the study was to establish guidelines of management for emergency departments. Methods : We performed a retrospective analysis of 334 free fall patients who were treated ay our emergency department during the 2-year period from January 1997 to December 1998. Age, sex, cause, previous history, height, injury severity scores, and clinical outcomes, including hospital mortality, are all the data collected from the medical records. Results : Among the 334 patients, 265 (79.3%) were male and 171 (51.2%) were work-related accidents. Only 7 had psychological problems, and 13 falls were from heights of more than 10 meters. Extremity injury, including fractures, were the most common injuries, accounting for 145 (43.4%), followed by spinal injuries and cranial injuries, accounting for 79 (23.7%) and 77 (23.7%) each. Ankle fractures, including talo-calcaneal fractures, were the most common injuries among the extremity injuries, accounting for 38. Correlation analysis with the Spearman coefficient revealed that mental status (r=0.646) at the emergency department was more corre-lated with mortality than hypotension(r=0.346). Conclusion : Among 334 free fall victims, extremity injuries were the most common injuries. Mental status at arrival was more correlated with hospital mortality than hypotension.$quot;
접촉식 초음파와 부분결합간섭계를 이용한 생체계측시 백내장수술 후 굴절력 예측의 비교
신정아,정성근,Jeing Ah Shin,Sung Kun Chung 대한안과학회 2013 대한안과학회지 Vol.54 No.5
Purpose: To compare ocular biometry measured by applanation ultrasonography and IOL Master<sup>®, and evaluate the accuracies of the refractive outcome after cataract surgery. Methods: The biometries of 76 cataractous eyes were measured using ultrasonography and IOL Master<sup>®. The SRK-T formula was employed to predict the patient’s implanted IOL power. Two months after cataract surgery, the refractive outcome was determined, and results from the 2 different biometry methods were compared. Results: There were no statistically significant differences in axial length (AXL) and anterior chamber depth (ACD) between ultrasonography and IOL Master<sup>® (p = 0.501). When using ultrasonography, the mean absolute error (MAE) of the ultrasonography and IOL Master<sup>® was 0.53 ± 0.30 diopter (D), 0.55 ± 0.41 D, respectively. The difference between the 2 biometry methods was not statistically significant (p = 0.110). Conclusions: Although the difference was not statistically significant, AXL measured by IOL Master<sup>® was longer and ACD measured by IOL Master<sup>® was deeper than when measured by A-scan. This difference was more pronounced in patients with a short AXL. The accuracy of IOL power calculation was similar between the 2 devices.