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뇌졸중 후 치매환자에서 도네피질(아리셉트^(?))이 인지기능 및 일상생활 수행능력, 삶의 질에 미치는 효과
이상열,장혁,송재은,조성옥,류정미,이미경,조진호,신용일 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.1
Background: This study evaluated the efficacy of administering Donepezil(Aricept^(?)) for improving cognitive function, activities of daily living, and quality of life in patients with post-stroke dementia. Methods: Patients(n=99; mean age, 69.89 years; 48.5% men) with post-stroke dementia, according to criteria of the DSM-IV and MRI, were treated with donepezil 5mg/day or 10mg/day during 24 weeks. They were examined using Mini-mental Status Examination(MMSE), Chinical Dementia Rating(CDR), Barthel Activities of daily living(B-ADL), Instrumental Activities of daily living(I-ADL), Short Form 36 Health Survey-Korean(SF-36-K), and Geriatric Depression Scale(GDS) at before treatment and 24 weeks after treatment. Results: The 97 patients completed the trial. At 24 weeks, they showed significant improvement in MMSE(p<0.001), CDR(p<0.001), B-ADL(p=0.002), I-ADL(p<0.001), and SF-36-K(p=0.003) except GDS(p=0.288). Donepezil was well tolerated. There was no withdrawal due to adverse events. Conclusion: This results demonstrate that donepezil was beneficial in improving the cognitive function, activities of daily living, and quality of life in patients with post-stroke dementia and was well toleraetd.
소규모 축산폐수 처리를 위한 RBC/AFBR 공정의 Package화
임재명,권재혁,류재근 江原大學校 附設 環境硏究所 1996 環境硏究 Vol.13 No.-
Using rotating biological contactor(RBC) with artificial endofleneus stage and aerobic fixed biofilm reactor(AFBR), organic material removal and biological nitrification of piggery wastewater has been studied at a pilot plant RBC was operated in the endogenous phase at a interval of every 25 days, The concentration of COD, BOO and TKN in influent wastewater were from 2,940 to 3,800 ㎎/L, from 1,190 to 1,850 ㎎/L and from 486 to 754 ㎎/L respectively, The maximum active biomass content represented as VSS per unit aera was 2.0㎎/㎠ and biofilm dry density of 17 ㎎/㎤ was observed at biofilm thickness of 900 ㎛. It was observed that the pilot scale RBC/AFBR process exhibited 72 percentage to 93 percentage of BOD removal, In order to obtain more than 90 percentage of BOD removal, the organic loading rate to the RBC/AFBR Process should be maintained less than 0,09 ㎥/㎡. day(125,9 gBOD/㎥.d), The TKN removal efficiencies was from 455 to 90,9 Percentage according to vary influent loading rate, It was estimated that the RBC/AFER Process consumed approximately 6,2 ㎎/L(as CaCO_(3) ) of alkalinity per 1 ㎎/L a of N_(3)-N oxidized as the nitrification took piace.
직접 황 회수공정에서 Ce_(1-x)Zr_(x)O₂촉매를 이용한 반응특성 연구 : H₂O 와 석탄가스의 영향 Effect of H₂O and Coal Gas
김봉석,이종대,전진혁,박노국,류시옥,이태진,김재창 한국화학공학회 2004 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.42 No.2
본 연구는 직접 황 회수공정에서 H_(2)O와 석탄가스의 영향에 대해서 조사하였다. Ce_(0.8)Zr_(0.2)O_(2)촉매를 이용하여 H_(2)O가 반응에 미치는 영향을 조사한 결과, 산화제인 H_(2)O의 첨가에 의해 반응가스의 환원력이 저하됨을 알 수 있었다. CO/H_(2)O-TRP 실험을 통해서는 반응온도 영역에서 water gas shift 반응이 일어나는 것을 확인 할 수 있었고, H_(2)O의 재산화 실험으로부터 환원된 촉매가 H_(2)O에 의해 재산화 됨을 알 수 있었다. Ce_(0.8)Zr_(0.2)O_(2) 촉매하에서 석탄가스를 환원제로 사용하여 반응온도 (500℃), 공간속도(30,000 ㎖/g-catㆍh), [CO+H_(2)]/[SO_(2)] 몰비(2.5)의 반응조건에서 실험한 결과 최대 75.8%의 원소 황 수율을 얻을 수 있었다. 이는 환원제로 석탄가스를 이용함으로써 H_(2)O에 의한 부반응을 억제할 수 있었으며 경제적인 측면에서 유리하므로 공정기술의 실증화 가능성을 향상시킬 수 있음을 확인할 수 있었다. The effect of H₂O and coal gas on a direct sulfur recovery process using Ce_(1-x)Zr_(x)O₂ catalysts was investigated in this study. As the reducing power of reactants was lowered in the present of H₂O, the activity of catalysts decreased. Temperature programmed reduction experiments showed that a water gas shift reaction took place in the temperature range of this study and that the reduced catalyst was re-oxidized by H₂O. DSRP was carried out on Ce_(1-x)Zr_(x)O₂ catalysts using a coal gas as a reductant. Maximum 76.8% yield of elemental sulfur was obtained at 500℃ with a space velocity of 30,000㎖/g-cat·h and [CO+H₂]/[SO₂] ratio of 2.5. The side reaction by H₂O could be inhibited using a coal gas.
최혁재(Hyuk Jae Choi),강성재(Sung Jae Kang),권칠용(Chil Yong Kwon),류제청(Jei Cheong Ryu),이석민(Suk Min Lee),문무성(Mu Seong Mun) 제어로봇시스템학회 2010 제어·로봇·시스템학회 논문지 Vol.16 No.9
In this study, the control method of assistive robot was developed for the elderly. The control method of gait-assistant-robot was proposed considering the change of COP (Center of Pelves), BOS (Base of Support) and comparative analysis of the moving velocity for the elderly. We analyzed the movement of COP of the body and its velocity of the elderly equipped with manual walker and gait-assistant-robot. As a result, change in COP was greater from left to right than from anterior to posterior; also, the average velocity of the movement of COP and manual walker for manual walker gait was 0.7(m/s). Therefore, it is necessary to concern more on the left-right balance and synchronization of the velocity of COP.
오디세우스/Parallel-OOSQL : 오디세우스 정보검색용 밀결합 DBMS를 사용한 병렬 정보 검색 엔진
류재준(Jae-Joon Ryu),황규영(Kyu-Young Whang),이재길(Jae-Gil Lee),권혁윤(Hyuk-Yoon Kwon),김이른(Yi-Reun Kim),허준석(Jun-Suk Heo),이기훈(Ki-Hoon Lee) 한국정보과학회 2008 정보과학회 컴퓨팅의 실제 논문지 Vol.14 No.4
최근 들어 인터넷의 성장으로 인하여 문서의 양이 기하급수적으로 증가함에 따라, 대용량의 문서를 빠르게 검색 할 수 있는 병렬 정보 검색 엔진에 대한 중요성이 더욱 대두되고 있다. 병렬 정보 검색엔진을 구현하기 위하여서는 역 색인을 분할하고, 분할된 역 색인을 통하여 병렬적으로 검색하는 것이 필요하다. 역 색인을 분할하는 기존 방법으로는 1) 문서 식별자 분할 방법과 2) 키워드 식별자 분할 방법이 있다. 그러나 각 분할 방법은 다음과 같은 단점들을 가지고 있다. 문서 식별자 분할 방법은 문서의 추가가 용이하고 처리량(throughput)이 높은 반면에 top-k 질의 처리 성능이 좋지 않다. 그리고 키워드 식별자 분할 방법은 top-k 질의 처리 성능이 좋은 반면에 문서의 추가가 어렵고 처리량이 낮다. 본 논문에서는 이러한 단점들을 해결하기 위하여 혼합 분할 방법을 제안하고 이를 정보 검색 기능과 밀결합된 DBMS인 오디세우스에 실현한 병렬 정보 검색 엔진을 설계하고 구현한다. 먼저, 제안된 병렬 정보 검색 엔진인 오디세우스/Parallel-OOSQL의 아키텍쳐를 설명한다. 그리고 체계적인 실험을 통하여 제안된 시스템의 유용성을 보인다. 실험 결과, 문서 식별자 분할 방법은 질의 처리 시간이 역 색인 분할의 블록의 개수에 근사적으로 역 비례함을 보였으며, 키워드 식별자 분할 방법은 top-k 질의 처리에 좋은 성능을 보였다. 본 논문에서 제안된 병렬 정보 검색 엔진은 세 가지 분할 방법을 모두 제공하기 때문에 응용 환경에 따라 분할방법을 커스터마이즈함으로써 항상 좋은 성능을 낼 수 있다. 오디세우스/Parallel-OOSQL 병렬 정보 검색엔진은 각 슬레이브 노드 당 1억 건의 웹 문서를, 시스템 전체로는 수십억 건의 웹 문서를 인덱스하여 저장하고 질의를 처리할 수 있다. As the amount of electronic documents increases rapidly with the growth of the Internet, a parallel search engine capable of handling a large number of documents are becoming ever important. To implement a parallel search engine, we need to partition the inverted index and search through the partitioned index in parallel. There are two methods of partitioning theinverted index: 1) document identifier based partitioning and 2) keyword-identifier based partitioning. However, each method alone has the following drawbacks. The former is convenient in inserting documents and has high throughput, but has poor performance for top-k query processing. The latter has good performance for top-k query processing, but is inconvenient in inserting documents and has low throughput. In this paper, we propose a hybrid partitioning method to compensate for the drawback of each method. We design and implement a parallel search engine that supports the hybrid partitioning method using the Odysseus DBMS tightly coupled with information retrieval capability. We first introduce the architecture of the parallel search engine-Odysseus/Parallel-OOSQL. We then show the effectiveness of the proposed system through systematic experiments. The experimental results show that the query processing time of the document-identifier based partitioning method is approximately inversely proportional to the number of blocks in the partition of the inverted index. The results also show that the keyword-identifier based partitioning method has good performance in top-k query processing. The proposed parallel search engine can be optimized for performance by customizing the methods of partitioning the inverted index according to the application environment. The Odysseus/Parallel-OOSQL parallel search engine is capable of indexing, storing, and querying 100 million web documents per node or tens of billions of web documents for the entire system.
활동성 크론병에서 초기 스테로이드 치료 반응에 따른 임상적, 생화학적, 병리학적 인자들에 관한 연구
김영호,장재권,김지은,최규완,박동일,도재혁,백승운,고광철,이풍렬,이종철,현재근,안병훈,김재준,류민규 대한소화기내시경학회 2001 Clinical Endoscopy Vol.22 No.6
Background/Aims: The predictory factors of the response to initial steroid therapy in active Crohn's disease has been controversial in numerous literature reviews. We evaluated any predictory faetor of the response to initial steroid therapy in active Crohn`s disease patients, Methods: The medical records of 32 patients with active Crohn`s disease who clinically responded to oral steroid therapy were retrospectively reviewed. The steroid responsive group was defined as the one showing maintenance of response for more than one month from steroid withdrawal and the steroid dependent group as the one showing relapse or exacerbation during steroid tapering or within 30 days from steroid withdrawal. The clinical, biochemical, and pathologic factors were evaluated. Results: There were 22 male and 10 female patients. The mean age was 28.9 years. The number of steroid responsive and dependent group was 22 (68.8%) and 10 (31.2%), respectively. There were no significant differences between these two groups in age, sex, time to diagnosis, perianal lesion, extent of disease, extraintestinal manifestations, presence of granuloma, presenting features, hemoglobin, ESR, and CRP, except serum albumin level. Conclusions: Serum albumin level was significantly lower in steroid dependent group than steroid responsive group, reflecting severe inflammation in steroid dependent group.