Syntheses, crystal structures, circular dichroism, and magnetic properties of chiral dinuclear and polymeric nickel(II) compounds

Shin, J.W.,Son, H.J.,Kim, S.K.,Min, K.S. Pergamon Press 2013 Polyhedron Vol.52 No.-

Chiral dinuclear nickel(II) complexes, [Ni(L<SUP>R,R</SUP>)(C<SUB>2</SUB>O<SUB>4</SUB>)Ni(L<SUP>R,R</SUP>)](ClO<SUB>4</SUB>)<SUB>2</SUB>.4CH<SUB>3</SUB>CN (3) and [Ni(L<SUP>S,S</SUP>)(C<SUB>2</SUB>O<SUB>4</SUB>)Ni(L<SUP>S,S</SUP>)](ClO<SUB>4</SUB>)<SUB>2</SUB>.4CH<SUB>3</SUB>CN (4) and chiral polymeric compounds, [Ni(L<SUP>R,R</SUP>)(CrO<SUB>4</SUB>)]<SUB>n</SUB>.2H<SUB>2</SUB>O.CH<SUB>3</SUB>CN (5) and [Ni(L<SUP>S,S</SUP>)(CrO<SUB>4</SUB>)]<SUB>n</SUB>.2H<SUB>2</SUB>O.CH<SUB>3</SUB>CN (6) have been synthesized and characterized (L<SUP>R,R/S,S</SUP>=1,8-di((R/S)-α-methylbenzyl)-1,3,6,8,10,13-hexaazacyclotetradecane). These chiral compounds were characterized by X-ray crystallography, circular dichroism, and molecular magnetism. The nickel(II) ions in 3 and 4 have a distorted octahedral geometry by coordination with four nitrogens of a macrocyclic ligand with chiral pendents in a folded conformation and two oxygens of an oxalate ion in the cis positions. The nickel(II) ions in 5 and 6 have a distorted octahedral geometry by coordination with four nitrogens of a macrocyclic ligand in a planar conformation and two oxygens of two chromate ions in the axial positions. Complexes 3 and 4 show strong antiferromagnetic interactions [3: g=2.36, J/k<SUB>B</SUB>=-29.9K (-20.8cm<SUP>-1</SUP>); 4: g=2.18, J/k<SUB>B</SUB>=-25.5K (-17.7cm<SUP>-1</SUP>)], while 5 and 6 exhibit weak antiferromagnetic couplings [5: g=2.25, J/k<SUB>B</SUB>=-1.20K (-0.83cm<SUP>-1</SUP>); 6: g=2.25, J/k<SUB>B</SUB>=-0.68K (-0.47cm<SUP>-1</SUP>)]. The former complexes occur strong antiferromagnetic interactions via the oxalato bridges within the nickel(II) dimers, the latter compounds are weak antiferromagnetic interactions through the chromate ions within the 1D polymers. The circular dichroism (CD) spectrum of 3 has exhibited two negative peaks at 336 and 533nm, and that of 4 has displayed an enantiomeric pattern. The CD spectrum of 5 has appeared a negative absorption above ca. 550nm, while that of 6 has shown an enantiomeric pattern in the same wavelength region.

Performance and carrier transport analysis of In_0.7Ga_0.3As quantum-well MOSFETs with Al₂O₃/HfO₂ gate stack

Son, S.W.,Park, J.H.,Baek, J.M.,Kim, J.S.,Kim, D.K.,Shin, S.H.,Banerjee, S.K.,Lee, J.H.,Kim, T.W.,Kim, D.H. Pergamon Press ; Elsevier Science Ltd 2016 Solid-State Electronics Vol.123 No.-

In this paper, we have fabricated and characterized In<SUB>0.7</SUB>Ga<SUB>0.3</SUB>As quantum-well (QW) metal-oxide-semiconductor field-effect-transistors (MOSFETs). We have employed the gate dielectric of the Al<SUB>2</SUB>O<SUB>3</SUB>/HfO<SUB>2</SUB> (0.6/2nm) bi-layer stack by ALD. The fabricated device with L<SUB>g</SUB>=4μm exhibits a record maximum transconductance (g<SUB>m_max</SUB>) in excess of 520μS/μm at >1μm region, and reasonably good electrostatic integrity, such as SS=110mV/decade and DIBL=43mV/V. Also, we have investigated the gate length scaling behavior in terms of output, transconductance, and transfer characteristics. In particular, our devices feature very uniform values of the electrostatic integrity, such as SS=100-110mV/decade, V<SUB>T</SUB>=-0.25V to -0.2V and DIBL=40-50mV/V, as L<SUB>g</SUB> decreases from 10μm to 4μm. Furthermore, we have explored the impact of source resistance (R<SUB>S</SUB>) onto the device characteristics of the InGaAs QW MOSFETs. In doing so, we have modeled both measured extrinsic transconductance (g<SUB>m_ext</SUB>) and intrinsic transconductance (g<SUB>m_int</SUB>) as a function of L<SUB>g</SUB>.

Hairy and Enhancer of Split 6 (Hes6) Deficiency in Mouse Impairs Neuroblast Differentiation in Dentate Gyrus Without Affecting Cell Proliferation and Integration into Mature Neurons

Nam, S. M.,Kim, Y. N.,Kim, J. W.,Kyeong, D. S.,Lee, S. H.,Son, Y.,Shin, J. H.,Kim, J.,Yi, S. S.,Yoon, Y. S. Springer Science + Business Media 2016 Cellular and molecular neurobiology Vol.36 No.1

<P>Hes6 is a member of the hairy-enhancer of split homolog (Hes) family of transcription factors and interacts with other Hes family genes. During development, Hes genes are expressed in neural stem cells and progenitor cells. However, the role of Hes6 in adult hippocampal neurogenesis remains unclear. We therefore investigated the effects of Hes6 on adult hippocampal neurogenesis, by comparing Hes6 knockout and wild-type mice. To this end, we immunostained for markers of neural stem cells and progenitor cells (nestin), proliferating cells (Ki67), post-mitotic neuroblasts and immature neurons (doublecortin, DCX), mature neuronal cells (NeuN), and astrocyte (S100 beta). We also injected 5-bromo-2'-deoxyuridine (BrdU) to trace the fate of mitotic cells. Nestin- and Ki67-positive proliferating cells did now show any significant differences between wild and knockout groups. Hes6 knockout negatively affects neuroblast differentiation based on DCX immunohistochemistry. On the contrary, the ratio of the BrdU and NeuN double-positive cells did not show any significance, even though it was slightly higher in the knockout group. These results suggest that Hes6 is involved in the regulation of neuroblast differentiation during adult neurogenesis, but does not influence integration into mature neurons.</P>

유전질환 등록 시스템 운영, 유전자 정보 Database 구축 및 유전자 진단 시스템 확립

구수경,이환석,손용규,김성수,이광수,김지인,서일선,진수정,정동기,오범석,정성철,이진성 국립보건연구원 2000 국립보건원보 Vol.37 No.-

간호대생과 비보건계열 여대생의 미세먼지 위험에 대한 인식과 지식, 건강 관리행위 비교 연구

김선미,김슬기,김진선,박주형,배다희,유수빈,유영주,임지향,최유진,Chen Mengyao,양숙자,손지희 이화여자대학교 간호과학대학 2019 이화간호학회지 Vol.- No.53

Purpose: This study aimed to know whether there is a comparison of perception, knowledge and health promoting behaviors about particular matter between nursing students and non-health departments college students. Methods: A quantitative research is used. Data were collected from August 1 to 19. The study sample was nursing students and non-health departments students. For the similar condition of samples, this study excluded whose first language is not Korean. Independent T-test and pearson’s correlation was used for this study. Results: A significant positive correlation did not existed between difference of major and perception(t=0.017, p=0.986), knwledge(t=0.652, p=.516) and health promoting behaviors(t=-0.114, p=.910) about particular matters. Conclusion: Based on the study results, there is no significant correlation of perception and actions about particular matters between nursing students and non-health department college students.

임상실습 간호대학생의 공감능력, 의사소통능력, 심리적 소진 간의 관계

고재원,김지은,박진영,서혜영,신유진,이동민,정다은,진서정,최서원,XIE WEI,YANG JING,배성희,손지희 이화여자대학교 간호학회 2018 이화간호학회지 Vol.- No.52

Purpose: The purpose of this study was to determine the relationship among empathy ability, communication ability, and psychological burnout in nursing students on clinical practice. Method: Data was collected using questionnaires between September 20th, 2017 to January 2th, 2018. Participants of this study were 159 of grade 3 and 4 nursing students who had completed at least one semester of clinical practice experience and currently attending universities located in Seoul. Data were analyzed using percentage, average, standard deviation, t-test, one-way ANOVA, Scheffe’s test and Pearson’s correlation coefficient using the SPSS WIN 24.0 program. Results: The empathy ability was positively correlated with communication ability(r=.437, p=.000). And the communication ability was negatively correlated with psychological burnout(r=-.390, p=.000). Also the empathy ability was negatively correlated with psychological burnout(r=-217, p=.006). Conclusion: These results suggest that psychological burnout is closely related to empathy ability and communication ability. Based on these results, empathy ability and communication ability need to be increased by efficient management and intervention to decrease the degree of psychological burnout in nursing students. Also, the findings should be considered when developing plans or education programs for nursing students’ major adjustment.

Spitz naevus is rare in Korea

Kim, Y. C.,Do, J. E.,Bang, D.,Cho, B. K.,Cho, K. H.,Choi, J. C.,Kim, M. B.,Kim, M. H.,Kim, S. Y.,Kim, S. N.,Lee, J. H.,Lee, S. J.,Shin, D. H.,Shin, J. H.,Son, S. J.,Suh, K. S.,Yoon, T. Y.,Park, C. K. Blackwell Publishing Ltd 2010 Clinical and experimental dermatology Vol.35 No.2

<P>Summary</P><P>Background. </P><P>Spitz naevi have not been widely studied in Asians.</P><P>Aim. </P><P>To compare the epidemiology and clinicopathological features of Spitz naevi in Koreans with lesions in western countries.</P><P>Methods. </P><P>In total, 80 Spitz naevi in 77 patients diagnosed over 10 years at 17 university hospitals in Korea were analysed.</P><P>Results. </P><P>The relative incidence of Spitz naevus vs. MM was 1 vs. 10.9. In most patients (75%) the Spitz naevi had been present for > 6 months. The size of the lesion was relatively large. Histologically, most of the lesions (54%) were the dermal type and pigmentation was common (49% of lesions). Immunohistochemical study found that all of the 34 lesions were positive for S-100 protein but only 14 (47%) were positive for HMB-45.</P><P>Conclusion. </P><P>Spitz naevus is rare in Korea. The lesions were more commonly larger, pigmented, and of the dermal type than reported in western countries.</P>

放射菌을 利用한 異種間 原形質體 融合과 그 融合體의 安定性에 관한 硏究(Ⅱ)

閔洪基,金昌珉,孫麗源,韓惠勝,崔英珠,丁大映,韓康玄,李相燮,李欽淑,元奉必 국립보건연구원 1992 국립보건원보 Vol.29 No.2

Inhibition of Staphylococcus aureus by antimicrobial biofilms formed by competitive exclusion microorganisms on stainless steel

Son, H.,Park, S.,Beuchat, L.R.,Kim, H.,Ryu, J.H. Elsevier Science Publishers 2016 International journal of food microbiology Vol.238 No.-

<P>The goal of this study was to develop a desiccation resistant antimicrobial surface using biofilm of competitive exclusion (CE) microorganism inhibitory to Staphylococcus aureus. We isolated 161 microorganisms from soils, foods, and food-contact surfaces that are inhibitory to S. aureus. Among them, three CE microorganisms (Streptomyces spororaveus strain Gaeunsan-18, Bacillus safensis strain Chamnamu-sup 5-25, and Pseudomonas azotoformans strain Lettuce-9) exhibiting strong antibacterial activity and high growth rates were selected for evaluation. These isolates formed biofilms within 24 h on stainless steel coupons (SSCs) immersed in Bennet's broth and tryptic soy broth at 25 degrees C. Cells in these biofilms showed significantly (P <= 0.05) enhanced resistance to a desiccation (43% relative humidity [RH]) compared to those attached to SSCs but not in biofilms. The antimicrobial activities of biofilms formed by these isolates on SSCs against S. aureus at 25 degrees C and 43% RH were determined. Compared to SSCs lacking biofilms formed by CE microorganisms, populations of S. aureus on SSCs harboring CE biofilms were significantly lower (P 0.05). Results indicate that persistent antimicrobial activity against S. aureus on stainless steel surfaces can be achieved by the presence of biofilms of CE microorganisms. This information will be useful when, developing strategies to improve the microbiological safety of foods during storage, processing, and distribution by facilitating the development of effective antimicrobial food-contact surfaces. (C) 2016 Published by Elsevier B.V.</P>

Direct Evidence of Allele-Specific Binding of CTCF and MeCP2 to <b><i>Tsix</i></b> in a HPRT-Deficient Female F₁ Hybrid Mouse Cell Line

Son, J.,Min, N.Y.,Choi, J.-H.,Ko, Y.J.,Liang, W.,Rhee, S.,Lee, K.-H. S. Karger AG 2012 Cytogenetic and genome research Vol.138 No.1

<P>Abstract</P><P>Mammalian dosage compensation requires silencing of one of the two X chromosomes in females and is controlled by the X inactivation center (Xic). Xic contains many of the regulatory elements for the mutual interplay of X-inactive specific transcript <I>(Xist)</I> and <I>Tsix</I>, the antisense counterpart of <I>Xist</I>. The regulatory elements control X chromosome inactivation (XCI) via the formation of DNA-DNA and DNA-protein complexes with <I>cis</I>- and <I>trans</I>-acting factors. However, the process-dependent regulation of <I>Xist/Tsix</I> by these elements in each XCI process remains largely unknown. In this study, a 6-thioguanine-resistant female F<SUB>1</SUB> hybrid mouse cell line (designated HOBMSKI2) was constructed from a cross between a female HPRT-deficient transgenic mouse (designated BM3) and a male wild type <I>Mus spretus</I> mouse (designated MS), which enabled the direct discrimination of both allele-specific expression of X-linked genes and allele-specific binding of proteins associated with XCI due to DNA polymorphisms between BM3 and MS. Using this cell line, we found that <I>Tsix</I> on the active X chromosome (Xa) was not expressed in somatic cells despite the fact that CTCF, which ensures <I>Tsix</I> expression in embryonic stem cells, was still bound to the 5′ end of <I>Tsix</I> on Xa, implying that CTCF may function differently during each XCI process and its <I>trans</I>-activating activity for <I>Tsix</I> expression may be lost in the maintenance process. In addition, the monoallelic expression of <I>Tsix</I> on Xa was inhibited by epigenetic modification of the chromatin in the maintenance process, which was mediated by protein complexes recruited by MeCP2. The results indicate the value of HOBMSKI2 in directly detecting the allele-specific binding of CTCF and MeCP2 to the 5′ end of <I>Tsix</I>. The HOBMSKI2 mouse line is a versatile and useful resource for studying the molecular mechanism of the XCI process.</P><P>Copyright © 2012 S. Karger AG, Basel</P>