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        Description and classification for facilitating interoperability of heterogeneous data/events/services in the Internet of Things

        Yim, H.J.,Seo, D.,Jung, H.,Back, M.K.,Kim, I.,Lee, K.C. Elsevier Science Publishers 2017 Neurocomputing Vol.256 No.-

        <P>The Internet of Things (loT) refers to an infrastructure that integrates things over standard wired/wireless networks and allows them to exchange information with each other. The loT is a very complex heterogeneous network, enabling seamless integration of these things is a huge challenge. A publish/subscribe method of integration can be formulated to solve the problems of interconnecting billions of heterogeneous things. In our work, an IoT framework that uses an abstraction layer that decouples an application from the service calls and network interfaces is required to send and receive messages on a particular thing. This paper provides definitions and classifications for heterogeneous data/events/services according to the properties of the things in order to integrate them into a framework for description. Based on these definitions and classifications, heterogeneous data/events/services in the loT were integrated via topic description through the Data Distribution Service (DDS) middleware standard for real-time publish/subscribe. This paper also concludes with general remarks and a discussion of future work. (C) 2017 Elsevier B.V. All rights reserved.</P>

      • Structural dynamics of keyword networks: Liquid crystal display and plasma display panel cases

        Yang, H.,Jung, W.S. Elsevier Science Publishers 2016 Journal of Engineering and Technology Management Vol.40 No.-

        <P>This study focuses on understanding scientific evolution by using keyword co-occurrence networks, where keywords appearing in a scientific article are linked with a weight equal to the number of co-occurrences. To characterize structural changes of the network, we examine distributions of sums of weights by node over time. In particular, a change of power-law behavior is utilized to explore scientific evolution, such as emerging scientific paradigms and advancing normal science. As an illustration of the method used, the development of Liquid Crystal Displays (LCDs) and Plasma Display Panels (PDPs) is tracked. We detect two-tiered power-law distributions in the initial stage of scientific growth in both technologies due to differences in research intensity between two groups. The groups of keywords more likely to attract researchers' interest than others are incrementally developed until the mid-2000s to overtake those prior. Finally, we can capture a merging point of the dichotomous structure of PDPs but LCDs maintain the structural separation throughout the adjustment area. We expect that this structural investigation of keyword co-occurrence networks provides an indicator to diagnose the research evolution in that field. (C) 2016 Published by Elsevier B.V.</P>

      • WITHDRAWN: Spectroscopic characterization of selected functionalized fullerenes - IR absorption and Raman scattering studies

        Lewandowska, K.,Barszcz, B.,Graja, A.,Nam, S.Y.,Han, Y.S.,Kim, T.D.,Lee, K.S. Elsevier Science Publishers 2014 Materials chemistry and physics Vol.148 No.3

        The Publisher regrets that this article is an accidental duplication of an article that has already been published in <Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 118, (2014) 204 - 209>, http://dx.doi.org/<10.1016/j.saa.2013.08.102>. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

      • Teriyaki sauce with carvacrol or thymol effectively controls Escherichia coli O157:H7, Listeria monocytogenes, Salmonella Typhimurium, and indigenous flora in marinated beef and marinade

        Moon, H.,Kim, N.H.,Kim, S.H.,Kim, Y.,Ryu, J.H.,Rhee, M.S. Applied Science Publishers ; Elsevier Science Ltd 2017 Meat science Vol.129 No.-

        <P>An effective bactericidal cold-marinating method for beef products is described, exploiting the synergism between soy sauce and natural compounds (carvacrol, CV or thymol, TM) to reduce microbiological risks. Beef slices inoculated with Escherichia coli 0157:H7, Listeria monocytogenes, and Salmonella Typhimurium (3.1-3.5 log CFU/g) were marinated in a teriyaki sauce with or without CV and TM (0.3 and 0.5%). After 1, 3, and 7 days at 4 degrees C, indigenous microflora population, color, lipid oxidation, marinade uptake, and pH of marinated beef and leftover marinade samples were examined. Teriyaki sauce alone did not reduce or inhibit any of the target pathogens or indigenous bacteria, while 0.5% CV- or TM-containing teriyaki sauce inactivated all inocula without recovery within 7 days (p < 0.05). The pathogens relocated from the beef into the leftover marinade (3.0-3.4 log CFU/mL) were also completely inactivated. The treatment inhibited growth of indigenous aerobic bacteria (p < 0.05) and inactivated coliform bacteria. Physicochemical parameters were not significantly affected (p > 0.05). (C) 2017 Elsevier Ltd. All rights reserved.</P>

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        Effect of tempering methods on quality changes of pork loin frozen by cryogenic immersion

        Choi, E.J.,Park, H.W.,Chung, Y.B.,Park, S.H.,Kim, J.S.,Chun, H.H. Applied Science Publishers ; Elsevier Science Ltd 2017 Meat science Vol.124 No.-

        <P>The quality characteristics of pork loin frozen by cryogenic immersion were examined, such as the drip loss, cooking loss, water holding capacity, moisture content, protein solubility, lipid and protein oxidation, color, and microstructure, and compared after different tempering methods: radio frequency (27.12 MHz), water immersion, forced-air convection, and microwave tempering. Forced-air tempering was the most time-consuming process, whereas electromagnetic energy methods (radio frequency and microwave) were the shortest. The tempering rate of radio frequency at 400 W was 5 and 94 times greater than that obtained with water immersion and forced-air tempering, respectively. The drip loss, water holding capacity, moisture content, color, and microstructure of pork samples all declined as a result of microwave tempering. By contrast, the least degree of changes in the drip loss, microstructure, and color of the pork loin samples was obtained with radio frequency tempering, suggesting its potential application in providing rapid defrosting without quality deterioration in the frozen meat industry. (C) 2016 Elsevier Ltd. All rights reserved.</P>

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        Identification and quantification of myosin heavy chain isoforms in bovine and porcine longissimus muscles by LC-MS/MS analysis

        Kim, G.D.,Jeong, T.C.,Cho, K.M.,Jeong, J.Y. Applied Science Publishers ; Elsevier Science Ltd 2017 Meat science Vol.125 No.-

        <P>To identify and quantify the myosin heavy chain (MHC) isoforms in porcine and bovine longissimus thoracis (LT) muscles, LC-MS/MS and label-free quantification were conducted. 2a, 2x, 2b and slow isoforms were identified in porcine LT muscle, whereas bovine LT muscle contained 2a, 2x and slow isoforms. The highest peak intensity (4432%) of MHC 2b was observed in porcine LT muscle, whereas the peak intensity of MHC 2a was the highest (71.15%) in bovine LT muscle (p < 0.05). MHC-based fiber compositions for porcine and bovine LT were also the highest in types BB (61.13%) and IIA (61.90%), respectively (p < 0.05). Spectral count and peak intensity had positive correlations with MHC-based fiber composition (p < 0.01), however the spectral count and peak intensity of total peptides were not acceptable for MHC quantification because of the limited reliability of the protein and common peptide, respectively. Therefore, the peak intensity of unique peptides would be the most acceptable trait for WHC quantification. (C) 2016 Elsevier Ltd. All rights reserved.</P>

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        Ultraviolet-C efficacy against a norovirus surrogate and hepatitis A virus on a stainless steel surface

        Park, S.Y.,Kim, A.N.,Lee, K.H.,Ha, S.D. Elsevier Science Publishers 2015 International journal of food microbiology Vol.211 No.-

        In this study, the effects of 10-300mWs/cm<SUP>2</SUP> of ultraviolet radiation (UV-C) at 260nm were investigated for the inactivation of two foodborne viruses: murine norovirus-1 (MNV-1; a human norovirus [NoV] surrogate) and hepatitis A virus (HAV). We used an experimentally contaminated stainless steel surface, a common food-contact surface, to examine the effects of low doses of UV-C radiation on MNV-1 and HAV titers. The modified Gompertz equation was used to generate non-linear survival curves and calculate d<SUB>R</SUB>-values as the UV-C dose of 90% reduction for MNV-1 (R<SUP>2</SUP>=0.95, RMSE=0.038) and HAV (R<SUP>2</SUP>=0.97, RMSE=0.016). Total MNV-1 and HAV titers significantly decreased (p<0.05) with higher doses of UV-C. MNV-1 and HAV were reduced to 0.0-4.4 and 0.0-2.6 log<SUB>10</SUB>PFU/ml, respectively, on the stainless steel surfaces by low-dose UV-C treatment. The d<SUB>R</SUB>-value, 33.3mWs/cm<SUP>2</SUP> for MNV-1 was significantly (p<0.05) lower than 55.4mWs/cm<SUP>2</SUP> of HAV. Therefore, the present study shows that HAV is more resistant to UV-C radiation than MNV-1. These data suggest that low doses of UV-C light on food contact surfaces could be effective to inactivate human NoV and HAV in restaurant, institutional, and industrial kitchens and facilities.

      • SCISCIESCOPUS

        Development of a novel proton dosimetry system using an array of fiber-optic Cerenkov radiation sensors

        Son, J.,Kim, M.,Shin, D.,Hwang, U.,Lee, S.,Lim, Y.,Park, J.,Park, S.y.,Cho, K.,Kim, D.,Jang, K.W.,Yoon, M. Elsevier Science Publishers 2015 Radiotherapy and oncology Vol.117 No.3

        This study describes the development and evaluation of a new dosimetric system for proton therapy using an array of fiber-optic Cerenkov radiation sensors (AFCRS). The AFCRS was superior to a conventional, multi-layer ion chamber (MLIC) system in real-time data acquisition and cost effectiveness.

      • SCISCIESCOPUS

        Asialoglycoprotein receptor targeted gene delivery using galactosylated polyethylenimine-graft-poly(ethylene glycol): In vitro and in vivo studies

        Kim, E.M.,Jeong, H.J.,Park, I.K.,Cho, C.S.,Moon, H.B.,Yu, D.Y.,Bom, H.S.,Sohn, M.H.,Oh, I.J. Elsevier Science Publishers 2005 Journal of controlled release Vol.108 No.2

        The asialoglycoprotein receptor (ASGP-R) on the hepatocyte membrane is a specific targeting marker for gene and drug delivery. Polyethylenimine (PEI) is a polycationic nonviral vector that is used for gene transfer. We have synthesized galactosylated polyethylenimine-graft-poly(ethylene glycol) (GPP) for performing gene delivery to the hepatocytes. The present study reports on the in vitro and in vivo data that was achieved in hepatoma bearing transgenic mice. The cytotoxicity was decreased with the increasing PEG content. The particle size of the complex was increased with the increasing PEG at an N/P ratio of 3.0, while the zeta potentials were decreased. The <SUP>99m</SUP>Tc labeled complexes were transfected into HepG2 and HeLa cells, while the GFP reporter genes were mainly expressed in the HepG2 cells. The in vivo data was achieved in ALB/c-Ha-ras transgenic mice. <SUP>99m</SUP>Tc labeled GPP<SUB>50</SUB>/DNA was injected into the mice via the tail vein, and the gamma images were acquired at 5, 15 and 30 min. The <SUP>99m</SUP>Tc labeled complexes were mainly localized in the heart and liver, and they were excreted through the kidneys. The GFP gene was mainly expressed in the proliferating cells at the tumor periphery. This result was confirmed by PCNA staining. The GPP<SUB>50</SUB>/DNA complexes were bound to ASGP-R of the proliferating hepatocytes in vitro and in vivo. The present results demonstrate the feasibility of nonviral gene transfer using galactosylated PEI-PEG in vivo.

      • SCISCIESCOPUS

        Genistein inhibits phorbol ester-induced NF-κB transcriptional activity and COX-2 expression by blocking the phosphorylation of p65/RelA in human mammary epithelial cells

        Chung, M.H.,Kim, D.H.,Na, H.K.,Kim, J.H.,Kim, H.N.,Haegeman, G.,Surh, Y.J. Elsevier Science Publishers 2014 Mutation research Vol.768 No.-

        Genistein, an isoflavone present in soy products, has chemopreventive effects on mammary carcinogenesis. In the present study, we have investigated the effects of genistein on phorbol ester-induced expression of cyclooxygenase-2 (COX-2) that plays an important role in the pathophysiology of inflammation-associated carcinogenesis. Pretreatment of cultured human breast epithelial (MCF10A) cells with genistein reduced COX-2 expression induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). There are multiple lines of evidence supporting that the induction of COX-2 is regulated by the eukaryotic transcription factor NF-κB. Genistein failed to inhibit TPA-induced nuclear translocation and DNA binding of NF-κB as well as degradation of IκB. However, genistein abrogated the TPA-induced transcriptional activity of NF-κB as determined by the luciferase reporter gene assay. Genistein inhibited phosphorylation of the p65 subunit of NF-κB and its interaction with cAMP regulatory element-binding protein-binding protein (CBP)/p300 and TATA-binding protein (TBP). TPA-induced NF-κB phosphorylation was abolished by pharmacological inhibition of extracellular signal-regulated kinase (ERK). Likewise, pharmacologic inhibition or dominant negative mutation of ERK suppressed phosphorylation of p65. The above findings, taken together, suggest that genistein inhibits TPA-induced COX-2 expression in MCF10A cells by blocking ERK-mediated phosphorylation of p65 and its subsequent interaction with CBP and TBP.

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