위궤양에 대한 Teprenone의 치료효과

양진모,김석헌,최명규,안병민,김재광,정인식,정규원,선희식,김부성 최신의학사 1991 最新醫學 Vol.34 No.3

전기비저항 검층으로 얻은 전기비저항과 터널 현장 암반등급의 상관관계에 관한 연구

이강현,서형준,박진호,안희윤,김기석,이인모,Lee, Kang-Hyun,Seo, Hyung-Joon,Park, Jin-Ho,Ahn, Hee-Yoon,Kim, Ki-Seog,Lee, In-Mo 한국터널지하공간학회 2012 한국터널지하공간학회논문집 Vol.14 No.5

터널 시공 중 암반등급은 지보패턴의 결정에 큰 영향을 주는 요소이다. 따라서 터널 설계 시에 터널이 시공되는 노선의 암반등급을 파악하기 위해서 시추조사를 수행한다. 시추구간 사이의 미시추 구간에서는 전기비저항 탐사, 탄성파 탐사 등과 같은 지구물리탐사를 통해 암반등급을 파악한다. 따라서 전기비저항과 암반등급의 상관관계를 찾기 위한 연구가 다수 수행되었다. 그러나 대부분의 연구는 실내시험 또는 전기비저항 탐사로부터 얻어진 전기비저항과 암반등급의 상관관계에 대한 연구이다. 따라서 본 연구에서는 현장의 전기비저항 검층 시험으로부터 얻어진 전기비저항과 RMR의 상관관계를 분석하였다. 현장 데이터 분석 결과, 전기비저항과 RMR은 약 90%이상의 매우 높은 상관관계가 있는 것으로 나타났다. 또한 RMR 평가 요소들과 전기비저항의 상관관계 분석을 수행한 결과, 전기비저항과 불연속면상태는 약 80%이상의 양호한 상관관계가 나타났으나 지하수상태는 약 57%이하의 낮은 상관관계가 나타났다. Rock mass rating (RMR) is the key factor when designing the appropriate support pattern of tunnel projects. Borehole drilling is usually performed along the tunnel route in order to determine the rock mass rating to be used for tunnel design. The rock mass rating at the non-boring region between boreholes is usually assessed through geophysical surveys such as electrical prospecting, seismic prospecting, etc. Many studies were carried out to find out the correlation between electrical resistivity and rock mass rating. However, most researches were aimed at obtaining the relationship between the two parameters utilizing experimental results obtained from laboratory tests or electrical prospectings. In this paper, efforts were made to analyze and obtain relationships between the electrical resistivity obtained from in-situ electrical resistivity logging data and the rock mass rating. Correlation studies using field data showed that the electrical resistivity is highly correlated with the rock mass rating with the determination coefficient more than 90%. The correlation analysis was also carried out between RMR classification parameters and the electrical resistivity. It was shown that the correlation between the condition of discontinuities and the electrical resistivity was very high with the determination coefficient more than 80%; that between the groundwater condition and the electrical resistivity was very low with the determination coefficient less than 57%.

치관보철용 글라스 세라믹 재료에서 조성비 변화에 따른 기계적 특성에 관한 연구

정인성,김형일,박성수,최경남,안진모,박희찬 대한치과기재학회 1999 대한치과재료학회지 Vol.26 No.1

Glass ceramics for dental crown prosthesis were prepared by heat-treatment of CaO-MaO-SiO₂-P₂O -TiO₂glasses. The crystallization behaviors of samples have been investigated as a function of heat-treated temperature, holding time and chemical composition with their mechanical properties. From the experiment, the following results were obtained: The nucleation rate of apatite increased with increasing CaO or P₂O and decreasing MgO or TiO₂. Vickers hardness and bending strength of samples increased with increasing MgO or TiO₂ and decreasing CaO or P₂O. Vickers hardness of samples increased due to the precipitation of apatite, whitlockite, β-wollastonite, magnesium titanate, and diopside crystal phases within glass matrix. The final crystalline phase assemblages and the microstructures of the samples were found to be dependent on glass compositions, heat-treatment temperature, and holding time.

대학생의 기본 심폐소생술 교육 평가 : 간호과와 비간호과를 대상으로

이정은,고봉연,이인모,최근명,박신일,안홍기 한국응급구조학회 2003 한국응급구조학회지 Vol.7 No.1

The purpose of this study was to evaluate the accuracy of CPR skills and the satisfaction of CPR Training targeted for college students. Also, this study made comparative study of nursing students and non-nursing students. The sample consisted of 248 students(132 nursing students, 116 non-nursing students). CPR Training was designed by two components which were a lecture and demonstration by one professor and individual practice 표 instructors. As tool of measurement estimation satisfaction of CPR Training questionnaires were developed based on educated contents. The accuracy of CPR skills were checked by SkillReporter CPR training manikin. Collected data were computerized and analyzed by SPSS-WIN program. The results were as follows : 1. The skills of CPR were cardiac compression 92.79 times/min, correct cardiac compression rate 90.85%, ventilation 9.93 times/min. correct ventilation rate 79.34%. 2. The mean of the accuracy of CPR skills were 2.94(SD .87). 3. When errors were analyzed, the highest item was stomach distension(51.2%) of ventilation skills and too little(70.6%) of cardiac compression skills. 4. The mean of the satisfaction of CPR training were 2.87(SD .17), the highest item of the satisfaction of CPR Training was practice. 5. We found significant statistical differences based on the accuracy and the error, non-nursing students were high in correct cardiac compression per minute(t=3.615, p=0...) and ventilation too much(t=4.292, p=.000), nursing students were high in correct ventilation rate(t=-3.885, p=.000) and cardiac compression too shallow) t=-2.842, p=.005).

Long-Term Exercise Improves Memory Deficits via Restoration of Myelin and Microvessel Damage, and Enhancement of Neurogenesis in the Aged Gerbil Hippocampus After Ischemic Stroke

Ahn, Ji Hyeon,Choi, Jung Hoon,Park, Joon Ha,Kim, In Hye,Cho, Jeong-Hwi,Lee, Jae-Chul,Koo, Hyun-Mo,Hwangbo, Gak,Yoo, Ki-Yeon,Lee, Choong Hyun,Hwang, In Koo,Cho, Jun Hwi,Choi, Soo Young,Kwon, Young-Guen SAGE Publications 2016 Neurorehabilitation and neural repair Vol.30 No.9

<P>Background. The positive correlation between therapeutic exercise and memory recovery in cases of ischemia has been extensively studied; however, long-term exercise begun after ischemic neuronal death as a chronic neurorestorative strategy has not yet been thoroughly examined. Objective. The purpose of this study is to investigate possible mechanisms by which exercise ameliorates ischemia-induced memory impairment in the aged gerbil hippocampus after transient cerebral ischemia. Methods. Treadmill exercise was begun 5 days after ischemia-reperfusion (I-R) and lasted for 1 or 4 weeks. The animals were sacrificed 31 days after the induction of ischemia. Changes in short-term memory, as well as the hippocampal expression of markers of cell proliferation, neuroblast differentiation, neurogenesis, myelin and microvessel repair, and growth factors were examined by immunohistochemistry and/or western blots. Results. Four weeks of exercise facilitated memory recovery despite neuronal damage in the stratum pyramidale (SP) of the hippocampal CA1 region and in the polymorphic layer (PoL) of the dentate gyrus (DG) after I-R. Long-term exercise enhanced cell proliferation and neuroblast differentiation in a time-dependent manner, and newly generated mature cells were found in the granule cell layer of the DG, but not in the SP of the CA1 region or in the PoL of the DG. In addition, long-term exercise ameliorated ischemia-induced damage of myelin and microvessels, which was correlated with increased BDNF expression in the CA1 region and the DG. Conclusions. These results suggest that long-term treadmill exercise after I-R can restore memory function through replacement of multiple damaged structures in the ischemic aged hippocampus.</P>

Effects of Silkworm Extract on Disaccharidase Activities of Small Intestine and Blood Glucose-Lowering in C57BL/6J Mice

Ahn, Jung-Mo,Hong, Jung-Hee,Kim, Mi-Lim,Lee, In-Seon,Rhee, Soon-Jae The Korean Society of Food Science and Nutrition 2005 Preventive Nutrition and Food Science Vol.10 No.1

This study examined the anti-diabetic effect of a silkworm extract in C57BL/6J mice, an ob/㏈ model, fed a high fat diet for 8 weeks. The body weight was not significantly different with the silkworm-extract supplement, nor did food intake and body weight gains also did not differ significantly among the high-fat diet groups. However, the water intake by the silkworm-extract supplemented groups increased significantly compared with that by the distilled-water supplement group, nonetheless, the FER did not differ significantly. For all groups, the blood glucose increased the most after 30 minutes and yet returned to a fasting level within 90 minutes. The fasting time and resulting glucose tolerance for the silkworm-extract supplemented groups were significantly decreased compared to that for the high fat diet with distilled water supplement group, while the level of blood glucose in silkworm-extract supplemented groups was significantly decreased compared with than in the diabetic control group. The HbA1c and insulin levels were no different among the groups. The sucrase and lactase activities in the proximal small intestine were significantly decreased in the silkworm-extract supplement groups compared to that in the diabetic control group. There was no significant difference in the glycogen contents in the liver and muscle among the groups. In conclusion, it was found that the silkworm-extract supplement repressed the disaccharidase activity in the small intestines mucosa of the C57BL/6J mice.

한국의 Amatoxins 중독증

안영민,이동수,이강문,강상범,양진모,박영민,이영석,정규원,선희식,박두호,노현주,강영모,이종명,허정욱,최성곤,김정호,이상인,최승옥,최홍엽,권오선,구창덕,석순자,김양섭 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.3

한국의 amatoxins 중독증은 강원 영서 지역이 호발지역으로 알려져 왔으며 최초로 보고된 원인버섯은 알광대버섯이었으나 현재까지 재 확인된 바가 없다. 원인버섯이 확인된 예로는 강원 영서지역이나 대전지역의 독우산광대버섯과 함께 1998년 경북 일원에서 발생한 집단 중독사고의 개나리광대버섯과 대전에서 발생한 1예에서 흰알광대버섯을 들 수 있다. 최근까지 amatoxins 중독증에 관해 보고된 국내의 문헌을 살펴보면 한국에서 발생하는 amatoxins중독증은 사망률에서 외국의 20-40% 와 큰 차이가 있는 것 처럼 보이나 사실상 전체적인 발생빈도나 사망률 등을 산출한 예가 없었을 뿐아니라, 높은 사망률의 원인이 무엇인지를 비교하는 것도 불가능하였다. 저자들은 국내에서 발생하는 amatoxins 중독증의 예방과 보다 효율적인 진단 및 치료를 위해 발생빈도나 사망률 및 원인버섯 등의 기초적인 조사와 함께 문헌을 통해 amatoxins 중독증에 대한 지견을 고찰하고자 하였다. 대상과 방법: 1999년 1년간 원인버섯 식별을 위해 의뢰되었던 증례들과 연례적 호발지역의 의료기관에서 병력 및 임상소견으로 amatoxins 중독증으로 진단 또는 추정된 증례들을 조사하였다. 원인버섯의 식별은 발생지역을 방문하여 원인버섯의 확보가 가능했던 소수의 증례에서는 외관과 현미경적 소견으로 원인버섯을 식별하였으며 원인버섯의 확보가 불가능한 증례에서는 특징적인 외관으로 추정되었다. 결과: 54명의 대상환자들 중 43명에서amatoxins 중독증으로 진단되었으며 그중 35명은 중등도 이상의 중독증으로 간주하였다. 중등도 이상의 중독증에서는 7명이 사망하여 20%의 사망률을 나타내었으며 원인버섯은 독우산광대버섯과 개나리광대버섯이 확인되었다. 흰알광대버섯은 확인되지 않았으나 사실상 독우산광대버섯과의 감별은 이루어지지 않았다. 4예에서는 원인버섯이 확인되지 않아 더 연구 되어야 한다. 사망례에서는 비사망군에 비해 혈소판이 유의하게 감소한 소견을 보였다. 전예에서 간이식등의 치료는 시행되지 않았으며 대부분 수액요법을 근간으로한 보존요법을 실시하였다. 결론: 한국의 amatoxins 중독증은 주로 강원 영서지역과 경북 일원에서 호발하고, 원인버섯은 외국과는 달리 독우산광대버섯과 개나리광대버섯이 주된 원인버섯이며, 1997년 까지의 증례보고를 대상으로한 70%의 사망률과는 달리 중등도 이상의 중독증례를 대상으로 하여도 사망률은 20%로 외국에 비해 높지 않다. 그러나 외국과 달리 간이식과 같은 보다 적극적인 치료를 시도한 예가 없는데, 대부분 갑자기 나빠지기 때문에 준비를 못하는 것이 원인이다. 따라서, 사망률을 더 낮추기 위해서는 혈액이나 소변과 같은 체액에서 단시간 내에 amatoxins을 측정할 수 있는 임상 검사법이 개발되어 조기 진단이 가능해져야 하며, 중독 초기에 나쁜 예후가 예측되는 심각한 증례를 선별하여 전문적인 치료를 받을 수 있는 기회를 제공해야 한다. 아울러 amatoxins 중독증에 대한 보다 정확한 통계를 산출하여야 할 것이다. 저자들은 본 연구에 1999년도에 발생한 대부분의 amatoxins 중독증의 증례가 포함되었으나 포함되지 않은 증례들이 다수 있다고 생각한다. 이러한 기초 조사를 철저히 하기 위해서는 전국 각지에서 발생하는 버섯중독 사고를 의뢰 또는 신고 할 수 있는 일원화 된 창구가 필요하리라고 사료된다. $quot;Background/Aims: From the review of Korean literature most fatal mushroom poisonings have been due to amatoxins with high mortality. So far there have never been investigations on the amatoxins poisonings such as annual incidence, mortality, common causal species, and endemic areas. This study was carried out to develop some basic statistics as part of studies for an effective management of amatoxins intoxications. Method: For the year 1999 authors collected cases of mushroom poisonings which had been mainly gathered from hospitals nation-wide. All of the cases with suggestive amatoxins poisonings were screened by symptomatology and laboratory findings. The causal species of mushrooms were identified grossly and microscopically. Results: A total of 54 victims with mushroom poisonings were evaluated. The causal mushroom toxins were diagnosed or strongly suggested as amatoxins in 43 of 54 victims. Eleven of 54 victims did not conform to the category of amatoxins intoxication due to absent or minimal elevation of aminotransferase. Mean age of the victims was 44.3 23.3 (range: 7-78) with male predominance (1.2 : 1). The causal species were confirmed, or strongly suggested, as Amanita virosa in 25 victims, Amanita subjunquillea in 14, and unknown species in 4. Thirty-five out of a total of 43 were regarded as moderate to severe intoxication (AST or ALT $gt; 1,000 IU/L) with 20% mortality. Most fatal victims showed marked thrombocytopenia (40,000 19,000/mm3) compared to non-fatal victims (109,066 42,245/mm3). A total of 88.4% of victims was developed in the Kangwon and Kyungpuk provinces. Both are west of the Taebaek Mountains (38/43). Conclusions: Although the common causal species for amatoxins poisonings in Korea are different from European countries and North America, the mortality is similar to that of those areas. In order to further reduce the mortality, bedside diagnostic methods using biological fluids and more effective herapy for liver failure should be established$quot;.

HYPERREFLECTIVE EXTERNAL LIMITING MEMBRANES AFTER SUCCESSFUL MACULAR HOLE SURGERY

Oh, In Kyung,Oh, Jaeryung,Yang, Sun Mo,Ahn, Soh Eun,Kim, Seong-Woo,Huh, Kuhl The Ophthalmic Communications Society, Inc. 2012 Retina Vol.32 No.4

PURPOSE:: To evaluate changes in external limiting membranes (ELMs) in the foveae of patients with surgically closed macular holes. METHODS:: In this retrospective observational case series, spectral-domain optical coherence tomography scan images were obtained from eyes of patients with macular holes closed after vitrectomy. The integrity of the ELMs was evaluated at the fovea. In eyes with a restored ELM, the reflectivity of the ELM was estimated. RESULTS:: At a mean of 19 months (range, 3.0–59.7 months) after surgery, the integrity of the ELM was restored in 21 (77.8%) of 27 eyes with closed macular holes. The ELM was not restored in six eyes with glial sealing, in which glial tissues were present in the entire retinal layer. All 21 eyes with restored ELMs had an area of hyperreflectivity within the ELM observed at the thinnest part of the fovea; this was associated with an underlying photoreceptor defect. CONCLUSION:: Abnormally hyperreflective ELMs were frequently observed at the thinnest point of the fovea after macular hole surgery. These hyperreflective ELMs may be newly formed after surgery.

Effects of Silkworm Extract on Disaccharidase Activities of Small Intestine and Blood Glucose - Lowering in C57BL / 6J Mice

Jung-Mo Ahn,Jung-Hee Hong,Mi-Lim Kim,In-Seon Lee,Soon-Jae Rhee 한국식품영양과학회 2005 Preventive Nutrition and Food Science Vol.10 No.1

This study examined the anti-diabetic effect of a silkworm extract in C57BL/6J mice, an ob/db model, fed a high fat diet for 8 weeks. The body weight was not significantly different with the silkworm-extract supplement, nor did food intake and body weight gains also did not differ significantly among the high-fat diet groups. However, the water intake by the silkworm-extract supplemented groups increased significantly compared with that by the distilled-water supplement group, nonetheless, the FER did not differ significantly. For all groups, the blood glucose increased the most after 30 minutes and yet returned to a fasting level within 90 minutes. The fasting time and resulting glucose tolerance for the silkworm-extract supplemented groups were significantly decreased compared to that for the high fat diet with distilled water supplement group, while the level of blood glucose in silkworm-extract supplemented groups was significantly decreased compared with than in the diabetic control group. The HbA1c and insulin levels were no different among the groups. The sucrase and lactase activities in the proximal small intestine were significantly decreased in the silkworm-extract supplement groups compared to that in the diabetic control group. There was no significant difference in the glycogen contents in the liver and muscle among the groups. In conclusion, it was found that the silkworm-extract supplement repressed the disaccharidase activity in the small intestines mucosa of the C57BL/6J mice.

괴사성 간경변증에서의 골이영양증

조성래(Sung Rae Cho),박경아(Kyung Ah Park),여준기(Joon Kee Yoe),박정모(Chung Mo Park),박근용(Geun Young Park),이인규(In Gyu Lee),허정욱(Jeong Wook Hur),안성훈(Sung Hoon Ahn),박승국(Soong Kook Park) 대한내과학회 1994 대한내과학회지 Vol.47 No.6

N/A Objectives: Patients with chronic liver disease are at increased risk to develop metabolic bone disease. Although the etiology of the osteopathy in patients with primary biliary cirrhosis has not been defined, vitamin D deficiency and calcium malabsorption have been suggested as possible pathogenetic factors. In Korea, Patients with postnecrotic liver cirrhosis due to chronic hepatitis B are numerous, however, data on the prevalence and severity of osteopenia in these patient are rare. This study was performed to elucidate the mechanism of osteopenia and to examine its severity in postnecrotic liver cirrhosis. Methods: Thirty four patients with postnecrotic liver cirrhosis and thirty controls matched in age and sex were included in this study group. To obtain bone mineral density of lumbar spines in postnecrotic liver cirrhosis and control groups, measurements and comparisons of following tests were performed: Dual energy xray absorptimetry, serum calcium, serum osteocalcin, and serum 25 (OH) vitamin D. In addition, initial morning urine sample was collected to measure pyridinoline crosslinks. Results: 1) The average bone density of lumbar spines was 1.03±0.03 gm/cm² in postnecrotic liver cirrhosis group and 1.15±0.02 gm/cm² in normal controls (p<0.01). 2) The prevalence of osteopenia in the lumbar spine was 50% in postnecrotic cirrhotics compaired to 13% in controls. 3) The levels of serum calcium, 25 (OH) vitamin D and serum osteocalcin were 2.12±0.04 mmol/L, 7.38±1.00 ng/ml and 1.92±0.18 ng/ml in postnecrotic liver cirrhosis, 2.54±0.05 mmol/L and 21.68±1.90 ng/ml and 3.31±0.31 ng/ml in control group (p<0.05). 4) The levels of urinary pyridinoline crosslinks in postnecrotic liver cirrhosis and control were 82.87±7.50 nM/mM and 43.48±3.52 nM/mM, respectively (p<0.05). Conclusion: This study suggests that the incidence of lumbar osteopenia is more common in postnecrotic liver cirrhosis patients. In addition, its pathogenesis is related to vitamin D deficiency, decreased osteoblastic activity, and increased osteoclastic activity. Further studies including several hormones and histopathology of bones are needed to clearly define the mechanisms of osteopenia in postnecrotic liver cirrhosis.