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RISS 인기검색어
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- 저자 : 여준기(Joon Kee Yoe) (검색결과 1 건)
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조성래(Sung Rae Cho),박경아(Kyung Ah Park),여준기(Joon Kee Yoe),박정모(Chung Mo Park),박근용(Geun Young Park),이인규(In Gyu Lee),허정욱(Jeong Wook Hur),안성훈(Sung Hoon Ahn),박승국(Soong Kook Park) 대한내과학회 1994 대한내과학회지 Vol.47 No.6
N/A Objectives: Patients with chronic liver disease are at increased risk to develop metabolic bone disease. Although the etiology of the osteopathy in patients with primary biliary cirrhosis has not been defined, vitamin D deficiency and calcium malabsorption have been suggested as possible pathogenetic factors. In Korea, Patients with postnecrotic liver cirrhosis due to chronic hepatitis B are numerous, however, data on the prevalence and severity of osteopenia in these patient are rare. This study was performed to elucidate the mechanism of osteopenia and to examine its severity in postnecrotic liver cirrhosis. Methods: Thirty four patients with postnecrotic liver cirrhosis and thirty controls matched in age and sex were included in this study group. To obtain bone mineral density of lumbar spines in postnecrotic liver cirrhosis and control groups, measurements and comparisons of following tests were performed: Dual energy xray absorptimetry, serum calcium, serum osteocalcin, and serum 25 (OH) vitamin D. In addition, initial morning urine sample was collected to measure pyridinoline crosslinks. Results: 1) The average bone density of lumbar spines was 1.03±0.03 gm/cm² in postnecrotic liver cirrhosis group and 1.15±0.02 gm/cm² in normal controls (p<0.01). 2) The prevalence of osteopenia in the lumbar spine was 50% in postnecrotic cirrhotics compaired to 13% in controls. 3) The levels of serum calcium, 25 (OH) vitamin D and serum osteocalcin were 2.12±0.04 mmol/L, 7.38±1.00 ng/ml and 1.92±0.18 ng/ml in postnecrotic liver cirrhosis, 2.54±0.05 mmol/L and 21.68±1.90 ng/ml and 3.31±0.31 ng/ml in control group (p<0.05). 4) The levels of urinary pyridinoline crosslinks in postnecrotic liver cirrhosis and control were 82.87±7.50 nM/mM and 43.48±3.52 nM/mM, respectively (p<0.05). Conclusion: This study suggests that the incidence of lumbar osteopenia is more common in postnecrotic liver cirrhosis patients. In addition, its pathogenesis is related to vitamin D deficiency, decreased osteoblastic activity, and increased osteoclastic activity. Further studies including several hormones and histopathology of bones are needed to clearly define the mechanisms of osteopenia in postnecrotic liver cirrhosis.
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