신부전이 동반된 당뇨병 환자에서 발생된 침습성 모균증 : 수술과 Liposomal amphotericin B 및 GM-CSF 병합 요법에 의한 성공적인 치험 1예

이원영,오기원,임국희,장재혁,이동건,최정현,강무일,신완식,차봉연,이광우,손호영,강성구 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.4

저자들은 신부전이 동반된 당뇨병 환자에서 발생된 부비동형 모균증에 대하여 수술과 함께 liposomal amphotericin B 및 GM-CSF의 복합치료를 하여 성공적으로 치료한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Mucormycosis (zygomycosis) primarily affects diabetic or immunocompromised patients and typically progresses rapidly, necessitating surgical excision and antifungal therapy with amphotericin B. Large doses of amphotericin B are needed for cure, but it has the risk of causing significant renal toxicity. The recent development of liposomal amphotericin B allows antifungal therapy to be administered with potentially improved efficacy and reduced nephrotoxicity. We have experienced a case of paranasal mucormycosis successfully treated with surgery, liposomal amphotericin B and GM-CSF. A 59-year-old male suffering from diabetes mellitus for 6 years was admitted with pain at left maxillary area. He was diagnosed as mucormycosis after cytologic exam on the necrotic nasal mucosa, which showed typical hyphae. He have had diabetic nephropathy with macroproteinuria and had rapidly rising serum creatinine levels with the amphotericin B treatment: creatinine levels reverted to basal level with the use of liposomal amphotericin B. Despite surgical excision and continued antifungal therapy, his infection was not effectively controlled. Therefore, GM-CSF was administered additionally to improve phagocytic activity of leukocytes. He was finally cured after receiving a combination of aggressive surgery, liposomal amphotericin B and GM-CSF. To our knowledge, this is the first detailed clinical description of the treatment of mucormycosis with liposomal amphotericin B in Korea.

Diatomaceous earth를 이용한 경제적이고 효율높은 homemade PCR purification column의 제조 및 평가

이동호,이승관,이창규,조경진,최명재,이국성 高麗大學校 倂設 保健大學 保健科學硏究所 2002 保健科學論集 Vol.28 No.2

In recent years the amount of sequencing has increased tremendously, especially due to the introduction of automated DNA sequencing. PCR is principal method for the synthesis of templates for DNA sequencing. Consequently, the need for PCR cleanup for template preparation has increased. Already, many PCR purification kits are marketed. This DNA purification kits uses most glass membrane or silica gel, So, can do rapidly efficient purification by simple miniprep. But, efficiency of purification kits is different according to manufacturer and is very expensive. Therefore, we compare the homemade Diatomaceous earth column with major manufacturer's spin column methods for DNA purification. As a result, we found that the homemade Diatomaceous earth column method resulted in equal or better yields relative to the commercial purification kits.

혼합형 자가면역성 용혈성 빈혈을 동반한 전신성 홍반성 루푸스 1예

이승철,김선임,이승훈,이현경,조남국,한성훈,유영진,조종래 인제대학교 2000 仁濟醫學 Vol.21 No.2

A 17-year-women developed mixed warm and cold antibody type autoimmune hemolytic anemia associated with systemic lupus erythematosus. The patients was admitted to our hospital for syncope. Jaundice was observed. Urinalysis revealed protein and hemoglobin. Her hemoglobin was 4.6g/dl and reticulocytes were 10%. Total bilirubin was elevated, while haptoglobin and complement were abnormally reduced. ANA and mitochondrial Ab were detected. The direct and indirect Coombs test were positive. The direct antiglobulin test was positive ; IgG and C3d were detected on the red cell surface. The cold agglutinin(CA) titer was 128. The patients was initially treated with high dose steroid therapy. However the patients did not responded to high dose steroid therapy. We treated the patients with plasmapheresis and synchronized cyclophosphamide therapy. Clinical remission of hematologic complications was achieved in this patients. We report a case of mixed type autoimmune hemolytic anemia with SLE that responded plasma pheresis and synchronized cyclophosphamide therapy.

중량물 들고 보행시 잡기유형의 차이에 대한 운동학적 분석

서국웅,윤양진,김용재,이훈식,정미라,이창민,이중숙 한국운동역학회 2000 한국운동역학회지 Vol.9 No.2

The purpose of this study was to examine the kinematic changes of the body according to various weight loads and the holding during carrying object. The experiments were conducted with utilizing image, analyses for five male and five female adults as subjects. The results were as followed. 1. Meaningful differences were shown partially in the angle changes of the subject's wrist joints, elbow joints and coxal articulations, but not in the angle changes of the subject's knee joints, according to the types of holding the objects while subjects carrying 5kg objects. So, carrying a light object of 5kg in workplaces or gyms doesn't have much influence on human joints and muscles. 2. Meaningful differences of angle changes were shown between right holding and vertical holding while subjects carrying 10kg objects. Female subjects had difficulties to hold the angles of their wrist joints and elbow joints, carrying 10kg objects, because the first loads were imposed on their wrists and female has weaker muscles than male. In right holding of 10kg objects, female subjects had backward body centers from their bodies, the angle of their coxal articulation became bigger and they had unstable behaviors. 3. Female subjects had wider angle of their wrist joints and elbow joints while carrying 15kg objects than male subjects. But male subjects had bigger angle of coxal articulation than female subjects. Because female has weaker muscles, female subjects couldn't maintain the angles of their wrist joints and elbow joints. 4. The 20kg objects influenced the angles of the wrist joints, the elbow joints and the coaxal articulations of both sex subjects in any type of holding during their carrying 20 kg objects, but didn't influence their knee joints. 5. in carrying 25kg objects, female subjects had wider angles of their wrist joints, elbow joints and knee joints in each holding type than male subjects and the significant difference were shown according to the holding type. But in the case of coxal articulation, male subjects had the bigger angles and meaningful differences. This comes from the weakness of female's muscle. N\Male subject's upper bodies were drawn back and the objects influenced their wrists more than their arms.

步速變化에 따른 미끄러짐의 생체역학적 연구

서국웅,윤양진,서국은,이중숙,김용재,이언석,이훈식 釜山大學校 附設 體育科學硏究所 1992 體育科學硏究所 論文集 Vol.8 No.-

The purpose of this study was to analyze walking steps to prevent unnecessary energy consuming and prevention of injury from sliding when someone was walking. The questionnaire, high speed video system, E.M.G. system, and force platform system were used to analyze sliding mechanism in biomechanical perspective. Several results were found as following: 1. According to questionnaire regarding sliding, 93.3% of participants have sliding experiences. People have sliding experiences by greasy floor(48.4%) and obstacle (22.5%). Sliding types were found from different kinds of shoes such as sneakers (48.8%) and boots (34.2%). The results were presented as following 44.6% of participants were fall down front direction and 40.3% of people fell down rear side. 2. According to the high speed video system analyzer, step sliding increased with increasing step speed from distance and acceleration speed experiment with 80 steps/min, 100 steps/min, 120 steps/min. Also, the most sliding were occurred with sneakers, boots, and bare feet as order. 3. According to E.M.G. test results, the vastus lateralis M., the vastus medialis m., and the tibialis anterior m. of electric action potential presented strongly when participants fell front, rear, and right side. The vastus lateralis m. and the tibialis anterior m. of electric action potential presented strongly when someone fell left side, but the vastus medialis m. and the gastrocnemius m. of electirc action potential presented as weaker. 4. According to the force platform test results, the most big change of floor antipower of x-axis presented when someone fell the left side. The most of big change of floor antipower of y-axis presented when someone fell down rear side. The most of big change of floor antipower of z-axis presented similarly when someone fell the front, rear, left, and right side.

중량물 운반시 잡기유형과 부하단계에 따른 생리학적 연구

윤양진,이훈식,윤길환,정미라,이재규,이중숙,서국웅 釜山大學校 附設 體育科學硏究所 1999 體育科學硏究所 論文集 Vol.15 No.-

The purpose of this study was to examine physiological changes of the body according to various weight loads and the holding during carrying object. The experiments were conducted with utilizing physiological analyses for five male and five female adults as subjects. The results were as followed. 1. Any significant difference was not shown in heart rate, ventilation and amount of oxygen uptake of male subjects in the case of no load and 5kg. And also no significant difference was shown in expiratory exchange ratio of male subjects of no load, 5kg and 10kg, but in other measure items and other stages of weight was shown. 2. Significant differences were shown in heart rate, ventilation, defluxion of carbon dioxide, oxygen uptake per body weights, respiratory exchange rate, respiration rate and all other measure items of female subjects in all stages of load. 3. In the MMH job, there was no influence on male subjects up to 5kg loads, but there was an significant difference in male subjects in load walking from 5kg. It shows that even in 5kg weight MMH work, female subject's expiratory function was influenced. 4. 10kg load was the limit weight of female subjects and 15kg was of male subjects when they walked on treadmills with 4km/h velocity for 3 minutes, holding loads in the right and vertical types.

멘토링의 철학적 구조와 인간관계를 토대로 한 반성적 멘토링 모형 개발

이영국(Young Kuk Lee) 한국스포츠교육학회 2013 한국스포츠교육학회지 Vol.20 No.2

이 연구의 목적은 반성적 멘토링 모형의 이론적 토대를 구축함으로써 체육교사의 수업전문성 함양을 위한 멘토링 모형을 개발하거나 적용하는 데 작은 지침을 제공하는 데 있다. 먼저 멘토링의 철학적 토대로서 Schon의 ``반성적 실천가``, 이홍우의 ``마음의 중층구조``, 후설의 ``현상학적 환원``이라는 개념을 안내했다. 두 번째는 멘토와 멘티의 인간관계 세 가지를 비유적으로 제시했는데 먼저 교사·학생의 관계로서 멘토와 멘티는 동일하게 체육수업전문성을 탐색하는 일을 하고 있다는 것을 밝혔으며, 이어서 교류교육적 관계로서 멘토와 멘티는 서로 부족한 부분을 가르칠 수 있다는 것을 강조했고, 마지막으로 줄탁동시의 관계로서 멘토의 열정과 멘티의 욕구가 동시에 수반되어야 멘토링이 성사될 수 있음을 드러냈다. 세 번째는 반성적 멘토링의 흐름을 멘토와 멘티의 만남이 이뤄지는 ``이해``의 단계, ``계획→실행→반성``의 순환과정과 함께 멘토와 멘티가 활발하게 상호작용을 하는 ``몰입``의 단계, 1년 동안의 멘토링을 되돌아보며 개선점을 모색하는 ``반성``의 단계 등과 같이 세 단계로 나누어서 멘토링의 리듬을 제시했다. The purpose of this study is to explore the theoretical grounds of reflective mentoring model for enhancing teaching professionalism of PE teachers. The contents of this study are summarized as follows. Firstly, in philosophical grounds of mentoring, conceptions such as Sch?n`s ``reflective practitioner``, Lee`s ``twofold structure of the mind``, and Husserl`s ``phenomenological reduction`` are presented. Secondly, the three metaphors for describing relationships between mentor and mentee are presented: (a) ``relationship of teacher and student`` means that both mentor and mentee are exploring aspects of teaching professionalism of physical education teachers together. (b) ``relationship of exchanging their roles`` means that a mentee is able to teach his or her mentor about something he or she knows better than a mentor does. c) ``relationship of JulTakDongSi`` means that mentoring requires both mentor`s passion for mentoring and mentee`s need for learning to teach PE. Lastly, three rhythms of mentoring have emerged: (a) ``understanding``, at the beginning of the mentoring, which consists of knowing each others` historical and social background, (b) ``immersion``, at the middle of the mentoring, which includes mentor and mentee`s active interaction accompanied with the cyclic process of ``plan→execute→reflect``, (c) ``reflection``, at the end of the mentoring, which enables mentors and mentees to change their roles into learners` ones.

Genetic Characterization of Haemagglutinin 1 Domain of Influenza B Viruses Isolated in Korea during $1988{\sim}1999$

Shin, Gu-Choul,Na, Byoung-Kuk,Lee, Joo-Yeon,Ahn, Jung-Bae,Park, Jong-Won,Lee, Jin-Soo,Kim, Jee-Hee,Kim, Woo-Joo,Kang, Chun The Korean Society for Microbiology 2003 Journal of Bacteriology and Virology Vol.33 No.4

Although Korean influenza virus isolates have been genetically associated with the vaccine strains of the corresponding year, influenza B viruses have prevailed almost every year in Korea during the past decades. We have 'analyzed the genetic characteristics and evolutionary patterns of the haemagglutinin (HA) 1 domains of influenza B viruses isolated during 1988-1999 using direct RT-PCR and sequencing. Phylogenetic analysis of influenza B viruses isolated in Korea indicated that antigenically and genetically distinguishable strains of the lineage II and lineage III variants had been cocirculated. Variants prevailed in early 1990s are represented in 1996/97 and 1998/99 and some different variants have been co circulated geographically and prevailed concurrently in Korea. All HA1s of Korean isolates have amino acid substitutions mainly in the region between position 124 and 310, which was previously proposed an immunodominant region. Insertion-deletion patterns of the HA gene revealed that Korean influenza B viruses were evolved from Lee40 with different manner between lineage II and III viruses. Lineage III viruses were also divided into two groups as conserved group and inserted group, in relation to Lee40. But lineage II viruses had evolved with directional pattern. Antigenic index proposed that influenza B isolates prevailed since 1996/97 seasons might had emerged from the antigenic variants of a Seo1697-like virus and that new variants might appear from the lineage II viruses resulting in persistent prevalence in Korea.

삼각측량 시스템을 이용한 물체의 3-D 정보추출 관한 연구

이호영,김국세,문정환,이철승,방극인,박영옥 조선대학교 전자정보통신연구소 2002 電子情報通信硏究所論文誌 Vol.5 No.2

The 3-D shape use to effect of movie, animation, industrial design, medical treatment service, education, engineering etc... But it is not easy to make 3-D shape from the information of 2-D image. There are two methods in restoring 3-D video image through 2-D image; First the method of using a laser; Second, the method of acquiring 3-D image through stereo vision. Instead of doing two methods with many difficulties, I study the method of simple 3-D image in this research paper. We present here a simple and efficient method, called direct calibration, which does not require any equations at all. The direct calibration procedure builds a lookup table(LUT) linking image and 3-D coordinates by a real 3-D triangulation system. The LUT is built by measuring the image coordinates of a grid of known 3-D points, and recording both image and world coordinates for each point; the depth values of all other visible points are obtained by interpolation.

顔貌 變形症 患者에 있어서 顎矯正 手術後 心理檢査 및 滿足度 評價에 關한 臨床的 硏究

이국엽,진우정 全北大學校 齒醫學硏究所 1991 전북치대논문집 Vol.9 No.1

The need to assess psychological characteristics of patients electing orthognathic surgery has recently been recognized. Systematic research on the relationship of personality predictors to patient recovery, postsurgical outcomes, and self-concept has not been reported widely in the clinical literature. This report examined the psychological responses and postsurgical outcomes in a clinical study of 37 patients who underwent orthognathic surgery for facial deformity. Each questionaire to assess a locus of control, Eysenck's personality dimension, self-concept, and postsurgical satisfaction was administered to the patients up to 11 months after surgery. Self-concept and postsurgical outcomes were compared according to age, sex, and operative technique And also the study was to determine the association among personality characteristics, postsurgical satisfaction, and self-concept. The results were as follows : 1. Males, tenages were significantly more improved with physical self-esteem than women, twenty-years old after surgery(P<0.01, P<0.05). 2. Total positive self-esteem was less improved in the groups with high scores of neuroticism, emotional dimension, and introversion(P<0.05). 3. Esthetic satisfaction with postsurgical results was more satisfied in the group of extroversion dimension, and there was a correlation with postsurgical satisfaction(P<0.05). 4. There was a correlation with self-concept in the group of introverion dimension(P<0.01).