호흡기 감염에서 Sparfloxacin 의 임상적 유용성에 대한 Enoxacin과의 비교 검토

김주옥,김선영,김관형,서지원,박석영,이종진,박성학 대한감염학회 1995 감염 Vol.27 No.4

목적:폐렴, 기관지염, 만성기관지염에서 fluoroquinolone제제로서 항균력이 강하고, 혈중 반감기가 길고, 객담과 조직내 농도가 높은 sparfloxacin의 안전성과 효과를 enoxacin과 비교하기 위해 본 연구를 시행 하였다. 방법:1994년 10월부터 1995년 4월까지 충남대 부속병원과 대전 성모병원에 내원한 폐렴, 급성기관지염, 만성기관지염이 급성으로 악화된 환자 63명을 대조군(32명)(enoxacin 100 mg 1일 3회 경구투여), 실험군(31명)(sparfloxacin 200mg 1일 1회 경구투여)으로 나누어 임상증상, 세균학적 객담 검사, 혈액검사, 실험실내 항균력검사로 그 치료율 및 안전성을 비교하였다. 결과: 1) 임상종합 평가, 세균학적 균소실, 안전성, 유용성에서 두군간에 의미 있는 차이는 없었다. 2) 시험관내 항균력검사상 MIC가 실험군이 대조군보다 현저하게 낮았다.(p<0.05). 3) 경미한 두통, 식욕감퇴, 상복부 불쾌감, 설사등이 대조군 9예, 실험군 7예에서 발생하였고, 검사실 소견상 SGOT 혹은 SGPT 의 일시적 경미한 상승이 대조군 2명, 실험군 3명에서, 혈중 creatinine 상승이 실험군 2명에서 있었으나 경미하였다. 결론:이상의 결과로 sparfloxacin은 폐렴, 급성기관지염, 만성기관지염의 악화에서 하루 한번 투여로 enoxacin 하루 3번 투여와 유사하게 효과적이고 안전하며, 시험관내 항균력이 enoxacin보다 월등히 우수하여 임상에서도 유용하게 사용될수 있을것으로 생각된다. Background: Sparfloxacin, a new oral quinolone, has a broad spectrum, potent antimicrobial activity, prolonged half life, high concentration in sputum. The clinical efficacy and safety of sparfloxacin have been reported by some previous clinical studies performed in Japan. The objectives of this study were to evaluate the clinical and antimicrobial efficacy of this drug in respiratory tract infections compared to those of enoxacin. Methods:We performed an open controlled, randomized study in 63 patients with acute bronchitis, pneumonia, and exacerbation of chronic bronchitis at Chung Nam University hospital and Dae Jeon St. Mary's hospital from October, 1994 to April, 1995. In the control group(n=32), 100 mg enoxacin was administered orally 3 times a day and in the test group(n=31), 200 mg sparfloxacin once a day. Results: The results were as follows; 1) There were no significant differences between the two groups in clinical efficacy, bacteriological finding, and usefulness. 2) Means and SD of MICs were 0.44±0.89 ㎍/ml in the control group, 0.13±0.24 ㎍/ml in the test group. There was a significant difference in MICs between the two groups(p<0.05). 3) Headache, epigastric discomfort, and loss of appetite were observed in 7 cases of the control group and in 9 cases of the test group, and transient elevations of hepatic enzyme in 2 cases of the control group, and in 3 cases of the test group. There was mild elevation of serum creatinine in 2 cases of the test group. Those laboratory abnormalities by therapy might be associated with their underlying diseases. There were no significant adverse effects caused by the drugs Conclusion:In conclusion, sparfloxacin of 200 mg once a day was as effective and well tolerated as enoxacin of 100 mg three times per day in the treatment of respiratory tract infections. Sparfloxacin is more potent antibiotics because MICs of sparfloxacin were very lower than those of enoxacin.

Natural Products,Organic Chemistry : Plant Growth-promoting Activity of Acremonium strictum MJN1 Isolated from Roots of Panax ginseng

Hyung Bum Lim,Yang Jo Chung,Ju Yun Bae,Dong Jin Kim,Hyung Jin Kwon,In Hyung Lee,Byung Chul Chung,Woong Sang Lee,Joo Won Suh 한국응용생명화학회 2000 Journal of Applied Biological Chemistry (J. Appl. Vol.43 No.2

투과전자현미경으로 살펴 본 자발형성 InAs/GaAs 양자점의 구조 및 응력 특성

김형석 ( Hyung Seok Kim ),서주형 ( Ju Hyung Suh ),박찬경 ( Chan Gyung Park ),이상준 ( Sang Jun Lee ),노삼규 ( Sam Kyu Noh ),송진동 ( Jin Dong Song ),박용주 ( Yong Ju Park ),최원준 ( Won Jun Choi ),이정일 ( Jung Il Lee ) 대한금속재료학회 ( 구 대한금속학회 ) 2006 대한금속·재료학회지 Vol.44 No.7

Self-assembled InAs/GaAs quantum dots (QDs) were grown by molecular-beam epitaxy and their structure and strain characteristics were studied by using transmission electron microscopy (TEM). TEM investigations were performed by conventional bright field TEM, high-resolution electron microscopy (HREM), annular dark field (ADF) and high angle annular dark filed (HAADF)-STEM techniques. In addition, strain analysis was performed on an atomic-length scale by measuring the space of lattices in HREM. The QDs were found to form a lens-shaped structure with side facet. Compressive strain was induced to uncapped QDs from GaAs substrate and the strain increased more than 3.5% after GaAs cap layer growth. On the other hand, tensile strain by capped QDs was induced to GaAs up tolO nm over the QDs, i.e. 15 nm over the wetting layer. It was also confirmed that the tensile strain extension resulted in aligned QD growth with 15 nm thick spacers. Vertically aligned QDs could be grown by the tensile strain from predeposited QDs when the thickness of GaAs spacer was less than 15 nm.

Plant Growth-promoting Activity of Acremonium strictum MJN1 Isolated from Roots of Panax ginseng

Lim, Hyung-Bum,Chung, Yang-Jo,Bae, Ju-Yun,Kim, Dong-Jin,Kwon, Hyung-Jin,Lee, In Hyung,Chung, Byung-Chul,Lee, Woong-Sang,Suh, Joo-Won 한국응용생명화학회 2000 Journal of Applied Biological Chemistry (J. Appl. Vol.43 No.2

The plant growth-promoting activity of Acremonium strictum MJN1 isolated from roots of Panox ginseng was explored. The myceliaI extract of A. strictum MJN1 enhanced the rice seedling growth by 14.5 and 9.0% in the dried weight of shoots and roots, and the growth of red pepper by 54 and 85% in the top length and the dried weight in pot experiments, respectively. The plant growth-promoting substances in the myceliaI extract of Acremonium strictum MJN1 were identified as D-adenosine and glycerol. Both commercial D-adenosine and glycerol also promoted significantly the rice seedling growth but, unlike the mycelial extract of A. strictum MJN1, hardly affected the yields of plants grown in pots or field. Therefore, it is possible that other plant growth-promoting substances are produced by A. strictum MJN1. However, this study shows that A. strictum MJN1 has a great potential as a biofertilizer.

Resveratrol에 의한 암 전이 관련 유전자 MMP-9의 발현 조절

우주형(Ju-Hyung Woo),김영호(Young-Ho Kim),백원기(Won-Ki Baek),서성일(Seong-Il Suh),서민호(Min-Ho Suh),박종욱(Jong-Wook Park),권택규(Taeg Kyu Kwon) 대한미생물학회 2003 Journal of Bacteriology and Virology Vol.33 No.3

TEM Study on the Growth Characteristics of Self-Assembled InAs/GaAs Quantum Dots

Kim, Hyung-Seok,Suh, Ju-Hyung,Park, Chan-Gyung,Lee, Sang-Jun,Noh, Sam-Gyu,Song, Jin-Dong,Park, Yong-Ju,Lee, Jung-Il Korean Society of Electron Microscopy 2006 Applied microscopy Vol.36 No.2

Self-assembled InAs/GaAs quantum dots (QDs) were grown by the atomic layer epitaxy (ALE) and molecular beam epitaxy (MBE) techniques, The structure and the thermal stability of QDs have been studied by high resolution electron microscopy with in-situ heating experiment capability, The ALE and MBE QDs were found to form a hemispherical structure with side facets in the early stage of growth, Upon capping by GaAs layer, however, the apex of QDs changed to a flat one. The ALE QDs have larger size and more regular shape than those of MBE QDs. The QDs collapse due to elevated temperature was observed directly in atomic scale, In situ heating experiment within TEM revealed that the uncapped QDs remained stable up to $580^{\circ}C$, However, at temperature above $600^{\circ}C$, the QDs collapsed due to the diffusion and evaporation of In and As from the QDs, The density of the QDs decreased abruptly by this collapse and most of them disappeared at above $600^{\circ}C$.

수지 말단부 피부에 전이된 편평상피 폐암 1예

서재철,김명훈,박희선,강동원,이규승,고동석,김근화,정성수,김형주,송규상,김주옥,김선영 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2

Cutaneous metastases from internal malignancy are uncommon. The frequency of metastases to the skin varies from 0.5-10%. Certain malignancy are more frequently associated than others with skin metastases. In men, the primary malignancy is most often found in the lung, in women, the most common primary malignancy is in the breast. The frequency of cutaneous metastasis from lung cancer varies from 0.7-3.1%. The incidence of cutaneous metastases is high for the large cell carcinomas and low for the squamous cell and small cell carcinomas. We report here a case of cutaneous metastasis from squamous cell lung cancer in a 60 year old male patient who has erythematous nodule on his finger. Biopsy specimen from the nodule showed squamous cell carcinoma like the primary lung cancer. We have reviewed the literature.

A Randomized Controlled Study to Compare Efficacy of Terlipressin 6 mg/day and Terlipressin 4 mg/day in Patients with Hepatorenal Syndrome

( Hyung Joon Yim ),( Sang Jun Suh ),( Yeon Seok Seo ),( Soo Young Park ),( Young Oh Kweon ),( Young Kul Jung ),( Yun Soo Kim ),( Moon Young Kim ),( Sae Hwan Lee ),( Heon Ju Lee ),( Joo Hyun Sohn ),( J 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Hepatorenal syndrome (HRS) exhibits grave prognosis. To improve the outcome of HRS, we compared the efficacies of higher dose (6 mg) vs. standard dose (4 mg) of terlipressin. Methods: The inclusion criteria were cirrhotic patients with type-I HRS. The cut-off of creatinine (Cr) for inclusion was initially >2.5 mg/dL, but was lowered to >1.5 mg/dL during the study period upon update of the Diagnostic Criteria. After randomization, patients received the 1 mg of terlipressin intravenously every 4 hours (test group) or every 6 hours (control group) together with albumin infusion for 15 days. If the Cr was not improved by >30% after 72 hours of initiation, the dose was increased to 12 mg/day in the test group. The primary end point was decrease of serum Cr to a value of 1.5 mg/dL or serum Cr level of less than 50% compared with the baseline value. As a post-hoc exploratory analysis, we compared the clinical outcome of the patients who had baseline Cr <2.5 mg/dL vs. ≥ 2.5 mg/dL. Results: A total of 60 patients were enrolled. Sixteen of 29 patients (55.2%) achieved the primary end point in the test group, while 15 of 31 patients (48.4%) achieved it in the control group (P = 0.735). The survival rates at day 15 were 58.6% (17/29) and 64.5% (20/31), respectively (P = 0.639). In the post-hoc analysis, achievement rates of the primary end point were not different in patients with baseline Cr<2.5 mg/dL vs ≥2.5 mg/dL, either (66.7% vs. 46.7%, respectively, P = 0.180). However, rate of Cr normalization to <1.5 mg/dL (66.7% vs. 26.7%, respectively, P = 0.005) and the survival rate at day 15 (92.9% vs. 48.8%, respectively, P = 0.004) were significantly higher in patients with Cr<2.5 mg/dL than in patients with Cr≥ 2.5 mg/dL at baseline. Conclusions: Higher dose of terlipressin did not improve the outcome of HRS. However, early initiation of terlipressin may improve the response rate and the survival in patients with HRS.

Personal behavior of smart phone users on information protection: Health psychology theory perspectives

( Ju Yong Han ),( Yung Ho Suh ),( Hyung Jin Yeo ) 한국품질경영학회 2014 한국품질경영학회 학술대회 Vol.2014 No.2

The purpose of this research is to understand smart phone users` personal behavior on information protection using health psychology theory. These days, personal information such as digital certificate for mobile banking, its passwords and account numbers are stored in smart phones in order to perform mobile banking and other mobile applications. Currently, the security threat on the smart phone users are almost as serious as on PC users. However, the perception and behavior of the smart phone users on the personal information protection are not sufficient enough. This study investigates factors affecting the adoption of information protection behavior of smart phone users. It will perform a comparative analysis on information protection behavior on personal information between PC and smart phone users using the factors such as perceived threat and perceived responsiveness.

Decline in non-smoking workers’ urine cotinine levels after increased smoking regulation in Korea

Ju-Hyoung Park,Chae-Kwan Lee,Se-Yeong Kim,Chunhui Suh,Kun-Hyung Kim,Jeong-Ho Kim,Byung-Chul Son,Jong-Tae Lee,Seung-Do Yu,Wookhee Choi,Hosub Im 대한직업환경의학회 2015 대한직업환경의학회지 Vol.27 No.-

Objectives: To identify any association between implementing smoking regulation policies and workers’ urine cotinine concentration levels in Korea. Methods: From the first stage of the Korean National Environmental Health Survey conducted by the National Institute of Environmental Research from 2009 to 2011, 2,475 non-smoking workers selected. We analyzed the trend in the changes of cotinine concentration in urine using the general linear model and linear regression, in various jobs as categorized by the National Center for Health Statistics (NCHS) and Korea Standard Classification of Occupations (KSCO). Results: The urine cotinine concentration tended to decrease every year (2.91 ng/ml in 2009, 2.12 ng/ml in 2010, and 1.31 ng/ml in 2011), showing a decreasing trend (P < 0.001). The total subjects’ decreased cotinine concentration in urine between 2009 and 2011 was 2.72 ng/ml (54.1 % relative decrease). The changes in each subgroup’s urine cotinine concentration ranged from 1.59 to 6.03 ng/ml (33.2 to 77.5 %). All groups except for the managerial group (n = 49), which had a small sample size, had statistically significant negative regression coefficients (p < 0.05). The ranges of the decrease in urine cotinine were 2.75 ng/ml (53.6 %) for males and 2.72 ng/ml (54.9 %) for females. The negative slope in urine cotinine level was statistically significantly greater in men than women. The changes in urine cotinine by occupation as classified by the NCHS occupational categories ranged from 2.43 to 3.36 ng/ml (46.6 to 61.5 % relative decrease). The negative slopes in urine cotinine levels of the white-collar and farm workers were statistically significantly greater than those of the service workers and blue-collar workers. The change by occupation as classified by the KSCO ranged from 1.59 to 6.03 ng/ml (a 33.2 to 77.5 % relative decrease). The negative slopes in urine cotinine levels of the professionals and related workers and clerks were statistically significantly greater than those of the service workers and plant and machine operators and assemblers. Conclusions: The cotinine concentration in urine among non-smoking worker groups tended to decline from 2009 to 2011. Such a result may be an indirect indicator of the effectiveness of smoking regulation policies including the revision of the National Health Promotion Act.