http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김보영,박용규,박형서,노상필,정승현,이유선,이정우,이재환,최시완,정진옥,성인환 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1
Atherosclerosis is now viewed as an inflammatory disease of the vascular system. Expression of several chemokines, including monocyte chemoattractant protein(MCP)-1, MCP-4, RANTES(regulated on activation normal T-cell expressed and secreted), and interleukin-8(IL-8) are increased in human atherosclerotic plaques compared with normal vessels. They are involved in the pathogenesis of atherosclerosis and plaque rupture by activating and directing leukocytes into the atherosclerotic lesions. However, some are involved in homeostatic functions such as normal leukocyte traffic and growth regulation. SDF-la is a multi-functional cytokine that is involved in myelogenesis, hematopoiesis, angiogenesis and injured gastric mucosal regeneration in the gastric ulcer patient. SDF-la is recently shown to be highly expressed in atherosclerotic plaques and a potent platelet agonist. At least in high concentrations, SDF-la may mediate antiinflammatory and matrix stabilizing effects in unstable angina. Many studies are going on to know the function of SDF-la in coronary artery diseases. I investigated the difference of the plasma level of SDF-la between control group and coronary artery disease group. Total 75 subjects were enrolled. The diagnosis of coronary artery disease was confirmed in all patients by coronary angiography. Control subjects in this study were confirmed normal by coronary angiography. Clinical profile and risk factors were also reviewed. Control subjects in this study were 27 (M=10, F=17). Plasma for the study was collected before the angiography and centrifuged. SDF-la analysis was performed by ELISA. Plasma level of SDF-la is significantly increased in patients with stable angina(n=20) and unstable angina group(n=28) compared with healthy control group(n=27). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases. In this study, plasma level of SDF-la is increased in patients with stable angina and unstable angina groups compared with healthy control group(P<0.05). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases.
관류 심장과 심장 세포에서 Insulin에 의한 Mg^(2+) 유리 조절
정창우,강형섭,김진상 한국수의공중보건학회 2002 예방수의학회지 Vol.26 No.3
It is well known that β-adrenergic stimulation increases the intracelluar cAMP concentration through activation of adenylate cyclase (AC) and evokes marked Mg^(2+) release in the heart, liver, and kidney. The goal of this study was to investigate the effect of insulin on isoproterenol (ISO), norepinephrine (NE), forskolin (FOS), cAMP, or dimaprit (DMP) induced Mg^(2+) efflux from the perfused rat or guinea pig heart and isolated myocytes. We hypothesized that insulin would regulate Mg^(2+) efflux induced by AC activators and cAMP analogues because insulin activates phosphodiesterase (PDE) in the hearts. The Mg^(2+) content in the perfusate was significantly higher in the presence than in the absence of insulin. The addition of ISO, NE, FOS, or cAMP to perfused rat or guinea pig heart and isolated myocytes induced a marked Mg^(2+) efflux. These effluxes were inhibited by insulin. The Mg^(2+) efflux could also be induced by DMP, a histamine H2-receptor agonist, in the perfused guinea pig heart and isolatd myocytes. This effect was also inhibited by insulin. In rat heart and myocytes, the histamine H2-receptor agonist had no effect on Mg^(2+) efflux. In conclusion, these data suggest that insulin regulates Mg^(2+) homeostasis and the inhibitory effect of insulin on adrenoceptor-stimulation or AC activation induced Mg^(2+) efflux may occur through a regulation of cAMP pathway in rat and guinea pig hearts.
유한요소법과 경계요소법의 결합을 이용한 2차원접촉문제의 해석
정진형,우호길 충남대학교 공업교육연구소 1997 論文集 Vol.20 No.1
The coupled finite element method and boundary element method is applied to 2 dimensional elastic contact problem. Coupling the FEM and BEM is achieved by using the non-symmetric method which is a boundary element-like approach. In order to verify the method, the problems of simple cantilever beam and infinite plate with a circular hole are analysed. The results obtained the proposed method are compared with other numerical and analytic solutions, they are coincided well.
정형진 안동대학교 기초과학연구소 1990 基礎科學 硏究論文集 Vol.1 No.1
The content of volatile acids such as 2.3-methylbutanoic acid and 3-methylpentanoic acid known as the major components influencing on tobacco aroma similar in both Hyangcho, a local variety, and Xanthi Basma, an oriental variety. Hyangcho contained 4.14 and 3.40mg/100g of 2.3-methyl butanoic acid and 3-methylpentanoic acid, respectively. However, these components of Hyangcho was about 80% of KA 101 and Izmir, the oriental varieties. In addition, volatile neutural compounds such as benzyl alcohol, 2-phenylethyl alcohol, solanone, β-damascene and ionone were also higher in Hyangcho than those of other local varieties. The early transplanting increased the volatile acid contents such as 2.3-methylbutanoic, 3-methylpentanoic acid and solanone etc. Volatile organic acids such as 3-methylpentanoic acids decreased under high soil moisture content.
이성분 양이온성 계면활성제 혼합용액의 임계미셀농도에 대한 연구 1. CTAB와 다른 양이온성 계면활성제 CTB 및 DTAB 혼합용액
김진형,오세웅,고정수 木浦大學校基礎科學硏究所 1999 基礎科學硏究誌 Vol.17 No.-
The critical micelle concentration (??) in a micellar state of the mixed surfactant systems of cetyltrimethylammonium bromide (CTAB) with cetylpyridinium bromide(CPB) and dodecyltrimethylammonium bromide (DTAB) were determined at 25℃ as a function of the overall mole fraction of CTAB by the use of surface tension method. CMC values of pure CTAB, CPB, and DTAB were 9.95×10-4 M, ?? M, and ?? M, respectively. Interaction parameterβ value of CPB-CTAB mixture was evaluated as -1.3. In case of DTAB-CTAB mixture, constancy in β value was not obtained over all composition of the mixture.
박정란,강진형,구효정,노지영,류형철,박상욱,고동현,조일환,이주영,황다니엘,김인경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2
Selective COX (cyclooxygenase)-2 inhibitors including celecoxib have been shown to induce apoptosis and cell cycle changes in various tumor cells. New inhibitors are recently being developed as chemomodulating agents. We evaluated celecoxib and screened 150 synthetic compounds for anti-proliferative activities in vitro. Effects of celecoxib on COX activity, cell growth, cell cycle distribution, and apoptosis induction were determined in A549 COX-2 overexpressing human non-small cell lung cancer (NSCLC) cells. The COX inhibition of celecoxib increased with concentration up to 82% at 1μM after 24 hr exposure. Forty μM and 50μM of celecoxib induce G_1 arrest, and TUNEL-positive apoptotic cells, respectively. Among 150 compounds, several compounds were selected for having greater COX-2 inhibitory activity and higher selectivity than celecoxib with growth inhibitory activity. Celecoxib showed concentration-dependent COX inhibitory activity, and ability to induce cell cycle arrest and apoptosis in human NSCLC cells in vitro. Among synthetic analogues screened, several compounds showed promising in vitro activity as COX-2 inhibitory anticancer agents, which warrant further evaluation in vitro and in vivo.
Wegener 씨 육아종 증례보고 1예 : A Case Report
정선관,임형근,정은택,노병석,김창근,원종진 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.2
Wegener's granulomatosis is characterized by necrotizing and granulomatous disease which involves upper, lower respiratory tract and kidney. The basic pathophysiologic mechanism of Wegener's granulomatosis is still unknown. We report a case of Wegener's granulomatosis which involved lung and pleura and was diagnosed by clinical symptoms, radiologic findings and anti-neutrophilic cytoplasmic autoantibodies.
황형준,권태진,최정우 慶熙大學校 材料科學技術硏究所 1999 材料科學技術硏究論集 Vol.12 No.-
We estimate the ground state energy and wavefunction in the biased quantum well structure by using the periodic boundary condition. In this calculation, we assumed that the probability of finding the particle has maximum value at the ground state energy and the amplitude of the wavefunction should not depend on a period. The obtained energy value was in good agreement with the result predicted by the complex energy method.
최영호,서홍주,임영혁,김정중,박성강,이석기,임진수,김은규 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2
Pulmonary blastoma is a very rare primary neoplasm of the lung. We experienced a case of pulmonary blastoma in a 40 years old man. The mediobasal segmentectomy of the right lower lobe was performed. The patient was discharge on the postoperative days 6. There is no evidence of recurrence or metastasis on followup study during 7 months period after operation.