酒精依存에서 血漿 Dopamine 및 Serotonin 濃度 變化의 意味

田珍淑,金玹壽,吳秉勳 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.3

Dopamine and serotonin drew much attention to understand a biological mechanism underlying alchohol dependence. There were three reasons. Frit, behavioral effects governed by them were quite similar with various psychopathology observed in alcoholism. Second, preference to alcohol drinking tended to be related to the genetically transmitted biochemical abnormalities of these neurotransmitters. Finally, reward-mediating brain areas which seemed to be related to alcoholism were include in dopaminergic and serotonergic pathways. The aims of this study were to look for any changes of dopamine and serotonin concentrations in alcohol dependence, to identify what psychopathology was associated with, and to understand a biological mechanisms underlying alcohol-related psychopathology. Subjects were consisted of 25 male patients admitted with alcohol dependence and 25 healthy male volunteers. Samples drawn after 1 to 3 weeks of detoxification were analyzed by HPLC for the measurement of plasma dopamine and serotonin concentrations. Otherwise, precise alcohol history including duration of alcohol drinking, onset age, family history, types of alcoholism, MAST score, and frequency of hospitalization was done. Furthermore, psychopathology was rated by several questionnares like BPRS, MMPI, Sexual Jealousy Questionnaire, BDI and CES-D. 1) Mean concentration of dopamine in alcoholics(61.8±22.6pg/ml) was significantly(p<0.01) lower than in controls(77.4±16.3pg/ml), while serotonin concentration in alcoholics tended to be higher than in controls. 2) Dopamine concentration was negatively correlated with 'hallucinatory behavior' item(p<0.01) and 'unusual thought content' item(p<0.01) of BPRS, and 'hypochondriasis' scale(p<0.05) of MMPI. While serotonin concentration was positively correlated with 'tension' item(p<0.001) of BPRS. 3) Dopamine concentration was negatively correlated with SJQ(p<0.05), while serotonin concentration was positively correlated with frequency of hospitalization(p<0.05) and total score of BPRS(p<0.001). In conclusion, reduced dopamine and increased serotonin concentrations seemed to be associated with psychosis developed in alcohol dependence. Otherwise, impulsivity-aggressivity easily found in alcoholics might be biologically related to decreased dopamine concentration.

기관지천식 환자에서 Furosemide, Disodium cromoglycate 및 Heparin 흡입이 고장액 식염수 기관지유발검사에 미치는 영향

강천일,현상훈,남언정,김건우,윤종수,서영익,이종명,김능수 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.3

목적 : 기관지천식 환자에서 고장액 식염수의 흡입은 기도수축을 유발할 수 있으며 이는 운동유발성 천식반응과 밀접한 관계가 있는 것으로 알려져 있다. 저자들은 알레르겐 흡입이나 운동에 의해 유발되는 천식에 예방효과가 있는 것으로 알려진 disodium cromoglycate(DSCG), furosemide 및 heparin 흡입이 4.5% NaCl 기관지유발검사(BPT)에 미치는 영향을 조사하였다. 대상 및 방법 : 4.5% NaCl BPT에서 양성반응을 보이는 기관지천식 환자 13명을 대상으로 하였으며 사용된 약물은 furosemide 40㎎, DSCG 40㎎ 및 heparin 1,000μ/㎏이었다. 먼저baseline 4.5% NaCl BPT를 시행한 다음 이들 약물로 전처치후 다시 4.5% NaCl BPT를 시행하여 약물의 효과를 관찰하였다. 결과 : Furosemide 40㎎, DSCG 40㎎및 heparin 1,000μ/㎏의 흡입 전처치는 고장액 식염수에 의한 기도수축 반응에 뚜렷한 예방효과를 보였다. Furosemide와 DSCG로 전처치한 군(n=6)에서 이들의 기도수축 방어율은 각각 100.6±6.6%, 91.1±17.2%였으며 furosemide와 heparin으로 전처치한 군(n=7)에서는 각각 58.7±29.2%, 59.0±51.1%로서 각 군에서 이들 약제간의 방어율에는 유의한 차이가 없었다. 결론 : Furosemide(40㎎), DSCG(40㎎) 및 heparin(1000μ/㎏)의 흡입 전처치는 고장액 식염수에 의한 기도수축 반응에 뚜렷한 예방효과를 보였으며, 적어도 이 용량에서 기도수축 예방 정도에는 유의한 차이가 없음을 알 수 있었다. Background: Hypertonic saline (4.5% NaCl) inhalation is known to induce broncho-constriction by affecting mast cell, epithelial cell and vagal afferent pathway in some asthmatics. Disodium cromoglycate (DSCG) is known to have a preventive effect on allergic asthma and exercise induced asthma, and recently it was reported that furosemide and heparin had similar effect. The purpose of this study was to evaluate the effects of furosemide, DSCG and heparin on hypertonic saline provocation test in asthmatics. Methods: Thirteen asthmatics with a positive response to hypertonic saline challenge were enrolled. Hypertonic saline and test drugs were generated by ultrasonic nebulizer. After taking baseline 4.5% NaCl challenge, subjects were rechallenged with 4.5% NaCl after inhalation of furosemide 40㎎, DSCG 40㎎ or heparin 1,000μ/㎏. Results: 1. There was a significant positive relationship between PC_20-methacholine and PTM-4.5% NaCl(r=0.5575, p = 0.024). 2. Furosemide, DSCG and heparin had no direct bronchodilating effects. 3. Premedication of furosemide and DSCG(n=6) showed significant protective effects on 4.5% NaCl induced broncho-constriction. The average protection rate were 100.6±6.6% and 91.1±17.2%, respectively. 4. Premedication of furosemide and heparin(n=7) showed significant protective effects on 4.5% NaCl induced broncho-constriction. The average protection rate were 58.7±29.2% and 59.0±51.1%. respectively. Conclusions: Furosemide(40㎎), DSCG(40㎎) and heparin(1.000μ/㎏) had significant protective effects on hypertonic saline induced broncho-constriction in asthmatics, and there were no significant differences in their potency of protection rate.

SM45C강의 Tempering 온도 변화에 따른 상온 및 300℃에서의 피로균열전파특성

장천수,김현철,임병수 成均館大學校 科學技術硏究所 1993 論文集 Vol.44 No.2

The effect of micros tructural and tempering temperature change on ΔK_th has been investigated at room temperature and 300℃ For the experiments, using SM4OC steel, specimens of different grain sizes, spacings between ΔK_th particles and tempering temperatures were prepared. Some of the conclusions obtained are as follows ; 1. ΔK_th values were greater at 300℃ when compared with those at room temperature and the crack growth rate decreased as test temperature increased. 2. ΔK_th was observed to increase with tempering temperature. However, ΔK_th value of 450℃ tempered specimen was very low, which is believed to be the result of Tempered Martensite Embrittlement(T.M.E.).

食餌 脂肪質의 不飽化/飽化脂肪酸 比率이 흰쥐의 肝臟 細胞膜의 脂質組成에 미치는 影響

崔鎭浩,金一星,金在一,朴泉洙,尹泰憲,吳成基 한국노화학회 1992 한국노화학회지 Vol.2 No.1

食餌 脂肪質의 不飽化/飽化脂肪酸 比率이 흰쥐의 血淸 脂質組成에 미치는 影響

崔鎭浩,金一星,金在一,朴泉洙,尹泰憲,吳成基 한국노화학회 1992 한국노화학회지 Vol.2 No.1

食餌 脂肪質의 不飽化/飽化脂肪酸 比率이 흰쥐의 리포단백 콜레스테롤의 含量에 미치는 影響

崔鎭浩,金一星,金在一,朴泉洙,尹泰憲,吳成基 한국노화학회 1992 한국노화학회지 Vol.2 No.1

우리나라 상차림의 영양적 평가

김영순,이정희,오순덕,김수현,이정민,남택수,박태식,천유정 高麗大學校 倂設 保健大學 保健科學硏究所 2002 保健科學論集 Vol.28 No.1

This study was carried out to investigate the current nutritional problems owing to the increased consumption of westernized food in Korea and also was conducted to compare the nutritional characteristics of Korean traditional meal with those of the Western diet in similar serving size. The results obtained from nutritional evaluation are as follows: 1. The percentage of calories represented by carbohydrate: lipid: protein was 65:15:20 respectively for Korean traditional meal (Table setting of 3 Chop) therefore these ratios meet the dietary recommended allowances for Koreans. 2. Nutrient values of Korean traditional 3-Chop were shown to be better balanced than those of Western diet when the nutrients of the two types of diet were estimated by similar serving sizes and calories. 3. Compared to the Korean traditional meal, most fast foods were nutritionally imbalanced especially in that most of them showed higher amounts of fats. These results show that Korean traditional meals supply ideal nutrient intakes in contrasts to the westernized diet, therefore much work remains in developing a variety of menus and standard recipes for Korean traditional meals according to the changes in diet trends as well as emphasing the importance of Korean traditional meals as part of an ideal, well-banlanced diet.

연폭로 근로자들에서 적혈구 Pyrimidine 5'-Nucleotidase 활성도 및 요중 N-Acetyl-β-D-Glucosaminidase 활성도와의 상관관계 연구

서홍규,이병국,황천현,장성훈,이성수,이원진,최재욱 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.2

In this study, we measured the activity of the erythrocyte pyrimidin 5'-nuclectidase(P5N) and urinary N-acetyl-β-D-glucosaminidase(NAG) from 154 workers exposed to lead and 43 workers not exposed. We analyzed the correlation of the P5N activity and NAG activity with other biololgical exposure indices of lead such as blood lead(PbB) and zinc protoporphyrin(ZPP). The measurement was performed by using high performance liquid chromatography(HPLC), spectrophotometer and atomic absorption spectrophotometer. The results are as follows : 1. The mean value of P5N activity for workers exposed to lead was 9.50±3.13 μmol uridine/hr/g Hb and 11.60±2.2 μmol uridine/hr/g Hb for workers not exposed. The P5N activity showed a normal distribution, but the other indices of lead showed logarithmic normal distributions. 2. The P5N activity and ZPP were decreased as PbB was increased. But the NAG activity had no correlation with changes of PbB. 3. The correlation coefficients of the P5N activity with other biological exposure indices of lead such as PbB, ZPP, NAG activity were -0.72, -0.55, and 0.05, respectively. We speculated that the P5N activity can be used as a reliable biological exposure index of lead but NAG activity can be used as a biological management index of lead.

아므르불가사리 (Asterias amurensis)의 배우자를 이용한 남해해역 연안해수의 생물학적 수질평가

유춘만,박지인,조기안,주현수,박종천,나명석 한국환경과학회 1999 한국환경과학회지 Vol.8 No.1

This study was carried out to evaluate off-shore water quality and to draw marine pollution map to Southern sea in Korea by bioassay using gametes and early development system of Asterias amurensis. From the bioassay, it was determined that the water qualites of Southern sea maintained the grade Ⅱ, because development of A. amurensis were moderately inhibited. However, Sunchon, Kwangyang, and Jinhae Bay belonged to grade Ⅲ, because development of A. amurensis were strongly inhibited. This could be due to the inflows of several river systems and poor water circulation. The water quality at Yosu island was the grade I, because A. amurensis were not inhibited in its early development.

魚油함유 飼料에 첨가한 α- 토코페롤의 含量이 흰쥐 血液의 肢質過酸化反應에 미치는 影響

崔鎭浩,金一星,金在一,金東右,朴泉洙,尹泰憲 부경대학교 기초과학연구소 1993 기초과학연구논문집 Vol.4 No.-

어유와 돈지의 혼합지질(3 : 1, wt/wt: P/S : 1.6)에 α-토코페롤을 용량별(0, 50, 100, 200, 400, 800mg/kg diet)로 첨가하여 조제한 어유 함유 사료로써 7주간 사육하여 이 사료에 혼합한 α-토코페롤의 첨가량이 혈청 중의 지질대사에 미치는 영향을 검토하였다. 중성지질(TG)과 인지질의 함량은 α-토코페롤 200mg 이상의 첨가군은 대조군에 비하여 유의적으로 감소하였고, 또한 총콜레스테롤의 함량은 α-토코페롤의 첨가에 따라 감소하는 경향이었지만 낮은 첨가농도에서만 유의성이 인정되었다. HDL-콜레스테롤의 함량은 100mg 이상의 α-토코페롤 첨가군에서 총콜레스테롤에 대한 HDL-콜레스테롤의 비(HDL-chol/T. chol)도 α-토코페롤의 모든 첨가군에서 유의적으로 증가효과가 인정되었다. 따라서 동맥경화 지표가 α-토코페롤 첨가군에서 유의적으로 감소하였다. 중성지질에 대한 과산화지질(TBA value/TG)의 비는 10mg 이상의 α-토코페롤의 첨가군에서 유의적으로 억제되???고, 중성지질에 대한 α-토코페롤(α-tocopherol/TG)의 비는 100mg 이상의 α-토코페롤 첨가군에서 유의적으로 증가되었다(p<0.001). 어유 함유 사료에 α-토코페롤을 첨가함으로써 C20 : 5/C20 : 4의 비를 효과적으로 억제할수 있었다. 따라서 혈액 중의 적절한 지질대사를 위해서는 이들 어유 함유 사료에 100mg 이상의 α-토코페롤이 첨가되어야 할것으로 생각된다. To evaluate the vitamin E requirement, Fischer 344 male rats were fed diets containing the fish oil-lard (3 : I, wt/wt: P/S ratio : 1.6) supplemented with 0, 50, 100, 200. 400 and 800 mg/kg diet of a-tocopherol for 7 weeks. The effects of a-tocopherol levels supplemented to fish oil rich diets on the lipid metabolism in serum were investigated. Triglyceride (TG) and total cholesterol significantly decreased by supplementation of a-tocopherol. The a-tocopherol supplementation of abme 100 mg diet caused an incressis in HDL-cholesterol. and HDL-cholesterol : T. chol ratio, and a decrease in the atherogenic index. The lipid peroxide : TG ratio significantly inhibited by a-tocopherol supplementation of above 100 mg. The ratios of α-tocopherol/TG or n-3 fatty acid (EPA+ DHA) significantly increased in all α-tocopherol supplemented groups. The ratio of eicosapentaenoic acid : arachidonic acid effectively inhibited by a-tocopherol supplementation of above 100 mg. The results suggest that a-tocopherol supplementation of above 100 mg to fish oil-rich diets map be requisite for adequate lipid metabolism.