Bupivacaine과 ropivacaine이 Xenopus oocyte에 발현된 HERG 전류에 미치는 영향

김국성,이규승,김효신,손숙진,이상도,김광진,전병화,김윤희,박진봉 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Bupivacaine is an amide-type local anesthetic widely used for regional anesthesia. Ropivacaine is developed as a less cardiotoxic alternatives to bupivacaine. In the present study, we have analyzed the effects of bupivacaine and ropivacaine on HERG currents expressed in Xenopus oocytes. Bupivacaine and ropivacaine(3∼1,000μM) blocked HERG currents in a concentration dependent manner. EC_(50) was 26.1±3.1μM(n_(R) 0.65±0.04) and 43.5±7.9μM(n_(H) 0.99±0.13) in bupivacaine and ropivacaine, respectively. Bupivacaine and ropivacaine did not affect the activation and deactivation kinetics of HERG channels. However, the drugs decreased the slope conductance measured from fully activated current-voltage relationship curves. These results suggest that bupivacaine and ropivacaine have a similarinhibitory effect on HERG channels, which could be a possible cellular mechanism of LQT or ventricular arrythmia by the drugs.

Si Bulk Micromachining을 위한 Wafer Rolling Etching 및 그 특성

김건년,이보나,박효덕,신상모,공경준,장동근,김병철,권혁채,이봉희 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

A wafer rolling etching system for the silicon bulk micromachining has been designed and fabricated. The silicon diaphragms were anisotropically etched in a 24.5 weight percent KOH solution. Compared to the conventional KOH etching systems, pyramidal hillocks, and wave-shaped structures on the etched surfaces were greatly reduced by using this system. After etching for time of 438 minutes, the average etched depth and the etch-rate were measured to be 537μm and 1.22μm/min, respectively. The average etching uniformity of etching depth was 0.87% in 5-inch wafer. Our results showed that the wafer rolling method enhanced etch uniformity and etch rate.

소아에서 Fogarty 카테터를 이용한 일측폐 환기 마취 경험

유수봉,강효석,임지훈,김두식,류시정 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Thoracic surgery may be greatly facilitated by causing selective atelectasis of the lung being operated on (one-lung ventilation anesthesia). But the tube used for one-lung ventilation is greater outer diameter than conventional endotracheal tube when compare to each other with same inner diameter, so in some young children it is impossible to one-lung ventilation using double lumen tube or bronchial blocker tube because of narrow vocal cord. We performed one lung ventilation anesthesia using conventional endotracheal tube and Fogarty catheter as a bronchial blocker in 11-year old women who received lung biopsy surgery and left lower lobectomy.

동방결절의 부위별 전기적 특성에 관한 연구

김봉식,조성일,방효원,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1986 中央醫大誌 Vol.11 No.1

In order to investigate the regional eiectrophysiological characteristics of the rabbit SA node, the node was tied with fine silk threads into small preparations(0.5XO.5mm in size) and electrotonic connection between them was insulated. The preparations were divided into three groups, as peripheral, transitional and central areas. Three glass microelectrodes were inserted into the cells in each area and the data were collected when transmembrane potentials of each area was recorded simultaneously. 1. As the Na^+ concentration of the solution was reduced to 80, 60, and 40% of control, the beating frequency, the maximum diastolic potential(MDP), overshoot and the maximum upstroke velocity(Vmax) were decreased. The decrease of the beating frequency was more marked in the central area, and the spontaneous beating was arrested by the reduction of Na^+ concentration more than 60%. 2. In the peripheral area, MDP was decreased as the 2mM K^+ concentration reduced to 1 mM. At high K^+ concentration(12mM), the spontaneous beating of the central area was stopped in the 50% of preparations. 3. The decrease of the spontaenous beating frequency, due to Ach(Acetylcholine) was more prominent in the central area. The increase of the MDP was marked in the central area, however, the decrease of overshoot was distinct in the peripheral area. 4. The peripheral area was the most sensitive to TTX(Tetrodotoxin). The effects of epinephrine which changed the parameters of the action potential were more marked in the central area, but the effects were more marked in the peripheral area when the preparations were pre-treated with TTX. 5. The amplitude of the Na^+-K^+ pump activity of the peripheral area was larger and decreased in the transitional and the central area in sequence. The electrophysiological characteristics of the SA nodal cells have shown various differences by the locations. Especially, the central area which considered as the leading pacemaker are generally more sensitive to the various interventions.

Cyclosporin에 의한 치은증식증의 치험 2례

김종배,박효상,김창환,이용규,최봉주,장학원 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.2

Cyclosporin is a relatively new immunosuppressive agent which has been used to prevent organ transplant rejection, to treat type-I diabetes mellitus and several other autoimmune disorders. It is anticipated that the therapeutic use of cyclosporin will increase progressively in the future to treat numerous other disorders. As its clinical use broadens, it will needed for health professionals to be familiar with the beneficial effects as well as some of the undesirable side effects of cyclosporin therapy. A side effect of this drug in dentistry appears to be pronounced gingival hyperplasia. Cyclosporin induced gingival hyperplasia is indistinguishable from gingival hyperplasia induced by phenytoin and nifedipine in clinical and histopathologic finding. We experienced two cases of gingival hyperplasia secondary to cyclosporin therapy in patients, 48-year old & 28-year old females who received a kidney allograft transplant. Clinical examinations revealed a severely overgrown and inflammed gingiva. Surgical excision of the excess tissue was accomplished under local anesthesia. On follow-up check, gingival hyperplasia in a 48-year old patient whose oral hygiene was very poor showed successive recurrence after three times surgical excision, another patient who could control oral hygiene thoroughly showed good healing. Conclusively, it seems to be very important to control oral hygiene thoroughly to decrease occurrence and recurrence of cyclosporin-induced gingival hyperplasia.

양성 백악아세포종의 치험례

김종배,박효상,최봉주,이용규,남동석,박관수 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.2

Benign cementoblastoma is uncommon odontogenic tumor of the jaw of mesenchymal origin. It is common in male below 25 years of age, commonly occurs in mandibular molar and premolar area. Principal symptom is painless swelling. Radiologically, radiopaque mass is fused with a root or roots of teeth, surrounded, and limited peripherally by a radiolucent halo. Histologically, the tumor is composed of sheets of an osteocementum like material with basophilic reversal line. Because of unlimited growth potential, the usual treatment is complete surgical excision with extraction of the associated teeth. The patient, 16-year old male, was admitted to our hospital with chief complaint of painless swelling on right mandible body area. Surgical excision of lesion and extraction of associated tooth was performed. On follow up check, we obtained good result without any signs of recurrence of the lesion.

교잡종 찰옥수수에 대한 연구 : Ⅰ. 찰옥수수 "연농×재래" 교잡종의 생육 및 수량특성 Ⅰ. Growth and Yield Characteristics in Waxy Maize Hybrid Yeonnong × Jaerae

이희봉,정재영,최현구,김기훈,김효기,주정일 충남대학교 농업과학연구소 2001 농업과학연구 Vol.28 No.2

재래종 찰옥수수 F₁ 교잡종에 대한 생육 및 수량비교를 위해 충남대학교 농과대학 실험포장에서 육성한 이들 교잡종의 식물학적 특성에 대한 연구 결과는 다음과 같다. 1. 간장은 대조구에 비해 대학찰×재래찰, FR805/1K₃×고령찰이 가장 크게 나타났으나, FR805/1K₃×대학찰, 찰옥 1호에서 대조구와 비슷하게 나타내었다. 2. 착수수는 간장에서와 마찬가지로 대학찰×재래찰, FR805/1K₃×고령찰이 대조구보다 높게 나타났으나 대학찰×재래찰, 찰옥 1호는 비슷하였다. 3. 분얼수는 각 교잡종들간에 큰 차이가 없었다. 4. 이삭의 길이는 대조구에 비해 교잡종들이 거의 2배이상의 크기를 나타내었다. 5. 이삭직경은 FR805/1K₃× 고령찰의 교잡종을 제외하고 대조구와 비슷하게 나타났다. 6. 이삭열수는 Daehakchal×1K₁/LE만이 대조구와 유의성을 나타내고 기타 교잡종은 대조구와 비슷하였다. In order to evaluate the characteristics of growth and yield in F_(1) waxy hybrids using Korean local maize lines, six hybrids including check, Chalok # 1, were planted at the experinental field of e Chungnam National University. Stem and ear heights of Yeonnong × Jaerae and FR805/IK_(3) × Koryong hybrids were higher than the check hybrid. Number of fillers per plant in all hybrids were similar as 0.3 to 0.5 per plant Ear length of waxy hybrids was longer than 15㎝ of check hybrid and ear diameter was also thicker than check except FR805/IK_(3) × Koryong waxy hybrid. A final result, Yeonnong × Jaerae among hybrids was comparatively superior to other hybrids in the test.

飮食物쓰레기의 效率的 管理를 위한 物理的 特性 및 處理

권효정,정영헌,김임경,심언봉,오광중 부산대학교 환경문제연구소 2003 環境硏究報 Vol.21 No.-

This study was conducted to manage food wastes in Korea efficiently. We carried out an experiments on food wastes generated from Yeonjae gu, Pusan as a representative boundary according to the measurement of apparent density, generation quantity, physical characteristics, proximate analysis, and elemental analysis as well as drying and carbonizing, and also tested the hazardous materials in fertilizer and compost from public and private recycling center in operation. The purposes of this study are to investigate current status of food wastes recycling methods and facilities, to examine the fuelization of food wastes, and to suggest the cost effective food wastes treatment plans. Based on the results of the analysis of apparent density and water content in food wastes, it was revealed that the apparent density of food wastes was in inverse proportion to the water content. The water content of food wastes was highly influenced by the fruit and vegetables such as watermelons. These results indicate that the food wastes with about 75 ~80wt% initial moisture content should be reduced under 70wt% moisture content by drying process pier to throwing away. Comparing the heating values of the food wastes which were calculated by Dulong's equation and Steuer's equation it was revealed that Steuer's equation(HHV 5,186 kcal/kg, LHV 880 kcal/kg) was more compatible than Dulong's equation(HHV 4,676 kcal/kg, LHV 330 kcal/kg) because the results of proximate analysis for the food wastes were very similar to those of sewage sludges. Additionally, to reduce water contents of food wastes under 60wt% as acceptable water contents for fuelization, it was also found that blending with 25wt% chars made from food wastes was more efficient than the drying of food wastes itself at 105°C, 45minutes in view of completion time. Furthermore, these chars generated from food wastes (about LHV 6,608 kcal/kg) comparable to commercial charcoal(LHV 7,134 kcal/kg) generated from oak trees and lower ash contents(under 15wt% of chars) than those.

교잡종 찰옥수수에 대한 연구 : Ⅱ. 새로 육성된 찰옥수수 교잡종 "대덕찰"에 대한 농업적 특성 Ⅱ. Agronomic Characteristics of the New Waxy Hybrids "Daedukchals"

이희봉,김효기,김동욱,김준표,정재영,최현구,강윤규 충남대학교 농업과학연구소 2002 농업과학연구 Vol.29 No.2

1. 새로 육성된 4개의 대덕찰 찰옥수수 교잡종에 대한 간장은 대조구인 찰옥 1호보다 큰 반면에 개화기는 약 4∼7일 늦었으며, 모든 공시 교잡종의 주당 분얼수는 한 개이하의 무효분얼로 나타났다. 2. 새로 육성된 대덕찰옥수수의 이삭길이와 직경은 대조구인 찰옥 1호보다 크게 나타났으며, 특히 대덕찰옥수수 1호와 2호의 과피두께는 대구조보다 얇았고, 당도 역시 높게 나타나 우수 교잡종으로 평가되었다. Stem height of the new developed "Daedekchals" waxy hybrids were higher than check hybrid. Chalok #1, while days to tasseling were delayed about four to seven days. Number of tillers per plant of the these new hybrids including check were appeared to be one less as non-effective tiller. Ear length and diameter of the new waxy hybrids were longer and thicker than check, respectively. In addition pericarp thickness of the Daedekchal #1 and #2 among new developed waxy hybrids were thinner and sugar content were higher than check.

제1형 Trichorhinophalangeal 증후군

손효성,오창근,김문범,이재봉,장호선,권경술 대한피부과학회 2003 대한피부과학회지 Vol.41 No.6

Trichorhinophalangeal syndrome(TRPS) typeⅠis characterized by sparse and slow-growing hairs, pear-shaped nose, elongated philtrum, thin upper lip, and bone deformities, especially, cone-shaped epiphyses of the phalanges. The syndrome is inherited in an autosomal dominant manner. We report a case of TRPS typeⅠ with alopecia like male pattern baldness and Perthes-like changes on the right hip joint. (Korean J Dermatol 2003;41(6) : 801~804)