관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

소아 전풍 환자에 대한 임상적 고찰

강효준,왕한영,성호석 ( Hyo Jun Kang,Han Young Wang,Ho Suk Sung ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.3

Background: Pityriasis versicolor(PV) is a superficial mycosis, theoretically unusual in children. Epidemiologic and clinical data for children with PV under 14 years were collected. Objective . The purpose of this study was to evaluate the clinical features of PV in the young. Method: We included all cases of PV in patients under 14 years of age observed in our department from 1981 to 1995. All cases were diagnosed on the basis of clinical criteria and were confirmed by microscopic examination. Results : From 1981 to 1995 we encountered 32 cases of PV in children, compared with 637 cases in adults; thus children represented 4.7% of all cases. The ratio of male to female was l. 7:1. Among the age groups, the incidence was the highest in the 10-14 years(43%). The monthly prevalence was the highest in August. Distribution of the lesions were the face(40.9%), neck (25%), chest(13.6%), back(11.3%), extremities(6.8%) and abdomen(2.2%). The incidence of hypopigmented lesions was 70.4% and that of hyperpigmented lesions was 29.6%. Conclusion : This study confirms that the face is a predilectionl site for PV in children and all facial lesions are hypopigmented. Other clinical features are variable and similar to those of adults. (Kor J .Dermatol 1997;35(3): 431-434)

Direct effectiveness of pneumococcal polysaccharide vaccine against invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia in elderly population in the era of pneumococcal conjugate vaccine: A case-control study

Kim, Jong Hun,Chun, Byung Chul,Song, Joon Young,Kim, Hyo Youl,Bae, In-Gyu,Kim, Dong-Min,Choi, Young Hwa,Jun, Yoon Hee,Choi, Won Suk,Kang, Seong Hee,Kwon, Hyun Hee,Jeong, Hye Won,Kee, Sae Yoon,Hur, Jia Elsevier Ltd. 2019 Vaccine Vol. No.

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>While herd effects and serotype replacement by childhood pneumococcal protein conjugated vaccines (PCVs) continues to accumulate worldwide, direct effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) against pneumococcal diseases in the elderly has been challenged. We estimated the direct effectiveness of PPV23 in the elderly population.</P> <P><B>Methods</B></P> <P>For a hospital-based case-control study, cases of invasive pneumococcal disease (IPD) and non-bacteremic pneumococcal pneumonia (NBPP) (adults ≥ 65 years) were identified in 14 hospitals participated in the pneumococcal surveillance program from March 2013 to October 2015, following implementation of PPV23 national immunization program (NIP) for the elderly in the Republic of Korea. Controls matched by age, sex, and hospital were selected at ratios of 1:2 (IPD) or 1:1 (NBPP). Clinical data and vaccination records were collected. Vaccine effectiveness was calculated as (1-adjusted odds ratio) × 100.</P> <P><B>Results</B></P> <P>We enrolled 148 IPD and 557 NBPP cases, and 295 IPD and 557 NBPP controls for analyses. Overall effectiveness of PPV23 against IPD was 28.5% [95% confidence interval (CI) −5.8%–51.6%] and against NBPP was 10.2% (-15.1-30.6) in all patients ≥ 65 years. However, in subgroup analysis of patients aged 65–74 years, PPV23 was protective against IPD [effectiveness 57.4% (19.4–77.5)] and against NBPP [effectiveness 35.0% (2.3–56.7)]. Furthermore, serotype-specific effectiveness of PPV23 against IPD was 90.6% (27.6–98.8) for PPV23-unique serotypes and 81.3% (38.6–94.3) for PPV23 serotypes excluding serotype 3.</P> <P><B>Conclusions</B></P> <P>This study indicates that PPV23 with broad serotype coverage might be beneficial in preventing IPD and NBPP due to non-PCV13 serotypes in the young-elderly, with potentially increasing effectiveness in the setting of childhood PCV NIP.</P> <P><B>Highlights</B></P> <P> <UL> <LI> National immunization program for PPV23 for the elderly was implemented in Korea. </LI> <LI> PPV23 was effective against IPD and NBPP for young elderly patients aged 65–74. </LI> <LI> Effectiveness of PPV23 against IPD was higher for PPV23 unique serotypes. </LI> <LI> PPV23 was non-protective against IPD caused by PCV13 serotypes. </LI> </UL> </P>

흰쥐 경동맥 손상 모형에서 체외 방사선조사에 의한 신내막 과증식억제 : Intercellular Adhesion Molecule-1과 Vascular cell Adhesion Molecule-1의 역할 The Possible Role of Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1

강동헌,승기배,장기육,임상현,정해억,임효영,김연실,채장성,김재형,홍순조,최규보 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.9

비소세포폐암에서 동시화학방사선요법을 받는 중 생긴 기관폐루1례

강건희,조성우,김성록,유영진,이효락 인제대학교 2008 仁濟醫學 Vol.29 No.-

최근 근치적 절제가 불가능한 국소진행성 비소세포 폐암에서 화학요법을 방사선요법과 동시에 투여하는 치료방법에 대한 연구가 활발이 이루어지고 있으며 이러한 치료과정 중 생긴 여러 부작용에 대한 연구도 이루어지고 있지만 아직까지 기관폐루가 생겼다고 보고는 없다. 따라서 치료과정 중 기관폐루가 의심되는 소견이 있을 경우 이에 대한 조기 진단과 치료를 통하여 부작용에 따른 사망률을 최소화하여야 하겠다. The incidence of lung cancer is increasing steadily and various methods have been attempted to enhance the cure rate of locally advanced non small cell lung cancer, which is hardly removable surgically, but the results are not satisfactory yet. Recently, research is being made actively on the simultaneous application of chemotherapy and radiotherapy for locally advanced non small cell lung cancer that cannot be radically resected and the we experienced a case of patient diagnosed with bronchopulmonary fistula during the treatment process, and therefore report it here.

할로페리돌로 유도한 신경세포 고사에 대한 신경성장인자 및 인슐린 유사 성장인자의 억제효과

강효정,강지윤,곽병주,정영기,노재성 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

연구목적: 본 연구는 생쥐 태자의 대뇌피질 세포 일차 배양을 이용하여 할로페리돌로 유도한 신경세포의 사멸에 대해 신경 성장인자인 brain-dervied neurtrophic factor(BDNF), Neurotrophin 4/5(NT 4/5)와 인슐린 유사 성장인자인 insulin-like growth factor Ⅰ(IGF-Ⅰ)및 IGF-Ⅱ의 조절효과를 실험한 것이다. 방법: 생쥐 태자의 신경세포를 배양한 후 할로페리돌을 처리하여 신경세포의 사멸을 유도하고 이에 대한 성장인자의 효과를 정량적으로 분석하였다. 결과: 30M의 할로페리돌을 배양한 일차 대뇌 신경세포에 24시간 처리하면 광범위한 신경세포의 사멸이 유도된다. 이때 신경세포는 세포의 응축, DNA의 단편화와 응집, 세포막보다 핵막의 이른 붕괴 등 고사 형태의 신경세포 사멸 특성을 보인다. 할로페리돌과 더불어 신경성장인자인 BDNF, NT 4/5 및 인슐린 유사 성장 인자인 IGF-Ⅰ 혹은 IGF-Ⅱ를 동시에 처리할 경우 용량 의존적으로 신경세포의 사멸을 억제한다. 결론: 본 연구의 결과는 할로페리돌에 의한 신경독성이 성장인다들에 의해 억제될 수 있음을 보여주는 것이며, 장기적인 항정신병약물의 사용 후에 발생하는 부작용인 지발성 운동장애의 한가지 원인 가설로 대두되고 있는 항정신병 약물에 의한 신경독성을 신경성장인자에 의해 억제할 수 있을 가능성을 제시하는 것이다. 중심단어:할로페리돌·고사·세포사멸·고사·BDNF·NT-4/5·IGF-Ⅰ·IGF-Ⅱ. Objectives: We examined the effects of neurotrophins and insulin-like growth factors on cell death induced by haloperidol, a typical anti-psychotic agent. Method: Neocortices from 14- or 5-daysold fetal mice for neuron-glia co-cultures were used for this experiment. Result: Twenty-four hours treatment of mouse cortical cell cultures with 30 M haloperidol-induced wide spread neuronal apoptosis characterized by cell body shrinkage, DNA frag-mentation and condensation. Concurrent treatment with growth factors, BDNF, NT4/5, IGF-Ⅰand IGF-Ⅱ, protect the neurons from the haloperidol-induced neuronal apoptosis(HINA) in a dose dependent manner(10-100ng/ml). Conclusion: The present study suggests the possibility that haloperidol toxicity can be hampered with growth factors. Further study about the mechanism underlying the protective capacity of the growth factors on HINA may lead to the development of the new protective strategy for tardive dyskinesia. KEY WORDS:Haloperidol·Apoptosis·Neuronal death·BDNF·NT4/5·IGF-Ⅰ·IGF-Ⅱ.

무혈혈당측정

강나루,우영아,김효진 동덕여자대학교 종합약학연구소 2001 동덕약학연구지 Vol.5 No.-

The purpose of this study is to develop a noninvasive blood glucose measurement method by using near infrared spectroscopy (NIRS). Reflectance NIR spectra of different parts of human body (finger tip, earlobe, and inner lip) were Recoreded by using a fiber optic probe. The spectra were collected over the spectral range 1100-1700nm. Partial least squares regression (PLS) was applied for the calibration and validation for the determination of blood glucose. The calibration with the use of PLS model predicted for validation set glucose concentration with a standard error of prediction (SEP) of 33㎎/㎗.

촉매 코팅방법에 따른 기능성 여과포의 NO 제거 반응 특성

강민필,송윤섭,이효송,김상도,박영옥,황택성,이영우 한국화학공학회 2002 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.40 No.6

NO_x와 먼지 동시 제거용 기능성 여과포 개발의 일환으로 V_2O_5/TiO_2계열의 상용촉매를 사용하여 P-84, Nomex, PTFE 여과포에 코팅하였다. 사용된 코팅 방법은 Sol-gel법, Spray법 그리고 Dip코팅 방법이었으며 코팅방법이 여과포의 NO_x 제거반응에 미치는 영향을 조사하였다. NO_x 제거반응실험은 여과포의 작동온도에 맞는 100-250℃의 반응온도범위에서, 공간속도 5,000hr^-1, 산소농도 6%, NH_3/NO 몰비는 1.0의 조건하에서 수행되었다. 본 연구에서 시도된 세 가지 코팅 방법 중 촉매량의 조절 및 균일한 코팅이 용이한 Sol-gel법에 의해 제조된 기능성여과포가 가장 좋은 NO_x 전환율을 나타냈다. A series of fabric filters including P-84, Nomex and PTFE were coated with a commercial V_2O_5/TiO_2 catalyst as an effort to develop a functional fabric filter of simultaneous removal of dust and NO_x. The coating methods employed are solgel coating method, spray coating method and dip coating method, and the effects of coating method on NO_x removal performance of functional fabric filter were investigated. Experimental conditions are as follows: the temperatures of 100-250℃ which are the normal operating temperature range of fabric filters, the space velocity of 5,000hr^-1, the oxygen concentration of 6%, and the NH_3/NO ratio of 1.0. Results showed that the sol-gel coating method gave the best NO_x removal performance mainly due to its ability in controlling the amount of catalyst and uniform coating.

Bifidobacterium의 成長促進物質에 관한 硏究

姜國熙,張永斅,閔海基 成均館大學校 科學技術硏究所 1992 論文集 Vol.42 No.2

The objective of this study wsa to improve the usability of Bifidobacterium for the fermantation milk products. Thus, various biological materials were tested for the growth enhancing effects of Bifidobacterium in a synthetic medium. The organism used to conduct this study was Bifidobacterium bifidum SKD-2001, originationg from the feces of a breast-fed infant. Lactose, sucrose, peptone, L-cysteine HCI+vitamine K_1, tomato extract, and yeaset extract enhanced the growth of the test organism. The mixture consist of these materials as mentioned previously. This mixtute added in 12% reconstituted skim milk. The total viable counts of the test organism were 4.3 X 10^9/ml at 37℃, 48 hrs incubation anaerobically.

우리 나라에서 재해방지를 위한 개선안 생활변화단위 모형 개발 및 응용

강영식,함효준,양성환 대한설비관리학회 2003 대한설비관리학회지 Vol.8 No.2

The major cause of the industrial accidents is often induced by the human error. It brings about all kind of accidents. Moreover, the more the information and system complicates, the more the human error brings about. So the active accident prevention policy by human behavior, life style, culture, and psychology should develop at this time. Especially, the behavior models have provided the accident proneness concept through the life change unit factors. According to the existing studies on the life change unit models, the oriental behavior models differs from the western model in the life style and ideas. Therefore, the purpose of this paper is to develop the proposed life change unit model by the improved life change unit factors, and to evaluate its application in real fields. The proposed model can be simply applied in real fields in order to minimize the industrial accidents