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      • 일부 흡연 대학생의 지각된 스트레스와 흡연실태에 대한 상관관계 연구

        강초록,권시내,권혜림,박수경,송인혜,오해인,이미지,한승아,황선아,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

        In spite of the seriousness of smoking harm has been developed these days. the increase of national smoking rate and that the people in the twenties are especially leading the rise of national smoking rate is an important issue of national health. Smoking of the university students can occur health problem and cause loss of manpower and expenses in their social activity period. So then the actual state for prevention of smoking and development of a program to prohibit smoking has to be seized urgently and starting with the study of the realities of university students, the effort to find a related fluent of smoking has to be studied. Related to this, the purpose of this study is to seize the general characteristics of smoking university students and to find out the relationship between perceived stress and smoking status among smoking university students. In addition, by collating the relationship between perceived stress and smoking status among smoking university students we have the purpose to furnish the basal data of stress care, the best way to cope with stress through group training and the plan for nursing implementation to decrease the smoking rate. For this study, a survey was conducted for 204 smoking university students of 13 universities in Seoul from 9th of May to 16th of May, 2003. The collected data was analyzed by t-test, Pearson Correlation and ANOVA in the statistical packages SPSS/PC. Major findings of this study are as follows; 1. Of the 204 respondents 85.4% of them were male and 14.6% of them were female. The average age of the sample was 23.19 years old and 41.8% of them were in senior, 21.4% in junior, 16.9% in sophomore, 19.9% in freshman grade. The major motivation to start smoking was 'because of curiosity'(33.8%) and the first smoking experience was at 'senior high school' (41.9%) and at 'college' (41.9%). 2 The highest scored stress factor of smoking university students were stresses about school work. 3. 72.7% had experience to quit smoking at least one or more times. Most of the reason to keep on smoking was 'short will to quit'(51.0%) and the smoking place was usually at 'school' (41.4%). Most respondents for the number ofsmoking friends were '5 people and above' (73.2%). 4. There was a negative relationship between the general characteristics and the entire perceived stress, however, there was a positive relationship between the general characteristics and the perceived stress in 4 categories which is 'sex distinction', 'major of study', 'residence form' and' inmate'. 5. There was a negative relationship between the general characteristics and the entire smoking status, however, there was a positive relationship between the general characteristics and the smoking status in 2 categories which is 'presence of hobby' and 'number of smoking friends'. 6. There was a negative relationship between the perceived stress and the smoking status. Through this study we have seized the relationship between the general characteristics, perceived stress and the smoking status of smoking university students. There was a positive relationship between some of the general characteristics with the perceived stress and the smoking status of smoking university students. Also there was a negative relationship between the perceived stress and the smoking status.

      • KCI등재

        中等學校 家政科 實驗學習 敎員ㆍ設備基準의 適正性에 關한 硏究

        강혜숙,윤인경 한국 가정과 교육 학회 1993 한국가정과교육학회지 Vol.5 No.-

        Because of the specificity of subjects belong to middle school curriculum of Home Economics Education of function training is very important. But it pointed out that the existing standards are out-dated, and because of it, it incongruent to our realities. Therefore, whenever the curriculum of education and the national textbook are reorgrnized periodically, the reform of standards of educational materials & facilities must be followed by it. But in my opinion, in korean middle school, especially in Home Economics Education, educational facilities are not reformed at a proper time. Therefore, to enhance the qualities of experimentation/practice of Home Economics Education, in the first place, the preparation for the given conditions of standards of educational materials & facilities are needed. But the educational facilities of Home Economics Education have many problems not only in the qualitative aspect but also in the quantitative aspect. And in addtion to it, lots of educational facilities which cannot match contents of national textbook of Home Economics Education are exist. Therefore, this thesis aims at examining comprehensively the problem of experimentation/practice of experimental materials & facilties of Home Economics Education, connect with contents of Home Economics Education, holding several problems of experimentation/practice of Home Economics Education in middle school, grouping ; the principles and ways concerning the innovation of experimental materials & facilties of Home Economics Education by which many teachers and students make sure of more efficient teaching/studying, and obtaining basic data which guarantee the ability of innovation concerning problems of the education of experimentation/practice of Home Economics Education. Methods are : 1) grasp our educational realities with my original(question). 2) integrate/analyse results of 1) 3) check the frequency, percentage with methods of X?-test, T-test, and 'One-way Analysis of Variances'. 4) suggest my own alternative proposal. Conclusions are : 1) To the problems concerning the plan, method, frequency, choice of contents, budget, and experimental materials & facilties of experimentation/practice, any meaningful difference are not revealed likewise, but, these problems can affect to teachers' guidance of practical examination, therefore it needs to give a indirect financial, and administration aids to teachers/schools from the government. 2) Contents of experimentation/practice are subjected to contents of textbook. In this reason, educational facilities are suitable to contents of textbook for the efficacy of experimentation/practice. Therefore, whenever contents of national textbooks are revised, the proper experimental materials & facilties must be established. And then, according to these standards, educational facilities must be prepared equally. 3) The capacity of educational facilities are conciderably different according to the type, region, and established pattern of school. Therefore, in order to eliminate these differences, it needs to prepare practice classrooms, and to import the new educational facilities. For these preperations, and for the efficient education of practical skill, financial aids from government are necessary. 4) In comparison with contents of textbook the educational facilities which are not enlisted in experimental materials & facilties but very important and very necessary for the classwork of Home Eocnomics Education must be included in new experimental materials & facilities. 5) The problems of existing experimental materials & facilties of Home Economics Education are identified as following ; i) disagreement between names of educational facilities and contents of the textbook of Home Economics Education. ii) the standard of need in relation to the number of class, isn't fit to our educational reality likewise. iii) the difficulty of elastic application. Therefore, to be sure of the development of Home Economics Education, various efficient methods of education must be groped, and endeavour for correction of imperfection must be maintained continuously.

      • P067 A retrospective analysis of low dose acitretin and cyclosporine combination therapy in psoriasis patients

        ( In-hye Kang ),( Hye-jin Ahn ),( Eun-jae Shin ),( Min Jae Gwak ),( Min Kyung Shin ),( Nack-in Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

        <div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Psoriasis is a chronic in.ammatory disorder. Approximately 25% of patients present with a moderate-to-severe form of psoriasis and may require lifelong systemic therapy. Up until recently, there have been few reports showing the effectiveness and safety of adding cyclosporine to acitretin for treatment. Objectives: The aim of our study was to gain more knowledge about systemic combination therapies with retinoids and cyclosporine. Methods: Retrospective review of the databases of dermatological departments at Kyung Hee Medical Center was performed. 11 patients treated with oral acitretin and cyclosporine combination therapy, 12 and 14 patients treated with acitretin and cyclosporine monotherapy, respectively were included in the study. The data including age, gender, comorbidity, treatment regimen, period, presence of adverse events, and the PASI score were collected. Results: There were no significant differences in the degree of reduction of PASI scores after 12 weeks among the three groups. The number of patients with adverse events was 19 in the acitretin monotherapy group, 10 in the cyclosporine monotherapy group, and 9 in the combination treatment group. Conclusion: Although low dose combination therapy of acitretin and cyclosporine has similar effects compared to the monotherapy, side effects was lower in combination therapy because of drug sparing effects. We suggest combination therapy employing systemic agents are becoming more widely used for the treatment of psoriasis.

      • 급성 담낭염에 대한 내과적 치료의 역할

        강성원,조한래,한설해,박현주,정인성,홍선미,김성걸,이헌영 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

        In 58 patients who were admitted to department of internal medicine, ChungNam national university hospital from January 1989 to March, 1993. We evaluated for medical treatments and the following results were obtained. 1) The ratio of male and female was 1 : 1 and mean age of the patients was 57.4 years. 2) At arrival on hospital, the most common clinical symptom was pain in right upper quadrant and epigastrium(93.1%), the remainders were fever and chill(79.3%), nausea(51.7%) and vomiting(36.2 %) in order of frequency. 3) The most common physical findings was tenderness on the right upper quadrant and epaigastrium(98%), the remainders were jaundice(50%) and palpable gall bladder(13.8%) in order of freguency. 4) In laboratory examination, elevated levels of ESR(82.8%), leukocytosis(67.2%), elevated levels of AST(62.0%), ALT(50.0%), serum total bilirubin(51.7%) and alkaline phosphatase (43.1%) were noted. 5) The mean period of NPO was 3.9 days and the mean hospital period was 13.5 days. 6) The rates of combined complications in patients with acute cholecystitis were 17.2%; these are gall bladder empyema(5.2%), hydrops(5.2%), perforation(3.4%), sepsis(3.4%) and intestinal obstruction (1.7%). 7) In 96.6 percent of 58 cases, the symptoms of acute cholecystitis were improved by conservative management. 8) The mean follow-up period was 25.5 months and the recurrence rate was 10% during this period.

      • 보선진료원의 업무분석에 관한 연구<Ⅱ> : 전라남도 보건진료원을 중심으로

        손인아,강혜영,정영 朝鮮大學校 附設 醫學硏究所 1988 The Medical Journal of Chosun University Vol.13 No.1

        전 세계적으로 80% 이상의 인구가 의료자원의 도시집중 및 의료비 상승 등의 이유로 기본적인 의료 혜택을 받지 못하고 있으며 심지어는 동일 국가 내에서 조차 보건의료 자원의 편중 현상으로 인하여 모든 주민이 균등한 혜택을 누리지 못하고 있기에 지구상의 모든 인류에게 적시에 가까운 거리에서 양질의 필요한 보건의료를 제공해 주기 위한 목적과 방법으로서 일차보건의료라는 개념이 대두하였고 우리나라에서도 이와 같은 목적으로 1981년 부터 보건진료원이라는 새로운 인력을 훈련, 배치시켜 1986년 7월에 목표를 달성함으로써 전국의 보건의료 취약지를 없애는데 성공하였다. 이러한 이 때 보건진료원의 업무 수행 정도를 파악하고 어떤 변수가 이들의 성공적 업무 수행에 영향을 미치는 가를 파악함으로써 보건의료 전달의 질적 향상을 도모하는데 도움이 될 기초자료를 제시하기 위해 본 연구를 시도 하였다. 본 연구의 대상은 전라남도에서 업무 수행 중에 있는 전체 보건진료원을 대상으로 하였고, 자료수집기간은 1986년 11월 11일부터 12월 30일 까지로서 보건사회부가 실시하는 보수교육 기간을 이용하여 동 교육담당자에게 연구 목적을 설명한 후 질문지를 배부하여 기입토록 한 후 곧 회수하였고 불참자에게는 2회에 걸쳐 우편을 이용하여 수집하였다. 총 회수 매수는 207매였으며 자료분석은 S.P.S.S. Programme을 이용하여 백분율, 평균값, 단계적 중회귀 분석을 구하였다. 본 연구를 통하여 얻은 결과는 다음과 같다. 1. 보건진료원의 업무 수행 정도에 가장 큰 영향을 준 변수는 단계적 중회귀 분석 결과 호봉과 학력으로서 9.969%의 설명력을 갖고 있었다. 2. 지역사회 조직 및 개발사업에 영향을 미친 변수의 서열은 단계적 중회귀 분석 결과 결혼상태, 근무 지역, 조건, 호봉, 보건진료소 시설 상태, 연령 순으로써 22.051%의 설명력을 갖고 있었다. 3. 보건사업 계획에 영향을 미친 변수의 서열은 단계적 중회귀 분석 결과 결혼상태, 근무지역 조건, 호봉, 보건진료소 시설 상태, 연령 순으로써 22.193%의 설명력을 갖고 있었다. 4. 지역사회 보건관리에 영향을 미친 변수는 단계적 중회귀 분석 결과 결혼 상태, 근무 지역 조건, 호봉, 보건진료소 시설 상태, 연령 순으로써 21.923%의 설명력을 갖고 있었다. 5. 모자 보건 및 가족계획에 영향을 미칠 변수는 단계적 중회귀 분석 결과 결혼 상태, 근무지역 조건, 호봉, 보건진료소 시설 상태, 연령 순으로써 20.124%의 설명력을 갖고 있었다. 6. 통상 질환 관리에 영향을 미친 변수는, 단계적 중회귀 분석 결과 결혼 상태, 호봉, 근무지역 조건, 보건진료소 시설 상태, 경력 순으로써 22.664%의 설명력을 갖고 있었다. 7. 보건사업 운영관리 및 지도에 영향을 미친변수는 단계적 중회귀 분석 결과 근무지역 조건, 결혼 상태, 호봉 순으로써 18.706%의 설명력을 갖고 있었다. 8. 보건 정보 체계 수립에 영향을 미친 변수는 단계적 중회귀 분석 결과 결혼상태, 근무지역 조건, 호봉, 보건진료소 시설 상태, 연령 순으로써 20.168%의 설명력을 갖고 있었다. 9. 보건진료원의 업무 수행 정도를 Likert 5점 척도로 측정한 결과 가장 큰 영향을 미친 변수는 호봉으로서 호봉이 높을 수록 업무 수행을 잘 하고 있는 것으로 나타난 데 비해 시간 소비량 조사에서는 결혼상태, 근무지역 조건, 호봉 순으로써 즉, 독신자일수록, 근무지역이 양호할수록, 고호봉일수록 업무 수행에 보다 많은 시간을 소비하는 것으로 분석되었다. 이상의 분석 결과 이에 포함되지 않은 몇가지 내용을 지적하여 차후 계속 연구가 되어지기를 기대한다. 1. 보건진료원의 일반적 특성과 업무와 관련된 변수간의 관계가 분석되지 못하였다. 2. 보건 진료원의 일반적 특성 및 업무와 관련된 변수와 영역별 업무 수행 정도와의 관계가 분석되지 못하였다. 3. 7가지 업무 영역 상호간의 수행 정도에 대한 상관 관계가 분석 되지 못 하였다. This study was undertaken to analyze that which variables effects on Professional Activities of Community Health Practitioners by measuring time spent, so as to provide some basic data which can be some help for establishing better Health Care Delivery System. The subjects of this study were all the Community Health Practitioners who are practicing in rural areas in Chunnam province, and the data were collected from 11th Nov. 1986 to 30th Dec. the same year. The data were analyzed by S.P.S.S. using Frequency, Mean and Stepwise Multiple Regression. The results were as follows; 1. The variables which have effects on the Professional Activities of C.H.P.s by measuring by Likert 5 scale by themselves are; the salary step, educational background. and they have 9.969% of predictability. 2. The variables which have effects on the Activitics of the Organization and Development of Community of C.H.P.s are; marital status, the condition of the Community, the salary step, the facilities of Community Health Centre, age, in order and they have 22.051% of predictability altogether. 3. The variables which have effects on the Activities of the Planning of Health Care for the Community of C.H.P.s are;marital status, the condition of Community, the salary step, the facilities of Community Health Centre, age, in order, and they have 22.192% of predictability altogether. 4. The variables which have effects on the Activities of the Management of the Community of C.H.P.s are; marital status, the condition of Community, the salary step, the facilities of Community Health Centre, age, in order, and they have 21.923% of predictability altogether. 5. The variables which have effects on the Activities of the Maternal Child Health and Family Planning of the Community of C.H.C., age, in order, and they have 20.124% of predictability altogether. 6. The variables which have effects on Activities of the Management of Common Minor Illness of C.H.P.s are; marital status, the salary step, the condition of the Commnity, the facilities of the C.H.C., the past experience as C.H.P., in order, and they have 22.664% of predictability altogether. 7. The variables which have effects on the Activities of the Administration, Management and Guidance of Health Care Activity of the Community of C.H.P.s are; the condition of Community, marital status, the salaty step, in order, and they have 18.706% of predictability altogether. 8. The variables which have effects on the Activities of the Establishment of Health Care Information System of the Community of C.H.P.s are; marital status, the condition of Community, the salary step, the facilities of C.H.C., age, in order, and they have 20.168% of predictability altogether.

      • KCI등재

        초고층 아파트 성인 거주자 건강과 실내주거환경의 관계분석

        백혜선,강인호 대한건축학회 2005 대한건축학회논문집 Vol.21 No.2

        The purpose of this study was to analyze the relationship between housing properties and the residents' health in super high-rise apartment. For the analysis of residents' health, Todai index which was invented for self-reported health measurement was used. The sample size was 595 households in S Newtown. The results of this study were as follows; The story of housing block was not related with the residents' health, which was different from the researches reported from abroad. Which was same in both of the general health condition and the Todai index score. In contrast with this, interior humidity of winter was deeply related with the health condition of residents, however, it had no difference according to the story of housing block in the level of statistical significance. The level of interior humidity of winter has relation with both of the general health condition and the Todai health index score. Opposed to this, the temperature of winter had weak relation with the mental health only. From the result, it was figured out that it is necessary to find out the architectural factors influencing the level of humidity and temperature of winter for improving the residents' health.

      • KCI등재

        마음챙김·수용전념에 기반한 심리기술훈련 프로그램의 개발 및 효과 - 고등학교 여자 유도선수를 중심으로 -

        강인혜(In Hye Kang),김도연(Doh Yun Kim) 한국발달지원학회 2021 발달지원연구 Vol.10 No.2

        본 연구의 목적은 마음챙김·수용전념에 기반한 심리기술훈련 프로그램을 개발하고 적용하여 고등학교 여자 유도선수들의 수용행동, 스포츠마음챙김, 스포츠심리기술, 수행력에 미치는 효과성을 검증하는 것이다. 본 연구에서는 마음챙김·수용전념 접근을 바탕으로 박인우(1995)의 체계적 상담 프로그램 개발 모형에 따라 조사, 분석, 설계, 구성, 적용, 평가의 6단계에 맞춰 프로그램을 구안하였다. 프로그램은 경기도 U시의 고등학교 여자 유도선수 10명을 실험집단으로, 경상북도 G시의 고등학교 여자 유도선수 12명을 통제집단으로 배치 후 실험집단에 본 연구자가 개발한 마음챙김·수용전념에 기반한 심리기술훈련 프로그램을 주당 2회기씩 총 9회기 동안 실시하였다. 프로그램 시행 전후 수용행동, 스포츠마음챙김, 스포츠심리기술, 수행력 검사를 실시하고 Mann-Whitney U 검정과 Wilcoxon Signed-Ranks 검정을 실시하였다. 그 결과, 실험집단의 수용행동, 스포츠마음챙김, 스포츠심리기술, 수행력의 수준이 유의미하게 향상된 것으로 나타났다. 이러한 결과를 바탕으로 청소년 운동선수들의 심리기술을 향상시키는데 있어 마음챙김·수용전념 접근의 활용을 위한 시사점을 논의하였다. The objective of this study is to develop and apply a psychological skills training program based on mindfulness/acceptance & commitment, and then to verify its effects on the performance, sport psychological skills, acceptance behavior, and sport mindfulness of high school female judo athletes. Following the systematic counseling program development model by Park In-Woo(1995) based on the mindfulness/acceptance & commitment approach, this study established a program based on total six steps like research, analysis, design, composition, application, and evaluation. After selecting ten high school female judo athletes in U city of Gyeonggi-do as experimental group, and selecting 12 high school female judo athletes in G city of Gyeongsangbuk-do as control group, total nine sessions of the psychological skills training program based on mindfulness/acceptance & commitment developed by the researcher were provided to the experimental group two times a week. On top of conducting the test on the performance, sport psychological skills, acceptance behavior, and sport mindfulness before/after the program, this study also performed the Mann-Whitney U Test and Wilcoxon Signed-Ranks Test. As a result, the level of performance, sport psychological skills, acceptance behavior, and sport mindfulness of the experimental group was significantly improved.

      • 국내산 과일 및 채소 추출물을 이용한 체중 조절 관련 기능성 식품소재 탐색

        김인혜;김종배;조강진;황유진;황경아;고정숙;엄애선 한양대학교 2011 韓國 生活 科學 硏究 Vol.31 No.1

        Obesity can be defined as a disorder of lipid metabolism and the control of this process is regulated by enzymes involved in lipid metabolic pathway. Obesity is also characterized increases in the number and size of adipocyte differentiated from fibroblastic pre-adipocytes in adipose tissue. The aim of this study was to screen ethanol extracts of 21 fruits and vegetables cultivated in Republic of Korea for identifying natural sources of lipase inhibitor and to investigate the effects of several extracts resulting in suppression of triglyceride (TG) accumulation in 3T3-L1 cells. Among the tested extracts, Diospyros kaki L. showed the highest contents of total sugar and the content of total phenolic compounds was detected 17 species while there was not detected in Ixeris dentate root and Allium fistulosum C. etc. We were screened 26 extracts of fruits and vegetables for pancreatic lipase inhibitory activity compared with orlistat. The strongest lipase inhibitory activities were shown by extract of Allium sativum L. stem, Allium sativum L. bulb, Apteryx australis, Diospyros kaki L. Malus Pumila, Perilla frutescens and Prunus mume regardless of concentrations treated. Eight extracts including Brassica juncea var. integrilolia had no effect on lipase inhibition. During the differentiation of 3T3-L1 preadipocyte to mature adipocyte, the cells were treated with carrier or 7 extracts(1, 5 and 10 ㎍/ml), which was shown to highest lipase inhibitory effects. We were quantified lipid contents secreted mature adipocytes and stained with Oil Red O. All cells treated with the Apteryx australis and Prunus mume significantly decreased TG contents than the control. These findings suggested that the screened fruit and vegetable could be a promising source as the effective and safe lipase inhibitors for isolating bioactive ingredients and developing functional foods.

      • KCI등재

        한국노인의 성공적 노후에 대한 경험

        김미혜(Mee-Hye Kim),신경림(Kyung-Rm Shin),강미선(Mi-Sun Kang),강인(In Kang) 한국노년학회 2004 한국노년학 Vol.24 No.2

        본 연구는 노인들이 체험하고 있는 노후의 삶을 이해하고 그 체험의 본질을 탐색하여 성공적인 노후에 대한 한국 노인들의 의식을 심층적으로 파악하기 위하여 질적 연구방법을 적용하였다. 연구 참여자는 서울시에 거주하는 노인 40명이었으며, 이들을 2003년 3월부터 5월까지 2회에 걸쳐 개별적으로 심층면담을 하여 자료를 수집하였다. 수집된 자료를 분석한 결과 연구 참여자들이 체험한 한국노인의 성공적 노후의 공통의 속성은 복(福)이었으며, 본질적 범주는 9가지로 나타났다. 9가지 범주는 '부부 복', '자식 복', '친구 복', '여가생활 복', '거처 복', '재산 복', '건강 복', '마음 복', '죽음 복'이었다. 노인은 자식과 가족의 연계 속에서 자신의 삶과 죽음을 인식하고, 자신의 노후에 자식에 대한 의존을 극도로 자제하려는 모습을 보여 죽음마저도 자식을 배려할 수 있고 깨끗하게 맞이할 수 있다면 그것이 하늘이 내려준 복이며 곧 성공적 노후라고 인식하고 있었다. 이러한 결과는 한국적 문화 안에서 노년기 삶을 이해함에 있어서 통합적인 시각을 제공하고, 노년기 삶에 대한 지식을 제공함으로써, 다양한 분야의 전문가들이 노인의 욕구에 맞는 개입방향 및 방법을 마련함에 있어서 기초 자료로 활용될 것이다. The purposes of this study are to understand the meanings and to explore the nature of successful aging experiences of Korean elderly. 40 elderly aged 65 and over participated in this study. Data of the experiences of successful aging were collected by using in-depth interviews with respondents from March, 2003 to May 2003. The analysis of data was made phenomenological analytic method by suggested by Colaizzi. Meaning of experience was categorized as '9 fortune'. This is consisted of nine theme-cluster: The couples live in health; They live happily in their neighbor which is familiar and convenient for them; They can even participate in daily activity such as doing volunteer work and doing some sports; Their children live better life than they did; They have a friend who can talk to and share their emotions with; They keep their health condition as good as now; They afford their daily living expense; They will die in peace; They accept current situation and live their life in a more positive way for the rest of their life. Significance of this study is that by understanding elderly's successful aging experience it will help the researchers, educators and practitioners to develop appropriate social services for them.

      • SCIESCOPUSKCI등재

        Serial Changes of Heat Shock Protein 70 and Interleukin-8 in Burn Blister Fluid

        ( Kicheol Yoo ),( Kang Yeol Suh ),( Gi Hun Choi ),( In-suk Kwak ),( Dong Kook Seo ),( Dohern Kym ),( Hyeon Yoon ),( Yong Se Cho ),( Hye One Kim ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.2

        Background: It has been reported that heat shock protein 70 (HSP70) and interleukin-8 (IL-8) play an important role in cells during the wound healing process. However, there has been no report on the effect of HSP70 and IL-8 on the blisters of burn patients. Objective: This study aimed to evaluate the serial quantitative changes of HSP70 and IL-8 in burn blisters. Methods: Twenty-five burn patients were included, for a total of 36 cases: twenty cases on the first day, six cases on the sec-ond, five cases on the third, three cases on the fourth, and two cases on the fifth. A correlation analysis was performed to de-termine the relationship between the concentration of HSP70 and IL-8 and the length of the treatment period. Results: The HSP70 concentration was the highest on the first day, after which it decreased down to near zero. Most HSP70 was generated during the first 12 hours after the burn accident. There was no correlation between the concen-tration of HSP70 on the first day and the length of the treat-ment period. No measurable concentration of IL-8 was de-tected before 5 hours, but the concentration started to in-crease after 11 hours. The peak value was measured on the fourth day. Conclusion: While HSP70 increased in the first few hours and decreased afterwards, IL-8 was produced after 11 hours and increased afterward in burn blister fluid. These findings provide new evidence on serial changes of in-flammatory mediators in burn blister fluid. (Ann Dermatol 29(2) 194∼199, 2017)

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