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( Jae Ho Choi ),( Sun Woo Jin ),( Eun Hee Han ),( Bong Hwan Park ),( Hyung Gyun Kim ),( Tilak Khanal ),( Yong Pil Hwang ),( Minh Truong Do ),( Hyun Sun Lee ),( Young Chul Chung ),( Hee Suk Kim ),( Tae 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
Purpose: The consequences of precipitously rising allergic skin inflammation rates worldwide have accelerated the risk of atopic dermatitis (AD). Natural product-based agents with good efficacy and low risk of side effects offer promising prevention and treatment strategies for inflammation-related diseases. We have already reported that Platycodon grandiflorum root-derived saponins (Changkil saponins, CKS) have many pharmacological effects, including anti-inflammatory and anti-allergic effects, but its influence on AD remains unclear. Therefore, we evaluated the inhibitory effect of CKS, mainly platycodin D, on AD-like skin symptoms in mice and the possible mechanisms in cells. Methods: Mice were sensitized and challenged with 2,4-dinitrochlorobenzene (DNCB). Four weeks after challenge, mice were treated with oral administration of CKS for 4 weeks. In addition, cells were used to evaluate the effect of CKS, mainly platycodin D, on the TARC expression regulated mechanism. Results: CKS attenuated DNCB-induced dermatitis severity, serum levels of IgE and TARC, and mRNA expression of TARC, TNF-α, IFN-γ, IL-4, IL-5, and IL-13 in mice. Histopathological examination showed reduced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells and mast cells in the ears. Moreover, CKS and platycodin D inhibited TNF-α/IFN-γ-induced TARC expression through the suppression of NF-κB and STAT1 and induction of Nrf2/ARE-mediated hemeoxygenase-1 (HO-1) expression in cells. Conclusion: We suggest that CKS and platycodin D inhibited the development of AD-like skin symptoms by regulating cytokine mediators and may be an effective alternative therapy for AD-like skin symptoms.ⓒ2014 Elsevler Gmbh. All rights reserved.
서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)
김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.
황재정,이문호 군산대학교 1987 群山水産專門大學 硏究報告 Vol.21 No.2
Digitizer system which is able to interface analog image signal with IBM PCXT is deviced and we processed digital data through Hadamed Transform Coding. Incorporaion of model of the human visual system into an image compression or quality assessment technique intuitively should (and has often proven to) improve performance. Clearly, the, it should prove highly beneficial to combine the image transform with a visual model. In the past, combining these two has been hindered by a fundermental problem resulting from the scene alteration that is necessary for proper transform utilization. A new analytical solution to this problem, taking the form of a straightforward multiplicative weighting function, is developed in this paper. Excellent performance is demonstrated in terms of mean square error and subjective assessment. Results are presented at a total rate of 0.5 bit/pixel for a stationary monochrome image.
황경충,윤종호,최재하,김성청 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.4
Inconel 690 alloy has widely been used in power plant and high temperature facilities because it has high thermal resistance and toughness. But, we have little design data about the creep behaviors of the alloy. Therefore, in this study, an apparatus has been designed and built for conduction creep tests under constant load conditions. A series of creep tests on Inconel 690 alloy have been performed to get the basic design data and life prediction of inconel products and we have gotten the following results. First, the stress exponents decrease as the test temperatures increase. Secondly, the creep activation energy gradually decreases as the stresses becomes bigger. Thirdly, the constant of Larson-Moller parameters on this alloy is estimated about 10. And last, the fractographs at the creep rupture show both the ductile and the brittle fracture according to the creep conditions.
황재호 경주대학교 2003 論文集 Vol.16 No.-
In this paper, the study of a design and fabrication of the substrate type isolator for 6.8 GHz band. The small isolator was designed using new simulation modeling result and fabricated using ferrite substrate and permanent magnet. Results of the manufactured isolator show that the center frequency is 6.8 GHz, the insertion loss is 0.33 dB at center frequency , the isolation is 21.11 dB at center frequency. The designed isolator size is 10 mm × 10 mm. Especially, the proposed design techniques with modeling can be applied to the design of various isolators.
황재호 慶州大學校 2005 論文集 Vol.18 No.2
Bluetooth stands for a technical specification for radio communication or a radio equipment that uses the Bluetooth specification of which the main purpose is to substitute the complicated communication cable of the informative device or electronic apparatus used at home or industrial fields, and was expected to be a mastermind of revolution in the short range radio communication. In This paper, a small inverted F antenna on the dielectric substrate using Bluetooth system is studied theoretically, characterized by numerical analysis with computer simulation. For the miniaturization of the antenna, dielectric substrate (ε_(r)=4.6) and planar line structure are used. Fabricated inverted F antenna is measured and the result is that resonant frequency is 2.45 GHz, input impedance is 50 Ω and bandwidth is about 100 MHz at VSWR 1.5. Especially, the proposed antennas can be applied to the design of various communication systems for 2.4 GHz band.
체계적인 보안 정책 관리를 위한 계층적 보안 모델 설계
황윤철,엄남경,장재웅,이상호 충북대학교 컴퓨터정보통신 연구소 2001 컴퓨터정보통신연구 Vol.9 No.1
인터넷 서비스의 다양화와 인터넷을 구성하는 네트워크의 대형화로 인해 다양한 특성을 갖는 구성요소와 환경 등의 요인으로 시스템간의 거래에 대한 보안정책 설정 및 제어가 어려운 문제로 등장하고 있다. 보안 정책 기술이란 인터넷상에서 정보보호 기능을 구현할 때 적용하는 정책들에 대한 검색, 접근제어, 분배 및 처리하는 기술을 의미한다. 이 논문에서는 이러한 현실적인 문제를 해결하기 위해 대형화되어 가는 인터넷 전체에 걸쳐 효율적으로 적용할 수 있는 계층적 구조의 보안 정책 모델을 설계한다. Security policy association and control about transaction between systems must be hard problem to solve because of the environment and composite factors with variable properties by diversity of internet service and enlarging a scale of organizing internet. Security policy technique means retrieval, access, control, distribute and process technique about adoptable policies when implementation is information security function on internet. In this paper, to solve this actual problems, Design of a hierarchical structure security policy model applicable to internet.