TRANSIENT ISCHEMIA-INDUCED EXPRESSION AND CHANGES OF TYROSINE KINASE A IN THE HIPPOCAMPAL DENTATE GYRUS OF THE GERBIL

HWANG, IN,LEE, HYEON,YOO, KI-YEON,KIM, DAE,KIM, JUNG,KIM, CHANG,LIM, BEONG,KANG, TAE-CHEON,BANG, KYUNG,SEONG, NAK,LEE, HAK,KIM, JONG,WON, MOO Taylor Francis 2006 International journal of neuroscience Vol.116 No.8

<P>The present study examined ischemia-related changes in tyrosine kinase A (trkA) immunoreactivity and its protein content in the dentate gyrus after 5 min of transient forebrain ischemia in gerbils. One day after ischemic insult, cresyl violet-positive polymorphic cells showed ischemic degeneration. The ischemia-induced changes in trkA immunoreactivity were found in the polymorphic layer (PL) and granule cell layer (GCL) of the dentate gyrus. In the sham-operated group, trkA immunoreactivity in the dentate gyrus was very weak. From 30 min after ischemia, trkA immunoreactivity was increased in the dentate gyrus and peaked in the dentate gyrus at 12 h after ischemia-reperfusion. Thereafter, trkA immunoreactivity was decreased time-dependently after ischemia-reperfusion. Four days after ischemic insult, trkA immunoreactivity was similar to that of the sham-operated group. In addition, it was found that ischemia-related changes in trkA protein content were similar to the immunohistochemical changes. These results suggest that the chronological changes of trkA in the dentate gyrus after transient forebrain ischemia may be associated with ischemic damage in polymorphic cells of the dentate gyrus.</P>

자궁근종의 임상 및 병리학적 연구

황성연,홍성진,김창홍,김흥곤 圓光大學校 醫科學硏究所 1997 圓光醫科學 Vol.13 No.1-2

Uterine myoma is the most common solid pelvic tumor in women. Nevertheless, etiology and symptomatology remain poorly understood, and management is inconsistent. In an effort to improve understanding of these aspects of uterine myoma, we have reviewed and analysed the data results obtained from myoma patients at department of obstetrics and gynecology, Wonkwang university hospital during the years 1995 to 1996. The following results have been obtained. 1. During the period the incidence of uterine myoma among 1,116 cases of major gynecologic surgery was 27.2 %. 2. Myoma was observed most frequently in the age group 40 to 49 years and the mean age was 43.6 years. 3. The intramural type was observed in 200 cases (65.8 %), mixed type in 53 cases (17.4 %), subserous type in 29 cases (9.5 %) and submucous type in 22 cases (7.3 %) respectively. 4. The symptoms commonly found in decreasing order were abnormal uterine bleeding (57.3 %), pain or pressure symptoms (53.3 %) and palpable mass (22.4 %). 5. Hypermenorrhea was observed in 96 cases (31.6 %) and there were significant correlations between the presence of hypermenorrhea and the type of myoma, associated adenomyosis. ( p< 0.05 ) 6. There were no significant correlations between the dysmenorrhea and the type of myoma, associated adenomyosis. ( p > 0.05 ) 7. Abnormal electrocardiographic findings were noticed in 18.8 %. 8. Mean hemoglobin level were 10.2 gm/㎗ and less than 10 gm/㎗ was found in 26.6 % and transfusion was performed in 20.8 %. 9. The most frequently associated disease in uterine myoma was adenomyosis seen in 43.4 %. 10. The secondary pathologic changes in uterine myoma were found in 5.0 % and the most common change was hyaline degeneration (3.0 %). 11. The infertility was observed in 10.2 % in which the primary infertility was 6.3 % and secondary 3.9 % respectively. 12. Total abdominal hysterectomy was performed in 84.2 % and vaginal hysterectomy in 11.8 %, myomectomy in 3.3 % respectively. 13. The postoperative complications were found in 26.6 % and the most common complication was the fever (13.8 %).

취학전 아동의 주거공간 이용실태에 관한 연구

황연숙,오찬옥 신라대학교 자연과학연구소 1997 自然科學論文集 Vol.3 No.-

The purpose of this study is to investigate the residential space use of pre-school children. The phisical elements of children's roam and the space use of pre-school children in residential environment are examined in this study. The data are analized by using frequency, percent, ANOVA, Duncan's multiple range test and χ²- test. The major findings are as follows: First, it is found that most of pre-school children do not live in the good residential environment. Second, the average size of children's room is 7.9m²(2.4 Pyung) and parents require bigger room in size. Third, children's areas in the living room need to be considered to play with family. Fourth, in order to form arrangement habits of pre-school children, toy shelves need to be furnished in the children's room.

아동실 실내환경에 대한 사용자평가에 관한 연구

장윤정;황연숙 한양대학교 2005 韓國 生活 科學 硏究 Vol.25 No.1

The purpose of this study was to investigate the user evaluation of children’s rooms in terms of satisfaction and affordance. Survey questionnaires were given to 205 elementary school children in the third or lower year grades and to their parents. Frequency analysis, t-tests, analysis of variance, and Duncan tests were mainly employed for data analysis. The findings indicated that the level of satisfaction among the respondents was found to be acceptable. Their satisfaction of the children’s rooms differed by children’s housing type and housing ownership. For example, children living in apartments were more positive about the size of the rooms, while those in detached rooms were negative about the general characteristics of the rooms. The most negatively evaluated environmental affordance of the rooms was social facilitation, followed by perceptual maintenance. The respondents’ evaluation of the rooms differed by children’s grade, while gender, housing type, housing ownership were statistically insignificant. In general, those in the third grade were more negative about the perceptual maintenance, while those in the first grade responded more negatively about the physiological maintenance of the rooms.

복식 전자궁적출술에 관한 임상적 고찰

황성연,김창홍,김홍곤 圓光大學校 醫科學硏究所 1997 圓光醫科學 Vol.13 No.1-2

Hysterectomy is one of the most common surgical procedures performed; after cesarean delivery, it is the second most frequently performed major surgical procedure in the U.S. This study was attempted to analysis 440 consecutive abdominal hysterectomies, especially concerned with its indication and complication, from January 1, 1995 to December 31, 1996 at the department of Obstetrics and Gynecology, Wonkwang University hospital. The results were summarized as follows: 1. The most common age distribution was 40 to 49 years with 41.4 years of mean age. 2. There couldn't be found any relationship between the indication of surgery and the parity. 3. The most common symptom and sign was lower abdominal pain(52.0 %) and followed by hypermenorrhea(31.3 %) and palpable mass(18.4 %). 4. 29.8 % of all cases was anemic in preoperative check of hemoglobin level, and in 14.3 % of all cases, correction of level was necessary. 5. The uterine myoma was most commonly indicated for Total abdominal hysterectomy (66.8 %) and cervical carcinoma was 7.7 % of all cases. 6. Majority of cases were received abdominal hysterectomies, including 25 cases of radical hysterectomies with pelvic lymphadenectomy. 7. Leiomyoma was the most common postoperative pathologic findings(69.1 %) and followed by adenomyosis(58.4 %). 8. Overall complication rate of abdominal hysterectomy was 21.5 %, which included febrile morbidity of 15.5 %, anemia of 14.1 % and upper respiratory tract infection of 6.1 %.

환자중심적 측면에서 본 여성전문병원 병동부의 실내환경 분석연구

황연숙;장윤정;김유연 한양대학교 2007 韓國 生活 科學 硏究 Vol.27 No.1

The purpose of this study is to analyze the wards of women's hospitals in the perspective of patientfocused design. An evaluation checklist of the patient wards was applied to seven women's hospitals that have constructed or remodeled since 2000. The findings indicate that patients' room was generally patient-focused in terms of social interaction and privacy. However, the lacks of kitchenette, balconies, and dimmers were evaluated negatively. Among the patients' room, corridor, and patients' lounge, the lounge was the most negative in terms of patient-focused design. Privacy and home-likeness were insufficient in patients' lounge while control of ventilation and sunlight was well considered. The future study needs to develop advanced survey and interview methodologies in order to support the relevant results.

기능부전 혈액투석동정맥루 치료법으로서 경피경관혈관성형술의 임상적 의의 및 효과

정연순,김민대,신호식,정규식,유창현,김홍기,황일용,임학 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.2

목 적 : 기능부전 혈액투석동정맥루의 치료로서의 경피경관혈관성형술의 임상적 의의와 장기개통률에 영향을 미치는 요소에 대하여 알아보고자 본 연구를 시행하였다. 방 법 : 기능부전 혈액투석동정맥루로 정맥조영술을 시행한 53명의 환자(총 61예) 중 동정맥루의 협착 및 폐쇄로 경피경관혈관성형술이 시도된 환자는 49명(총 57예)이었으며 이들의 정맥조영술 적응증을 알아보았다. 이 중 경피경관혈관성형술을 성공적으로 시행받은 38명의 환자(총 46예)를 대상으로 하여 임상적 특성과 6, 12, 24개월의 개통률을 분석하였다. 환자의 연령, 당뇨병의 유무, 만성신부전의 병력기간, 동정맥루의 종류와 사용기간, 혈액투석동정맥루의 위치와 협착의 길이, 잔여협착의 정도 등이 장기개통률에 미치는 영향을 Kaplan-Meier method에 의한 log-rank test를 이용하여 평가하였고, multivariate analysis로 Cox Regression Model을 사용하여 평가하였다. 통계적 유의성 검정은 p값이 0.05 미만인 경우로 하였다. 경피경관혈관성형술을 실패한 경우의 정맥조영술 소견과 시술 전후의 합병증을 조사하였다. 결 과 : 시술의 성공률은 80.7%(46/57)였으며 성공한 예의 추적 검사에서 개통률(postintervention primary patency)은 6, 12, 24개월 각각 68, 38, 5%였다. 재협착으로 인해 2번의PTA를 시행받은 환자가 8명 있었으며, 이들 경우를 포함했을 때의 개통률(postintervention assisted primary patency)은 6, 12, 24개월 각각 69, 40, 10%였다. 환자의 연령, 당뇨병의 유무, 만성신부전의 병력기간, 동정맥루의 종류와 사용기간, 혈액투석동정맥루의 위치와 협착의 길이, 잔여협착의 정도 등이 장기 개통률에 미치는 영향은 통계학적으로 유의한 경우는 없었다(p>0.05). 혈관성형술을 실패한 경우는 총 11예로 대량혈전으로 인한 완전폐쇄가 6예, 광범위한 과도한 혈관협착이 5예였다. 시술과 연관된 합병증은 없었다. 결 론 : 이상의 결과로 동정맥루 협착이 동반된 혈액투석 환자에서 경피적경관혈관성형술은 안전하고 비교적 효과적인 치료법으로 사료되며, 장기 개통률에 영향을 미치는 요소는 없었다. Purpose : The purpose of this study was to evaluate the effect of percutaneous transluminal angioplasty( PTA) and to determine patency rates and the factors affecting the long-term patency rates in the management of insufficient arteriovenous fistulae. Methods : Sixty-one cases of insufficient dialysis shunts in 53 patients underwent venography of the fistula. These patients' indications of venographys were reviewed. Forty-six cases of insufficient dialysis shunts in 38 patients were treated by PTA. These patients' clinical characteristics and patency rates were evaluated. According to the patient's age, history of diabetes mellitus, duration of renal failure, type and age of the arteriovenous fistula, the site of AVF and length of the stenosis, and to the degree of residual stenosis, patency rates were compared within each subgroup using the Kaplan-Meier logrank test. To estimate reasons for the incidence of vascular access failure, Cox regression model was used. Venographic findings of failed PTAs and PTA related complications were evaluated. Results : The success rate was 80.7%. In cases in which initial success was obtained, postintervention primary patency rate at 6, 12 and 24 months were 68%, 38% and 5% respectively. With repeatitive PTAs, postintervention assisted primary patency rate at 6, 12 and 24 months were 69%, 40% and 10% respectively. The effect of the above mentioned factors(age, DM, duration of CRF etc.) on long-term patency was not statistically significant(p>0.05). Among 11 cases of failed PTA, there were 6 cases of total obstruction due to massive thrombosis and 5 cases of extensive vascular stenosis(>5 cm of length, >4 sites of stenosis and >75% of stenosis in all cases). There were no PTA related complications. Conclusion : PTA is considered to be an effective and safe treatment modality for shunt stenosis. No factors affected long-term patency rates in our study. (Korean J Nephrol 2002;21(2):276-284)

퍼머제의 중금속 농도에 관한 연구

윤복연,문덕환,박명희,황용식,함성애,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objective : This study was conducted to prepare the fundamental data on heavy metal concentration in hair permanents agents and to prevent the health impairment due to heavy metal. Methods and Material : The author determined of 5 heavy metals(Pb, Cr, Mn, Ni, and Cu) concentration hair permanent agents in the market with flameless atomic absorption spectrophotometer. Results : The results were as follows: 1. The geometic mean concentrations of total subjects were 0.04㎍/g for Pb, 0.09㎍/g for Cr, 0.06㎍/g for Mn, 0.03㎍/g for Ni, and 0.04㎍/g for Cu. 2. The most highest mean concentrations of heavy metals in hair permanent agents by using type were Cr for wave agent and straight cream agent, Cu for setting iron agent, Cr and Cu for coating perm agent. 3. Metal most hlghest mean concentrations of heavy in hair permanent agents by type of color was green for Cu. 4. The mean concentration of Cu among 5 heavy metals in hair permanent agents by marker was most highest. 5. There was most statistically significant difference on mean concentration in hair permanent agents between domestic and foreign products. 6. The exposure amount of heavy metal concentration by one time using the permanent agent were 4.O㎍ for Pb, 9.O㎍ for Cr, 6.0㎍ for Mn, 3.O㎍ for Ni and 4.0㎍ for Cu. Conclusion : As above results author suggest to prepare the preventive program of health impairment due to heavy metal by long term chronic exposure to who were using the hair permanent agents hair designer and customers.

Fluoroacetate(Platol)중독 증상 연구 : 자살기도자를 중심으로

한창환,황주연,김경식,안석철 大韓神經精神醫學會 1984 신경정신의학 Vol.23 No.1

This study was designed to evaluate the clinical problems of fluoroacetate intoxication. The total number of the fluoroacetate intoxication patients who came to the emergency room of Han Gang Sacred Heart Hospital from Jan. 1, 1983 to Aug. 31, 1983 were 96 cases. Among them, 41 attempters who were consulted to the psychiatrist were evaluated and observed in detail. The following results were obtained. 1. The rodenticide poisoning accounts for 37.2% of all toxic substance intoxication(total 266 cases) at Han Gang Sacred Heart Hospital from Jan. 1983 to Aug. 1983. Among them, 96 cases(36.1%) of fluorcacetate intoxication were observed. 2. Female was affected 2.4 times more frequently than male. 35.5% of total cases belonged to age group 21∼30years, when incidence was most prevalent 3. As the route of drug obtainment, supplement were commonest(63.3%), purchase in 29.4%. 4. CNS disturbances such as drowsiness, stupor, semicoma and irritability were observed in 75.6% of the cases. Speech disturbances such as dysarthria, childish speech was observed in 9.8%of the cases. Convulsion(29.3%), tremor(12.2%) spasm and twitching(4.9%) were also frequently observed. Tachycardia was found in 43.8% of the cases and other frequent symptoms were nausea and vomiting(53.7%), abdominal pain(34.2%), mild or high fever(26.8%). Lower calcium(below 9mg) was found in 29.3% of the cases and lower potassium(below 3.5mEq) was found in 22.0% of the cases. EKG findings revealed QT prolongation(22.0%), ST-T change(22.0%) and u-wave, RBBB, and PVC(14.6%). 5. 92 cases(95.8%) recovered without sequelae and 4 cases(4.2%) expired.

대장수술 후에 발생한 급성신부전의 위험인자

이혜미,황창재,김재황,김흥대,박대팔,서일숙,송선옥,김세연,이덕희,지대림 영남대학교 의과대학 2007 Yeungnam University Journal of Medicine Vol.24 No.2

연구 배경 : 급성 신부전은 술 후 발생할 수 있는 합병증 중에서 사망률은 큰 영향을 줄 수 있으므로 이 연구를 통해 위험인자를 알아보려고 한다. 재료 및 방법 : 2004년 1월부터 2006년 12월까지 3년간 영남대학교 의과대학 부속병원에서 대장 수술을 받은 570명의 환자들을 대상으로 하였다. 환자들의 성별과 연령, 미국 마취과학회 신체등급, 동반질환, 수술의 종류, 응급수술의 여부, 수술 시간, 재수술의 여부, 술 중의 투약 상황, 술 후에 자가 통증 조절기에 사용한 약제, 술 중에 저혈압의 유무, 수혈 여부, 술 후 기계적 환기를 시행한 경우를 비교하였다. 결과 : 비교 결과에서 성별과 수술의 종류, 응급 수술의 여부, 개복여부 등에는 유의한 차이를 보이지 않았다. 반면 환자의 나이와 수술 시간, 재수술의 여부, 술중에 이뇨제 등을 사용한 경우, 술 중에 저혈압의 유무, 술 후에 기계적 환기를 시행한 경우 등에는 유의한 차이를 보였다. 결론 : 이상의 결과로 급성신부전의 원인은 어느 한 가지라고 하기 보다는 위험인자에 얼마나 노출되어 있는가가 결정하는 것 같고, 그 원인들이 모여서 상승효과를 내는 것 같다. 그러므로 수술 전부터 많은 위험에 노출된 환자는 술 중 더 적극적인 감시를 시행하여 수술 후의 합병증 발생을 줄이는 노력을 기울여야 하겠다. Background : Acute renal failure is one of the leading causes of postoperative morbidity and mortality. The purpose of this study was to determine the risk factors that are associated with acute renal failure after colorectal surgery. Materials and Methods : Five hundred seventy patients who operated colorectal surgery at the Yeungnam University Medical Center over three years from 2004 to 2006 were enrolled in this study. The effects of gender, age, ASA classification, concomitant disease, surgery type and duration, reoperation, urogenital manipulation, medication, hypotension, hypovolemia, transfusion, and postoperative ventilatory care on the occurrence of acute renal failure after colorectal surgery were studied. Results : The major risk factors of acute renal failure after colorectal surgery were age of patients (P=0.003), ASA classification (P<0.001), concomitant disease (P<0.001), duration of the time surgery (P=0.034), reoperation (P=0.001), use of intraoperative diuretics (P=0.005), use of postoperative diuretics (P<0.001), intraoperative hypotension (P=0.018), intraoperative transfusion (P<0.001), postoperative transfusion (P<0.001), and postoperative ventilatory care (P=0.001). Conclusion : Multiple factors cause synergistic effects on the development of acute renal failure after colorectal surgery. Therefore, efforts to reduce the risk factors associated with acute renal failure are needed. In addition, intensive postoperative care should be provided to all patients.