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Nguyen Hoang Loc,Truong Thi Phuong Lan,Nguyen Duc Huy,Nguyen Ngoc Luong,Hoang Tan Quang,Trinh Huu Tan,Le Thi Anh Thu,Nguyen Xuan Huy 한국식물생명공학회 2019 JOURNAL OF PLANT BIOTECHNOLOGY Vol.46 No.3
The aim of this study is to evaluate the effect of yeast extract (YE) and salicylic acid (SA) on the expression of curcuminoid-biosynthesis genes (CzDCS and CURS1-3), and accumulation of curcumin in Curcuma zedoaria cell cultures. The results showed that, in cells treated with YE or SA, the expression levels of curcuminoid genes were 1.14- to 3.64-fold higher than the control (untreated cells), in which the YE exhibited a stronger effect in comparison with SA. Curcumin accumulation also tended to be similar to gene expression, curcumin contents in YE- or SA-treated cells were 1.61- to 2.53-fold higher than the control. The SA treatment at the fifth day of culture stimulated the curcumin accumulation and expression in all four genes compared to that at the beginning. While the YE treatments gave different results, the CzCURS1 and CzCURS3 genes were expressed strongly in cells that were treated at the beginning. However, the CzDCS and CzCURS2 genes showed the opposite expression pattern, they were activated strongly in the treatments at day five of the culture. However, the content of curcumin reached its maximum value on the fifth day of culture in all investigations.
Advanced Magnetic Materials Produced by Using Rapid Quenching Technology
Nguyen Hoang Nghi,Nguyen Van Dung,Trinh Thi Thanh Nga,Bui Thi Khanh Nhung,Mai Thanh Tung,Nguyen Huu Tinh,Hoang Nhat Hieu,Bui Xuan Chien,Nguyen Thi Hong Tam 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.6
Amorphous alloys produced by using a rapid quenching technique are considered to be a precursor for producing nanosized and multiphase structures by precipitation (the top-down method). By using this technique, several new magnetic materials with different magnetic properties based on different physical mechanisms have been manufactured and investigated. Three new magnetic materials, a nanocrystalline soft magnetic material, a soft-hard permanent magnet and a Me-3d granular alloy with a GMR effect, what were prepared under local conditions, are presented and discussed in the experimental point of view. Amorphous alloys produced by using a rapid quenching technique are considered to be a precursor for producing nanosized and multiphase structures by precipitation (the top-down method). By using this technique, several new magnetic materials with different magnetic properties based on different physical mechanisms have been manufactured and investigated. Three new magnetic materials, a nanocrystalline soft magnetic material, a soft-hard permanent magnet and a Me-3d granular alloy with a GMR effect, what were prepared under local conditions, are presented and discussed in the experimental point of view.
Nguyen Huu-Manh,Duong The-Khang,Nguyen Van-Khuyen,Nguyen Thi-Khanh-Ly,Dong Thi-Hoang-Yen,Nguyen Canh-Hung,Tung Nguyen-Thach 한국약제학회 2024 Journal of Pharmaceutical Investigation Vol.54 No.2
Purpose A two-step experimental design was used to develop a lornoxicam (LOR)-loaded topical hydrogel patch. We specifically focused on the simultaneous effect of the ion pair formation agent (triethanolamine [TEA]) and the chemical enhancer (cremophor RH40 [RH40]) on flux and conducted physicochemical studies and skin physiology assessments to obtain further information. Methods Drug-in-adhesive patches were fabricated using a micrometer-adjustable film applicator. The applied Design of Experiments (DoE) approach consisted of the Fractional Factorial Resolution V + design and the Central Composite Face design established by the MODDE® 12.0 software. Molecular-level drug-excipient interactions were investigated using infrared (IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy. The effects on skin physiological function was assessed using DermaLab Combo. Results DoE results revealed that TEA enhanced flux by 3.14-fold, whereas RH40 reduced it by 4.62-fold. The addition of RH40 resulted in the disappearance of the proton peak within the region of 12–13 ppm, suggesting competition for hydrogen bonding with LOR between TEA and RH40. The optimized formulation (4% TEA, 0% RH40, and 0.2% Al(OH)3) increased skin hydration by 6.20-fold. Opposing effects of TEA and RH40 on skin elasticity were observed. Conclusion Expected flux and adhesion strength for the optimized formulation were 7.18 μg·cm–2·h–1 and 11.79 mJ, respectively. Our understanding of the conflicting effects of TEA and RH40 has been advanced. The integrated use of the two-step DoE, physicochemical studies, and skin physiology assessments was proven to be effective in elucidating the simultaneous effects of different permeation-modifying strategies on patches, thus having substantial value for the successful execution of future research endeavors.
Phuc Nguyen Thien,Giang Nguyen Thi Huong,An Vu Nguyen Thien Truong,Nam Nguyen Thanh Hoai,Anh Ly Duc,Nguyen Huynh Cam,An Hoang,Phong Mai Thanh,Hieu Nguyen Huu 한국탄소학회 2023 Carbon Letters Vol.33 No.2
In this study, graphene oxide (GO) was synthesized by the improved Hummers’ method. The degree of oxidation from graphite (Gi) to GO was determined through interlayer spacing calculated from X–ray diffraction. Besides, the effect of KMnO4:Gi ratios (X1), H2SO4 volume (X2), oxidation temperature (X3), oxidation time of stage 1 (X4), and oxidation time of stage 2 (X5) was screened by the Plackett–Burman model. The simultaneous impact of three factors that influenced the degree of oxidation (X1, X2, and X3) was studied by the Box–Behnken experimental model of response surface methodology to achieve suitable conditions for the GO synthesis process. The characterization of GO product was investigated via the modern analytical methods: X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, UV–Vis spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and atomic force microscopy. In addition, the study was also carried out on a pilot scale for orientation in industrial application with the yield of 14 g/batch.
Magnetic Properties of Bulk Nd50Co10Fe30Al10-xVx Alloys
Hoang Duc Anh,Cao Xuan Huu,Nguyen Chau,Nguyen Hoang Luong 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.5
This paper presents the results of study on the structure and the properties of the bulk Nd50Co₁0Fe₃0Al₁0xVx (x = 0, 2, 4, 6, 8, 10) alloys prepared by arc-melting and suction cast- ing with water cooling. The cast surfaces of the samples are partly crystalline and the amorphous volume fraction increases with distance into cast samples. With increasing V content, the crys- tallization volume fraction increases and for x = 10, the alloy is fully crystallized. In general, the melting temperature increases, but Ms and Hc decrease with V content. The Curie temperature increases clearly from 430 K (x = 0) to 512 K (x = 10). Thermomagnetic measurements of all samples done in low elds indicate the existence of the Hopkinson effect, which shows a coherent rotation magnetization and a strong reduction of the magnetic anisotropy in partly crystallized sam- ples. The eld-cooled (FC) and the zero field-cooled (ZFC) curves measured in low elds reveal an obvious separation from each other at low temperatures, pointing to the existence of a cluster-glass state. The cluster-glass fraction decreases with increasing V content in the samples. This paper presents the results of study on the structure and the properties of the bulk Nd50Co₁0Fe₃0Al₁0xVx (x = 0, 2, 4, 6, 8, 10) alloys prepared by arc-melting and suction cast- ing with water cooling. The cast surfaces of the samples are partly crystalline and the amorphous volume fraction increases with distance into cast samples. With increasing V content, the crys- tallization volume fraction increases and for x = 10, the alloy is fully crystallized. In general, the melting temperature increases, but Ms and Hc decrease with V content. The Curie temperature increases clearly from 430 K (x = 0) to 512 K (x = 10). Thermomagnetic measurements of all samples done in low elds indicate the existence of the Hopkinson effect, which shows a coherent rotation magnetization and a strong reduction of the magnetic anisotropy in partly crystallized sam- ples. The eld-cooled (FC) and the zero field-cooled (ZFC) curves measured in low elds reveal an obvious separation from each other at low temperatures, pointing to the existence of a cluster-glass state. The cluster-glass fraction decreases with increasing V content in the samples.
Nguyen Huu Khanh Nhan,Tran Hoang Quang Minh,Tan N. Nguyen,Miroslav Voznak 한국광학회 2017 Current Optics and Photonics Vol.1 No.6
Due to optimal advances such as chromatic performance, durability, low power consumption, highefficiency, long-lifetime, and excellent environmental friendliness, white LEDs (WLEDs) are widely usedin vehicle front lighting, backlighting, decorative lighting, street lighting, and even general lighting. In thispaper, the remote packaging WLEDs (RP-WLEDs) with bi-layer red-emitting Sr2Si5N8: Eu2+ and yellowemittingYAG:Ce phosphor was proposed and investigated. The simulation results based on the MATLABsoftware and the commercial software Light Tools indicated that the color rendering index (CRI) of bi-layerphosphor RP-WLEDs had a significant increase. The CRI had a considerable increase from 72 to 94. Inconclusion, the results showed that bi-layer red-emitting Sr2Si5N8:Eu2+ and yellow-emitting YAG:Cephosphor could be a prospective approach for manufacturing RP-WLEDs with enhanced optical properties.
Inhibitory Activity of Plantago major L. on Angiotensin I-converting Enzyme
Nguyen Xuan Nhiem,김영호,Bui Huu Tai,Phan Van Kiem,Chau Van Minh,Nguyen Xuan Cuong,Nguyen Huu Tung,Vu Kim Thu,Trinh Nam Trung,Hoang Le Tuan Anh,조성훈,장해동,권영인 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3
Eight compounds were isolated from methanol extract of Plantago major L. leaves and investigated for their ability to inhibit angiotensin I-converting enzyme activity. Among them, compound 1 showed the most potent inhibition with rate of 28.06 ± 0.21% at a concentration of 100 μM. Compounds 2 and 8 exhibited weak activities. These results suggest that compound 1 might contribute to the ability of P. major to inhibit the activity of angiotensin I- converting enzyme.
A New Dimeric Lignan from the Stems of Willughbeia edulis
Nguyen, Hai Xuan,Do, Truong Nhat Van,Le, Tho Huu,Dang, Phu Hoang,Nguyen, Mai Thanh Thi,Nguyen, Nhan Trung The Korean Society of Pharmacognosy 2022 Natural Product Sciences Vol.28 No.2
As part of our continued study on the chemical constituents of Willughbeia edulis stems, a new dimeric lignan named edulignan (1) was isolated from its EtOAc-soluble extract. Based on NMR spectroscopic interpretation, the planar structure of 1 has been suggested to have two 2-substituted 4-chromanone subunits with different stereochemical configurations. In addition, the MS/MS analysis of the products obtained by acid-catalyzed hydrolysis of 1 was supportive of its structure. Unfornatually, the new compound 1 did not show 𝛼-glucosidase inhibitory activity with an IC<sub>50</sub> value > 250 𝜇M.
Nguyen Huu Khanh Nhan,Tran Hoang Quang Minh,Nguyen Doan Quoc Anh 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.4
In this paper, a novel solution and application of the red Y2O3:Eu3+ dopant phosphor for enhancing color rendering index to more 86 for multi-chip white LED lamps (MCW-LEDs), which have correlated color temperature (CCT) of 7700 K, 6600 K, 5600 K, are presented. Then the effect of the concentration of Y2O3:Eu3+ phosphor on the color rendering index (CRI) is simulated, analyzed and demonstrated. After that the lumen output of MCW-LEDs depended on concentration Y2O3:Eu3+ phosphor is discovered. The lumen output has a decrease tendency at large weight range due to the enhancement extinction coefficient, according to Mie-scattering theory. Simulation results provided important conclusions for selecting and developing the phosphor materials in MCW-LEDs manufacturing.