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Nguyen Huu-Manh,Duong The-Khang,Nguyen Van-Khuyen,Nguyen Thi-Khanh-Ly,Dong Thi-Hoang-Yen,Nguyen Canh-Hung,Tung Nguyen-Thach 한국약제학회 2024 Journal of Pharmaceutical Investigation Vol.54 No.2
Purpose A two-step experimental design was used to develop a lornoxicam (LOR)-loaded topical hydrogel patch. We specifically focused on the simultaneous effect of the ion pair formation agent (triethanolamine [TEA]) and the chemical enhancer (cremophor RH40 [RH40]) on flux and conducted physicochemical studies and skin physiology assessments to obtain further information. Methods Drug-in-adhesive patches were fabricated using a micrometer-adjustable film applicator. The applied Design of Experiments (DoE) approach consisted of the Fractional Factorial Resolution V + design and the Central Composite Face design established by the MODDE® 12.0 software. Molecular-level drug-excipient interactions were investigated using infrared (IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy. The effects on skin physiological function was assessed using DermaLab Combo. Results DoE results revealed that TEA enhanced flux by 3.14-fold, whereas RH40 reduced it by 4.62-fold. The addition of RH40 resulted in the disappearance of the proton peak within the region of 12–13 ppm, suggesting competition for hydrogen bonding with LOR between TEA and RH40. The optimized formulation (4% TEA, 0% RH40, and 0.2% Al(OH)3) increased skin hydration by 6.20-fold. Opposing effects of TEA and RH40 on skin elasticity were observed. Conclusion Expected flux and adhesion strength for the optimized formulation were 7.18 μg·cm–2·h–1 and 11.79 mJ, respectively. Our understanding of the conflicting effects of TEA and RH40 has been advanced. The integrated use of the two-step DoE, physicochemical studies, and skin physiology assessments was proven to be effective in elucidating the simultaneous effects of different permeation-modifying strategies on patches, thus having substantial value for the successful execution of future research endeavors.
Tai, Bui Huu,Jung, Bong Yong,Cuong, Nguyen Manh,Linh, Pham Thuy,Tung, Nguyen Huu,Nhiem, Nguyen Xuan,Huong, Tran Thu,Anh, Ngo Thi,Kim, Jeong Ah,Kim, Sang Kyum,Kim, Young Ho Pharmaceutical Society of Japan 2009 Biological & pharmaceutical bulletin Vol.32 No.12
<P>Nine compounds, including six phenylethanoid glycosides: acteoside (1); bioside (2); echinacoside (3); poliumoside (4); phenylethyl glycoside (5); salidroside (6) and three flavonoids; linarin (7); apigenin (8); isorhoifolin (9), were isolated from the flowers of <I>Buddleja officinalis</I> M<SMALL>AXIM</SMALL>. (Buddlejaceae). Chemical structures were confirmed by <SUP>1</SUP>H-, and <SUP>13</SUP>C-NMR, and MS spectral methods and compared with those reported in the literature. Antioxidant activities of the methanol and water extracts, and all isolated compounds were evaluated using the total oxidant scavenging capacity (TOSC) assay against peroxynitrite. Results of the assay showed that the phenylethanoid glycosides, a major class of compounds of the flowers of <I>B. officinalis</I>, possess strong antioxidant activity. Of these, acteoside, echinacoside and poliumoside have 9.9-, 9.8- and 9.5-fold TOSC value, respectively, compared with the positive control, Trolox.</P>
Tai, Bui Huu,Nhut, Nguyen Duy,Nhiem, Nguyen Xuan,Quang, Tran Hong,Thanh Ngan, Nguyen Thi,Thuy Luyen, Bui Thi,Huong, Tran Thu,Wilson, Jennifer,Beutler, John A.,Ban, Ninh Khac,Cuong, Nguyen Manh,Kim, Yo Informa Healthcare 2011 PHARMACEUTICAL BIOLOGY Vol.49 No.10
<P><I>Context</I>: Acquired immune deficiency syndrome (AIDS) is a severe pandemic disease especially prevalent in poor and developing countries. Thus, developing specific, potent antiviral drugs that restrain infection by human immunodeficiency virus type 1 (HIV-1), a major cause of AIDS, remains an urgent priority.</P><P><I>Objective</I>: This study evaluated 32 extracts and 23 compounds from Vietnamese medicinal plants for their inhibitory effects against HIV-1 ribonuclease H (RNase H) and their role in reversing the cytopathic effects of HIV.</P><P><I>Materials and methods</I>: The plants were air-dried and extracted in different solvent systems to produce plant extracts. Natural compounds were obtained as previously published. Samples were screened for RNase H inhibition followed by a cytopathic assay. Data were analyzed using the Microsoft Excel.</P><P><I>Results and discussion</I>: At 50 μg/mL, 11 plant extracts and five compounds inhibited over 90% of RNase H enzymatic activity. Methanol extracts from <I>Phyllanthus reticulatus</I> and <I>Aglaia aphanamixis</I> leaves inhibited RNase H activity by 99 and 98%, respectively, whereas four extracts showed modest protection against the cytopathic effects of HIV.</P><P><I>Conclusion</I>: The screening results demonstrated that the butanol (BuOH) extract of <I>Celastrus orbiculata</I> leaves, methanol (MeOH) extracts of <I>Glycosmis stenocarpa</I> stems, <I>Eurya ciliata</I> leaves, and especially <I>P. reticulatus</I> leaves showed potential RNase H inhibition and protection against the viral cytopathic effects of HIV-1. Further chemical investigations should be carried out to find the active components of these extracts and compounds as potential anti-HIV drug candidates.</P>
Chi Linh, Dinh,Thi Ha, Nguyen,Huu Duc, Nguyen,Giang Nam, Le Huu,Bau, Le Viet,Manh An, Nguyen,Yu, Seong-Cho,Dang Thanh, Tran Elsevier 2018 PHYSICA B-CONDENSED MATTER - Vol.532 No.-
<P><B>Abstract</B></P> <P>In this work, we have investigated the magnetic properties and the magnetocaloric effect of La<SUB>0.7−x</SUB>Na<SUB>x</SUB>Ca<SUB>0.3</SUB>MnO<SUB>3</SUB> compounds, which were prepared by a conventional solid-state reaction technique. The Rietveld refinement results suggested that the samples are single phase belonging to an orthorhombic structure (space group <I>Pnma</I>). Analyzing temperature dependence of magnetization <I>M</I>(<I>T</I>) revealed that the Curie temperature (<I>T</I> <SUB>C</SUB>) increases with increasing Na content (<I>x</I>). Their <I>T</I> <SUB>C</SUB> value is found to be 260–298K for <I>x</I>=0.0–0.1, respectively. Base on <I>M</I>(<I>T</I>) data measured at different applied magnetic fields (<I>H</I>), temperature dependence of magnetic entropy change Δ<I>S</I> <SUB>m</SUB>(<I>T</I>) data for all the samples was calculated by using a phenomenological model. In the vicinity of <I>T</I> <SUB>C,</SUB> -Δ<I>S</I> <SUB>m</SUB>(<I>T</I>) curve reaches a maximum value (denoted as |Δ<I>S</I> <SUB>max</SUB>|), which gradually increases with increasing <I>H</I>. Under 12kOe, the value of |Δ<I>S</I> <SUB>max</SUB>| is in a range of 1.47–5.19J/kgK corresponding to the relative cooling power RCP=57.12–75.88J/kg. Applied the universal master curve method for the magnetic entropy change, we concluded that Na-doped in La<SUB>0.7−x</SUB>Na<SUB>x</SUB>Ca<SUB>0.3</SUB>MnO<SUB>3</SUB> compounds leads to modification the nature of the magnetic phase transition from the first- to the second-order.</P>
Synthesis and Anti-osteoporosis Potential of Two New Indirubin-3`-oxime Derivatives
( Nguyen Manh Cuong ),( Bui Huu Tai ),( Dang Hoang Hoan ),( Pham Quoc Long ),( Eun Mi Choi ),( Young Ho Kim ) 한국응용생명화학회 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.1
Two new indirubin-3`-oxime derivatives, indirubin-3`-[O-(3-bromoprop-1-yl)-oxime] (2) and indirubin-3`-[O-(methoxycarbonylmethyl)-oxime] (3) were synthesized. Their structures were confirmed by ESI-MS and NMR spectroscopic method. Both of them (5 μg/mL) significantly caused a elevation of cell growth, alkaline phosphate activity, and mineralization in osteoblastic MC3T3-E1 cells (p<0.05).
Inhibitory effects of indirubin derivatives on the growth of HL-60 leukemia cells.
Cuong, Nguyen Manh,Tai, Bui Huu,Hoan, Dang Hoang,Huong, Tran Thu,Kim, Young Ho,Hyun, Jae-Hee,Kang, Hee-Kyoung Natural Product Communications 2010 Natural product communications Vol.5 No.1
<P>Six indirubin derivatives have been synthesized and their inhibitory effects on the growth of HL-60 human promyelocytic leukemia cells investigated. Cell viability was determined using the trypan blue exclusion method. Indirubin-3'-oxime (I-1) inhibited the growth of HL-60 cells with a GI50 value of 36.6 microM, whereas I-0, I-2, I-3, I-4 and I-6 showed only weak cytotoxic activities against HL-60 cancer cells with GI50 values in the range of 97.3 to over 100 microM. These results indicate that indirubin derivatives might be useful candidate agents for exploring potential antileukemic drugs.</P>
Synthesis and Anti-osteoporosis Potential of Two New Indirubin-3'-oxime Derivatives
Cuong, Nguyen Manh,Tai, Bui Huu,Hoan, Dang Hoang,Long, Pham Quoc,Choi, Eun-Mi,Kim, Young-Ho The Korean Society for Applied Biological Chemistr 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.1
Two new indirubin-3'-oxime derivatives, indirubin-3'-[O-(3-bromoprop-1-yl)-oxime] (2) and indirubin-3'-[O-(methoxycarbonylmethyl)-oxime] (3) were synthesized. Their structures were confirmed by ESI-MS and NMR spectroscopic method. Both of them (5 ${\mu}g/mL$) significantly caused a elevation of cell growth, alkaline phosphate activity, and mineralization in osteoblastic MC3T3-E1 cells(p<0.05).