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Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities
Ban, Ninh Khac,Thoa, Nguyen Thi Kim,Linh, Tran My,Trang, Do Thi,Van Kiem, Phan,Nhiem, Nguyen Xuan,Tai, Bui Huu,Van Minh, Chau,Song, Jae-Hyoung,Ko, Hyun-Jeong,Kim, Seung Hyun Springer-Verlag 2018 Journal of Natural Medicines Vol.72 No.1
Chemical Constituents of the Morinda tomentosa Leaves and their α-Glucosidase Inhibitory Activity
Vu, Huong Giang,Ninh, Khac Ban,Nguyen, Xuan Nhiem,Phan, Van Kiem,Chau Van, Minh,Hoang, Le Tuan Anh,Pham, Hai Yen,Bui, Huu Tai,Nguyen, Xuan Cuong,Nguyen, Hoai Nam,Kim, Seung Hyun,Kwon, Young-In,Kim, Yo Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.5
Phenylpropanoid Glycosides from Heterosmilax erythrantha and Their Antioxidant Activity
Nguyen Xuan Nhiem,김영호,Phan Van Kiem,Chau Van Minh,Ninh Khac Ban,Nguyen Xuan Cuong,Bui Huu Tai 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.10
By various chromatographic methods, one new phenylpropanoid glycoside, heterosmilaside(1), two known phenylpropanoid glycosides, helonioside B (2), and 2',6'-diacetyl-3,6-diferuloyl sucrose (3), and three known flavonoids, isoquercetin (4), quercetin-3-O-β-D-glucuronopyranoside (5), and quercetin-3-O-(2''-α-L-rhamnopyranosyl)-β-D-glucuronopyranoside (6) were isolated from the methanolic extract of the aerial part of Heterosmilax erythrantha Baill. Their structures were elucidated on the basis of spectroscopic analyses. All the isolated compounds were tested for antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among them, compounds 5 and 6 showed significant antioxidant activity with SC50 values of 3.7 and 6.5 μg/mL, respectively.
Nhiem, Nguyen Xuan,Kiem, Phan Van,Minh, Chau Van,Ban, Ninh Khac,Cuong, Nguyen Xuan,Tung, Nguyen Huu,Ha, Le Minh,Ha, Do Thi,Tai, Bui Huu,Quang, Tran Hong,Ngoc, Tran Minh,Kwon, Young-In,Jang, Hae-Dong,K The Pharmaceutical Society of Japan 2010 Chemical & pharmaceutical bulletin Vol.58 No.5
<P>Fourteen cucurbitane-type triterpene glycosides (1—14) were isolated from a methanol extract of <I>Momordica charantia</I> fruits, including three new compounds, charantosides A—C (1, 5, 6). Their structures were elucidated by chemical and spectroscopic methods. All isolated compounds were evaluated for α-glucosidase inhibitory effect. Of which, 12 and 13 showed moderate inhibitory activity against α-glucosidase. Whereas, 2, 3, 6—11, and 14 showed weak inhibitory activity, and 1, 4, and 5 were inactive.</P>
Cucurbitane-type triterpene glycosides from the fruits of Momordica charantia
Nhiem, Nguyen Xuan,Kiem, Phan Van,Minh, Chau Van,Ban, Ninh Khac,Cuong, Nguyen Xuan,Ha, Le Minh,Tai, Bui Huu,Quang, Tran Hong,Tung, Nguyen Huu,Kim, Young Ho John Wiley Sons, Ltd. 2010 Magnetic resonance in chemistry Vol.48 No.5
<P>The chemical study of Momordica charantia fruits led to the isolation of three new cucurbitane triterpene glycosides, momordicosides U, V, and W (1–3). The structures of these compounds were determined to be (19R, 23R)-5β, 19-epoxy-19-methoxycucurbita-6,24-diene-3β, 23-diol 3-O-β-D-allopyranoside (1), (23R)-5β, 19-epoxycucurbita-6,24-diene-3β, 23-diol 3-O-β-D-allopyranoside (2), and (19R)-5β, 19-epoxy-19,25-dihydroxycucurbita-6,23(E)-diene-3β-ol 3-O-β-D-glucopyranoside (3), by chemical and spectroscopic methods. Copyright © 2010 John Wiley & Sons, Ltd.</P> <B>Graphic Abstract</B> <P>Three new cucurbitane triterpene glycoside named momordicosides U-W (1–3), respectively, have been isolated from Momordica charantia. Their chemical structures were identified by chemical and spectroscopic methods. <img src='wiley_img_2010/07491581-2010-48-5-MRC2582-gra001.gif' alt='wiley_img_2010/07491581-2010-48-5-MRC2582-gra001'> </P>
Chemical constituents and antioxidant activity of Ficus callosa.
Van Kiem, Phan,Cuong, Nguyen Xuan,Nhiem, Nguyen Xuan,Hang, Dan Thi Thuy,Nam, Nguyen Hoai,Ban, Ninh Khac,Minh, Chau Van,Bing, Zhou,Jang, Hae Dong,Kim, Young Ho Natural Product Communications 2011 Natural product communications Vol.6 No.2
<P>One new megastigmane glycoside, ficalloside (1), and eleven known compounds, were isolated from methanol extract of Ficus callosa leaves by repeated column chromatography. Their structures were established on the basis of spectral and chemical evidence. The antioxidant activities of these compounds were measured using the oxygen radical absorbance capacity (ORAC) assay. Compound 8 exhibited potent antioxidant activity of 10.6 microM trolox equivalents at the concentration of 2 microM. At this concentration, compounds 4-7 and 9-12 showed significant antioxidant activity with ranging of 2.1-6.1 microM trolox equivalents.</P>
Phan Van Kiem,김영호,Chau Van Minh,Nguyen Xuan Nhiem,Nguyen Xuan Cuong,BUIHUU TAI,TRANHONG QUANG,Hoang Le Tuan Anh,Pham Hai Yen,Ninh Khac Ban,김승현,Mingjie Xin,차지윤,이영미 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.12
Bioassay-guided fractionation based on the anti-inflammatory activity of a methanol extract of Ficus microcarpa leaves led to the isolation of seven galactolipids: 2(S)-3-O-octadeca-9Z,12Z,15Ztrienoylglyceryl-O-β-D-galactopyranoside (1), (2S)-2,3-O-dioctadeca-9Z,12Z,15Z-trienoylglyceryl-O-β-D-galactopyranoside (2), (2S)-2,3-O-dioctadeca-9Z,12Z-dienoylglyceryl-O-β-D-galactopyranoside (3), (2S)-3-O-octadeca-9Z,12Z,15Z-trienoylglyceryl-6'-O-(α-D-galactopyranosyl)-β-D-galactopyranoside (4), (2S)-2,3-O-dioctadeca-9Z,12Z,15Z-trienoylglyceryl-6'-O-(α-D-galactopyranosyl)-β-D-galactopyranoside (5), gingerglycolipid B (6), and (2S)-2,3-O-dioctadeca-9Z,12Z-dienoylglyceryl-6'-O-(α-D-galactopyranosyl)-β-D-galactopyranoside (7). Their chemical structures were elucidated by mass, 1D-, and 2D-NMR spectroscopic methods as well as chemical methods. The antiinflammatory effect of these compounds on TNF-α induced IL-8 secretion in the HT-29 cell line was evaluated. All above galactolipids showed significant inhibition ranging 40% at a concentration of 50 μM. The results suggest that galactolipids from the leaves of F. microcarpa may be used as potent anti-inflammatory agents.
Tai, Bui Huu,Nhut, Nguyen Duy,Nhiem, Nguyen Xuan,Quang, Tran Hong,Thanh Ngan, Nguyen Thi,Thuy Luyen, Bui Thi,Huong, Tran Thu,Wilson, Jennifer,Beutler, John A.,Ban, Ninh Khac,Cuong, Nguyen Manh,Kim, Yo Informa Healthcare 2011 PHARMACEUTICAL BIOLOGY Vol.49 No.10
<P><I>Context</I>: Acquired immune deficiency syndrome (AIDS) is a severe pandemic disease especially prevalent in poor and developing countries. Thus, developing specific, potent antiviral drugs that restrain infection by human immunodeficiency virus type 1 (HIV-1), a major cause of AIDS, remains an urgent priority.</P><P><I>Objective</I>: This study evaluated 32 extracts and 23 compounds from Vietnamese medicinal plants for their inhibitory effects against HIV-1 ribonuclease H (RNase H) and their role in reversing the cytopathic effects of HIV.</P><P><I>Materials and methods</I>: The plants were air-dried and extracted in different solvent systems to produce plant extracts. Natural compounds were obtained as previously published. Samples were screened for RNase H inhibition followed by a cytopathic assay. Data were analyzed using the Microsoft Excel.</P><P><I>Results and discussion</I>: At 50 μg/mL, 11 plant extracts and five compounds inhibited over 90% of RNase H enzymatic activity. Methanol extracts from <I>Phyllanthus reticulatus</I> and <I>Aglaia aphanamixis</I> leaves inhibited RNase H activity by 99 and 98%, respectively, whereas four extracts showed modest protection against the cytopathic effects of HIV.</P><P><I>Conclusion</I>: The screening results demonstrated that the butanol (BuOH) extract of <I>Celastrus orbiculata</I> leaves, methanol (MeOH) extracts of <I>Glycosmis stenocarpa</I> stems, <I>Eurya ciliata</I> leaves, and especially <I>P. reticulatus</I> leaves showed potential RNase H inhibition and protection against the viral cytopathic effects of HIV-1. Further chemical investigations should be carried out to find the active components of these extracts and compounds as potential anti-HIV drug candidates.</P>