http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Nguyen Thi-Khanh-Ly (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Bioactive Antibacterial Modification of Orthodontic Microimplants Using Chitosan Biopolymer
Nguyen Thi Khanh Ly,신한별,Kailash Chandra Gupta,강인규,유원재 한국고분자학회 2019 Macromolecular Research Vol.27 No.5
Titanium alloy (Ti6Al4V)-based microimplants are extensively used as anchorage units in orthodontic treatment; however, they have a high failure rate (10 to 30%). This study aimed to enhance the survivability of these small implants by improving their bioactive and antibacterial properties, via modifying their surface with chitosan. For a stable covalent bond, microimplant surfaces were first functionalized with 3-triethoxysilylpropylamine (APTES) and then grafted either with a succinic acid or polyacrylic acid spacer, followed by attachment with chitosan. Validity tests were conducted on titanium alloy disk (TI) specimens treated with the same chemical process (TI specimens were used to avoid the practical difficulties in testing the small and complex-shaped microimplants). The results confirmed successful APTES functionalization and grafting of succinic- or polyacrylic acid. Anchoring of chitosan was confirmed via X-ray photoelectron spectroscopy (XPS) and confocal laser scanning microscopy (CLSM); furthermore, the anchoring ability of succinic acid, as a spacer, for chitosan was superior to that of polyacrylic acid. Chitosan-modified TI specimens (TI-SA-Ch) showed better biocompatibility with pre-osteoblastic MC3T3-E1 cells, as confirmed from their enhanced adhesion, proliferation, and from cell viability analysis. Biofilm formation of Streptococcus mutans and Streptococcus sobrinus was effectively reduced by 53% and 31%, respectively, on the surface of TI-SA-Ch. These results clearly indicated that chitosan modification might be a promising approach to enhance the bioactive- and antibacterial properties of orthodontic microimplants, and thus, increase their stability in the jaw bone in clinical practice.
-
Nguyen Huu-Manh,Duong The-Khang,Nguyen Van-Khuyen,Nguyen Thi-Khanh-Ly,Dong Thi-Hoang-Yen,Nguyen Canh-Hung,Tung Nguyen-Thach 한국약제학회 2024 Journal of Pharmaceutical Investigation Vol.54 No.2
Purpose A two-step experimental design was used to develop a lornoxicam (LOR)-loaded topical hydrogel patch. We specifically focused on the simultaneous effect of the ion pair formation agent (triethanolamine [TEA]) and the chemical enhancer (cremophor RH40 [RH40]) on flux and conducted physicochemical studies and skin physiology assessments to obtain further information. Methods Drug-in-adhesive patches were fabricated using a micrometer-adjustable film applicator. The applied Design of Experiments (DoE) approach consisted of the Fractional Factorial Resolution V + design and the Central Composite Face design established by the MODDE® 12.0 software. Molecular-level drug-excipient interactions were investigated using infrared (IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy. The effects on skin physiological function was assessed using DermaLab Combo. Results DoE results revealed that TEA enhanced flux by 3.14-fold, whereas RH40 reduced it by 4.62-fold. The addition of RH40 resulted in the disappearance of the proton peak within the region of 12–13 ppm, suggesting competition for hydrogen bonding with LOR between TEA and RH40. The optimized formulation (4% TEA, 0% RH40, and 0.2% Al(OH)3) increased skin hydration by 6.20-fold. Opposing effects of TEA and RH40 on skin elasticity were observed. Conclusion Expected flux and adhesion strength for the optimized formulation were 7.18 μg·cm–2·h–1 and 11.79 mJ, respectively. Our understanding of the conflicting effects of TEA and RH40 has been advanced. The integrated use of the two-step DoE, physicochemical studies, and skin physiology assessments was proven to be effective in elucidating the simultaneous effects of different permeation-modifying strategies on patches, thus having substantial value for the successful execution of future research endeavors.
-
Chien Minh Tran,Ngoc Thi‑Thanh Nguyen,Minh Hieu Ho,Vinh Khanh Doan,Khanh Loan Ly,Nhi Ngoc‑Thao Dang,Nam Minh‑Phuong Tran,Hoai Thi‑Thu Nguyen,Long Phuoc Truong,Thai Minh Do,Quyen Ngoc Tran,Hien Quoc Ng 한국섬유공학회 2023 Fibers and polymers Vol.24 No.1
In this study, we proposed a straightforward electrospun polycaprolactone (PCL) loaded with silver nanoparticles (SNPs)membrane fabrication process, in which SNPs were directly synthesized from silver nitrate (AgNO3) in PCL–acetone mixtureby gamma irradiation. The insolubility of AgNO3in PCL solution was solved using an auxiliary dimethyl sulfoxide solvent. As a physical approach, gamma rays readily converted silver ions into SNPs without the addition of harmful reductionagents, which reduced the cytotoxicity of the synthesized material. By avoiding some processes such as purification, solventremoval, or redispersion of SNPs, this method was more time-saving compared to other related studies. SNPs formation wasconfirmed by both UV–Visible spectrum (UV–Vis) and X-ray diffraction analysis. Scanning electron microscopy (SEM)revealed that the addition of SNPs significantly reduced the fiber diameter of PCL–Ag membranes compared to that of rawPCL. Uniform spherical-shaped SNPs incorporated in PCL fibers were observed under transmission electron microscopy(TEM). The tensile test showed that the electrospun PCL–Ag membranes exhibited good mechanical characteristics. Moistureeasily penetrated the porous microstructure of PCL–Ag, facilitating wound humidity regulation. Inductively coupledplasma-mass spectroscopy (ICP-MS) was employed to study the release profiles of SNPs at different time intervals. Overall,the PCL–Ag 500 ppm sample exerted excellent antibacterial activity against Pseudomonas aeruginosa and Staphylococcusaureus strains and low in vitro cytotoxicity.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
