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Nguyen Phuong Thao,Bui Thi Thuy Luyen,Nguyen Thi Thanh Ngan,Le Duc Dat,Nguyen Xuan Cuong,Nguyen Hoai Nam,Phan Van Kiem,Seok Bean Song,Chau Van Minh,김영호 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.5
Peroxisome proliferator-activated receptors(PPARs) are ligand-activated transcription factors thatregulate the expression of multiple genes involved inmetabolic, anti-inflammatory, and developmental processes. This study evaluated the PPARs transactivationaleffects of thirteen cembranoid diterpenoids 1–13 from thesoft coral Lobophytum crassum, using PPAR-responsiveelements–luciferase reporter and GAL4–PPAR chimeraassays. All isolated compounds activated the transcriptionof PPARs in a dose-dependent manner, with EC50 valuesranging from 2.07 ± 1.73 to 130.20 ± 1.85 lM. Moreover,compounds 6–9 affected the transactivation of allthree PPAR types, PPARa, c, b(d), in a dose-dependentmanner, with EC50 values in a ranging from 11.92 ± 1.23to 122.50 ± 2.12 lM. These results provide a scientificrationale for further studies on the soft coral L. crassum andits diterpenoid constituents to develop medicinal productsagainst inflammatory and metabolic diseases.
Nguyen Phuong Thao,Bui Thi Thuy Luyen,Chau Ngoc Diep,Bui Huu Tai,김은지,강희경,이상현,장해동,Nguyen The Cuong,Nguyen Van Thanh,Nguyen Xuan Cuong,Nguyen Hoai Nam,Chau Van Minh,김영호 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.4
This study performed phytochemical and bioactiveassessments of the mangrove Lumnitzera racemosaWilld. leaves. Bioassay-guided fractionation of the methanolicextracts led to the identification of thirty-six compounds(1–36), their structures were elucidated using detailed NMRspectroscopic and MS analysis. The extracts, fractions, andthe isolated compounds were screened for potential antioxidantand cytotoxic activities. Antioxidant assays wereperformed using peroxyl radical-scavenging and reducingassays, whereas cytotoxicity was measured using MTTassays in HL-60 and Hel-299 cell lines. The methanolicextract, CH2Cl2 and n-BuOH fractions (10.0 lg/mL)exhibited potent antioxidant activity, with Trolox equivalent(TE) values of 24.94 ± 0.59, 28.34 ± 0.20, and27.09 ± 0.37 (lM), respectively. In addition, the isolatedcompounds exerted cytotoxic effects in a dose-dependentmanner; compounds 1 and 14 exhibited the most potentcytotoxicity in HL-60 cells, with IC50 values of 0.15 ± 0.29and 0.60 ± 0.16 lM, respectively. To clarify the mechanism(s) behind these cytotoxic effects, we measured thetime-dependent changes in apoptotic markers including thecondensation and fragmentation of nuclear chromatin, andthe downregulation of p-ERK1/2, p-AKT, and c-Myc levels.
A New Sterol from the Soft Coral Lobophytum crassum
Nguyen, Phuong Thao,Nguyen, Hoai Nam,Nguyen, Xuan Cuong,Nguyen, Xuan Nhiem,Pham, The Tung,Tran, Hong Quang,Nguyen, Thi Thanh Ngan,Phan, Van Kiem,Chau, Van Minh,Kim, Young Ho Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.1
Anti-inflammatory tirucallane saponins from Paramignya scandens.
Phan, Nguyen Huu Toan,Thuan, Nguyen Thi Dieu,Ngoc, Ninh Thi,Thao, Nguyen Phuong,Kim, Sohyun,Koh, Young Sang,Thanh, Nguyen Van,Cuong, Nguyen Xuan,Nam, Nguyen Hoai,Kiem, Phan Van,Kim, Young Ho,Minh, Cha Pharmaceutical Society of Japan 2015 Chemical & pharmaceutical bulletin Vol.63 No.7
<P>Five new tirucallane saponins, paramignyosides A-E (1-5), were isolated from the water fraction of the Paramignya scandens stem and leaves. Their structures were elucidated on the basis of spectroscopic evidence including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and one dimensional (1D)- and 2D-NMR. The effects of isolated compounds on pro-inflammatory cytokines were evaluated by measuring the production of interleukin (IL)-12 p40, IL-6, and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs). Paramignyoside C (3) exhibited selective and potent inhibitory effect (IC50=5.030.19??M) on the production of IL-12 p40 comparable to that of the positive control, SB203580 (IC50=5.000.16??M). Further studies are required to confirm efficacy in vivo and the mechanism of anti-inflammatory effects.</P>
Anti-inflammatory Asterosaponins from the Starfish <i>Astropecten monacanthus</i>
Thao, Nguyen Phuong,Cuong, Nguyen Xuan,Luyen, Bui Thi Thuy,Thanh, Nguyen Van,Nhiem, Nguyen Xuan,Koh, Young-Sang,Ly, Bui Minh,Nam, Nguyen Hoai,Kiem, Phan Van,Minh, Chau Van,Kim, Young Ho American Chemical Society and American Society of 2013 Journal of natural products Vol.76 No.9
<P>Four new asterosaponins, astrosteriosides A–D (<B>1</B>–<B>3</B> and <B>5</B>), and two known compounds, psilasteroside (<B>4</B>) and marthasteroside B (<B>6</B>), were isolated from the MeOH extract of the edible Vietnamese starfish <I>Astropecten monacanthus</I>. Their structures were elucidated by chemical and spectroscopic methods including FTICRMS and 1D and 2D NMR experiments. The effects of the extracts and isolated compounds on pro-inflammatory cytokines were evaluated by measuring the production of IL-12 p40, IL-6, and TNF-α in LPS-stimulated bone marrow-derived dendritic cells. Compounds <B>1</B>, <B>5</B>, and <B>6</B> exhibited potent anti-inflammatory activity comparable to that of the positive control. Further studies are required to confirm efficacy <I>in vivo</I> and the mechanism of effects. Such potent anti-inflammatory activities render compounds <B>1</B>, <B>5</B>, and <B>6</B> important materials for further applications including complementary inflammation remedies and/or functional foods and nutraceuticals.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2013/jnprdf.2013.76.issue-9/np400492a/production/images/medium/np-2013-00492a_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np400492a'>ACS Electronic Supporting Info</A></P>
Phuc Nguyen Thien,Giang Nguyen Thi Huong,An Vu Nguyen Thien Truong,Nam Nguyen Thanh Hoai,Anh Ly Duc,Nguyen Huynh Cam,An Hoang,Phong Mai Thanh,Hieu Nguyen Huu 한국탄소학회 2023 Carbon Letters Vol.33 No.2
In this study, graphene oxide (GO) was synthesized by the improved Hummers’ method. The degree of oxidation from graphite (Gi) to GO was determined through interlayer spacing calculated from X–ray diffraction. Besides, the effect of KMnO4:Gi ratios (X1), H2SO4 volume (X2), oxidation temperature (X3), oxidation time of stage 1 (X4), and oxidation time of stage 2 (X5) was screened by the Plackett–Burman model. The simultaneous impact of three factors that influenced the degree of oxidation (X1, X2, and X3) was studied by the Box–Behnken experimental model of response surface methodology to achieve suitable conditions for the GO synthesis process. The characterization of GO product was investigated via the modern analytical methods: X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, UV–Vis spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and atomic force microscopy. In addition, the study was also carried out on a pilot scale for orientation in industrial application with the yield of 14 g/batch.
Cuong, Nguyen Xuan,Thao, Nguyen Phuong,Luyen, Bui Thi Thuy,Ngan, Nguyen Thi Thanh,Thuy, Dinh Thi Thu,Song, Seok Bean,Nam, Nguyen Hoai,Kiem, Phan Van,Kim, Young Ho,Minh, Chau Van WILEY‐VCH Verlag 2014 Chem Inform Vol.45 No.28
<P><B>Abstract</B></P><P>isolation, structure determination and antiinflammatory effects of nine cembranoid diterpenes including four new compounds, crassumols D—G (I)—(IV), respectively</P>
Van Thanh, Nguyen,Jang, Hyun-Jae,Vinh, Le Ba,Linh, Kieu Thi Phuong,Huong, Phan Thi Thanh,Cuong, Nguyen Xuan,Nam, Nguyen Hoai,Van Minh, Chau,Kim, Young Ho,Yang, Seo Young Elsevier 2019 Bioorganic chemistry Vol.88 No.-
<P><B>Abstract</B></P> <P>In a search for anti-inflammatory activity in resources from Vietnamese mangroves, we found that a methanolic extract from the leaves of <I>Calophyllum inophyllum</I> (CIL) showed significant anti-inflammatory effects <I>in vitro</I>. Using various chromatographic techniques, we subsequently isolated 12 compounds (<B>1</B>–<B>12</B>) from a methanolic extract of CIL, including two novel compounds (<B>1</B>–<B>2</B>). The inhibitory effects of these compounds on lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells were also evaluated. Compound <B>1</B> significantly suppressed NO production (IC<SUB>50</SUB> = 2.44 ± 0.88 µM), the secretion of pro-inflammatory cytokines (including interleukin-1 beta and tumor necrosis factor alpha), and the expression of inducible nitric oxide synthase through downregulation of nuclear factor-kappa-B signaling cascades. These results suggest that <I>C. inophyllum</I> leaves might be a useful resource for the development of drugs for the treatment of inflammation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Twelve compounds were isolated from Vietnamese mangrove <I>Calophyllum inophyllum</I>. </LI> <LI> Two new compounds <B>1</B> and <B>2</B> were determined by spectroscopic methods. </LI> <LI> Compound <B>1</B> showed significant anti-inflammatory activity. </LI> <LI> These results suggested that <I>C. inophyllum</I> might useful as the anti-inflammation drug. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Cembranoid Diterpenes from the Soft Coral Lobophytum crassum and Their Anti-inflammatory Activities
Cuong, Nguyen Xuan,Thao, Nguyen Phuong,Luyen, Bui Thi Thuy,Ngan, Nguyen Thi Thanh,Thuy, Dinh Thi Thu,Song, Seok Bean,Nam, Nguyen Hoai,Kiem, Phan Van,Kim, Young Ho,Minh, Chau Van Pharmaceutical Society of Japan 2014 Chemical & pharmaceutical bulletin Vol.62 No.2