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Nguyen Huu-Manh,Duong The-Khang,Nguyen Van-Khuyen,Nguyen Thi-Khanh-Ly,Dong Thi-Hoang-Yen,Nguyen Canh-Hung,Tung Nguyen-Thach 한국약제학회 2024 Journal of Pharmaceutical Investigation Vol.54 No.2
Purpose A two-step experimental design was used to develop a lornoxicam (LOR)-loaded topical hydrogel patch. We specifically focused on the simultaneous effect of the ion pair formation agent (triethanolamine [TEA]) and the chemical enhancer (cremophor RH40 [RH40]) on flux and conducted physicochemical studies and skin physiology assessments to obtain further information. Methods Drug-in-adhesive patches were fabricated using a micrometer-adjustable film applicator. The applied Design of Experiments (DoE) approach consisted of the Fractional Factorial Resolution V + design and the Central Composite Face design established by the MODDE® 12.0 software. Molecular-level drug-excipient interactions were investigated using infrared (IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy. The effects on skin physiological function was assessed using DermaLab Combo. Results DoE results revealed that TEA enhanced flux by 3.14-fold, whereas RH40 reduced it by 4.62-fold. The addition of RH40 resulted in the disappearance of the proton peak within the region of 12–13 ppm, suggesting competition for hydrogen bonding with LOR between TEA and RH40. The optimized formulation (4% TEA, 0% RH40, and 0.2% Al(OH)3) increased skin hydration by 6.20-fold. Opposing effects of TEA and RH40 on skin elasticity were observed. Conclusion Expected flux and adhesion strength for the optimized formulation were 7.18 μg·cm–2·h–1 and 11.79 mJ, respectively. Our understanding of the conflicting effects of TEA and RH40 has been advanced. The integrated use of the two-step DoE, physicochemical studies, and skin physiology assessments was proven to be effective in elucidating the simultaneous effects of different permeation-modifying strategies on patches, thus having substantial value for the successful execution of future research endeavors.
Nguyen Huu Tung,Chau Van Minh,Phan Van Kiem,Hoang Thanh Huong,Tran Thu Ha,Nguyen Tien Dat,Nguyen Xuan Nhiem,Nguyen Xuan Cuong,Jae-Hee Hyun,Hee-Kyoung Kang,김영호 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.12
One new C29 sterol with a cyclopropane ring at C-25 and C-26, aragusteroketal B (1), and aragusterol B (2) were isolated from the Vietnamese marine sponge Ianthella sp. Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic activity against MCF-7, SK-Hep-1, and HeLa cell lines with IC50 in the range of 12.8-27.8 μM.
Chemical Components from the Vietnamese Soft Coral Lobophytum sp.
Tung, Nguyen Huu,Minh, Chau Van,Kiem, Phan Van,Huong, Hoang Thanh,Nam, Nguyen Hoai,Cuong, Nguyen Xuan,Quang, Tran Hong,Nhiem, Nguyen Xuan,Hyun, Jae-Hee,Kang, Hee-Kyoung,Kim, Young-Ho 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.4
Chromatographic separation resulted in the identification of one new squalene derivative, named lobophytene (1), three cembranoid diterpenes (2-4), and two sterols (5 and 6) from the Vietnamese marine soft coral Lobophytum sp. Their structures were identified on the basis of extensive spectroscopic data and comparison of those with reported data. Compounds 1 and 2 showed significant cytotoxic activities against lung (A549) and colon (HT-29) cell lines with $IC_{50}$ values of 8.2 and $5.6\;{\mu}M$ for 1; 5.1 and $1.8\;{\mu}M$ for 2, respectively.
Phenolic Components from the Leaves of Panax ginseng and Their Effects on HL-60 Human Leukemia Cells
Nguyen Huu Tung,Jeong-Hyun Son,Kyoungwon Cho,김정아,Jae-Hee Hyun,강희경,Gyu Yong Song,Chun Jung Park,김영호 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.1
This study investigates phenolic components from the Panax ginseng C.A. Meyer leaves led to the isolation of 3 flavonoids (1-3). Their structures were characterized on the basis of physicochemical properties,nuclear magnetic resonance (NMR) spectra, electron spray ionization-mass spectrometry (ESI-MS) data, and comparison with those in the literature. Of them, sophoraflavonoloside (2) and prunin (3) were found to inhibit the growth of HL-60 human leukemia cells with IC50 in values of 29.8 and 21.4 μM by the induction of apoptosis.
Steamed Ginseng-Leaf Components Enhance Cytotoxic Effects on Human Leukemia HL-60 Cells
Tung, Nguyen Huu,Song, Gyu Yong,Minh, Chau Van,Kiem, Phan Van,Jin, Long Guo,Boo, Hye-Jin,Kang, Hee-Kyoung,Kim, Young Ho The Pharmaceutical Society of Japan 2010 Chemical & pharmaceutical bulletin Vol.58 No.8
<P>Three new dammarane-type glycosides, named ginsenosides SL<SUB>1</SUB>—SL<SUB>3</SUB> (<B>1</B>—<B>3</B>), and eleven known compounds (<B>4</B>—<B>14</B>) were isolated from the heat-processed leaves of <I>Panax ginseng</I>. Their structures were elucidated on the basis of extensive chemical and spectroscopic methods. Cytotoxic-activity testing of compounds <B>1</B>—<B>14</B> against human leukemia HL-60 cells showed that ginsenosides Rh<SUB>3</SUB> (<B>11</B>) and Rk<SUB>2</SUB> (<B>12</B>) exhibited potent effects with IC<SUB>50</SUB> values of 0.8 and 0.9 μ<SMALL>M</SMALL>. In addition, ginsenosides SL<SUB>3</SUB> (<B>3</B>), 20<I>S</I>-Rg<SUB>2</SUB> (<B>7</B>), F<SUB>4</SUB> (<B>10</B>), 20<I>S</I>-Rh<SUB>2</SUB> (<B>13</B>) displayed strong activity with IC<SUB>50</SUB> values of 9.0, 9.0, 7.5, and 8.2 μ<SMALL>M</SMALL>, respectively. This is the first report on chemical components of the steamed ginseng leaves.</P>
An Anti-influenza Component of the Bark of Alnus japonica
Nguyen Huu Tung,권혁준,김재홍,라정찬,김정아,김영호 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.3
This study to identify anti-influenza components of the bark of Alnus japonica resulted in the isolation of four lupane-type triterpenes (1-4) and one steroid (5). Their structures were characterized on the basis of physicochemical properties, NMR evidence, and ESI-MS data compared with reported data in the literature. Betulinic aldehyde (3) exhibited a particularly strong anti-influenza effect against KBNP-0028 relative to a positive control.
Nguyen Huu Tung,Seok Bean Song,Gyu Yong Song,김정아,구정은,강희경,Young-Sang Koh,김영호 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.4
Ginseng leaves and flowers have been known to be rich in various ginsenosides. The aim of present study is to screen the effect of 34 ginsenosides from ginseng leaves and flowers on interlukin (IL)-12 production in bone marrow-derived dendritic cells induced by lipopoly-saccharide (LPS). Noticeably, floralginsenoside Kc (5),floralginsenoside J (26), and ginsenoside I (33) exhibited particularly inhibitory effect on LPS-induced IL-12 production with IC50 values of 16.3, 25.8, and 6.7 μM, respectively. In addition, floralginsenoside Kc (5) suppressed significantly LPS-stimulated IL-6 and tumor necrosis factor-α (TNF-α)production. These results warrant further studies concerning potential of saponin extracts of Panax ginseng leaves and flowers for medicinal foods.
Inhibitory Activity of Plantago major L. on Angiotensin I-converting Enzyme
Nguyen Xuan Nhiem,김영호,Bui Huu Tai,Phan Van Kiem,Chau Van Minh,Nguyen Xuan Cuong,Nguyen Huu Tung,Vu Kim Thu,Trinh Nam Trung,Hoang Le Tuan Anh,조성훈,장해동,권영인 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3
Eight compounds were isolated from methanol extract of Plantago major L. leaves and investigated for their ability to inhibit angiotensin I-converting enzyme activity. Among them, compound 1 showed the most potent inhibition with rate of 28.06 ± 0.21% at a concentration of 100 μM. Compounds 2 and 8 exhibited weak activities. These results suggest that compound 1 might contribute to the ability of P. major to inhibit the activity of angiotensin I- converting enzyme.