통합심리치료의 인지분화훈련이 정신분열병 환자의 기초 인지기능에 미치는 영향

이희상,현명호,조현상,이연희,김태용,장순아,노규식,정기립,이만홍,유계준 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

연구목적 : 정신분열별 환자들을 대상으로 통합심리치료의 소프로그램인 인지분화훈련을 실시하여 실행기능, 개념형성능력, 언어능력 및 추론력에 대한 훈련이 보다 더 하위단계의 인지기능인 주의력, 기억력, 반응시간 등을 호전시킬 수 있는 지를 알아보고자 하였다. 연구방법 : DSM-IV상 정신분열병으로 진단된 24명의 입원환자를 무작위로 양분하여 한 군은 인지분화훈련군으로 다른 한 군은 대조군으로 나누었다. 훈련군은 4주동안 1주일에 3회(매회 60분간)로 총 12회의 통합심리치료의 인지분화훈련을 받았으며 대조군은 동일한 시간동안 정신건강교육을 받았다. 훈련전후에 훈련군과 대조군을 대상으로 개정판 Wechsler 기억검사로 주의집중력, 장·단기 기억력을 측정하였고 Vienna test system중 결정반응시간검사로 반응시간, 반응결정시간, 반응운동시간을 평가하였다. 연구결과 : 1) 주의집중력에서는 훈련군과 대조군사이에 집단간 효과, 집단내 효과 및 상호작용 효과가 없었다. 2) 단기기억력에서는 훈련군과 대조군사이에 집단내 효과는 있었으나(F(1,24)=10.46. p〈.05). 집단간 효과, 상호작용 효과는 없었다. 3) 장기기억력에서는 훈련군과 대조군사이에 집단내 효과는 있었으나(F(1,24)=15.09. p〈.05). 집단간 효과, 상호작용 효과는 없었다. 4) 반응시간에서는 상호작용 효과(F(1,24)=5.18, p〈.05)가 있었다. 5) 반응운동시간에서는 집단간 효과, 집단내 효과 및 상호작용 효과가 없었다. 6) 반응결정시간에서는 상호작용 효과(F(1.24)=6.00, p〈.05)가 있었다. 결 론 : 통합심리치료의 인지분화훈련은 정신분열병 환자에서 하위단계의 인지기능 중 반응시간(특히 반응결정시간)을 단축시키는 효과가 있었다. Objectives : The purpose of this study was to investigate the effects of cognitive differentiation training of Integrated Psychological Therapy(a training program of executive function, concept formation, language, and abstraction) on micro-level cognitive function such as attention, memory and reaction time in patients time in patients with schizophrenia. Methods : Twenty-four inpatients diagnosed as schizophrenia using DSM-IV were randomly assigned to 2 groups. The training group went through a total of 12 sessions of cognitive differentiation training for 4 weeks. The control group received psychoeducation program during the same period. Wechsler Memory Scale-Revised and Decision-Reaction Timer of Vienna Test System were administered to all patients, both before and after the training program. Results : 1) In the attention and concentration scores of Wechsler Memory Scale-Revised, between group, within group and interaction effects of training were not significant. 2) In the short-term memory scores of Wechsler Memory Scale-Revised, within group effect of training was significant(F(1,24)=10.46, p〈0.05), but the between group and interaction effects did not reach significance. 3) In the long-term memory scores of Wechsler Memory Scale-Revised, within group effect of training was significant(F(1,24)=15.09, p〈0.05), but the between group and interaction effects did not reach significance. 4) In the reaction time scores of Decision-Reaction Timer, interaction effect of training was significant(F(1,24)=5.18, p〈0.05). 5) In the motor time scores of Decision-Reaction Timer, between group, within group and interaction effects of training were not significant. 6) In the decision time scores of Decision-Reaction Timer, interaction effect of training was significant(F(1,24)=6.00, p〈0.05). Conclusion : Our findings suggest that cognitive differentiation training of Integrated Psycho-logical Therapy is partly effective on improving micro-level cognitive functions such as reaction time(especially, decision time) in patents with schizophrenia.

포도상구균 초항원과 연관된 만성 비·부비동염의 병인에서 감마 인터페론 생산 T세포의 역할

김창수,조규섭,이현순,박희영,노환중 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.24

Background and Objectives: The etiology and pathogenesis of chronic rhinosinusitis (CRS) is multifactorial and the role of infectious agents in CRS is not clear. S. aureus is the most frequent cultured pathogen in CRS and it expresses toxin, SEA, SEB and TSST-l, with superantigen (SAG) activity. Recently an importnat role of these staphylococcal toxins in CRS with nasal polyposis (CRSwNP) has been suggested. CRSwNP is a severe chronic inflammation characterized by massive infiltration of lymphocytes and eosinophils in the sinonasal mucosa and nasal polyp. However, there has been no further studies evaluating the properties of infiltrating T lymphocytes in CRSwNP and the cytokine profiles in activated T-Iymphocyte relating with SAGs. The aims of this study was to know what kind of T lymphocytes infiltrates in nasal mucosa and polyp tissue of CRSwNP, to analyze the cytokine profiles in infiltrating T cells, and to determine whether infiltrating T lymphocytes are specific for SAGs. Patients and Methods: Ethmoid sinus mucosa and polyp tissue samples were collected from 13 patients with CRSwNP and control sinus mucosa were obtained from 10 patient without CRS. Tissue infiltrating cells and T cells were isolated from tissue samples and flow cytometry, enzyme-linked immunosorbent assay, reverse transcriptase-polymerase chain reaction, in vitro T lymphocyte stimulation with S. aureus toxin were performed. Results: The mean total CD3+ T cell count was significantly higher in the mucosa and polyp tissue of patients with CRSwNP compared with control mucosa. Most infiltrating T cells in mucosa and polyp tissue were activated type, expressing CD45RO. CD8+ T cells were significantly increased in mucosa and polyp tissue of patients with CRSwNP compared with CD4+ cells IFN-γ was highly expressed in infiltrating T cells in both mucosa and polyp tissue, whereas IL-10 was expressed a small amount and IL-4 was not expressed. IFN-γ levels were significantly higher than IL-4 and IL-10 when isolated T cells were stimulated with SAGs in vitro. Conclusion: CD8+ T-cytotoxic and IFN-γ producing Th1 cells could paly an important role in the CRSwNP if sinonasal chronic inflammation is induced by SAGs.

교직전문성 제고를 위한 사범대학 교육과정 개정방향 탐색

이숙재(Sook Jae, Lee),장영희(Young Hee, Chang),노석준(Seak Zoon, Roh) 성신여자대학교 교육문제연구소 2007 교육연구 Vol.41 No.-

본 연구는 성신여자대학교 사범대학 구성원인 교수와 학생들이 현행 사범대학 교육과정과 교육내용, 교육방법 등을 어떻게 생각하고, 어떠한 방향으로 개편되기를 원하는지에 관한 요구분석을 함으로써 향후 사범대학 교육과정을 개편하는데 있어서 중요한 참고자료로 사용하기 위하여 행해졌다. 연구 결과 교수와 학생들은 교육과정 영역별 이수학점 구성에 대하여는 대체적으로 적절하다고 생각하였으며, 사범대학에 개설된 교직과목에 대하여는 교육철학 및 교육사, 교육방법 및 교육공학 등 통합교과의 경우 분리. 운영하는 것이 바람직하다는 의견이 많았다. 교육실습과 관련하여 2학점으로 운영되는 학점 수에 대하여는 28%의 학생만이 만족한다는 반응을 보였으며, 현행 실습기간(4주)에 대하여는 교수(44%), 학생(63%)가 만족한다는 반응을 보여 교육실습 전반에 걸친 세심한 대책을 마련. 시행할 필요가 있다고 본다. 이러한 연구결과에 기초하여 교직이수학점에 대한 변화추세 등을 고려하여 각 학과별 교육과정을 재조정하고 실습학점 및 시기, 기간 등 보다 체계적인 교사양성 교육과정에 대한 지속적인 개선방안을 마련ㆍ 시행할 필요가 있다. The purposes of this study were 1) to identify how professors and students at the College of Education, Sungshin Women's University think about current curricular offered from the college, and instructional methods, and 2) to analyze their needs about how they want those curricular and instructional methods to be changed. To achieve these purposes, the questionnaire was distributed to two groups of participants(23 professors; 270 students at the college) and 253 questionnaires(16 professors; 237 students) were collected. Using SPSS 12.0, the frequency and percentage of the collected data were analyzed. Open-ended questions were categorized and analyzed by frequency. The results were as follows: First, professors thought that the number of the credits for general major and in-depth major was appropriate, and teacher-training courses being consisted of 20 credits were also suitable. Second, the statistics showed that professors(57%) and students at the college(70%) were satisfied with the subjects dealing with the theories of teaching professions, which were offered from the college, and most professors and students insisted that the combined courses which were currently offered for teaching professions should be divided into two courses. Third, professors(50%) were more highly satisfied with the current teaching practice credits(2 credits) than students(28%) at the college did. In summary, the trends of the courses and credits for teaching professions should be widely announced and the curriculum of each department should be reorganized. In addition, continuing reorganization efforts for developing systematic and effective curricular in order to train the qualified pre-service teachers should also be made.

척추 후외방 유합술후의 인접분절의 변화 : 3년 이상 추시 결과 Follow-up more than Three Years after Spinal Fusion

조재림,박예수,한주희,이창훈,노원일 대한척추외과학회 1998 대한척추외과학회지 Vol.5 No.2

Study design : A retrospective analysis of 166 patients was undertaken to observe radiologically the changes of adjacent segments at follow-up more than three years after lumbar fusion. Objectives : The purpose of this study is to analyze the changes of adjacent segments and to correlate these changes to the length of using level and to the degree of deviation from physiologic lumbar lordosis. The authors also correlate these radiologic changes to the clinical symptoms. Materials and Methods : In simple x-ray, authors observed traction spur, disc space narrowing, endplate sclerosis and vacuum phenomenon of adjacent segments. Authors used Gelb's criteria in segmental lordosis angle(SLA) and Katz's classification in clinical results. Results : The average age was 49.6 years old and the average follow-up period was 57.2 months(4 years and 9.2 months). We observed radiologically the traction spurs in 35 cases(21.1%), end-plate sclerosis in 32 cases(19.3%), disc space narrowing in 33 cases(19.9%) and the vacuum phenomenon in 10 cases(6.0%). The numbers of fusion segments and the degree of unphysiologic segmental lordosis angle in fusion segments were related with the frequency and degree of changes of adjacent segments (P<0.05). The clinical results showed satisfaction in 142 cases(85.5%), unsatisfaction in 24 cases(14.5%) and low back pain in 24 cases(14.5%), leg pain in 11 cases(6.6%) and extension of fusion level in 4 cases(2.4%). In low back pain patients more than two kinds of radiological changes were frequently observed than the patients without low back pain(P<0.05 ). Conclusions : The radiological changes of adjacent segments were more frequently observed in long fusion and in fusion with unphysiologic lumbar lordosis angle. And these changes are frequently associated with low back pain. Thus long fusion and fusion with unphysiologic lumbar lordosis angle should be avoided if possible.

Differential expression of forkhead box M1 and its downstream cyclin‐dependent kinase inhibitors p27^kip1 and p21^waf1/cip1 in the diagnosis of pulmonary neuroendocrine tumours

Ha, Seung Yeon,Lee, Chang Hun,Chang, Hee Kyung,Chang, Sunhee,Kwon, Kun Young,Lee, Eun Hee,Roh, Mee Sook,Seo, Boram Blackwell Publishing Ltd 2012 Histopathology Vol.60 No.5

<P>Ha S Y, Lee C H, Chang H K, Chang S, Kwon K Y, Lee E H, Roh M S & Seo B 
(2012) <I>Histopathology</I>?<B>60,</B> 731–739
<B>Differential expression of forkhead box M1 and its downstream cyclin‐dependent kinase inhibitors p27</B><SUP><B>kip1</B></SUP><B> and p21</B><SUP><B>waf1/cip1</B></SUP><B> in the diagnosis of pulmonary neuroendocrine tumours</B></P><P><B>Aims: </B> Pulmonary neuroendocrine (NE) tumours represent a spectrum of phenotypically distinct entities with different biological behaviours. Difficulties in classifying these tumours are frequently encountered in clinical practice. Forkhead box M1 (FoxM1) is essential for the development of various cancers and is a proliferation‐specific transcription factor that regulates transcription of cell cycle genes, including cyclin‐dependent kinase inhibitors p27<SUP>kip1</SUP> and p21<SUP>waf1/cip1</SUP>. This study was performed to determine the utility of FoxM1, p27<SUP>kip1</SUP> and p21<SUP>waf1/cip1</SUP> as immunomarkers for subtyping pulmonary NE tumours.</P><P><B>Methods and results: </B> FoxM1, p27<SUP>kip1</SUP> and p21<SUP>waf1/cip1</SUP> expression was evaluated by immunohistochemistry in 60 pulmonary NE tumours [19 typical carcinoids (TCs), six atypical carcinoids (ACs), 17 large cell neuroendocrine carcinomas (LCNECs) and 18 small cell lung cancers (SCLCs)]. The frequencies of FoxM1 and p21<SUP>waf1/cip1</SUP> expression were significantly different between TCs and ACs (each <I>P</I> = 0.009), and those of FoxM1 and p27<SUP>kip1</SUP> expression were significantly different between LCNECs and SCLCs (<I>P </I>= 0.012 and <I>P </I>= 0.002, respectively). The combined FoxM1<SUP>(−)</SUP>/p21<SUP>waf1/cip1(−)</SUP> and FoxM1<SUP>(+)</SUP>/p27<SUP>kip1(high)</SUP> phenotypes had the best diagnostic accuracy for distinguishing TCs from ACs, and SCLCs from LCNECs, respectively.</P><P><B>Conclusions: </B> FoxM1, p27<SUP>kip1</SUP> and p21<SUP>waf1/cip1</SUP> showed distinct immunoreactivity according to histological subtype, which may be of value as an ancillary test in the differential diagnosis of pulmonary NE tumours.</P>

Addition of MgO nanoparticles and plasma surface treatment of three-dimensional printed polycaprolactone/hydroxyapatite scaffolds for improving bone regeneration

Roh, Hee-Sang,Lee, Chang-Min,Hwang, Young-Hyoun,Kook, Min-Suk,Yang, Seong-Won,Lee, Donghun,Kim, Byung-Hoon Elsevier 2017 Materials Science and Engineering C Vol.74 No.-

<P>Magnesium (Mg) plays an important role in the body in mediating cell-extracellular matrix interactions and controlling bone apatite structure and density. Hydroxyapatite (HAp) has been used for osteoconductive bone replacement because of its good compressive strength and biocompatibility. The object of this study is to investigate the effects of adding Magnesium oxide (MgO) nanoparticles to polycaprolactone (PCL)/HAp composites and treating PCL/HAp/MgO scaffolds with oxygen and nitrogen plasma. The 3D PCL/HAp/MgO scaffolds were fabricated using a 3D bioextruder. PCL was mixed with 1-15 wt of MgO and HAp. The scaffolds were treated with oxygen and nitrogen plasma under anisotropic etching conditions to improve the bioactivity. The plasma treated surfaces were analyzed by X-ray photoelectron spectroscopy, scanning electron microscopy, and atomic force microscopy. In addition, the proliferation and differentiation of pre-osteoblast (MC3T3-E1) cells were examined by 3-(4,5-Dimethylthiazol-2-y1)-2,5-diphenyltetrazoliurn bromide assay and alkaline phosphatase activity. Cell mineralization within the produced scaffolds was analyzed by the quantification of alizarin stainings. The addition of MgO/HAp nanopartides and plasma treatment enhanced the adhesion, proliferation, and differentiation of MC3T3-E1 cells in the PCL scaffolds. Hence, changes in physical surface morphology and surface chemical properties of the 3D scaffold by plasma treatment can affect the behavior of MC3T3-E1 cells. (c) 2016 Elsevier B.V. All rights reserved.</P>

High performance dye-sensitized solar cells using graphene modified fluorine-doped tin oxide glass by Langmuir–Blodgett technique

Roh, Ki-Min,Jo, Eun-Hee,Chang, Hankwon,Han, Tae Hee,Jang, Hee Dong Elsevier 2015 Journal of solid state chemistry Vol.224 No.-

<P><B>Abstract</B></P> <P>Since the introduction of dye-sensitized solar cells (DSSCs) with low fabrication cost and high power conversion efficiency, extensive studies have been carried out to improve the charge transfer rate and performance of DSSCs. In this paper, we present DSSCs that use surface modified fluorine-doped tin oxide (FTO) substrates with reduced graphene oxide (r-GO) sheets prepared using the Langmuir–Blodgett (LB) technique to decrease the charge recombination at the TiO<SUB>2</SUB>/FTO interface. R-GO sheets were excellently attached on FTO surface without physical deformations such as wrinkles; effects of the surface coverage of r-GO on the DSSC performance were also investigated. By using graphene modified FTO substrates, the resistance at the interface of TiO<SUB>2</SUB>/FTO was reduced and the power conversion efficiency was increased to 8.44%.</P> <P><B>Highlights</B></P> <P> <UL> <LI> By LB technique, r-GO sheets were coated on FTO without physical deformation. </LI> <LI> DSSCs were fabricated with, r-GO modified FTO substrates. </LI> <LI> With surface modification by r-GO, the interface resistance of DSSC decreased. </LI> <LI> Maximum PCE of the DSSC was increased up to 8.44%. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>DSSCs with graphene modified FTO glass were fabricated with the Langmuir Blodgett technique. GO sheets were transferred to FTO at various surface pressures in order to change the surface density of graphene and the highest power conversion efficiency of the DSSC was 8.44%.</P> <P>[DISPLAY OMISSION]</P>

항공이동통신 환경에서의 메시지 우선순위 할당 기술에 관한 연구

노희창(Hee Chang Roh),김용균(Yong-Kyun Kim),조윤현(Yun-Hyun Jo),정선웅(Seon-Woong Jeong),김진욱(Jin-Wook Kim),박효달(Hyo-Dal Park) 한국통신학회 2009 한국통신학회 학술대회논문집 Vol.2009 No.6

생체 조직의 국소 강도 측정을 위한 마이크로 콘 팁을 가진 압전 캔틸레버 제작

노희창(Hee Chang Roh),양다솜(Dasom Yang),류원형(WonHyoung Ryu) 대한기계학회 2017 大韓機械學會論文集B Vol.41 No.11

체외 및 체내 삽입형 이미징 기술 등에 의해서는 판별이 어려운 질환의 조기 진단을 위해 인체 내 삽입이 가능하며 체내 국소부위의 정밀 측정이 가능한 새로운 진단기술이 필요하다. 동맥경화로 발전할 수 있는 죽상경화반의 경우 이미징 기술로는 판별이 어려우나 건강한 조직 대비 미세한 기계적 물성치의 차이를 가질 것으로 예상되어 정밀한 국소 조직의 기계적 강도 측정을 통한 조기 진단이 가능할 것으로 기대된다. 본 연구에서는 궁극적으로 체내 삽입이 가능하며 국소 조직의 강도 측정이 가능한 압전 재료 기반 캔틸레버 센서를 제작하고자 하였다. 압전 기능을 갖는 캔틸레버 제작을 위해 BaTiO₃ 나노입자 기반의 압전 고분자 복합재 최적화 연구 및 열 인장 공정으로 캔틸레버 끝 단에 마이크로 콘 구조의 팁을 제작하였다. 이 압전 캔틸레버 센서를 이용하여 기계적 물성치가 다른 생체 조직의 강도 측정을 통해 센서로서의 기능을 확인하였다. For diseases that are difficult to detect by conventional imaging techniques, the development of a diagnostic method that allows sensors to be inserted into the human body to aid the diagnosis of local spots of the target tissue, is highly desirable. In particular, it is extremely difficult to determine whether vulnerable plaque can later develop into atherosclerosis using only imaging techniques. However, vulnerable plaques are expected to have slightly different mechanical properties than healthy tissue. In this study, we aim to develop a piezoelectric cantilever-type sensor that can be inserted into the human body and can detect the local mechanical properties of the target tissue. A piezoelectric polymer composite based on BaTiO₃ nanoparticles was optimized for fabrication of a piezoelectric cantilever. Next, a micro-cone tip was fabricated at the end of the piezoelectric cantilever by thermal drawing. Finally, stiffness of biological tissue samples was measured with the piezoelectric cantilever sensor for verifying its functionality.

MS 마커를 활용한 지역별 오계 유전자원의 다양성 및 유연관계 분석

노희종(Hee-Jong Roh),김관우(Kwan-Woo Kim),이진욱(Jin-Wook Lee),전다연(Da-Yeon Jeon),김승창(Seung-Chang Kim),전익수(Ik-Soo Jeon),고응규(Yeoung-Gyu Ko),이준헌(Jun-Heon Lee),김성희(Sung-Hee Kim),백준종(Jun-Jong Baek),오동엽(Dong-Yep Oh) 한국가금학회 2018 韓國家禽學會誌 Vol.45 No.3

본 연구는 연산오계(천연기념물 제265호)와 이를 기원으로 하는 5개 지역별 오계 집단의 유전적 특성 및 차별성을 분석하기 위해 25개의 초위성체(MS) 마커를 이용하여 총 9개 집단 243수를 대상으로 유전자형을 분석하였다. 마커별 다형성 분석 결과, 총 153개의 대립유전자가 확인되었으며, Hexp와 PIC의 경우 MCW0145에서 각각 0.640, 0.570으로 가장 높았고, Hobs는 MCW0252에서 0.607로 가장 높은 값을 나타내었다. 반면, LEI0166에서 Hexp, Hobs, PIC가 각각 0.248, 0.204, 0.202로 가장 낮았다. 집단간 유전거리 분석 결과로는 9개 집단중 YSO 집단과 SUO 집단이 가장 가까운(0.073) 반면, LG 집단과 CBO 집단 사이에서 가장 먼(0.937) 것으로 확인되었다. 집단의 실제 구조를 확인하기 위한 집단별 균일도를 분석한 결과, 공시된 9개의 집단은 3개의 집단으로 구분했을 때 최적의 K값(7.96)을 얻을 수 있었으며, 5개의 오계 집단(YSO, ARO, CBO, CNO, SUO) 및 LG 집단과 CN․RIR 집단은 각각 1, 2, 3번 군집에 분포하고 있는 것으로 나타났다. 한편, GBO 집단의 경우 1번과 3번 클러스터에 걸쳐서 분포하고 있는 것으로 보아 사육과정에서 타집단과의 교잡이 일어났을 것으로 추정된다. 이러한 결과를 통해 추후 오계 유전자원에 대한 국가 수준의 유전적 특성평가 및 관리의 기초 자료로 유용하게 활용될 것으로 기대된다. The aim of this study was to evaluate the genetic diversity and relationships of Ogye populations in Korea. A total of 243 genomic DNA samples from 6 Ogye population (Yeonsan Ogye; YSO, Animal Genetic Resources Research Center Ogye; ARO, Chungbuk Ogye; CBO, Chungnam Ogye; CNO, Gyeongbuk Ogye; GBO, Seoul National University Ogye; SUO) and 3 introduced chicken breeds (Rhode Island Red; RIR, White Leghorn; LG, Cornish; CN) were used. Sizes of 25 microsatellite markers were decided using GeneMapper Software(v 5.0) after analyzing ABI 3130XL. A total of 153 alleles were observed and the range was 2 to 10 per each locus. The mean of expected and observed heterozygosity and PIC (Polymorphism Information Content) value was 0.53, 0.50, 0.46 respectively. The lowest genetic distance (0.073) was observed between YSO and SUO, and the highest distance (0.937) between the RIR and CBO. The results of clustering analysis suggested 3 clusters (ΔK=7.96). Excluding GBO population, 5 Ogye populations (YSO, ARO, CBO, CNO, SUO) were grouped in same cluster with high genetic uniformity (0.990, 0.979, 0.989, 0.994, 0.985 respectively). But GBO population was grouped in cluster 1 with low genetic uniformity (0.340). The results of this study can be use to basic data for the genetic evaluation and management of Ogye populations in Korea.