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Hao Qiu,Jinshan Huang,Zhupeng Zheng 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.79 No.6
It is necessary to identify structures with unknown mass and unknown seismic excitations simultaneously, but very limited methods have been proposed. In this paper, an algorithm is proposed to identify structural element mass, stiffness, and seismic excitations using only partial absolute structural responses of chain-like systems. In the first stage, the identification of structural element stiffness-mass coupled coefficients and unknown seismic excitations is conducted based on the generalized extended Kalman filter with unknown input (GEKF-UI) developed by the authors. In the second stage, these coupled coefficients are decoupled by cluster analysis and the least squares estimation (LSE) to obtain structural element stiffness and mass changes. The effectiveness of the proposed algorithm is numerically investigated using a four-story frame structure under three scenarios of changed conditions. Moreover, experimental validation by the shaking table test of a shear structure under two scenarios is also performed to identify structures and seismic excitations simultaneously.
Qiu, Hao,Duan, Wei-Ming,Shu, Jie,Cheng, Hong-Xia,Wang, Wei-Ping,Huang, Xin-En,Chen, Hui-Li Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
The epidermal growth factor receptor (EGFR) is an important surface receptor with N-glycans in its extracellular domain, whose glycosylation is essential for its function, especially in tumor cells. Here, we demonstrated that polylactosamine is markedly increased in H7721 hepatocellular carcinoma cells after treatment with EGF, while it apparently declined after exposure to all-trans retinoic acid (ATRA). In the study of the enzymatic mechanism of this phenomenon, we explored changes in the expression of poly-N-acetyllactosamine (PLN) branching glycosyltransferases using RT-PCR. Among the four glycosyltransferases with altered expression, GnT-V was most elevated by EGF, while GnT-V and B3GNT2 were most declined by ATRA. Next, we conducted co-immunoprecipitation experiments to test whether B3GNT2 and EGFR associate with each other. We observed that EGFR is a B3GNT2-targeting protein in H7721 cells. Taken together, these findings indicated that the altered expression of B3GNT2 will remodel the PLN stucture of EGFR in H7721 cells, which may modify downstream signal transduction.
Study on the Seismic Optimization Scheme of Steel Bundled-Tube Structure with Vertical Setback
Yong Hao,Feng Chen,Yun-hui Han,Xue-qian Hao,Chun-hui Du,Qiu-yu Ding 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.2
In order to improve the seismic performance of vertical setback steel bundled-tube structure and meet the dynamic multi-objective requirements of seismic performance-based design, the optimization effects under rare earthquakes on the zone of fortification intensity 7 and 8 in China are researched by improving members stiffness and adding dampers in the weak parts of structure, based on dynamic elastic-plastic analysis. The results show that: 1) Under rare earthquakes on the zone of fortification intensity 7, increasing the stiffness of weak skirt beam can improve the seismic performance of spiral and symmetrical setback structure; 2) For the spiral setback structure, under rare earthquakes on the zone of fortification intensity 7, the damper can only be arranged at the junction of the first layer of the setback frame unit and the frame unit without setback. However, under rare earthquakes on the zone of fortification intensity 8, it is not advisable to install dampers at the weak areas; 3) After incorporating dampers at the weak areas of symmetrical setback structure, the optimized members experienced a reduction in stress levels, significantly decreased the inter-layer displacement angles with a maximum reduction of 43%, and the optimization effect is significant.
Hao Wang,Qian Yuan,Linjiang Chai,Ke Zhao,Ning Guo,Jun Xiao,Xing Yin,Bin Tang,Yuqiong Li,Shaoyu Qiu 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.6
A typical ferritic/martensitic (F/M) steel sheet was subjected to pulsed laser surface remelting (LSR) andcorrosion test in lead-bismuth eutectic (LBE) at 550 C. There present two modification zones withdistinct microstructures in the LSRed specimen: (1) remelted zone (RZ) consisting of both bulk d-ferritegrains and martensitic plates and (2) heat-affected zone (HAZ) below the RZ, mainly composed ofmartensitic plates and high-density precipitates. Martensitic transformation occurs in both the RZ andthe HAZ with the Kurdjumov-Sachs and Nishiyama-Wassermann orientation relationships followedconcurrently, resulting in scattered orientations and specific misorientation characteristics. Hardnessesof the RZ and the HAZ are 364 ± 7 HV and 451 ± 15 HV, respectively, considerably higher than that of thematrix (267 ± 3 HV). In oxygen-saturated and oxygen-depleted LBE, thicknesses of oxide layers developed on both the as-received and the LSRed specimens increase with prolonging corrosion time (oxidelayers always thinner under the oxygen-depleted condition). The corrosion resistance of the LSRed F/Msteel in oxygen-saturated LBE is improved, which can be attributed to the grain-refinement acceleratedformation of dense FeeCr spinel. In oxygen-depleted LBE, the growth of oxide layers is very low withboth types of specimens showing similar corrosion resistance
Qiu-Yan Chen,Shao-Yan Guo,Lin-Quan Tang,Tong-Yu Lu,Bo-Lin Chen,Qi-Yu Zhong,Meng-Sha Zou,Qing-Nan Tang,Wen-Hui Chen,Shan-Shan Guo,Li-Ting Liu,Yang Li,Ling Guo,Hao-Yuan Mo,Rui Sun,Dong-Hua Luo,Chong Zha 대한암학회 2018 Cancer Research and Treatment Vol.50 No.3
Purpose Little is known about combination of the circulating Epstein-Barr viral (EBV) DNA and tumor volume in prognosis of stage II nasopharyngeal carcinoma (NPC) patients in the intensity modulated radiotherapy (IMRT) era. We conducted this cohort study to evaluate the prognostic values of combining these two factors. Materials and Methods By Kaplan-Meier, we compare the differences of survival curves between 385 patients with different EBV DNA or tumor volume levels, or with the combination of two biomarkers mentioned above. Results Gross tumor volume of cervical lymph nodes (GTVnd, p < 0.001) and total tumor volume (GTVtotal, p < 0.001) were both closely related to pretreatment EBV DNA, while gross tumor volume of nasopharynx (GTVnx, p=0.047) was weakly related to EBV DNA. EBV DNA was significantly correlated with progress-free survival (PFS, p=0.005), locoregional-free survival (LRFS, p=0.039), and distant metastasis-free survival (DMFS, p=0.017), while GTVtotal, regardless of GTVnx and GTVnd, had a significant correlation with PFS and LRFS. The p-values of GTVtotal for PFS and LRFS were 0.008 and 0.001, respectively. According to GTVtotal and pretreatment EBV DNA level, patients were divided into a low-risk group (EBV DNA 0 copy/mL, GTVtotal < 30 cm3; EBV DNA 0 copy/mL, GTVtotal 30 cm3; or EBV DNA > 0 copy/mL, GTVtotal < 30 cm3) and a high-risk group (EBV DNA > 0 copy/mL, GTVtotal 30 cm3). When patients in the low-risk group were compared with those in the high-risk group, 3-year PFS (p=0.003), LRFS (p=0.010), and DMFS (p=0.031) rates were statistically significant. Conclusion Pretreatment plasma EBV DNA and tumor volume were both closely correlated with prognosis of stage II NPC patients in the IMRT era. Combination of EBV DNA and tumor volume can refine prognosis and indicate for clinical therapy.
Qiu Kai,Wang Xiao-cui,Wang Jing,Wang Hao,Qi Guang-hai,Zhang Hai-jun,Wu Shu-geng 아세아·태평양축산학회 2023 Animal Bioscience Vol.36 No.4
Objective: This study aimed to determine and compare the apparent ileal digestibility (AID) and the standardized ileal digestibility (SID) of amino acids (AA) in soybean meal (SBM), cottonseed meal (CSM), and low-gossypol cottonseed meal (LCSM) fed to broiler chickens and laying hens. Methods: Three semi-purified diets containing the identical crude protein concentration at 20% were formulated to contain SBM, CSM, or LCSM as the sole source of N. A N-free diet was also formulated to estimate the basal ileal endogenous losses of AA for broilers and hens. A total of 300 male Ross 308 chicks at one-day-old and 144 Hy-Line Brown laying hens at 30-week-old with initial egg production rate of 88.3%±1.0% were randomly allocated into 1 of 4 dietary treatments, respectively. Results: CSM and LCSM showed more Arg and Cys+Met while less Lys, Ile, Leu, and Thr relative to SBM. Significant interactions existed between species and experimental diets for AID (except for Arg, Asp, Glu, Gly, and Pro) and SID (except for Arg, His, and Phe) of most AA. Most AA in diets showed higher AID (except for Lys) and SID (except for Lys, Met, and Ser) in broilers relative to laying hens. The AID and SID of all AA were significantly different between the three diets. In broilers, the AID and SID of most indispensable AA except for Arg in SBM and LCSM was higher than CSM. In laying hens, the AID and SID of most indispensable AA except for Arg, Met+Cys, and Phe in SBM was higher than CSM and LCSM. Conclusion: The accurate determination of AID and SID of AA in CSM and LCSM for broilers and layers benefits the application of CSM and LCSM in chicken diets. The cottonseed by-products CSM or LCSM showed the species-specific AA digestibility values for broilers and layers.
Qiu-Yan Chen,Qing-Nan Tang,Lin-Quan Tang,Wen-Hui Chen,Shan-Shan Guo,Li-Ting Liu,Chao-Feng Li,Yang Li,Yu-Jing Liang,Xue-Song Sun,Ling Guo,Hao-Yuan Mo,Rui Sun,Dong-Hua Luo,Yu-Ying Fan,Yan He,Ming-Yuan C 대한암학회 2018 Cancer Research and Treatment Vol.50 No.3
Purpose The measuring Epstein-Barr virus (EBV) DNA is an important predictor of nasopharyngeal carcinoma (NPC). This study evaluated the predictive value of pretreatment serum amyloid A (SAA) and C-reactive protein (CRP) comparing with EBV DNA in patients with NPC. Materials and Methods In an observational study of 419 non-metastatic NPC patients, we prospectively evaluated the prognostic effects of pretreatment SAA, CRP, and EBV DNA on survival. The primary endpoint was progress-free survival (PFS). Results The median level of SAA and CRP was 4.28 mg/L and 1.88 mg/L, respectively. For the high- SAA group (> 4.28 mg/L) versus the low-SAA ( 4.28 mg/L) group and the high-CRP group (> 1.88 mg/L) versus the low-CRP ( 1.88 mg/L) group, the 5-year PFS was 64.5% versus 73.1% (p=0.013) and 65.2% versus 73.3% (p=0.064), respectively. EBV DNA detection showed a superior predictive result, the 5-year PFS in the EBV DNA 1,500 copies/mL group was obviously different than the EBV DNA < 1,500 copies/mL group (62.2% versus 77.8%, p < 0.001). Multifactorial Cox regression analysis confirmed that in the PFS, the independent prognostic factors were including EBV DNA (hazard ratio [HR], 1.788; p=0.009), tumour stage (HR, 1.903; p=0.021), and node stage (HR, 1.498; p=0.049), but the SAA and CRP were not included in the independent prognostic factors. Conclusion The results of SAA and CRP had a certain relationship with the prognosis of NPC, and the prognosis of patients with high level of SAA and CRP were poor. However, the predictive ability of SAA and CRP was lower than that of EBV DNA.
Multi-winding Boost Multi-input DC-DC Converter Type Distributed Generation System
Hao He,Daolian Chen,Yanhui Qiu 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
The multi-winding Boost multi-input DC-DC converter type distributed generation system is proposed in the paper, the circuit topology, the maximum power and the master-slave power phase-shift PWM energy management control strategy are studied. Through the magnetic flux superposition of the high-frequency transformer, multiple input sources could supply power to the load simultaneously in a high-frequency switching period. Designed and developed 1kVA dual-input grid-connected and grid-off inverter prototypes have the advantages such as highfrequency isolation, wide regulating range of duty cycle, high conversion efficiency, smooth transition among different operating modes, etc.
Su,Hao(소호),Liu,Lu-Qiu(유로추) 한국관광레저학회 2021 한국관광레저학회 학술발표대회 Vol.2021 No.7
This study is conducted to analyze the improvement and progress of regional tourism vitality by explaining the changes of tourism policies and laws in Hainan Province of China. Focusing on the offshore duty-free policy of Hainan International Tourism Island, it has collected data from relevant laws and regulations and explores the impact of policies on the tourism industry. Combined with the domestic strategic tendency, it also makes a comprehensive comparison and in-depth interpretation of the policies. By analyzing the implementation of the offshore duty-free policy, it proposes feasible and necessary suggestions for the adjustment of the offshore duty-free policy.