Esomeprazole magnesium enteric-coated pellet-based tablets with high acid tolerance and good compressibility

Jiang‑Yan Liu,Xiao‑Xue Zhang,Hao‑Yan Huang,이범진,Jing‑Hao Cui,Qing‑Ri Cao 한국약제학회 2018 Journal of Pharmaceutical Investigation Vol.48 No.3

The aim of this study was to develop esomeprazole magnesium (EMZ-Mg) enteric-coated pellets and pellet-based tablets, as well as to investigate the effects of pellet size and compression method on acid tolerance, content uniformity, compressibility, and stability of preparations. This study used two types of pellet cores, namely, microcrystalline cellulose (MCC) core with a particle size of 150–300 μm and sucrose core with a particle size of 600–700 μm. Enteric-coated pellets, which consisted of a drug-free core, a drug layer, a sub-coating layer (hydroxypropyl methylcellulose, 6 cps), and an enteric-coating layer ( Eudragit®L30D-55), were prepared by using a bottomspray fluidized bed-coating technique. Pellet-based tablets were prepared by using a direct compression method or a wet granulation method. The acid tolerances of the two types of enteric-coated pellets (MCC and sucrose cores) reached up to 98% in simulated gastric fluid (pH 1.0) within 2 h, and the dissolution rates in simulated intestinal fluid (pH 6.8) reached up to 85% of the labeled amount within 15 min. When compressed into tablets, the pellets based on MCC core (smaller particle size) displayed a significantly higher acid tolerance (up to 92%) compared with the pellets based on sucrose core (larger particle size). In addition, the MCC core-based tablets (F8), especially those prepared by using a granulation method, showed higher drug content uniformity and compressibility than the sucrose core-based tablets (F10), and no lamination phenomenon was observed during compression. The crystallinity of EMZ-Mg was altered during drug layering process, and some physicochemical interactions were observed between the drug and excipients. Moreover, the two types of enteric-coated pellets showed a relatively high stability after storage under high temperature and strong light. However, they showed poor stability under high humidity, resulting in remarkable degradation of active compound. The EMZ-Mg entericcoated pellets and pellet-based tablets were successfully developed, and reduction in pellet size and wet granulation reduced the differences in content uniformity and better protected the pellet coating from damages during compression.

A Weight Cluster-Based Hybrid Routing Algorithm of ZigBee Network

Yan Li,An-na Yuan,Xue Liu,Yong-bin Du,Tian-xin Huang,Hao-xin Cui 보안공학연구지원센터 2014 International Journal of Future Generation Communi Vol.7 No.2

Comparison Study of Percutaneous Kyphoplasty and Bone Cement-augmented Short-segment Pedicle Screw Fixation for Kummell Disease

( Yan-sheng Huang ),( Ding-jun Hao ),( Yong-ai Zhang ) 한국감성과학회 2017 한국감성과학회 국제학술대회(ICES) Vol.2017 No.-

Purpose : The purpose of this study was to compare the efficacy of percutaneous kyphoplasty (PKP) and bone cement-augmented short segmental fixation (BCA+SSF) for treating Kummell disease. Methods : Between June 2013 and December 2015, 60 patients were treated with PKP or BCA+SSF. All patients were followed up for 12-36 months. We retrospectively reviewed outcomes, including Oswestry Disability Index (ODI), visual analogue scale (VAS), and kyphotic Cobb angle. Results : VAS, ODI, and Cobb angle, measured postoperatively and at the final follow-up, were lower than those measured preoperatively in both groups (P< 0.05). VAS, ODI, and Cobb angle measured postoperatively demonstrated no significant differences when compared with those measured at the final follow-up in the PKP group (P >0.05). In the BCA+SSF group, VAS and ODI at the final follow-up were lower than those measured postoperatively (P< 0.05), but no significant difference was found in the Cobb angle (P >0.05). The PKP group had better VAS and ODI than the BCA+SSF group, postoperatively (P< 0.05). No significant difference was found in VAS and ODI at the final follow-up (P >0.05) or the Cobb angle measured postoperatively and at the final follow-up (P>0.05) between the two groups. Operative time, blood loss, and hospital stay in the PKP group were lower than those in the BCA+SSF group (P< 0. 05). No significant difference was found in complications (P >0.05). Conclusions : PKP patients had better early clinical outcomes, shorter operation and hospital admission times, and decreased blood loss, but similar complications, radiographic results, and long-term clinical outcomes compared with BCA+SSF patients.

Multicomponent assessment and ginsenoside conversions of Panax quinquefolium L. roots before and after steaming by HPLC-MSⁿ

Huang, Xin,Liu, Yan,Zhang, Yong,Li, Shuai-Ping,Yue, Hao,Chen, Chang-Bao,Liu, Shu-Ying The Korean Society of Ginseng 2019 Journal of Ginseng Research Vol.43 No.1

Background: The structural conversions in ginsenosides induced by steaming or heating or acidic condition could improve red ginseng bioactivities significantly. In this paper, the chemical transformations of red American ginseng from fresh Panax quinquefolium L. under steaming were investigated, and the possible mechanisms were discussed. Methods: A method with reversed-phase high-performance liquid chromatography coupled with linear ion trap mass spectrometry ($HPLC-MS^n$)-equipped electrospray ionization ion source was developed for structural analysis and quantitation of ginsenosides in dried and red American ginseng. Results: In total, 59 ginsenosides of protopanaxadiol, protopanaxatriol, oleanane, and ocotillol types were identified in American ginseng before and after steaming process by matching the molecular weight and/or comparing $MS^n$ fragmentation with that of standards and/or known published compounds, and some of them were determined to be disappeared or newly generated under different steaming time and temperature. The specific fragments of each aglycone-type ginsenosides were determined as well as aglycone hydrated and dehydrated ones. The mechanisms were deduced as hydrolysis, hydration, dehydration, and isomerization of neutral and acidic ginsenosides. Furthermore, the relative peak areas of detected compounds were calculated based on peak areas ratio. Conclusion: The multicomponent assessment of American ginseng was conducted by $HPLC-MS^n$. The result is expected to provide possibility for holistic evaluation of the processing procedures of red American ginseng and a scientific basis for the usage of American ginseng in prescription.

The completemitochondrial genome of the endangered Apollo butterfly, Parnassius apollo (Lepidoptera: Papilionidae) and its comparison to other Papilionidae species

Yan-hong Chen,Dun-yuan Huang,Yun-liangWang,Chao-dong Zhu,Jia-sheng Hao 한국응용곤충학회 2014 Journal of Asia-Pacific Entomology Vol.17 No.4

The Apollo butterfly, Parnassius apollo is a representative species of the butterfly subfamily Parnassiinae. Thischarming species is one of the most endangered butterfly species in the world. In this study, we sequenced itscomplete mitochondrial genome (mitogenome), with the aim of accumulating genetic information for furtherstudies of population genetics and mitogenome evolution in the Papilionidae. The 15,404-bp long mitogenomeharbors a typical set of 37 genes and is the largest butterfly mitogenome determined, except for Papiliomaraho (16,094 bp). Like many other sequenced lepidopteran species, one tRNATrp-like and onetRNALeu(UUR)-like sequences were detected in the AT-rich region. A total of 164 bp of non-codingsequences are dispersed in 14 regions throughout the genome. The longest intergenic spacer (68 bp) islocated between tRNASer(AGN) and tRNAGlu, and is the largest spacer at this location among Papilionidaespecies. This spacer may have resulted from an 8-fold repetition of a TTTCTTCT motif or a 4-fold repetitionof a CTTTATTT motif.

Changes of Soil Microbial Community Structure During Soil Mineralization under Two Kinds of Shrubland in Mountainous Area of Southern Ningxia,Northwest China

Huang Yi-Mei,Yan Hao,Jiang Yue-Li 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Flexural behavior of ultra high performance concrete beams reinforced with high strength steel

Jun-Yan Wang,Jin-Ben Gu,Chao Liu,Yu-Hao Huang,Ru-Cheng Xiao,Biao Ma 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.81 No.5

A detailed experimental program was conducted to investigate the flexural behavior of ultra high performance concrete (UHPC) beams reinforced with high strength steel (HSS) rebars with a specified yield strength of 600 MPa via direct tensile test and monotonic four-point bending test. First, two sets of direct tensile test specimens, with the same reinforcement ratio but different yield strength of reinforcement, were fabricated and tested. Subsequently, six simply supported beams, including two plain UHPC beams and four reinforced UHPC beams, were prepared and tested under four-point bending load. The results showed that the balanced-reinforced UHPC beams reinforced with HSS rebars could improve the ultimate loadbearing capacity, deformation capacity, ductility properties, etc. more effectively owing to interaction between high strength of HSS rebar and strain-hardening characteristic of UHPC. In addition, the UHPC with steel rebars kept strain compatibility prior to the yielding of the steel rebar, further satisfied the plane-section assumption. Most importantly, the crack pattern of the UHPC beam reinforced with HSS rebars was prone to transform from single main crack failure corresponding to the normal-strength steel, to multiple main cracks failure under the condition of balanced-reinforced failure, which validated by the conclusion of direct tensile tests cooperated with acoustic emission (AE) source locating technique as well.

Nonviral delivery systems for antisense oligonucleotide therapeutics

Si Huang,Xin-Yan Hao,Yong-Jiang Li,Jun-Yong Wu,Da-Xiong Xiang,Shilin Luo 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4

Antisense oligonucleotides (ASOs) are an important tool for the treatment of many genetic disorders. However, similar to other gene drugs, vectors are often required to protect them from degradation and clearance, and to accomplish their transport in vivo. Compared with viral vectors, artificial nonviral nanoparticles have a variety of design, synthesis, and formulation possibilities that can be selected to accomplish protection and delivery for specific applications, and they have served critical therapeutic purposes in animal model research and clinical applications, allowing safe and efficient gene delivery processes into the target cells. We believe that as new ASO drugs develop, the exploration for corresponding nonviral vectors is inevitable. Intensive development of nonviral vectors with improved delivery strategies based on specific targets can continue to expand the value of ASO therapeutic approaches. Here, we provide an overview of current nonviral delivery strategies, including ASOs modifications, action mechanisms, and multi-carrier methods, which aim to address the irreplaceable role of nonviral vectors in the progressive development of ASOs delivery.

Mixed H∞ and L2-L∞ Anti-synchronization Control for Chaotic Delayed Recurrent Neural Networks

Zhilian Yan,Yamin Liu,Xia Huang,Jianping Zhou,Hao Shen 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.12

This paper deals with the issue of mixed H∞ and L2 − L∞ anti-synchronization control for chaotic delayed recurrent neural networks with unknown parameters and stochastic noise. By means of the LyapunovKrasovskii functional method and some stochastic analysis techniques, an adaptive controller strategy is proposed to guarantee the mixed H∞ and L2 −L∞ anti-synchronization of the drive and response systems. When there is no stochastic noise, it is shown that the present control strategy is less conservative and less complex than a previously reported adaptive control method. Finally, a numerical example is employed to illustrate the applicability of the proposed adaptive control strategy.

Effects of Aluminum Nanoparticles on Thermal Decomposition of Ammonium Perchlorate

Zhu, Yan-Li,Huang, Hao,Ren, Hui,Jiao, Qing-Jie Korean Chemical Society 2013 대한화학회지 Vol.57 No.1

The effects of aluminum nanoparticles (AlNs) on the thermal decomposition of ammonia perchlorate (AP) were investigated by DSC, TG-DSC and DSC-TG-MS-FTIR. Addition of AlNs resulted in an increase in the temperature of the first exothermic peak of AP and a decrease in the second. The processing of non-isothermal data at various heating rates with and without AlNs was performed using Netzsch Thermokinetics. The dependence of the activation energy calculated by Friedman's isoconversional method on the conversion degree indicated the decomposition process can be divided into three steps. They were C1/D1/D1 for neat AP, determined by Multivariate Non-linear Regression, and changed to C1/D1/F2 after addition of AlNs into AP. The isothermal curves showed that the thermal stability of AP in the low temperature stage was improved in the presence of AlNs.