한국인에서 검출된 불규칙항체

조한익,차영주,안우성,송운홍 大韓血液學會 1984 大韓血液學會誌 Vol.19 No.1

증후성 단독 중뇌동맥협착의 예후

이수주,이광호,정진상,조수진,이원용,이한보 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

비강 및 비인두에 발생한 도립유두종과 편평상피암종의 p53단백 및 세포증식능에 관한 연구

한주호,윤기중,이재규,신대균,박근호,조향정,문형배 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2

The inverted papilloma and squamous cell carcinoma are common neoplasia in the sinonasal cavity and nasopharynx, but the incidence of these tumors are very low and the study on the oncogenesis or biological activity of the tumor cells are not well known. This study was designed to evaluate the oncogenic roles of the p53 gene and the proliferative activity of the tumor cells in the inflammatory polyp, inverted papilloma and squamous cell carcinoma. The experiment was carried by the immunohistochemical stains about the p53 protein, PCNA and Ki-67, histochemical stain about the AgNORs. and flow cytometric analysis about the DNA ploidy using the formalin fixed paraffin embedded tissues. The frequency of the expression of p53 protein was 0%(0/16 cases) in the inflammatory polyps, 18.8% (3/16 cases) in the inverted papillomas, and 87.5%(14/16 cases) in the squamous cell carcinomas. The labelling index(%) of the PCNA and Ki-67 was 5.3% and 3.3% in the inflammatoy polyps, 29.6% and 25.2% in the inverted papillomas, and 51.9% and 36.8% in the squamous cell carcinoma. The expression of the PCNA and Ki-67 was distributed in the periphery of the tumor islands of the inverted papilloma and was distributed in the both of center and periphery of the tumor islands of the squamous cell carcinoma. The number of nuclear AgNORs was increased in the order of inflammatory polyps (0.96), inverted papillomas(1.34) and squamous cell carcinoma(2.09). The frequency of the DNA aneuploidy was 0%(0/16 cases) in the inflammatory polyps, 18.8%(3/16 cases) in the inverted papillomas. and 12.5%(2/16 cases) in the squamous cell carcinomas. Above results indicates that the changes of the p53 gene and proliferative activity of the tumor cells are involved on the oncogenesis and the biological activity of the inverted papilloma or squamous cell carcinoma in the nasopharynx and sinonasa cavity.

장기간 댄스스포츠가 혈중 지질 및 효소 활성도에 미치는 영향

조현철,김준희,한주희 龍仁大學校 體育科學硏究所 1999 體育科學硏究論叢 Vol.9 No.1

The purpose of this study was to assay effect on blood lipid and ezyme activity during 20 weeks of dance sport and acute exercise. Ten females participated in dance sport program(90min./day. 2day/week) for 20 weeks. The results were obtained as follow : 1. CHOL and TG were decreased during dance sport program but no significant, also no significant between before exercise and after. 2. Amylase, Lipase, GGT and LDH were slightly increased during dance sport program but no significant, however, GOT was significantly(p<.05) increased between after 10 weeks and after 20 weeks. Also, LDH was significantly(p<.05) increased before exercise and after 10 weeks only in acute exercise variance. Conclusively, it is showed that CHOL and TG were decreased and enzyme activity was increased induced 20 weeks of dance sport program and acute exercise. It is suggested that dance could be serviceable effectively not only leisure but also good for health.

패널식 토론을 활용한 역사과 학습지도 모형 개발 연구

조한주 이화여자대학교 교육대학원 2004 이화교육논총 Vol.14 No.-

This study presents a panel-debate model of history education that stimulates students' interest in history, improves their ability to perceive history and critically develops their ability for self-study. This study verifies that the suggested panel-debate model can be practied very easily and we can achieve the education objective very effectively using the model in history classes. Results of tests and questionnaires strongly wupport this argument. The empirical framework for measuring the effect of discussions on students' performance is designed as follows. The 366 students of 11 classes (3rd graders) of J middles school in Seoul region are studied. They are divided into two groups: one experimental class used panel discussions when each chapter of history text was finished and summarized. Panel debate is organized with two groups that adopt contrasting views on the same issus for example, one proup represents advocates of the open-door policy of the Chosun dynasty in the 19th century with the other representing the closed-door policy and the two groups debate with each other on the pros and cons of their respective policies. Three topics of Chapter 4 of the textbook of Korean History are tested in this study to estimate the effect of the debated model on student performance (enhancement in historical thinking). The validity and reasonability of all the problems are evaluatied by questionnaires answered bjy history teachers in the Seoul metorpolitan region. The basic results are summarized as follows. First, student ability in historical thinking clearly impjroved through the introduction of debate into classrooms. Second, discussion leads students to have stronger motivation for studies than before and to regard historical knowledge as useful and applicable. Third, students participating in panel debate class records better performance than before and than those who do not. Fourth, self-studying ability is clearly increased. This is mainly due to excellent motivation for learning and thorough reviews on various aspects of historical fact. Fifth, in a questionnaire, history teachers evaluated the panel-debate model as being practiced easily in classrooms to improve student scholatic achievement, historical thinking and self-studying ability. Therefore, we can conclude that the debate model is highly manageable and develops historical and high-level thinking to enhance the ability for self-study.

Stroke에서 감압적 개두술, 정위적 조직 생검과 병리적 소견 고찰 : 중증 제뇌탈출을 동반한 초급성 뇌경색과 신경교종 내 출혈 감별 To differentiate the Herniated hyperacute Cerebral Infarction from the Glioma bleeding

이주용,조준,박호권,장상근,문창택,한혜승,이경룡 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

The authors in this manuscript aimed to provide a practical importance of the differential diagnosis of intracranial brain tumor with emphasis on non-neoplastic abnormalities such as cytotoxic edema of the penumbra zone in strokes. The well known SOLs are cerebral ischemic, inflammatory and dysplastic lesions, which intraaxially imitate glioma and other neurogenic tumors. Brain tumor is the one of common intracranial space-occupying lesions (SOLs) on the diagnostic images. However, many non-neoplastic lesions may be indistinguishable from tumors. Especially, early mortality used to be caused by space-occupying hyperacute ischemic stroke, brain edema and herniations. For the retrospective analysis, the authors reviewed the patient charts, the emergency brain Computerized Tomography (CT), magnetic resonance imaging (MRI), clinical stroke history. From Jan. 2003 to Dec. 2003, we managed total 61 acute strokes in ICU. Even though we operated six decompressive craniotomies, nine stereotactic craniotomies including two procedures of brain biopsy and three extraventricular drainage procedures, three patients (4.91%) were finally expired out from the induced herniation and medullary failure by those aggressive strokes. 43 patients (70.5%) were recovered good from stroke attack. 15 patients (24.6%) were improved with residual neurologic deficits. In conclusion, aside from growing efforts of the radiologist to make the early diagnostic impression, the authors suggest that urgent neurosurgical explorations with the pathologic diagnostic decision should be requested to decrease the fatality.

운동 종료 후의 당질·단백질·지질의 혼합물 섭취가 근 글리코겐 회복에 미치는 효과

육조영,송영주,류기성,장창현,김한수,김대경 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

In this study 8 male athletes and 8 female athletes for matches requiring endurance were examined for the purpose of comparison and analysis on the effect of absorption of sugars and effect of absorption of sugars+protein+fats restoration of muscular glycogen after elapse of 4 hours subsequent to closing 90 minutes exercise. (Amount of energy absorbed was same). Examinees were tested with 3 kinds of performance such as CPF Performance whereby they were made to take ① sugars (0.75 g/㎏) and protein (0.1g/㎏) and fats (0.02 g/㎏) after elapse of 1 hour subsequent to long hours of exercise and CHO Performance whereby examines were made to take ② sugars (1g/㎏) alone and Performance whereby they were made to take ③ placebo (which does not contain any sugars, protein or fats). Also the examinees took meals which had same amount of energy and nitrogen during the Performance on the date prior to experiment or on the date of experiment. Women during the exercise showed significantly higher rate of oxidation of fats, basic element of energy than that of men. In CHO Performance and CPF Performance value of blood sugar and density of insulin were significantly higher in comparison with performance with placebo. At such cases there was no difference between different genders. Same kind of phenomena were confirmed with restoration of muscular glycogen. From such fact it could be observed that absorption of fats alone and absorption of sugars+protein+fats in comparison with absorption of placebo after exercise promoted relatively higher level of restoration of muscular glycogen for both men and women.

융모성림프구를 보이는 비장변연부 림프종 1예

진한영,손창학,주영돈,박정하,이재익,조영완,이원식 인제대학교 2006 仁濟醫學 Vol.27 No.-

Splenic marginal zone lymphoma is very rare B-cell lymphoma, characterized by an indolent clinical course. Clinical features are moderate-to severe splenomegaly, absolute lymphocytosis, and bone marrow intrasinusoidal infiltration of lymphocyte. We report the case of a 37-year-old male with SMZL. He complained of LUQ pain, who had a massive splenomegaly and moderate lymphocytosis in peripheral blood. Immunophenotyping findings and morphologic findings were consistent with SMZL. He underwent splenectomy and received chemotherapy with cyclophosphamide for eight months. Now, one year later after surgery he has a nearly normal blood count with no treatment.

RE-17 : Recurrence of ovarian endometrioma in adolescents after conservative surgical treatment

( Yeon Jean Cho ),( Soo Yoon Lee ),( Mi La Kim ),( Joo Myoung Kim ),( Seok Joo Song ),( Jong Woon Bae ),( Jung Woo Park1,),( Hee Suk Lee ),( Myoung Seok Han1 ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

목적: To evaluate the cumulative recurrence rate of endometriomas after a laparoscopic endometriotic cyst enucleation in adolescents and to find the factors associated with recurrence. 방법: A multicenter retrospective cohort study was performed at 3 gynecologic surgery centers between January 2000 and December 2010. Patients surgically treated by laparoscopic enucleation of endometriotic cysts younger than 20 years old were selected. We excluded patients who had reproductive tract anomalies. Endometrioma recurrence was considered when transvaginal or transrectal sonography indicated a cystic mass with a diameter of ≥ 20 mm. 결과: In total, 105 patients were followed up for 47.3 ± 44.3 months (range, 3 - 161 months). Seventeen patients (16.2 %) experienced recurrence after the first-line surgery and 8 patients (7.6 %) underwent a second surgery. The median time to recurrence was 51.1 ± 9.1 months (SEM) (range, 8 - 111 months). The cumulative recurrence rates of endometrioma per patient at 24, 36, 60 and 96 months after the first-line surgery were 6.4 %, 10 %, 19.9 % and 30.9 %, respectively. Surgical characteristics such as the diameter of the cyst, rAFS stage, unilateral or bilateral involvement, co-existence of deep endometriosis were not associated with the recurrence in this age group. 결론: The short-term recurrence rate in adolescent after the first-line surgery is relatively low but is appears to be higher according to the follow- up duration. Long-term and strict follow up is needed who have undergone surgical treatment for endometriosis in adolescent period.

혈액에서 분리된 세균의 항생제감수성 : Vitek System을 이용한 최소억제농도측정 Minimal Inhibitory Concentration Determined by Vitek System

김의종,김선주,신보문,박명희,조한익,김상인 대한화학요법학회 1988 대한화학요법학회지 Vol.6 No.1

Minimal inhibitory concentrations of total 148 strains isolated from blood culture at Seoul National University Hospital were determined by Vitek System. 90% MIC of gram-negative bacteria against amikacin was 2-16㎍/㎖, and those against beta-lactams was > 16㎍/㎖ in general, Except Salmonella spp,. 90% MIC against chloramphenicol and tetracycline was >8㎍/㎖. Range of 90% MIC against vancomycin was ≤.5-4㎍/㎖ in case of garm-positive bacteria, except Enterococcus spp. which showed 90% MIC as >16㎍/㎖. Against ampicillin, 90% MIC of Staphylococcus spp. was >16㎍/㎖, but those of Streptococcus spp. was ≤.25-2㎍/㎖. Streptococcus viridans group showed 90%MIC against penicillin as ≤.03㎍/㎖. Susceptibility of gram-negative bacteria was generally 98% against amikacin, and those of gram-positive bacteria was 80% against vancomycin. 34% of Staphylococcus spp. was resistant of oxacillin. These results may be useful for the primary selection and the dosage determination of antibiotics in the treatment of patients with bacteremia.