호흡기 완자의 대조군의 혈청학적검사에 의한 Chlamydia Pneumoniae의 감염률

이해숙,천병력,진수희,이원길 대한임상미샐물학회 2004 Annals of clinical microbiology Vol.7 No.1

미용사들의작업관련성 근골격계 장애에 관한 연구

박수경,최영진,문덕환,전진호,이종태,손혜숙 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.3

목적 : 미용사의 작업관련 근골격계 장애 실태와 관련 요인을 알아보고자 한 것이다. 방법 : 최종 대상이 된 미용사 267명에 대하여 2000년 3월부터 5월까지 Karasek의 J7Q와 N10SH의 표준화 설문지를 이용하여 일반적 특성, 직무관련 스트레스, 근골격계 장애 자각증상 등을 자기 기입식으로 작성하게 하였다. 결과 : N10SH 감시기준에 의한 근골격계 자각 증상 호소율은 전체적으로 94.4%으로 높은 편이었으며, 각 신체부위별로는 어깨 부위(61.0%), 목 부위(59.9%), 허리 부위(53.2%), 손 및 손목 부위(41.6%)의 증상 호소율이 비교적 높게 나타났으며, 상대적으로 무릎 및 허벅다리 부위(36.7%), 발 및 발목 부위(34.8%), 등 부위(28.8%), 팔 및 팔꿈치부위 (28.5%), 종아리 부위 (28.5%), 손가락 (22.8%) 등은 낮았다. 다변량 분석 결과, 미용사들의 WRMDS는 직무 스트레스와 건강관련 습관 등에 영향을 받은 것으로 관찰되었으며, 부위별로 목부위는 직무의 불안정성, 허리부위는 여자, 음주, 결정의 허용범위, 손 및 손목부위는 음주, 무릎 및 허벅다리 부위는 흡연, 발 및 발목부위는 흡연, 결정의 허용범위, 그리고 등부위는 직무의 불안정성 등이 유의한 요인으로 관찰되었다. 결론 : 주관적인 증상 호소만을 이용한 제한점에도 불구하고 산업보건의 명확한 대상이 되지 않고 있는 미용사 등의 서비스업 종사자에 대한 WRMDS 연구의 기초자료로서 활용될 수 있을 것이다. Objectives : To determine the prevalence and related factors of work related musculoskeletal symptoms in hairdressers. Methods : Informations on general characteristics, job strain, and musculoskeletal symptoms were obtained by a self-administered questionnaire, through adopting NIOSH instrument and JCQ (Job content questionnaire) , from 267 hairdressers, between March and May, 2000. Results : The symptom prevalence by N10SH surveillance criteria in total was high as 94.4%; shoulder (61.0%), neck (59.9%), low back (53.2%), hand and wrist (41.6%), etc. In multiple logistic regression, significant factors affecting the symptoms by body region , job insecurity on neck; gender, alcohol, decision latitude on low back; alcohol on hand and wrist; smoking on thigh and knee; smoking, decision latitude on ankle and foot; job insecurity on upper back. Conclusions : Musculoskeletal symptoms of hairdresser were highly prevalent, and associated with job strain and their health habits. This Is a basic data of work related musculoskeletal disorders among hairdressers who are not the subjects of occupational health service at the present time in Korea.

의사국가시험성적과의 상관관계로 살펴본 임상종합평가시험의 가치 : 2002년 연세대 원주의대 졸업생을 대상으로

김명수,김춘배,차병호,박기창,권상옥,신계철,이혜용,강성준,차봉석 한국보건의료인국가시험원 2004 보건의료교육평가 Vol.1 No.1

Korean Medical Licensing Examination(KMLE) 2002 focused on evaluation of the integrative medical knowledge such as primary clinical care or problem-solving competence. We analyzed the correlation among the year-wise student academic scores(grade score), trial examination scores and KMLE score by correlation analysis and multiple regression method. Four times of trial examination were taken in 2001, which were composed according to the principles of KMLE. Trial examination scores were significantly correlated with student grade scores (p(0.05). KMLE score also correlated with student grade score a nd trial examination score. The grade score at senior had higher correlation coefficient than the grade score at junior in correlation analysis. In multiple regressions, grade score at senior and mean score of trial examinatio n score were significant variants affecting KMLE score. Based on this result, regression formula such as [KMLE score] = 110.596+21.449^*[6th grade score of student] + 0.577^*[mean of trial examination score] was established (R2=0.764, p<0.001). Our results show that the trial examination is useful evaluation tool for final assessment of medical achievements. Also a trial examination is used as a reference data for student guidance and control in preparing for KMLE.

알레르기 환자에서 특이알레르겐 항체 양성율과 관련요인

이선화,남해선,이성수,안현철,황규윤,박준수,,박춘식 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.2

Recently, allergic diseases are very prevalent in Korea, resulting in physical and economic losses during the life. It is well-known that the principle therapy is identification, eradication, and desensitization of allergens. There are many allergic diagnostic tools for identification of specific-allergens. However, none of them is satisfied with its efficiency due to lack of validity. Recently MAST-CLA has been widely used in the allergic clinical fields because of its simplicity and simultaneous identification of allergens. This study was designed to determine the positivity of allergen-specific antibodies using MAST-CLA in patients with allergic diseases, and evaluate the efficacy for allergen detection, compared to results of skin prick test. During June 2000 - September 2001, 325 study subjects visited Soonchunhyang University Chunan Hospital for the evaluation of allergic problems. Among them, 289 subjects were diagnosed with allergic disease and included for the study. Thirty four subjects visited children's allergic unit were evaluated specific allergens using a skin prick test at the same time. Our result as follows; 1. The positive rates of allergen-specific antibodies and total IgE were 51.2% and 73.4%, retrospectively. 2. There was significant difference in positive rate in age group, showing highest in teen ages(73.6%), but insignificant difference in sex in allergen-specific antibodies. 3. The positive rate was 60.4% in allergic rhinitis, 51.3% in allergic dermatitis, 46.9% in bronchial asthma, and 39.1% in urticaria in order(P=0.073). 4. Significant difference in month or season was observed, with highest rate in April(78.1%) and May(72.1%). The highest season was in spring(62.7%), and then summer(52.8%), fall(50.3%), and winter(41.4%) in order (P=0.04). 5. The three highest allergen-specific antibodies were D. pteronyssinus(39.3%), D. farinae(38.3%), and house dust(24.3%) in Korean inhalant pannel, However, in food pannel types of allergen-specific antibody were different as D. farinae(18.5%), Alternaria(18.5%), house dust(17.3%). 6. There were significant agreements between MAST-CLA and Skin prick test (D. farianae Kappa=0.636;D. pteronyssinus Kappa=0.78, both P<0.001) In conclusion, MAST-CLA could detect allergen-specific antibodies in patients with allergic diseases as a simple and valid tool of screening of allergy. Especially, it could be a useful measure of multiple allergens simultaneously in children However, more detailed allergens and valid assay for unmeasured allergens should be identified for Korean-specific allergens.

국내에서 유행하는 HIV의 전파 경로에 따른 Subtype 분포

이주실,남정구,김성순,강춘,최병선,김옥진,박미선,성봉모,서순덕,전수경,변승옥,신영오,조해월 대한감염학회 2001 감염 Vol.33 No.5

Background : Previous data have been reported that subtype B is prevalent in South Korea, but neither the extent nor the proportion of subtypes could be evaluated. This study was designed to analyze the distribution of HIV-1 subtypes, temporal instructions and transmission dynamics between epidemiological groups. Methods : 1,280 Koreans had been diagnosed as HIV seropositive during the period 1985 to 2000. Among them, 134 individuals were selected for this molecular epidemiological study. 134 DNAs were isolated from uncultured or cultured peripheral blood mononuclear cells. V3-V5 (0.7 kb) fragment of HIV-1 env gene was amplified by nested polymerase chain reaction and was sequenced. Results : HIV-1 isolates from thirty-seven homosexuals were all subtype B (100%). On the other hand, 66 isolates from 94 heterosexuals were subtype B (70%) and 28 were non B subtypes (30% : 13 A, 4 C, 2 D, 8 E , 1 G). Only subtype B strains were isolated from 73 males who were infected with HIV inside Korea while 16 B and 20 non B subtype strains were isolated from 36 males who were HIV infected outside of Korea. However, B and non B strains were isolated half and half from females who were infected inside Korea except one. Conclusion : The HIV-1 subtype B strains are prevalent in Korea from the early HIV infection until present in both homo and heterosexuals. Non B strains have been transmitted from men who were infected outside Korea to their spouses and casual partners. So, we need further study to monitor subtype B and non B HIV transmission in epidemiological groups of Korea, (Korean J Infect Dis 33:311∼318, 2001)

Development of mushroom mediums of Pleurotus eryngii using persimmon peels

Hae Soo Kim,Su Cheol Kim,Jong-Chun Cheong,Soo Jeong Cho 한국버섯학회 2014 버섯 Vol.18 No.2

Development of mushroom mediums of Pleurotus eryngii using persimmon peels

Hae Soo Kim,Su Cheol Kim,Jong-Chun Cheong,Soo Jeong Cho 한국버섯학회 2014 버섯 Vol.18 No.2

Five to thirty percent of persimmon peels were added to mushroom medium to investigate mycelial growth. Mycelial growth on the medium with persimmon peels was 82~96 mm (28 days) and was slower than that of the control without persimmon peels as, 100 mm (28 days). Mycelial growth time on medium with 5 to 15% persimmon peels was similar to the control without persimmon peels as 28 days but that on medium with 30% persimmon peels was delayed for 4 days. The time of pinhead formations in medium with 10 to 20% persimmon peels was 8 days, the growth time to harvest was 10 days. These results were similar to those of the control without persimmon peels. The sizes of pileus of treatments with 10 to 30% persimmon peels were tend to be smaller compared with the control. The length of stipe of 10% persimmon peels treatment was 89 mm which was shorter than that of the control with 90 mm. The thickness of stipes of 10 to 20% persimmon peels treatments were 40 to 46 mm which were tend to be thicker than that of the control with 42 mm.

Ion Shower Doping Effect in Diamond - Like Carbon Films

Soo Chul Chun,Kyu Chang Park,Kyo Jun Song,Jae Gak Kim,Seung Min Lee,Min Park,Myung Hwan Oh,Seong Soo Choi,Jung Hae Park,In Sang Yang,Jin Jang 한국진공학회 1995 한국진공학회 학술발표회초록집 Vol.- No.-

Is methylation analysis of SFRP2, TFPI2, NDRG4, and BMP3 promoters suitable for colorectal cancer screening in the Korean population?

( Soo-kyung Park ),( Hae Lim Baek ),( Junghee Yu ),( Ji Yeon Kim ),( Hyo-joon Yang ),( Yoon Suk Jung ),( Kyu Yong Choi ),( Hungdai Kim ),( Hyung Ook Kim ),( Kyung Uk Jeong ),( Ho-kyung Chun ),( Kyunge 대한장연구학회 2017 Intestinal Research Vol.15 No.4

Background/Aims: Colorectal cancer (CRC) screening using stool DNA was recently found to yield good detection rates. A multi-target stool DNA test (Cologuard^®, Exact Sciences), including methylated genes has been recently approved by the U.S. Food and Drug Administration. The aim of this study was to validate these aberrantly methylated genes as stool-based DNA markers for detecting CRC and colorectal advanced adenoma (AA) in the Korean population. Methods: A single-center study was conducted in 36 patients with AA; 35 patients with CRC; and 40 endoscopically diagnosed healthy controls using CRC screening colonoscopy. The methylation status of the SFRP2, TFPI2, NDRG4, and BMP3 promoters was investigated blindly using bisulfate-modified stool DNA obtained from 111 participants. Methylation status was investigated by methylation-specific polymerase chain reaction. Results: Methylated SFRP2, TFPI2, NDRG4, and BMP3 promoters were detected in 60.0%, 31.4%, 68.8%, and 40.0% of CRC samples and in 27.8%, 27.8%, 27.8%, and 33.3% of AA samples, respectively. The sensitivities obtained using 4 markers to detect CRC and AA were 94.3% and 72.2%, respectively. The specificity was 55.0%. Conclusions: Our results demonstrate that the SFRP2, TFPI2, NDRG4, and BMP3 promoter methylation analysis of stool sample DNA showed high sensitivity but low specificity for detecting CRC and AA. Because of the low specificity, 4 methylated markers might not be sufficient for CRC screening in the Korean population. Further large-scale studies are required to validate the methylation of these markers in the Asian population and to find new markers for the Asian population. (Intest Res 2017;15:495-501)

부인암 환자에서 발견되는 대장 선종의 특징

전정현,정성애,김성은,이종수,남승현,신정은,문혜성,김승철,유권 梨花女子大學校 醫科大學 醫科學硏究所 2003 EMJ (Ewha medical journal) Vol.26 No.1

연구목적 : 2형 Lynch 증후군에 대한 관심이 높아지면서 부인과 종양 환자에게 대장암과 대상 선종의 검사 필요성이 언급되어지고 있다. 본 연구에서는 본원의 부인과 종양 환자에서 병기 결정을 위해 시행되어지는 S상 결장경 검사에서 발견되는 대상 선종의 특징을 알아보고자 하였다. 방법 : 1993년 9월부터 2001년 3월까지 본원에서 부인과 종양을 진단받고 대장 증상 없이 병기 결정을 위해 S상 결장경검사를 시행한 187명을 대상으로 하였고(자궁경부암 139명, 난소암 35명, 자궁 내막암 13명) 정상대조군으로는 대장 증상 없이 건강 검진 목적으로 대장경 검사를 시행한 58명을 대상으로 하였다. 결과 : 부인과 종양 환자 187명 중 21명에서 대장 선종이 발견되었고(11.2%) 다발성 선종이 있어 모두 26예의 선종이 관찰되었다. 정상 대조군 58명에서는 3명에서 선종이 발견되었고(5.2%) 다발성 선종은 없었다. 부인과 종양 중 자궁 내막암 환자군에서 선종의 빈도는 38.5%로 정상 대조군에 비해 통계학적으로 유의하게 많았다. 진행성 선종의 빈도도 자궁 경부암 환자 12.5%, 난소암 환자 25.5%, 정상 대조군 33.3%에 비해 자궁 내막암 환자 83.5%로 유의하게 많았다. 부인과 종양의 선종 위치는 직장이 23.1%, S상결장이 76.9%였다. 결론 : 부인과 종양 환자의 대장 선종 빈도는 정상 대조군에 비해 많은 경향을 보였으나 통계학적 의의는 없었다. 그러나 자궁 내막암 환자군에서는 다른 부인과 종양 환자나 정상 대조군에 비해 유의하게 많은 선종과 진행성 선종의 빈도를 부였다. 따라서 부인과 종양 환자에게 대장경 검사를 통한 대장 선종 유무 검사가 필요하리라 생각된다. Objectives : In Lynch syndrome Ⅱ, colon cancer was associated with endometrial and ovarian cancer. The aim of this study was an evaluation for the clinicopathologic characteristics of rectosigmoid adenomas on preoperative sigmoidoscopy in gynecologic cancer patients. Methods : A total 187 gynecologic cancer patients(139 cervical, 35 ovarian, 13 endometrial cancer) and 58 normal controls were reviewed sigmoidscopic finding and pathologic reports retrospectively from September 1993 to March 2001. Results : The mean age of gynecologic cancer patients was 54(38-82) year-old and normal controls was 50(20-68) year-old. Total 26 adenomas were in 21 patients(11.2%) and 3 adenomas were in 3 normal controls(5.2%). The incidence of adenomas was 9.4% in cervical cancer, 8.6% in ovarian cancer and 38.5% in endometrial cancer. Multiple adenomas were in 5 gynecologic cancer patients and 0 normal controls. The incidence of advanced adenoma was 12.5% in cervical cancer, 25.5% in ovarian cancer, 83.5% in endometrial cancer and 33.3% in normal controls. The location of adenoma was 23.1% in rectum and 76.9% in sigmoid colon. Conclusion : The incidence of adenomas and multiple adenomas were higher in gynecologic cancer patients than normal controls but not significantly. The incidence of advanced adenoma and adenomas were significantly higher in endometrial cancer than normal controls. Colonoscopic evaluation of whole colon will be recommanded in gynecologic cancer than sigmoidoscopy.