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외과계 집중치료실에서 입원한 환자에서 APACHE II score의 의의
이영재,이영준,박순태,하우송,정민화,권수인,조영현,권진용,최상경,손신 대한외상학회 1997 大韓外傷學會誌 Vol.10 No.1
This study attempts to evaluate the prognostic value of the APACHE II scoring system in patients of surgical intensive care unit(SICU) and to examine its usefullness in stratifying these patients according to their surgical risk and as a potential aid in making rational and objective treatment decision. The records of 161 patients admitted to the Department of Surgery, Gyeong-Sang National University Hospital between Jan. 1991 and Dec. l995 were reviewed. 1) Of a total of 161 patients, 87 were male, 74 were female, and male to female ratio was 1.71: 1. 2) This group was seen most commonly in the age group of 55-64 which occupied 30.3% of entire group. 3) The distribution of patients according to the etiology were 74 patients(46%) in trauma, 61 patients(37%) iin postop-complication, 26 patients(9%) in others. 4) The distribution of patients according to the APACHE II scores was 9 to 29 point in adm. Day and the most patients was located between 10 and 14 of 62 patient(39%). 5) The length of hospitalization was 9 days in survived patients and 8 days in non-survived patients. The length of hospitalization of 77% of patients in this study was below 10 days. 6) The death rate was 45.45%(73 patient), this patients according to APACHE II scores was 13 to 29, median 19.2 in adm. Day, the most patients was located 20 to 24(20%). Non of the survived patients had the APACHE II score of above 20 points, but all recovered patients were below 13 points. 7) The median APACHE II score in survived patients was 10.52 point at adm. Day and 6.55 point at 5 days after admission. And non-survived patients was 20.25 point at adm. Day and 30.48 point 5 days after admission(p$lt;0.001). 8) Among the patients with low APACHE II score (below 14 points), there was no mortality. But, there was mortality with APACHE II score of above l5 points. We conclude that APACHE II scoring system is useful in measuring the severity of acute disease and predicting the outcome.
Multi-Dimensional Suppression of Normal Hematopoietic Cells by MN1-Induced Leukemic Cells
( Gyeong Sin Park ),( Ga Young Lee ),( Jae Seung Shim ),( Bin Cho ),( Chang Ki Min ),( Il Hoan Oh ) 한국조직공학과 재생의학회 2010 조직공학과 재생의학 Vol.7 No.5
Leukemogenesis comprises engraftment and self-renewal of leukemic stem cells, but also causes insufficiency in normal hematopoietic cells. Here we have investigated the influence of leukemia on various stages of normal hematopoietic functions using meningioma 1 (MN1)-induced acute myelogeneous leukemia model. When normal hematopoietic stem cells (HSCs) were co-transplanted with MN1 leukemia cells, the ability of normal HSCs to execute self-renewal was profoundly suppressed, as demonstrated by lower numbers of competitive repopulating units (CRUs) in the reconstituted bone marrows. The inhibitory effects become more prominent in the competition of leukemic cells for bone marrow niche. Moreover, when normal bone marrow cells were co-cultured with MN1 cells in vitro, the apoptosis of normal bone marrow cells (BMCs) were >2 fold increased, as compared to the culture of normal BMCs alone (p<0.05), whereas MN1 cells in the culture were not affected. The apoptosis of normal BMCs occurred more frequently in the mature myeloid cells than in lineage-negative populations in a manner dependent on direct contact with leukemic cells. Interestingly, the mean survival of leukemia mice was more closely correlated to the extent of bone marrow ablation caused by different dose of radiation to mice than the numbers of leukemic cells transplanted into the irradiated mice. Taken together, our results show that leukemia cells exert inhibitory effects on the multiple stages of normal hematopoiesis, and that such inhibitory influence should play as a key factor in the morbidity of leukemia during the course of illness.
박경신 ( Gyeong Sin Park ),강창석 ( Chang Suk Kang ) 대한내과학회 2012 대한내과학회지 Vol.83 No.6
Early gastric mucosa-associated lymphoid tissue (MALT) lymphoma is considered as an antigen-dependent disease associated with long standing antigenic stimulation by Helicobacter pylori (H. pylori) which induces chronic immune response and lymphoid tissue development at the gastric mucosa normally devoid of lymphoid tissue. With disease progression, antigen-independent clones occur via genetic alterations inducing aberrant activation of nuclear factor κB (NF-κB) pathway which is essential for regulation of normal lymphocyte development and activation. Four major translocations, including t (11;18)/API2-MALT1, t (1;14)/BCL10-IGH, t (14;18)/(IGH-MALT1 and t (3;14)/FOXP1-IGH, occur mutually exclusively and lead to generation of cIAP2-MALT1 fusion protein or overexpression of BCL10, MALT1 and Foxp1. Translocation t (3;14)(q27;q32)/BCL6-IGH and t (1;2)(p22;p12)/BCL10-IGκL also occur in some MALT lymphomas. Mutational inactivation of A20, global NF-κB inhibitor, involve the development of especially translocation-negative MALT lymphoma. Downstream effects of most genetic alteration converge on the same NF-κB mediated oncogenic pathway. This review discusses the current advances in the pathophysiology underlying the development of gastric MALT lymphoma and its progression. (Korean J Med 2012;83:689-698)
갑상선 세포에서의 요오드에 의한 Sodium-Iodide Symporter 조절 기전
박영주 ( Park Yeong Ju ),김태용 ( Kim Tae Yong ),이희수 ( Lee Hui Su ),김경원 ( Kim Gyeong Won ),김원배 ( Kim Won Bae ),박도준 ( Park Do Jun ),신찬수 ( Sin Chan Su ),박경수 ( Park Gyeong Su ),김성연 ( Kim Seong Yeon ),이홍규 ( Lee 대한내과학회 2003 대한내과학회지 Vol.65 No.5
목적 : Sodium-iodide symporter (NIS)는 갑상선호르몬의 생합성에 이용되는 요오드를 갑상선 내로 섭취시키는 역할을 담당하고 있는 중요한 당단백질로서 세포막에 위치해있다. 그러나 요오드가 NIS의 기능을 조절하는 기전에 대해서는 잘 밝혀져 있지 않은데, 최근에는 전사후 과정 중의 변화가 중요한 조절 기전일 가능성이 제시되기도 하였다. 그러므로 본 연구에서는 FRTL-5 갑상선세포에 요오드가 요오드 섭취능, NIS mRNA, 단백의 발 Background : The sodium-iodide symporter (NIS) is a key plasma membrane glycoprotein that mediates active iodide transport in the thyroid gland. Whereas relatively little is known about the mechanisms by which iodide regulates NIS activity, post-transcrip
박경찬 ( Park Gyeong Chan ),권중구 ( Kwon Jung Gu ),유길종 ( Yu Gil Jong ),배종석 ( Bae Jong Seog ),신재욱 ( Sin Jae Ug ),원태경 ( Won Tae Gyeong ),조규현 ( Jo Gyu Hyeon ),허성욱 ( Heo Seong Ug ),김은영 ( Kim Eun Yeong ),이창형 ( 대한소화기학회 2003 대한소화기학회지 Vol.42 No.6
There are diverse ring-like narrowings in the lower esophagus: mucosal ring, muscular ring, ring-like annular peptic stricture. Esophageal muscular ring is extremely rare and generally asymptomatic. It occurs at the proximal border of the esophageal vestibule that corresponds to the upper end of the lower esophageal sphincter. We experienced a case of lower esophageal muscular ring with a symptom of intermittent mild dysphagia for 40 years and report the findings with a review of the literature.(Korean J Gastroenterol 2003;42:539-543)