Caffeine이 지구성 운동 수행능력에 미치는 영향과 억제성 아미노산에 의하여 활성화되는 이온통로의 조절작용

김은경,김영표,천병옥,이계영,김연정,임백빈,조영욱,김창주,김성수 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

To investigate the effect and mechanism of caffeine on endurance exercise, two experiments were performed. First, to test caffeine effect on aerobic exercise, 200-300g Sprague-Dawley rats were used and three groups, control group, low caffeine injection group and high caffeine injection group, were divided. Blood smpling by heart puncture were done at rest, after 30 min treadmill exercise, and after maximal exercise. Blood glucose, free fatty acid concentration were detected and following results were obtained. Glucose concentration showed significant difference between groups(p=0.0305) and also significant changes were exhibited between time(p=0.0004). Free fatty acid concentration had no difference between groups. but had significance between times(p=0.00065). Exercise endurance performance time showed significant difference(p=0.02350 in high caffeine injection group compared to control group. In this experiments, endurance exercise capacity was increased by caffeine injection. Therefore, second experiment was performed to investigate the effect of caffeine on ion current induced inhibitory amino acid neurotransmitter. GABA and glycine. Single periaqueductal gray neuron was acutely dissociated and nystatin perforated patch clamp was performed under voltage clamping condition. Caffeine evoked outward current in PAG neuron dose dependent manner. 1mM of caffeine application had no response. but 3mM caffeine evoked about 32.5±8.539pA outward ion current and 10mM caffeine evoked about 215.46±19.4pA outward current. 10^-2mM GABA activated Cl￣current and recorded by inward current. Caffeine inhibited GABA activated Cl￣ current concentration dependent manner. 10^-2mM of caffeine had no effect on 1-^-2mM of GABA response. but 10^-1mM caffeine inhibited GABA activated Cl￣ current about 5.74±2.13%, 1mM caffeine inhibited about 17.25±2.70%, 10mM caffeine inhibited GABA response about 45.31±7.71%. 10^-1mM of glycine activated Cl￣ current and also recorded by inward current. Caffeine inhibited glycine activated Cl￣ current concentration dependent manner. 10^-2mM caffeine decreased glycine activated Cl￣ current about 4.61±1.650%, 10^-1mM caffeine decreased about 6.49±2.24%, 1mM caffeine decreased about 26.82±4.27%, and 10mM caffeine decreased glycine response about 94.47±1.39%. These results suggest that caffeine inhibite inhibitory amino acid, GABA and glycine, this response causes excitation of CNS and this seems to be the basic mechanism of increasing effect to aerobic exercise performance by caffeine.

미세전류자극 치료법의 진통효과

김계엽,오명화,김선은 東新大學校 2003 論文集 Vol.13 No.-

The purpose of study is that we will observe the change of CGRP(calcitonin gene-related peptide) within the cell with the immunohistochemistry method and then we will study the effect of microcurrent stimulation therapy following the frequency after inducing pain to rats with capsaicin. Eighty rat were classified to SD and they have growed for 8 weeks. I classify to four groups, ordinal group is used in experiment Ⅰ, the group which we induce pain is used in experiment Ⅱ, the application group which we induce pain and then the high frequency micro current stimulation is used in experiment Ⅲ, the application group which we induce pain and then the low frequency micro current stimulation is used in experiment Ⅳ, I get the following result. Compare with experiment Ⅱ, experiment Ⅲ, and expriment Ⅳ react from CGRP immunoreactive weakly, seven days later, they decrease remarkably. According to these results, from rats induced pain, micro current stimulation effect to reducing pain, but following frequency micro current stimulation therapy isn't different from immunoreactive CGRP.

병풀(Centella asiatica) 엑스-베타시클로텍스트린 고체 분산체를 함유한 폴록사머 407 히드로겔 제조 및 피부투과

김경국,곽은선,이계원,박진규,박목순,지웅길 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-

Extract of Centella asiatica(ECA), which is poorly water-soluble extract from the Centella asiatica is known to express excellent wound healing properties. ECA-β-cyclodextrin (asiaticoside-β-cyclodextrin and genin-β-cyclodextrin) solid dispersion system, which was prepared by freeze-drying method, was formulated as gels containing poloxamer 407 and propylene glycol, and evaluated with respect to their viscosity. stability, skin permeation and drug amount in the skin of hairless mouse. The average molar ratio asiaticoside-β-CD and genin-β-CD was 1:1,7 and 1:22, respectively. When the molar ratio of genin and β-CD was 1:5, madecassic acid made 100% solid dispersion system and asiatic and about 65%. In dissolution study, >99% of asiaticoside from asiaticoside-β-CD was dissolved in 5 minutes, and >99% madecassic acid and >64% asiatic acid from genin-β-CD. The apparent viscosity of poloxamer 407 gels with ECA-β-CD solid dispersion system increased in proportion to poloxamer 407 and gels showed that asiaticoside was most stable and madecassic acid stable and asiatic acid similar to stability of gel with free ECA. The permeation amount of asiaticoside in poloxamer gels through-hairless mouse skin decreased as the concentration of poloxamer 407 increased. When propylene glycol was added at the level of 10%, the permeation amount of asiaticoside at poloxamer gels through hairless mouse skin increased but from 15% it decreased. The permeation of asiaticoside into the skin of hairless mouse was estimated to be about 0.10 ㎍/㎠.

N値에 따른 地盤評價에 關한 硏究

박은규,류제천,김송만,박춘수 忠南大學校 産業技術硏究所 2002 산업기술연구논문집 Vol.17 No.1

In this paper, parameters of soil which are estimated with N-value and the results from laboratory test with the sample in construntion field are compared and analyzed. As a result, modification methods caused by existed weight is nearly same with the Equation of Liao & Whitman. Under same existed weight, the difference of N'/N is 0.9~2.1 in the Equation of Peck & Bazzaraa and Gibbs & Holtz. The Equation of O-Ja-Ki (&?'§) is more accurate with average value than any other equations in estimating a angle of internal friction of sand. The result of laboratory test is similar to the Equation of terzaghi & Peck. When unconfined compression strength of clay is estimated, the equation, q_(u) ≒ N/0.722, may represent many suggested equations. Standard Penetration Test is one of the most popular method to estimate parameters of soil because of its simplicity. Correlation between N-value and parameters of soil has been studied by many people but the absurd is still remain and we can face it on the construction field. Therefore field investigation and understanding about N-value are required when engineers estimate parameters of soil with N-value. There should be more study to get high accuracy of N-value and trustable parameters of soil.

식육산업의 발전을 위한 정육점에 관한 조사 연구

조규석,김계웅,김석은 公州大學校 産業開發硏究所 1998 産業開發硏究 Vol.6 No.-

This survey was carried out in order to investigate and analyse the current status of 81 total of fresh meat stores located in Chungnam, Seoul, Kyonggi, and Inchon districts for making a development strategy. The results obtained were as follows; 1. Of 81 total of fresh meat stores, family size were the largest in group of 4∼5 persons(77.8%), the number of stores below 10 pyeong were 63.0 percentage(51 stores), the number of stores for rent were 72.8 percentage(59 stores), the number of getting average monthly income below 1,500 thousand won 63.0 percentage(51 stores). 2. In duration of store management, the number of stores below 5 years-career were 42.0 percentage(34 stores), the number of stores over 16 years-career were 4.9 percentage(4 stores), and then, 52 total of stores answered that they would manage only duration of their generation(64.2%). 3. Fresh meats at 46 stores had been supplied through wholesale stores(56.8%), and those at 14 stores had been supplied through feeding and slaughtering at manager's farm(17.3%). 4. At sides of consumer's preference of fresh beef and pork, consumers preferred to loin muscle(40.7%) and bacon part(54.4%), respectively. 5. 22 total of managers would like to change the name of stores(27.2%), and then they answered to be changed in order of marketing center of animal products, fresh meat center, and marketing store of animal products. 6. All stores had been marketing beef and pork, chicken meat and eggs had been saled at 27 stores(33.3%) and 19 stores(23.5%), respectively. And then, other animal products had been supplied and saled at only 2 stores. 7. The sale price-down at 41 stores wanted to be controlled according to going down at farm price(50.7%). However, that at 25 stores didn't want to be gone down(30.9%).

일부 의과대학생의 음주 실태와 관련 요인

류소연,윤혜은,김기순,박종,강명근,박계남 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

Objectives : This study was performed to investigate the drinking status and the related factors with problem drinking in some medical students. Methods : The study subjects were 345 premedical students (freshmen and sophomore) and medical students (sophomore) in a medical school who replied to the self-administered questionnaire survey during March 2002. The questionnaire was composed of general characteristics, drinking status, social value about drinking, health status, satisfaction of life and alcohol use disorders identification test (AUDIT) . Results : The experience rate of drinking was 88.8% in male and 88.3% in female and it was tended to increase with going up the grade. Prevalence of hazardous, dependence, harmful and problem drinking classified by AUDIT score criteria were 66.2%, 3.0%, 7.0% and 5.1% in male and 34.9%, 0.9%, 1.9%, 1.9% in female. In male, the statistically significant related factors to Al JDIT scores were grade, religion, maternal drinking status, social value about drinking, affectionate feelings of those around one and satisfaction of life. Only social value about drinking was statistically significant correlated factor with AUDIT scores in female. As a result of multiple regression analysis, the related factors with AUDIT scores were sex, maternal drinking status, satisfaction of life and social value a bout drinking. Conclusion : The experience rate of drinking in medical students was higher than that in other college students. Grade, family drinking history, negative psychological feelings, social value about drinking were risk factors to problem drinking.

분무건조법을 이용한 방출 제어형 케토로락 고형지질마이크로스피어의 제제설계

윤재남,이은미,김동우,박용근,전일순,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-

Ketorolac (KA) and ketorolac tromethamine (KT) is the nonsteroidal anti-inflammatory drugs (NSAIDs) and has been used widely. To improve its frequent administration by control of drug release. we prepared SLM of KA and KT using Mirj 45 and 52 as surfactants and tripalmitin and tristearin as lipids by spry drying method SLM, as a disperse system for injection, were evaluated by measurement of particle sizes. SEM and drug release pattern As a result. spherical SLM were prepared and their particle size were in the range of 25-125 μm, which were dependant on the types and contents of lipid and sururfactants. Their dissolution rate were decreased as increasing lipid contents.

폴리메타크릴레이트를 이용한 케토로락 트로메타민 서방성 정제의 제조와 용출평가

전일순,윤재남,이은미,박용근,김동우,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-

To improve administration of ketolorac tromethamine, we prepared matrix tablets with Eudragit (RS 100 or 30D), diluents (avicel:lactose=l:l or Ca phosphate) and Mg stearate using wet-granulation method. Sustained release matrix tablets using Eudragit® RS 100 7 and 10% decreased dissolution rate at pH 1.2 and 68 Ca. phosphate as diluents showed more decreased dissolution rate than that of avicel:lactose (1:l). Sustained release matrix tablets using Eudragit® RS 30D also showed very effective sustained release of KT.

[P9-23] Histopathologic and Immunohistologic Studies of Achyranthes Radix Extracts and Swimming Exercise in Rheumatoid Arthritis Rats

Gye-Yeop Kim,Ki-Bok Choi,Eun-Jung Kim,Kyung-Yoon Kim,Ki-Won Nam,Ki-Cheol Sim,Gi_do Kim,Young-Jeoi Yoon,Tae-Yeol Kim 한국식품영양과학회 2008 한국식품영양과학회 학술대회발표집 Vol.2008 No.10

IoT를 적용한 알람 램프 및 스피커 모듈 제작에 관한 연구

황계호(Gye-Ho Hwang),김정현(Jung-Hyun Kim),김형준(Hyung-Jun Kim),박지환(Ji-Hwan Park),문원식(Won-Sik Moon),김홍용(Hong-Yong Kim),김경신(Kyoung-Shin Kim),김은영(Eun-Young Kim),김윤(Youn Kim),이봉섭(Bong-Seob Lee) 한국조명·전기설비학회 2021 한국조명·전기설비학회 학술대회논문집 Vol.2021 No.11

This paper focuses on user convenience, safety, and security to remotely notify an alarm with sound(auditory) and light(visual) for the alarm function when indoor/outdoor help is needed for the visually impaired, deaf, and children. proposed, designed, and manufactured a circuit configuration with a remote control function added without temporal and spatial restriction, and confirmed its applicability. In the future, children and the visually/hearing-impaired will also test whether the proposed device can be controlled remotely.