통풍성 관절염의 임상적 고찰

윤채중,정승문,김영학,김동규,허광식,김태원,배학연,정종훈,이승일,김평남 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.2

통풍은 Purine 대사의 이상으로 발생하는 질환으로, 고뇨산혈증인 사람의 전부가 통풍으로 발현되지 않고 증상의 출현 양상이 다양하여 진단과 치료에 주의가 필요하며, 조기에 적절한 조치를 한다면 충분히 조절이 가능한 질환이다. 본대학 내과학교실에서는 통풍으로 치료한 32명의 환자에서 임상양상, 병력과 검사소견을 분석하여 다음과 같음 결과를 얻었다. 1. 32명 모두 남자이며, 최초 발병 시기는 24세에서 72세로 평균 43.8±11.9세이었으며, 30대에서 40대까지가 19명(59.4%)으로 대부분을 차지하였다. 내원 당시 나이는 27세에서 75세까지로 평균 52.3±10.4세였으며, 내원시 까지 평균 유병기간은 8.5±6.8년으로 나타났다. 2. 동반 질환으로는 고지혈증 12례, 신장질환 10례, 고혈압 12례, 비만 8례, 당뇨 2례 등이었다. 3. 이환된 관절은 단관절 침범이 19례(59.4%), 다관절 침범이 13례 이었으며, 최초 이한된 관절은 족무지 중족골지골 관절로 19례(59.4%)로 가장 많았고, 통풍 결절은 20례(62.5%)에서 관찰되었으며, 유병기간이 10년 이상된 12례중 11례 (91.7%)에서 결절이 관찰되었다. 4. 평균 혈중 요산치는 9.17±1.75 ㎎/dl이었으며, 8.0 ㎎/dl에서 9.9 ㎎/dl 사이가 19명으로 전체의 59.4%를 차지하였다. Objective: The gout is a heterogeneous group of diseases resulting from tissue deposition of monosodium urate or uric acid crystals from extracellular fluids supersaturated with respect to this end product of human purine metabolism. The clinical manifestations are such as hyperuricemia, gouty arthritis, gouty nephropathy, uric acid nephrolithiasis. We analyze of clinical manifestations and associated factors in gout. Method: We have reviewed the medical records, radiologic findings and clinical results of thirty-two patients admitted at our department from April 1996 to July 1997. Result: 1) All patients were male. The mean age at initial attack was 43.8 years old, ranging from 24 to 72 years old. 2) The mean level of serum uric acid was 9.17mg/dl on admission. 3) The first metatarsopharyngeal joint was involved in 19 cases (59.4%). Tophus was observed in 20 cases (62.5%). 4) Hyperuricemia was associated with hypertension, obesity, nephrolithiasis and hyperlipidemia.

국내 동물실험윤리위원회의 설치 및 운영 현황

Moon Seok Yoon,Gwang Hee Lee,Hwang Lee,Tae Jun Lee 한국실험동물학회 2015 한국실험동물학회 학술발표대회 논문집 Vol.2015 No.8

Effects of wintering waterfowl's feces on nutrient dynamics of paddy fields and rice growth

Lee, Gwang Moon,Kim, Heung-Tae,Kim, Jae Geun The Ecological Society of Korea 2012 Journal of Ecology and Environment Vol.35 No.4

This experiment was conducted to investigate the effects of the addition of wintering waterfowl's feces prior to planting rice on nutrient dynamics, rice growth, and decomposition of rice straws in a controlled mesocosm. Waterfowl's feces and rice straws were placed on paddy soils in a mesocosm and the water level maintained at 5 cm. The amounts of supplied feces were 0 (control), 222, and 444 g/$m^2$. While the addition of feces showed no immediate effects, nutrients in the surface water increased in the month following treatment. Nutrients increased to a greater degree in the treatments with more feces added. Simultaneously, the decomposition of rice straws was promoted, indicating that more nutrients would be made available over time. The rice showed high productivity in the period during which nutrient level was increased, when rice needs more nutrients for the tillering stage. Therefore, the wintering waterfowl's feces could be associated with increased productivity during the growing season of rice through promoting nutrient supply and rapid decomposition of rice residue.

Catalytic combustion of BTX Compounds over CuO supported on TiO₂ Prepared by Sol-Gel method

( Gwang-ho Lee ),( Sung-woo Moon ),( Man-sig Lee ),( Gun-dae Lee ),( Seong-soo Hong ) 한국공업화학회 2002 한국공업화학회 연구논문 초록집 Vol.2002 No.0

Catalytic combustion is one of the most important air pollution control technology for eliminating volatile organic compounds present at low concentration in effluent streams. Supported copper-titanium oxide catalysts by FT-Raman, XRD, ESR, TPR with hydrogen. In situ activation of BTX(benzene, toluene and xylene) combustion on copper-titanium oxide of different copper loading and calcination temperature were studied. The catalyst activities were evaluated through conversion versus temperature(light-off curves). All catalysts used in this study were prepared by incipient wetness impregnation method. The aqueous solutions of copper nitrate were used as precursors and TiO₂ supports were impregnated with appropriate amounts of precursors solution to incipient wetness. The reaction characteristics were tested using quartz tubular reactor. The light off curve shifted to lower temperature with increasing copper loading. Among the catalysts calcined at various temperature, At 400°C calcined catalyst shows the highest activity among copper-titanium oxide catalysts. TPR indicates the formation of two types of dispersed species, which possibly are isolatec and polymeric, respectively. The dispersed species have high catalytic activity for combustion. At higher copper oxide loading, bulk CuO is formed, contributing little to the activity.

Synthesis of F-18 Labeled Capecitabine Using [¹⁸F] F₂ Gas as a Tumor Imaging Agent

Moon, Byung-Seok,Shim, Ah-Young,Lee, Kyo-Chul,Lee, Hyun-Jung,Lee, Byoung-Se,An, Gwang-Il,Yang, Seung-Dae,Chi, Dae-Yoon,Choi, Chang-Woon,Lim, Sang-Moo,Chun, Kwon-Soo Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.11

Plasma lipid profile comparison of five different cancers by nanoflow ultrahigh performance liquid chromatography-tandem mass spectrometry

Lee, Gwang Bin,Lee, Jong Cheol,Moon, Myeong Hee Elsevier 2019 Analytica chimica acta Vol.1063 No.-

<P><B>Abstract</B></P> <P>A comprehensive lipidomic analysis at the molecular level using nanoflow ultrahigh performance liquid chromatography-electrospray ionization-tandem mass spectrometry (nUHPLC-ESI-MS/MS) was performed to elucidate the lipid profiles of patient blood samples from five commonly found cancers (liver, lung, gastric, colorectal, and thyroid), which were then compared with the lipid profiles of healthy controls. From a total of 335 lipids identified and quantified, 50 high abundance lipids showing significant changes (>2-fold and <I>p</I> < 0.01) in at least one of the five cancers (vs. controls) were analysed. Lipid species were found to be significantly associated with more than one type of cancer; the numbers of lipid species found as significantly changed in all five, four, three, two, and one type of cancer were 1, 8, 8, 15, and 17, respectively. Among these, the high abundance phosphatidylethanolamine species, including lysophosphatidylethanolamine and PE plasmalogen, was significantly low in four cancer types, but was high in thyroid cancer. Receiver operating characteristic analysis resulted in the selection of lipids specific to each cancer: liver (four phosphatidylinositols and diacylglycerol 16:1_18:0), gastric (phosphatidylcholine 34:2, 36:3, and 36:4, and lysophosphatidic acid 18:2), lung (lysophosphatidylinositol 16:0, sphingomyelin d18:1/20:0, and triacylglyceride 50:1 and 54:4), and thyroid (lysophosphatidylinositol 18:0 and 18:1). Our results provide a basis for future validation of cancer-specific lipid markers with high diagnostic ability.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Plasma lipids from patients with five different cancers were compared by nUHPLC-MS/MS. </LI> <LI> PE, LPE, and PE plasmalogen were significantly decreased in all cancers, except thyroid cancer. </LI> <LI> Of 50 selected lipids (>2-fold change; <I>p</I> < 0.05), 33 were significantly changed in multiple cancers. </LI> <LI> Eighteen lipids were found to be unique to only one cancer type. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Gyro-Mouse for the Disabled: 'Click' and 'Position' Control of the Mouse Cursor

Gwang-Moon Eom,Kyeong-Seop Kim,Chul-Seung Kim,James Lee,Soon-Cheol Chung,Bongsoo Lee,Hiroki Higa,Norio Furuse,Ryoko Futami,Takashi Watanabe 대한전기학회 2007 International Journal of Control, Automation, and Vol.5 No.2

This paper describes a 'gyro-mouse', which provides a new human-computer interface (HCI) for persons who are disabled in their upper extremities, for handling the mouse-click and mouse-move function. We adopted the artificial neural network to recognize a quick-nodding pattern of the disabled person as the gyro-mouse click. The performance of our gyro-mouse was evaluated by three indices that include 'click recognition rate', 'error in cursor position control', and 'click rate per minute' on a target box appearing at random positions. Although it turned out that the average error in cursor positioning control was 1.4-1.5 times larger than that of optical mouse control, and the average click rate per minute was 40% of the optical mouse, the overall click recognition rate was 93%. Moreover, the click rate per minute increased from 35.2% to 44% with repetitive trials. Hence, our suggested gyro-mouse system can be used to provide a new user interface tool especially for those persons who do not have full use of their upper extremities.

Rosin Microparticles as Drug Carriers: Influence of Various Solvents on the Formation of Particles and Sustained-release of Indomethacin

Lee Chang Moon,Lim Seung,Kim Gwang Yun,Kim Do Man,Kim Dong Woon,Lee Hyun Chul,Lee Ki Young The Korean Society for Biotechnology and Bioengine 2004 Biotechnology and Bioprocess Engineering Vol.9 No.6

The aim of this study was to formulate a sustained release system for indomethacin (IND) with rosin gum obtained from a pine tree. Rosin microparticles were prepared by a disper­sion and dialysis method without the addition of surfactant. In order to investigate the influence of solvents on the formation of colloidal microparitcles, various solvents like ethanol, DMF, DMAc, and acetone were used. The rosin microparticles containing IND were characterized by X­ray differactometry (XRD) and differential scanning calorimetry (DSC). The morphologies of rosin microparticles observed by scanning electron microscopy (SEM) were spherical. The solvents used to dissolve rosin significantly affected the drug content and drug release rate of IND. The release behaviors of IND from the rosin microparticles were dependent on the drug content and size of the particles. Rosin micorparticles with a higher drug content and of a larger particle size had a slower drug release rate. Also, the IND release rate from the rosin microparticles could be regulated by the rosin content in the microparticles. From these results, rosin microparticles have the potential of being used as a sustained release system of IND.

국내 동물실험시행기관의 실험동물 사용 현황

Moon Seok Yoon,Gwang Hee Lee,Hwang Lee,Tae Jun Lee 한국실험동물학회 2015 한국실험동물학회 학술발표대회 논문집 Vol.2015 No.8

기능성 소화불량증 환자에서 자율신경 기능 이상과 위배출시간의 연관성

이종철,김영호,김창섭,손희정,박동일,김재준,최규완,백승운,고광철,이풍렬,이문규,김지은,심상군,현재근,성인경,장재권,이경한 대한소화기학회 2000 대한소화기학회지 Vol.36 No.5

Background/Aims: Autonomic nerve dysfunction may be responsible for the pathophysiologic mechanisms of various functional gastrointestinal disorders including functional dyspepsia. We evaluated whether the autonomic nerve dysfunction is related with delayed gastric emptying time. Methods: Forty patients (M:F=11:29, mean age=42.9 years) with functional dyspepsia and 14 asymptomatic controls (M: F=6:8, mean age=41.9 years) were enrolled in this study. Autonomic nerve function was measured by a standardized battery of five cardiovascular reflex tests. Gastric emptying time of solid meal was measured by scintigraphic method and expressed as the retention rate at 120 minutes (RR120). Results: RR120 was greater in the patients group than in the controls (48.1±19.7% vs 28.3±14.1%). Definite, severe, and atypical abnormal autonomic nerve functions were observed in 45% (18/40) of the patients group but not in the controls. The controls showed normal or early abnormality (5/14). Autonomic nerve dysfunction was not reted to delayed gastric emptying (p=0.42) and there was no significant correlation between the autonomic score and RR120 (p=0.55). Conclusions: Patients with functional dyspepsia had significant autonomic nerve dysfunction, as compared to asymptomatic controls. However, autonomic nerve dysfunction was not related with delayed gastric emptying time.