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RISS 인기검색어
- 검색키워드
- 저자 : Guiming Liang (검색결과 3 건)
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A reduced time-varying model for a long beam on elastic foundation under moving loads
Guiming Mei,Caijin Yang,Shulin Liang,Jiangwen Wang,Dong Zou,Weihua Zhang,Yunshi Zhao,Zhong Huang,Shuqi Song,Mengying Tan,Yao Cheng,Bingrong Miao 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.9
Dynamics of a long beam on the elastic foundation subjected to moving loads is studied in the present paper. The sliding window technique is used to dynamically truncate the long beam and a reduced time-varying beam system is obtained. The Hamilton’s principle is employed to establish the equations of motion of the reduced system. The variable separation method is adopted to solve dynamical responses of the reduced system. Examples of a long simply supported Timoshenko beam on the nonlinear foundation subjected to a single moving load and multiple loads are included. Numerical results of the reduced model compared with the ones obtained from the moving element model adapted in literature are carried out to show the validity and the good efficiency of the method proposed in the present paper.
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Chen Liang,Liu Yuting,Wang Zheyu,Zhang Leiyang,Xu Yi,Li Yinan,Zhang Lan,Wang Guiming,Yang Shuofei,Xue Guanhua 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Neutrophil extracellular traps (NETs) play an important role in abdominal aortic aneurysm (AAA) formation; however, the underlying molecular mechanisms remain unclear. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) may exert therapeutic effects on AAA through their immunomodulatory and regenerative abilities. This study aimed to examine the role and mechanism of MSC-EVs in regulating the development of NET-mediated AAA. Excessive release of NETs was observed in patients with AAA, and the levels of NET components were associated with the clinical outcomes of the patients. Datasets from the Gene Expression Omnibus database were analyzed and revealed that the PI3K/AKT pathway and ferroptosis were strongly associated with NETosis during AAA formation. Further experiments verified that NETs promoted AAA formation by inducing ferroptosis in smooth muscle cells (SMCs) by inhibiting the PI3K/AKT pathway. The PI3K agonist 740 Y-P, the ferroptosis inhibitor ferrostatin-1, and Padi4 deficiency significantly prevented AAA formation. MSC-EVs attenuated AAA formation by reducing NET release in an angiotensin II-induced AAA mouse model. In vitro experiments revealed that MSC-EVs reduced the release of NETs by shifting NETosis to apoptosis. Our study indicates an important role for NET-induced SMC ferroptosis in AAA formation and provides several potential targets for AAA treatment
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Ting Huang,Zhongning Guo,Guiming Liang,Shunzhi Qiao,Pengcheng Cai,Zhixiang Zou 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.8
The mask jet electrochemical deposition was used to deposit the large-scale micro cylinders array in this study. The effect of the pulse peak current density, pulse frequency, pulse duty cycle, injection pressure and scanning speed on the deposition characteristics (i.e. deposition height, surface roughness and surface quality of micro cylinders) have been investigated. The experiment results showed that the mean height and the surface roughness of micro cylinders increased form the peak current density. Moreover, due to a high pulse frequency provided a shorter pulse on-time, and significantly facilitating the renewal of the ion concentration in the electroforming fluid. A higher pulse frequency and larger duty cycle provide a better deposition characteristic. The injection pressure was found to have a significant effect on the height, the surface roughness and surface appearance of micro cylinders. Furthermore, when using higher scanning speed, the crystalline particles of the cast layer decrease, significantly decreasing the surface roughness. Based on discussed, the pulse current density of 12 A/dm 2 , a pulse frequency of 3000 Hz, a pulse duty cycle of 30 %, a jet inlet pressure of 80 kPa, a scanning speed of 8 mm/s and a number of scans of 100 is optimal parameters. Finally, by using these parameters, a large-area micro cylindrical array structures with a height of 22.53±2.46 μm and diameter of 205±3.21 μm were successfully fabricated. It can be concluded that the mask jet electrochemical deposition is a simple method to realize the electrodeposition of large-area array structures.
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