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      • KCI등재

        Coffin-Siris syndrome in two chinese patients with novel pathogenic variants of ARID1A and SMARCA4

        Liu Mingjie,Wan Linlin,Wang Chunrong,Yuan Hongyu,Peng Yun,Wan Na,Tang Zhichao,Yuan Xinrong,Chen Daji,Long Zhe,Shi Yuting,Qiu Rong,Tang Beisha,Tang Beisha,Chen Zhao 한국유전학회 2022 Genes & Genomics Vol.44 No.9

        Background: Coffin-Siris syndrome (CSS) is a rare congenital syndrome characterized by developmental delay, intellectual disability, microcephaly, coarse face and hypoplastic nail of the fifth digits. Heterozygous variants of different BAF complex-related genes were reported to cause CSS, including ARID1A and SMARCA4. So far, no CSS patients with ARID1A and SMARCA4 variants have been reported in China. Objective: The aim of the current study was to identify the causes of two Chinese patients with congenital growth deficiency and intellectual disability. Methods: Genomic DNA was extracted from the peripheral venous blood of patients and their family members. Genetic analysis included whole-exome and Sanger sequencing. Pathogenicity assessments of variants were performed according to the guideline of the American College of Medical Genetics and Genomics. The phenotypic characteristics of all CSS subtypes were summarized through literature review. Results: We identified two Chinese CSS patients carrying novel variants of ARID1A and SMARCA4 respectively. The cases presented most core symptoms of CSS except for the digits involvement. Additionally, we performed a review of the phenotypic characteristics in CSS, highlighting phenotypic varieties and related potential causes. Conclusions: We reported the first Chinese CSS2 and CSS4 patients with novel variants of ARID1A and SMARCA4. Our study expanded the genetic and phenotypic spectrum of CSS, providing a comprehensive overview of genotype-phenotype correlations of CSS.

      • KCI등재

        Television Viewing Time and the Risk of Colorectal Cancer Mortality among Japanese Population: The JACC Study

        Yuting Li,Ehab S. Eshak,Renzhe Cui,Kokoro Shirai,Keyang Liu,Hiroyasu Iso,Satoyo Ikehara,Akiko Tamakoshi,Shigekazu Ukawa,JACC Study Group 대한암학회 2021 Cancer Research and Treatment Vol.53 No.2

        Purpose Sedentary behavior attributes to the increased risk of some cancers and all-cause mortality. The evidence is limited for the association between television (TV) viewing time, a major sedentary behavior, and risk of colorectal cancer death. We aimed to examine this association in Japanese population. Materials and Methods A prospective cohort study encompassed of 90,834 men and women aged 40-79 years with no prior history of colorectal cancer who completed a self-administered food frequency questionnaire, and provided their TV viewing information. The participants were followed-up from 1988-1990 to the end of 2009. The hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated by the Cox proportional hazard regression for risk of colorectal cancer mortality according to TV viewing time. Results During the median 19.1-year follow-up period, we documented 749 (385 men and 364 women) colorectal cancer deaths. The multivariable-adjusted HRs for mortality from colorectal cancer were 1.11 (0.88-1.41) for 1.5 to < 3 hr/day, 1.14 (0.91-1.42) for 3 to < 4.5 hr/day and 1.33 (1.02-1.73) for ≥ 4.5 hr/day in comparison to < 1.5 hr/day TV watching; p-trend=0.038, and that for 1-hour increment in TV viewing time was 1.06 (1.01-1.11). Moreover, the multivariable-adjusted HR (95% CI) of colon cancer for 1-hour increment in TV viewing time was 1.07 (1.02-1.13). Age, body mass index, and level of leisure-physical activity did not show significant effect modifications on the observed associations. Conclusion TV viewing time is associated with the increased risk of colorectal cancer mortality among Japanese population, more specifically colon rather than rectal cancer.

      • SCIESCOPUSKCI등재

        Correlation analysis of muscle amino acid deposition and gut microbiota profile of broilers reared at different ambient temperatures

        Yang, Yuting,Gao, Huan,Li, Xing,Cao, Zhenhui,Li, Meiquan,Liu, Jianping,Qiao, Yingying,Ma, Li,Zhao, Zhiyong,Pan, Hongbin Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.1

        Objective: Temperature could influence protein and amino acid deposition as well as gut microbiota profile and composition. However, the specific effects of ambient temperature on amino acids deposition and gut microbiota composition remain insufficiently understood. Methods: A total of 300 one-day-old Avian broilers were randomly divided into three groups and reared at high, medium, and low temperature (HT, MT, and LT), respectively. Breast muscle and fecal samples were collected for amino acid composition analysis and 16S rRNA gene sequence analysis. Results: Our data showed that compared to the MT group, there was a decrease of muscle leucine and tyrosine (p<0.05), as well as an increase of methionine in the HT group (p<0.05) and a decrease of serine in the LT group. Examination of microbiota shift revealed that at genus level, the relative abundance of Turicibacter and Parabacteroides was increased in the HT group (p<0.05) and that the relative abundances of Pandoraea, Achromobacter, Prevotella, Brevundimonas, and Stenotrophomonas in the LT group were higher than those in the MT group (p<0.05). In addition, there were substantial correlations between microbes and amino acids. In the HT group. Turicibacter was negatively correlated with aspartic acid and tyrosine, whereas Parabacteroides was positively correlated with methionine (p<0.05). In the LT group, there were multiple positive correlations between Achromobacter and arginine, isoleucine or tyrosine; between Prevotella and cysteine or phenylalanine; between Brevundimonas and cysteine; and between Stenotrophomonas and cysteine as well as a negative correlation between Stenotrophomonas and serine. Conclusion: Our findings demonstrated that amino acid content of breast muscle and intestinal microbiota profile was affected by different ambient temperatures. Under heat exposure, augmented abundance of Parabacteroides was correlated with elevated methionine. Low temperature treatment may affect muscle tyrosine content through the regulation of Achromobacter.

      • KCI등재

        Catalytic pyrolysis of corncob with Ni/CaO catalysts for hydrogen-rich gas: Synthesis modes and catalyst/biomass ratios

        Hongyu Liu,Yuting Tang,Xiaoqian Ma,Wenchang Yue 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-

        With the depletion of traditional fossil fuels, biomass has evolved as a new environmentally friendly andsustainable alternative energy source. Ni/CaO catalysts are promising for CO2 capture and biomass catalyticuse. In this study, we examined four different synthesis modes for Ni/CaO catalysts: impregnationmethod, sol–gel method (citric acid complexation), sol–gel method with propionic acid modification andsedimentation method, and used the catalysts in the pyrolysis of corncob to produce hydrogen-rich gas at600 C. According to the results of the fixed-bed experiments, adding the propionic acid modification tothe citric acid complexation boosted hydrogen generation by 24.93 vol.%. The global behavior of the catalystssynthesized by the different methods follows the order sol-Ni1/Ca7-P > sol-Ni1/Ca7 > sed-Ni1/Ca7imp-Ni1/Ca7-A. At a catalyst/biomass ratio of 2:1, the maximum H2 concentration of 84.45 ± 1.02vol.% and H2 production of 26.84 ± 1.26 mmol/gbiomass were attained, as well as CO2 concentrations of just2.08 ± 0.03 vol.%. The H2 production was about 20 times higher than without the addition of the catalyst. Optimizing the synthesis modes and catalyst/biomass ratio produced high-quality hydrogen-rich gaswith a high H2 conversion of 88.95 ± 2.20 % and the energy efficiency of 52.73 %.

      • KCI등재

        A Dominant Mutation in ARL2 Causes Impaired Adventitious Root Development in Rice

        Shiping Liu,Yanhong Xue,Xiaofei Wang,Botao Zhang,Yuting Bi,Min Qiu,Guangxi Wang,Ping Wu 한국식물학회 2011 Journal of Plant Biology Vol.54 No.4

        Adventitious roots are vital for water and nutrient assimilation by cereal crops because they comprise the bulk of the fibrous root system. We isolated and analyzed a rice mutant, adventitious rootless 2 (arl2), which failed to initiate adventitious root primordia during early development. Its seminal root produced fewer lateral roots than from the wild type. This mutant also exhibited pleiotropic phenotypes of longer and thicker seminal roots, a different morphology for the first leaf, delayed heading, and a greater tiller angle. Physiological experiments showed that exogenous auxin and ethylene could rescue adventitious root growth, a response opposite that for two previously reported mutants, arl1 and gnom1. Activity in the auxin signal pathway and the polar auxin transport system was normal for arl2. Compared with the wild type, arl2 plants showed enhanced sensitivity to ethephon but decreased sensitivity to AgNO_3, an inhibitor of ethylene. Genetics analysis demonstrated that this mutant is controlled by a single dominant gene; ARL2 was mapped within a 100-kb interval on the short arm of chromosome 2.

      • KCI등재

        Advancing understanding of microbial biofilms through machine learning-powered studies

        Ting Liu,Yuting Zhai,정광철 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.12

        Microbial biofi lms are prevalent in various environments and pose signifi cant challenges to food safety and public health. The biofi lms formed by pathogens can cause food spoilage, foodborne illness, and infectious diseases, which are diffi cult totreat due to their enhanced antimicrobial resistance. While the composition and development of biofi lms have been widelystudied, their profound impact on food, the food industry, and public health has not been suffi ciently recapitulated. Thisreview aims to provide a comprehensive overview of microbial biofi lms in the food industry and their implication on publichealth. It highlights the existence of biofi lms along the food-producing chains and the underlying mechanisms of biofi lmassociateddiseases. Furthermore, this review thoroughly summarizes the enhanced understanding of microbial biofi lmsachieved through machine learning approaches in biofi lm research. By consolidating existing knowledge, this review intendsto facilitate developing eff ective strategies to combat biofi lm-associated infections in both the food industry and public health.

      • KCI등재

        Comparative Study of Basic Characteristics of Ordinary and Dark Muscle in Skipjack Tuna (Katsuwonus pelamis)

        Shulai Liu,Xiangyang Li,Xuxia Zhou,Xilin Zhang,Yuting Ding 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.5

        Differences between ordinary and dark muscleof skipjack tuna (Katsuwonus pelamis) including proximatecomposition, flavor, color, texture, and freshness wereinvestigated. Ordinary muscle had a higher crude proteincontent, but a lower crude lipid content than dark muscle. Alcohols (30.41%) and aldehydes (25.56%) were theprominent flavor compounds present in ordinary muscle,whereas hydrocarbons (39.51%) and ketones (21.81%)were more abundant in dark muscle. Different L*, a*, andb* values were also observed. Texture profile analysis(TPA) showed that dark muscle had higher values foradhesiveness, and lower values for cohensiveness, chewiness,and resilience. After mechanical breaking, large myofibrilfragments were observed in ordinary muscle under phasecontrast microscopy, but not in dark muscle. Freshnessindices, including K values, total volatile basic nitrogen(TVB-N), and thiobarbituric acid (TBA) values of darkmuscle were higher than for ordinary muscle.

      • KCI등재

        Experimental Research on Self-repairing of Diverging Stepped Magnetic Fluid Seals with Single Magnetic Source

        Xiaolong Yang,Yuting Liu,Ruibo Zhang,Shanghan Gao 한국자기학회 2021 Journal of Magnetics Vol.26 No.4

        To improve the self-repairing capability of common magnetic fluid seal structures after rupture due to excessive differential pressure in small clearance conditions and to verify the superiority of diverging stepped magnetic fluid seals, a diverging stepped magnetic fluid seal device with single magnetic source was tested. The effect of injection volume, clearance and numbers of teeth on the self-repairing performance of a diverging stepped magnetic fluid seals was investigated experimentally and compared with a common magnetic fluid seal. The experimental results indicate that the self-repairing performance of one stepped magnetic fluid seal device is better. The repair rate of a diverging stepped magnetic fluid seal structure decreases first and then increases with the increase of injection volume, and a minimum value is reached near the saturation value. The smaller the sealing gap and the fewer the number of bore teeth, the higher the repair rate of this structure.

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